Article
Biochemistry & Molecular Biology
Hajnal A. Kovacs, Eniko Lazar, Gyorgy Varady, Gabor Sirokmany, Miklos Geiszt
Summary: The study reveals that PXDN undergoes proteolytic cleavage in vivo, with the involvement of furin. Only the proteolytically processed PXDN can integrate into the extracellular matrix, highlighting the importance of proteolysis in PXDN's collagen IV-crosslinking activity. Additionally, peroxidase activity is shown to play a key role in the proteolytic processing of PXDN.
Article
Biochemistry & Molecular Biology
Bianca Dempsey, Litiele Cezar Cruz, Marcela Franco Mineiro, Railmara Pereira da Silva, Flavia Carla Meotti
Summary: Uric acid, the main substrate for peroxidases in plasma, can generate urate free radical and urate hydroperoxide through oxidation by human peroxidases. This process may affect endothelial function and contribute to the harmful effects of uric acid on the vascular system. Peroxidasin (PXD N), a recently discovered heme-peroxidase, has been associated with cardiovascular disease, cancer, and renal fibrosis. The present study aimed to investigate the interaction between uric acid and PXD N, and its impact on the function of the enzyme in human endothelial cells.
Article
Cardiac & Cardiovascular Systems
Guanxin Zhang, Qing Qin, Chen Zhang, Xiaobo Sun, Kyosuke Kazama, Bing Yi, Fang Cheng, Zhi-Fu Guo, Jianxin Sun
Summary: The study finds that NDRG1 plays an essential role in cell differentiation, proliferation, and stress responses. The expression of NDRG1 significantly increases in cytokine-stimulated endothelial cells and atherosclerotic lesions. Inhibition of NDRG1 not only suppresses the expression of procoagulant molecules but also exerts antithrombotic effects in endothelial cells, highlighting its potential as a therapeutic target for vascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Warkala, Dongying Chen, AnnJosette Ramirez, Ali Jubran, Michael Schonning, Xia Wang, Huaning Zhao, Sophie Astrof
Summary: The development of the fourth pharyngeal arch arteries involves a multistep process with contributions from SHF-derived ECs, remodeling of endothelial plexus into PAAs, and remodeling of PAAs into the aortic arch artery and its major branches. Cell-ECM interactions regulated by integrin alpha 5 beta 1 and Fn1 are essential at each developmental stage.
CIRCULATION RESEARCH
(2021)
Article
Cell Biology
Jasmin Maier, Manuel Rogg, Martin Helmstaedter, Alena Sammarco, Oliver Schilling, Benedikt Sabass, Jeffrey H. Miner, Joern Dengjel, Gerd Walz, Martin Werner, Tobias B. Huber, Christoph Schell
Summary: EPB41L5 protein plays a critical role in regulating podocyte adhesome function, affecting extracellular matrix assembly and deposition of core GBM components. This study reveals how EPB41L5 influences cell-cell force transmission and ECM formation by controlling the maturation of integrin adhesion complexes.
Article
Biochemistry & Molecular Biology
Fabio Bertani, Dalila Di Francesco, Maria Dolores Corrado, Maria Talmon, Luigia Grazia Fresu, Francesca Boccafoschi
Summary: Cardiovascular diseases, including ischemic heart disease and stroke, are the leading cause of global mortality, with almost all sharing a common feature of endothelial dysfunction. Research suggests that ECs stimulated at low shear stress may be involved in paracrine induction of peripheral endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qinghua Di, Yansu Li, Shuzhen Li, Aokun Shi, Mengdi Zhou, Huazhong Ren, Yan Yan, Chaoxing He, Jun Wang, Mintao Sun, Xianchang Yu
Summary: This study reveals the signaling mechanisms involved in cold acclimation memory and highlights the essential role of photosynthesis mediated by RBOH-dependent signaling in cold acclimation memory.
