Article
Oncology
Gianni Bisogno, Joerg Fuchs, Roshni Dasgupta, Andrea Ferrari, Josephine H. Haduong, Timothy Rogers, David O. Walterhouse, Beatrice Coppadoro, Wei Xue, Christian Vokuhl, Douglas S. Hawkins, Guido Seitz, Johannes H. M. Merks, Monika Sparber-Sauer, Rajkumar Venkatramani
Summary: This study aimed to investigate the prognosis of completely resected embryonal RMS at sites other than paratesticular, uterine, or vaginal primary sites. The results showed that patients with nonalveolar RMS completely resected at diagnosis have excellent survival rates when arising from nonparatesticular, uterine, and vaginal sites, and can be successfully treated with low-intensity chemotherapy.
Article
Microbiology
Feng Lu, Xinhui Wu, Huiqun Hu, Zixuan He, Jiacheng Sun, Jiapeng Zhang, Xiaoting Song, Xiangang Jin, Guofu Chen
Summary: Antibiotic therapy is the first choice for clinical treatment of osteomyelitis. However, the emergence of drug-resistant strains and bacterial biofilm formation have created a need for alternative treatments. Recent research has shown that low-frequency and low-intensity ultrasound combined with a sonosensitizer may be a safe and effective method for debridement and antibacterial therapy. The study found that combining ultrasound and the sonosensitizer emodin had significant antibacterial effects, possibly through the production of reactive oxygen species and the inhibition of related gene expression. This approach may provide new prospects for clinical treatment and help address the challenge of drug-resistant bacteria and biofilm formation.
MICROBIOLOGY SPECTRUM
(2022)
Article
Oncology
Mengshan Ni, Lijun Geng, Fangfang Kong, Chengrun Du, Ruiping Zhai, Yingchen Lyu, Chaosu Hu, Hongmei Ying
Summary: The study analyzed the therapeutic effect and prognostic factors of NPC patients with distant metastases at initial diagnosis receiving induction chemotherapy with IMRT. The results showed that platinum-containing induction chemotherapy combined with IMRT could prolong survival for some patients, but factors like pre-treatment SLDH, number of chemotherapy cycles, and M1 subcategories were associated with poor overall survival. Prospective clinical trials are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Peirong Wang, Feng Dong, Chuanshu Cai, Chunlin Ke
Summary: The study evaluated the efficacy of a combinatorial treatment strategy involving IC, IMRT, and AC for locoregionally advanced NPC. Results showed that a total of 4 cycles of IC and AC were more beneficial compared to 3 cycles, as well as a total of 6 chemotherapy cycles compared to 4 in terms of DFFR and PFS.
Article
Biochemistry & Molecular Biology
Junyong Dai, Yunfang Wu, Ziqun Chen, Linkang Xiao, Weili Zhang, Yang Cao
Summary: Prostate cancer is a common cancer type and early detection is crucial for successful treatment. This study presents a noninvasive imaging-guided therapy using targeted nanoparticles to enhance the efficacy and safety of cancer treatments. The modified sonosensitive nanoparticles can specifically accumulate in prostate tumors and release chemotherapy drugs in a controlled manner, providing a potential clinical treatment for prostate cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Erica A. K. DePasquale, Daniel Ssozi, Marina Ainciburu, Jonathan Good, Jenny Noel, Martin A. Villanueva, Charles P. Couturier, Alex K. Shalek, Sary F. Aranki, Hari R. Mallidi, Gabriel K. Griffin, Andrew A. Lane, Peter van Galen
Summary: The immune system plays a major role in inhibiting cancer progression, and the study of immunoregulatory interactions between malignant cells and T-cells in BPDCN provides valuable insights. By analyzing single-cell transcriptomes, it was observed that T-cells in BPDCN patients upregulate IFNA response and downregulate TNFA pathways, indicating T-cell exhaustion and immune evasion mechanisms in BPDCN.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zhining Yang, Zeman Cai, Qingxin Cai, Yingji Hong, Cuidai Zhang, Kaichun Huang, Zhixiong Lin, Mei Li
Summary: The study compared the efficacy and safety of induction chemotherapy followed by intensity-modulated radiotherapy versus concurrent chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma. The results showed similar outcomes in terms of PFS, OS, LRRFS, and DMFS between the two treatment arms, but the IC plus IMRT arm had lower incidences of leukopenia and anemia.
Article
Oncology
Qun Zhang, Zhen-Wei Peng, Zhuo-Sheng Gu, Yan Wang, Fang He, Wen-Bin Zhao, Wei Luo, Yong-Yu Mei
Summary: Combining Epstein-Barr virus load with TNM staging can be used to determine the individualized chemotherapy intensity for patients with locally advanced nasopharyngeal carcinoma, and it can reduce treatment toxicity.
Article
Oncology
Lifang Huang, Fan Wang
Summary: This study investigates the clinical characteristics and prognostic factors of primary Blastic plasmacytoid dendritic cell neoplasm (BPDCN) patients. The results show that BPDCN is a rare and poorly understood hematopoietic malignancy with a poor prognosis. Advanced age, second primary malignancies (SPMs), and radiation therapy are associated with survival outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Ijele J. Adimora, Nathaniel R. Wilson, Naveen Pemmaraju
Summary: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy arising from precursor dendritic cells. The treatment options for BPDCN have traditionally been limited, but with increased understanding of the disease, targeted therapies have emerged as promising approaches.
Review
Oncology
Celina Amaya, Elizabeth R. Smith, Xiang-Xi Xu
Summary: Taxane drugs, such as Taxol and Taxotere, are commonly used in chemotherapy for solid tumors. However, their major side effects, including neuropathy and alopecia, limit their efficacy. A recent laboratory finding suggests that low intensity ultrasound may be an effective solution to counter taxane cytotoxicity.
