Article
Pharmacology & Pharmacy
Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Fumiaki Oka, Yuichi Maruta, Naomasa Mori, Natsumi Fujii, Michiyasu Suzuki, Hideyuki Ishihara
Summary: This study aimed to investigate the effects of TRPM8 agonist on hyperthermia-induced Febrile Seizures (FSs). It was found that the TRPM8 agonist can reduce the occurrence of FSs and decrease the amplitude of fast ripple, suggesting its potential as a therapeutic option for hyperthermia-induced FSs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Lindsay Willmore, Courtney Cameron, John Yang, Ilana Witten, Annegret Falkner
Summary: This research reveals differences in DA neuron activity and behavior between resilient and susceptible individuals after experiencing stress. Resilient mice show more activity near the aggressor, while susceptible mice exhibit more activity at the end of attacks and the beginning of fleeing. Optogenetic stimulation of NAc-projecting DA neurons can promote resilience and alter behavior during defeat.
Article
Dentistry, Oral Surgery & Medicine
Yun Sook Kim, Munkh-Ochir Otgonsuren
Summary: This study investigates the role of transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential melastatin 8 (TRPM8) in responding to environmental stimuli in human odontoblast-like cells (hOLCs) and their involvement in the regulation of the inflammatory process.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Psychology, Biological
C. M. Sutton, R. L. Ziegler, K. J. Austin, B. M. Alexander
Summary: The expression of TRPM8 channel varies in different tissues of different genders, but it is not important in the expression of sexual behavior.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Neurosciences
Yuji K. Takahashi, Thomas A. Stalnaker, Lauren E. Mueller, Sevan K. Harootonian, Angela J. Langdon, Geoffrey Schoenbaum
Summary: This study investigates the validity of the single-stream assumption by recording dopamine neuron activity. The results show that in complex settings, dopamine neurons can access and update multiple independent predictive streams, reflecting beliefs in the timing and identities of expected rewards.
NATURE NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Takao Inoue, Yuichi Fujiyama, Kohei Haji, Yuichi Maruta, Hideyuki Ishihara, Michiyasu Suzuki
Summary: TRPM8 agonist suppresses EDs and epileptic seizures in wildtype mice, but not in TRPM8KO mice. TRPM8KO mice show exacerbated EDs and epileptic seizures compared to wildtype mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Naoki Aizawa, Yoshikazu Fujimori, Osamu Nakanishi, Takemitsu Hayashi, Yoshiaki Goi, Jun-Ichi Kobayashi, Tomoe Fujita
Summary: This study found that KPR-5714 acts neither on beta(3)-adrenoceptors nor M3 receptors; in normal rats, KPR-5714 and mirabegron significantly reduced the frequency of bladder contractions, with a combined administration showing an additive effect; in rats exposed to cold temperature, KPR-5714 and tolterodine tartrate significantly reduced voiding frequency along with an increased mean voided volume, and a combined administration showed additive effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Akiko Terauchi, Patricia Yee, Erin M. Johnson-Venkatesh, Mariel P. Seiglie, Lisa Kim, Julia C. Pitino, Eli Kritzer, Qiyu Zhang, Jie Zhou, Yulong Li, David D. Ginty, Wei-Chung A. Lee, Hisashi Umemori
Summary: Dopaminergic projections play a role in various brain functions and are involved in neuropsychiatric disorders. Two groups of TGF-(3 family members regulate the development of dopaminergic synapses in nigrostriatal and mesolimbic neurons. Specific activation of Smad1 and Smad2 is required for the development and function of dopaminergic synapses in nigrostriatal and mesolimbic projections.