Review
Cell Biology
Scott S. Kemp, Prisca K. Lin, Zheying Sun, Maria A. Castano, Ksenia Yrigoin, Marlena R. Penn, George E. Davis
Summary: This article discusses the functional importance and role of pericytes in capillary tube network assembly, as well as their association with EC sprouting behavior and tube formation, and the structure of EC tubes and deposition of basement membranes. It was found that various factors derived from ECs are crucial for pericyte recruitment, proliferation, and basement membrane deposition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuan Li, Qingya Dang, Zhiyi Li, Chuting Han, Yan Yang, Miaoling Li, Pengyun Li
Summary: This study found that acacetin protects against endothelial dysfunction in hypertension by activating the AKT/eNOS pathway and modulating mitochondrial function. The findings suggest that acacetin may be a potential therapeutic agent for the prevention and treatment of hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xin Lyu, Lizhong Zeng, Jie Shi, Zongjuan Ming, Wei Li, Boxuan Liu, Yang Chen, Bo Yuan, Ruiying Sun, Jingyan Yuan, Nannan Zhao, Xia Yang, Guoan Chen, Shuanying Yang
Summary: The resistance to icotinib treatment is associated with the autophagy mechanism induced by the STAT3/FOXM1/ATG7 signaling, providing new insights into the potential clinical value of ATG7-dependent autophagy in icotinib treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Hematology
Chonghe Zhang, Hao He, Jianing Dai, Yunxia Li, Jing He, Wu Yang, Jialin Dai, Feng Han, Wenyan Kong, Xiaohong Wang, Xiangjian Zheng, Jing Zhou, Weijun Pan, Zhongwen Chen, Singhal Mahak, Yaoyang Zhang, Feng Guo, Junhao Hu
Summary: This study reveals a novel role for KANK4 in arteriogenesis in response to ischemia. KANK4 links VEGFR2 to TALIN-1, resulting in enhanced VEGFR2 activation and increased EC proliferation, highlighting that KANK4 is a potential therapeutic target for promoting arteriogenesis for arterial occlusive diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Zehua Zuo, Jie Liu, Zhihao Sun, Yu-Wei Cheng, Michael Ewing, Thomas H. Bugge, Toren Finkel, Stephen H. Leppla, Shihui Liu
Summary: The current antitumor microenvironment strategies have limited efficacy due to poor understanding of the roles and contributions of tumor stromal cells in tumor development. Researchers have developed a versatile in vivo delivery system for an anthrax toxin protein, which allows for clear genetic evaluation of individual tumor stromal elements. The findings reveal the specific contribution of tumor endothelial cells (ECs) to the antitumor activity of the toxin, highlighting the importance of the MEK-ERK-c-Myc central metabolic axis in tumor ECs for tumor progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Gastroenterology & Hepatology
Zhongxing Liang, Peijian He, Yiran Han, C. Chris Yun
Summary: The LPA(5) receptor is identified as a potent regulator of the survival of stem cells and transit-amplifying cells in the intestine, with its loss leading to increased apoptosis and decreased proliferation of crypt epithelial cells. Loss of LPA(5) also induces ablation of the intestinal mucosa, which increases morbidity in Lpar5(KO) mice.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Hematology
Emily M. Nordquist, Punashi Dutta, Karthik M. Kodigepalli, Carol Mattern, Michael R. McDermott, Aaron J. Trask, Stephanie LaHaye, Volkhard Lindner, Joy Lincoln
Summary: This study demonstrates that aortic valve endothelial injury can trigger beneficial responses in young mice, but not in aging mice with known endothelial dysfunction. Within 48 hours following injury, young wild-type mice restore endothelial barrier function through increased cell proliferation and upregulation of specific molecular pathways.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Oncology
Yuan Xie, Liqun He, Yanyu Zhang, Hua Huang, Fan Yang, Min Chao, Haiyan Cao, Jianhao Wang, Yaling Li, Lingxue Zhang, Lele Xin, Bing Xiao, Xinxin Shi, Xue Zhang, Jiefu Tang, Lene Uhrbom, Anna Dimberg, Liang Wang, Lei Zhang
Summary: Inhibiting the Wnt signaling pathway can increase Temozolomide (TMZ) delivery and sensitize glioma to chemotherapy. Transcriptome analysis revealed that Wnt signaling inhibition enhances vascular transcytosis by upregulating PLVAP and downregulating MFSD2A. Additionally, Wnt signaling inhibition also enhances caveolae-mediated transcytosis in tumor endothelial cells (ECs). These findings suggest that Wnt signaling regulates MFSD2A-dependent TMZ delivery through a caveolae-mediated pathway, highlighting Wnt signaling as a promising therapeutic target for GBM treatment.