☆ 4.5 Article

Return On Investment From Immunization Against 10 Pathogens In 94 Low- And Middle-Income Countries, 2011-30

HEALTH AFFAIRS (2020)

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HEALTH AFFAIRS

卷 39, 期 8, 页码 1343-1353

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PROJECT HOPE

DOI: 10.1377/hlthaff.2020.00103

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Health Care Sciences & Services Health Policy & Services

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Bill & Melinda Gates Foundation [OPP1128214]
World Health Organization
Bill and Melinda Gates Foundation [OPP1128214] Funding Source: Bill and Melinda Gates Foundation

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Reagent

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Estimating the value of global investment in immunization programs is critical to helping decision makers plan and mobilize immunization programs and allocate resources required to realize their full benefits. We estimated economic benefits using cost-of-illness and value-of-a-statistical-life approaches and combined this estimation with immunization program costs to derive the return on investment from immunization programs against ten pathogens for ninety-four low- and middle-income countries for the period 2011-30. Using the cost-of-illness approach, return on investment for one dollar invested in immunization against our ten pathogens was 26.1 for the ninety-four countries from 2011 to 2020 and 19.8 from 2021 to 2030. Using the value-of-a-statistical-life approach, return on investment was 51.0 from 2011 to 2020 and 52.2 from 2021 to 2030. The results demonstrate continued high return on investment from immunization programs. The return-on-investment estimates from this study will inform country policy makers and decision makers in funding agencies and will contribute to efforts to mobilize resources for immunization. Realization of the full benefits of immunization will depend on sustained investment in and commitment to immunization programs.

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AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2020)

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Article Public, Environmental & Occupational Health

Socioeconomic associations of poorly controlled epilepsy in the Republic of Guinea: cross-sectional study

Dylan R. Rice, Foksouna Sakadi, Nana Rahma Tassiou, Andre C. Vogel, Abdoul Bachir Djibo Hamani, Aissatou Kenda Bah, Alex Garcia, Bryan N. Patenaude, Abass Fode Cisse, Farrah J. Mateen

TROPICAL MEDICINE & INTERNATIONAL HEALTH (2020)

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Review Economics

Cost of Nine Pediatric Infectious Illnesses in Low- and Middle-Income Countries: A Systematic Review of Cost-of-Illness Studies

Gatien de Broucker, So Yoon Sim, Logan Brenzel, Margaret Gross, Bryan Patenaude, Dagna O. Constenla

PHARMACOECONOMICS (2020)

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Article Economics

Economic Benefits of Immunization for 10 Pathogens in 94 Low- and Middle-Income Countries From 2011 to 2030 Using Cost-of-Illness and Value-of-Statistical-Life Approaches

Elizabeth Watts, So Yoon Sim, Dagna Constenla, Salin Sriudomporn, Logan Brenzel, Bryan Patenaude

Summary: Vaccination has brought significant economic benefits in LMICs in the past decade, and there is potential for further economic gains in the future by maintaining vaccination coverage levels.

VALUE IN HEALTH (2021)

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Article Economics

Costs of Immunization Programs for 10 Vaccines in 94 Low- and Middle-Income Countries From 2011 to 2030

So Yoon Sim, Elizabeth Watts, Dagna Constenla, Shuoning Huang, Logan Brenzel, Bryan N. Patenaude

Summary: From 2011 to 2030, the total aggregate cost of immunization programs for ten vaccines in 94 low- and middle-income countries is estimated to be between $70.8 billion and $84.1 billion, with costs increasing over the two decades. The relative proportion of vaccine and delivery costs for certain vaccines like pneumococcal conjugate, human papillomavirus, and rotavirus vaccines is expected to increase as more countries introduce these vaccines. Moreover, uncertainty in vaccine prices for some self-financing countries could lead to total costs that are significantly higher than the base case scenario.

VALUE IN HEALTH (2021)

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Article Health Care Sciences & Services

The relationship between development assistance for health and public health financing in 134 countries between 2000 and 2015

Bryan N. Patenaude

Summary: The study found that development assistance for health (DAH) had limited impact on overall domestic public health investment, but had a positive effect on HIV-specific investments. In the private sector, DAH was positively correlated with overall and malaria-related spending, with no significant impact on HIV spending. Additionally, an increase in public financing had a positive effect on reducing under-5 mortality rates.

