期刊
GENOMICS
卷 112, 期 4, 页码 2857-2865出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2020.03.025
关键词
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资金
- Junta de Extremadura [PO17024]
- European Social Fund [09.3.3-LMT-K-712-01-0016]
- Research Council of Lithuania (LMTLT)
- Swedish Research Council [2016-03419]
- Swedish Research Council [2016-03419] Funding Source: Swedish Research Council
- Vinnova [2016-03419] Funding Source: Vinnova
Plasmodium parasites are present in a wide range of host species, some of which tend to be more susceptible than others, potentially as an outcome of evolved tolerance or resistance. Common starlings seem to cope with malaria infection while common crossbills are more susceptible to the same infections. That raises the question if the parasites rely on the same molecular mechanisms regardless of host species or do Plasmodium parasites change gene-expressions in accordance to the environment different hosts might provide? We used RNA-sequencing from starlings and crossbills, experimentally infected with Plasmodium homocircumflexum (lineage pCOLL4). The assembled transcriptome contained a total of 26,733 contigs. Parasite expression patterns differed between bird species. Parasites had higher expression of cell-invasion genes when infecting crossbills compared to starlings whereas in starlings genes related to apoptosis or/and oxidative stress showed higher expression levels. This article reveals how a Plasmodium parasite might adjust its expression and gene function depending on the host species infected.
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