Article
Oncology
Maria Rosaria Sapienza, Giuseppe Benvenuto, Manuela Ferracin, Saveria Mazzara, Fabio Fuligni, Claudio Tripodo, Beatrice Belmonte, Daniele Fanoni, Federica Melle, Giovanna Motta, Valentina Tabanelli, Jessica Consiglio, Vincenzo Mazzara, Marcello Del Corvo, Stefano Fiori, Alessandro Pileri, Gaetano Ivan Dellino, Lorenzo Cerroni, Fabio Facchetti, Emilio Berti, Elena Sabattini, Marco Paulli, Carlo Maria Croce, Stefano A. Pileri
Summary: This study described neuronal features in blastic plasmacytoid dendritic cell neoplasm (BPDCN) for the first time, potentially changing our understanding of the disease and leading to new strategies for treatment. The identified neural metastatic inducers in BPDCN may offer therapeutic approaches for patients. The upregulation of neural genes in BPDCN is currently being investigated as therapeutic targets.
Article
Otorhinolaryngology
Yan He, Zhihao Zhao, Ying Wang, Jialing He, Jiamin Chai, Zhigong Wei, Hui Guan, Jingjing Wang, Zheran Liu, Ruidan Li, Xiaoli Mu, Ling He, Xingchen Peng
Summary: The study compared the efficacy and toxicities of induction chemotherapy followed by intensity-modulated radiotherapy (IC-RT) versus concurrent chemoradiotherapy (CCRT) in treating nasopharyngeal carcinoma (NPC) patients. Results showed no significant difference in overall survival, progression-free survival, distance metastasis-free survival, and locoregional relapse-free survival between IC-RT and CCRT groups. Tumor and lymph node stages were predictive of higher overall survival, while EBV-DNA levels were associated with locoregional relapse-free survival.
CLINICAL OTOLARYNGOLOGY
(2021)
Article
Oncology
Beung-Chul Ahn, Charny Park, Sang-Jin Lee, Sehwa Hong, Ji-Eun Hwang, Kyoungsuk Kwon, Jin Young Kim, Kyung-Hee Kim, Hyae Young Kim, Geon Kook Lee, Youngjoo Lee, Ji-Youn Han
Summary: This study investigated the efficacy of cyclophosphamide and adriamycin induction therapy prior to nivolumab in previously treated non-squamous non-small-cell lung cancer patients with low PD-L1 expression. It was found that the induction therapy reduced myeloid-derived suppressor cells and resulted in a durable response. Additionally, higher baseline levels of transferrin receptor protein predicted a favorable response to nivolumab in patients with low PD-L1 expression.
Review
Oncology
James M. Dolezal, Ari J. Rosenberg
Summary: HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) is rapidly increasing in incidence and has become the most common head and neck cancer. Although it has a better prognosis compared to HPV-negative OPSCC, standard multimodality therapy is often associated with significant toxicity. The role of induction chemotherapy in HPV-positive OPSCC remains uncertain, while immunotherapy shows potential in the recurrent/metastatic setting. Further investigation is needed to determine the effectiveness of induction therapy in HPV-positive OPSCC and the role of immunotherapy in the curative setting.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Oncology
Toma S. Omofoye, Anganile Kalinga, Ramapriya Ganti, Frank J. Minja, Timothy B. Rooney
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Prarthna V. Bhardwaj, Renuka Dulala, Senthil Rajappa, Chandravathi Loke
Summary: The management of breast cancers in India needs greater emphasis on awareness, early detection, standard pathologic testing, and cost-effective solutions. With standardized management, outcomes similar to those of developed countries can be expected. Additionally, clinical trials aimed at a more diverse population in LMICs like India should be undertaken.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Victoria E. Forbes, Mary D. Chamberlin, Vincent Dusabejambo, Tim Walker, Steve P. Bensen, Norrisa Haynes, Kathryn Nunes, Veauthyelau Saint-Joy, Frederick L. Makrauer
Summary: Global health education needs to adapt to the challenges we face, such as inequities and pandemics. Virtual teaching models are effective in delivering global health education and improving outcomes through bidirectional learning and equitable partnerships.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Tefta Isufaj Haliti, Ilir Hoxha, Rubena Mojsiu, Rohini Mandal, Goksu Goc, Kreshnike Dedushi Hoti
Summary: The IOTA Simple Rules have high diagnostic performance in distinguishing between benign and malignant adnexal masses, providing a reliable tool for early diagnosis of ovarian cancer.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Cecilia Felix Penido Mendes de Sousa, Jared Pasetsky, Gustavo Nader Marta, Megan Kassick, Fabio Ynoe Moraes, Luqman K. Dad
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Mary D. Chamberlin, Dafina Ademi Islami, Shqiptar Demaci, Richard J. Barth Jr
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Review
Oncology
Jeta Bunjaku, Arber Lama, Tawanda Pesanayi, Jeton Shatri, Mary Chamberlin, Ilir Hoxha
Summary: The evidence suggests that lifestyle factors such as alcohol and coffee intake may increase the risk of lung cancer, while tea intake may have a protective effect. However, the quality of evidence is currently low and further research is needed.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Mary Chamberlin, Christopher Booth, Gabriel A. Brooks, Achille Manirakiza, Fidel Rubagumya, Verna Vanderpuye
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Anne Christine Buteau, Alicia Castelo-Loureiro, Regina Barragan-Carrillo, Suyapa Bejarano, Alba J. Kihn-Alarcon, Enrique Soto-Perez-de-Celis
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Review
Oncology
Ilir Hoxha, Fitim Sadiku, Lot Hoxha, Midhet Nasim, Marie Anne Christine Buteau, Krenare Grezda, Mary D. Chamberlin
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)