HEALTH POLICY AND PLANNING (2021)

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Article Public, Environmental & Occupational Health

Change in full immunization inequalities in Indian children 12-23months: an analysis of household survey data

Brian Wahl, Madhu Gupta, Daniel J. Erchick, Bryan N. Patenaude, Taylor A. Holroyd, Molly Sauer, Madeleine Blunt, Mathuram Santosham, Rupali Jayant Limaye

Summary: In India, both national and most state-level immunization coverage and wealth-related equality have improved over the last decade. Factors contributing to wealth-related full immunization inequality include antenatal care, maternal education, and socioeconomic status in 2005-06 and continued to play a role in 2015-16.

BMC PUBLIC HEALTH (2021)

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Article Infectious Diseases

The economic burden of diarrhea in children under 5 years in Bangladesh

Md Zahid Hasan, Gazi Golam Mehdi, Gatien De Broucker, Sayem Ahmed, Md Wazed Ali, Jorge Martin Del Campo, Dagna Constenla, Bryan Patenaude, Md Jasim Uddin

Summary: This study estimated the cost of illness due to diarrhea in Bangladesh, finding that the average cost per episode for caregivers was $62, with $71 from the societal perspective. Investing in vaccines can help reduce the prevalence of diarrheal diseases and alleviate the public health burden.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Health Policy & Services

An Empirical Examination of the Inequality of Forgone Care in India

Bryan Patenaude, Krishna D. Rao, David H. Peters

Summary: This study examines inequity in forgone care for maternal and child health services in India. Results show that forgone care is disproportionately concentrated among the poor, especially in rural areas, with significant state-level inequalities. Decomposition analysis highlights socioeconomic status, maternal education, rural status, and state-level per capita health spending as key drivers of observed inequalities.

HEALTH SYSTEMS & REFORM (2021)

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Article Immunology

The economic burden of pneumonia in children under five in Uganda

Elizabeth Ekirapa-Kiracho, Gatien De Broucker, Anthony Ssebagereka, Aloysius Mutebi, Rebecca Racheal Apolot, Bryan Patenaude, Dagna Constenla

Summary: The study estimated the economic burden of treating pneumonia on households, showing that the treatment of pneumonia incurred significant costs in both public healthcare facilities and private medical institutions, with direct and indirect costs impacting families significantly.

VACCINE: X (2021)

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Article Public, Environmental & Occupational Health

A standardized approach for measuring multivariate equity in vaccination coverage, cost-of-illness, and health outcomes: Evidence from the Vaccine Economics Research for Sustainability & Equity (VERSE) project

Bryan Patenaude, Deborah Odihi, Salin Sriudomporn, Joshua Mak, Elizabeth Watts, Gatien de Broucker

Summary: This study proposes a standardized approach, called the Vaccine Economics Research for Sustainability & Equity (VERSE), to measure multivariate equity in vaccine coverage. The methods are applied to data from India's National Family Health Survey to assess the equity in vaccination coverage. The results show that the most disadvantaged group is more likely to be unvaccinated and less likely to be fully immunized, with maternal education being the primary factor contributing to observed inequality.

SOCIAL SCIENCE & MEDICINE (2022)

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Article Health Care Sciences & Services

Contingent Valuation: A Pilot Study for Eliciting Willingness to Pay for a Reduction in Mortality From Vaccine-Preventable Illnesses for Children and Adults in Bangladesh

Deborah Odihi, Gatien De Broucker, Zahid Hasan, Sayem Ahmed, Dagna Constenla, Jasim Uddin, Bryan Patenaude

Summary: This study utilized the contingent valuation (CV) method to estimate willingness to pay (WTP) and calculated the value of statistical life (VSL) in Bangladesh. Results showed a higher proportion of males, with a mean annual self-reported income of $5,683.36. The average VSL was $11,339.70 with a high level of stability. The vaccine intervention had the highest proportion of $0 WTP, and 93% of participants were able to describe the vaccine effectiveness using their own family as an example.

VALUE IN HEALTH REGIONAL ISSUES (2021)

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