Article
Multidisciplinary Sciences
Nihaad Paraouty, Catherine R. Rizzuto, Dan H. Sanes
Summary: This study examined the role of dopamine signals in social learning, revealing that providing a reward linked to the demonstrator's performance can significantly enhance learning speed for unrewarded observers, and this effect is abolished by using a D1/D5 dopamine receptor antagonist during exposure sessions, which also reduces the learning rate for unrewarded observers. On the other hand, administering a D1/D5 receptor agonist during exposure sessions without any reward present can accelerate the learning process significantly.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Ming-Shuo Shao, Xiao Yang, Chen-Chun Zhang, Chang-You Jiang, Ying Mao, Wen-Dong Xu, Lan Ma, Fei-Fei Wang
Summary: This study found that protein O-GlcNAcylation in DAergic neurons in the VTA plays an important role in regulating the response to natural reward and motor learning in mice.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Yunyao Xie, Longwen Huang, Alberto Corona, Alexa H. Pagliaro, Stephen D. Shea
Summary: It is unclear how social contact is perceived as rewarding and modifies interactions. A study finds that dopamine from the VTA plays a role in regulating sociality, with DA neurons incrementally refining parental retrieval behavior through reinforcement learning. The study also shows that DA signals convey reward prediction error and that inactivation of DA neurons slows the emergence of parental care.
Article
Multidisciplinary Sciences
Tasuku Kayama, Yuji Ikegaya, Takuya Sasaki
Summary: Dopaminergic neurons in the VTA play a crucial role in reward processing and peripheral immunity. Optogenetic phasic stimulation of these neurons increases serum cytokine levels, while encounters with females also lead to elevated serum IL-2 levels. These findings have important implications for the treatment and management of immune-related disorders.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Elise Bousseyrol, Steve Didienne, Samir Takillah, Clement Solie, Maxime Come, Tarek Ahmed Yahia, Sarah Mondoloni, Eleonore Vicq, Ludovic Tricoire, Alexandre Mourot, Jeremie Naude, Philippe Faure
Summary: We developed a task where mice self-determine their actions based on their knowledge of the outcomes and found that a sequence of oscillations and firings in the VTA, OFC, and PFC co-encodes and co-determines self-initiation and choices. Interactions between these structures varied with the reward context, particularly the uncertainty associated with the different options.
Article
Multidisciplinary Sciences
John N. J. Reynolds, Riccardo Avvisati, Paul D. Dodson, Simon D. Fisher, Manfred J. Oswald, Jeffery R. Wickens, Yan-Feng Zhang
Summary: Dopamine-dependent long-term plasticity is a cellular mechanism underlying reinforcement learning. The coincidence of phasic dopamine activation and pauses in striatal cholinergic interneuron firing plays a critical role in long-term potentiation of corticostriatal synapses.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Marc Behrendt, Hans Juergen Solinski, Martin Schmelz, Richard Carr
Summary: This study found that the inflammatory mediators prostaglandins and bradykinin inhibit TRPM3, while preceding activation of cultured mouse DRG neurons by bradykinin enhances TRPM3-mediated calcium responses. These findings suggest that BK-mediated activation of intracellular signaling pathways may contribute to TRPM3 sensitization during inflammation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jennifer M. Walters, Eung Chang Kim, Jiaren Zhang, Han Gil Jeong, Archit Bajaj, Brian C. Baculis, Gregory C. Tracy, Baher Ibrahim, Catherine A. Christian-Hinman, Daniel A. Llano, Graham R. Huesmann, Hee Jung Chung
Summary: This study is the first to demonstrate that the drug TC-2153 has inhibitory effects on hippocampal excitability and seizure severity in both sexes. TC-2153 can reduce seizure severity and decrease overall hippocampal excitability.
Article
Acoustics
Jihun Kim, Mathew R. Lowerison, Nathiya V. Chandra Sekaran, Zhengchang Kou, Zhijie Dong, Michael L. Oelze, Daniel A. Llano, Pengfei Song
Summary: Ultrasound localization microscopy (ULM) shows potential for visualizing tissue microvasculature at depth with high spatial resolution. A novel ULM imaging sequence based on MB uncoupling via transmit excitation (MUTE) is proposed, which silences MB signals to facilitate MB separation and localization, resulting in reduced data acquisition time and improved temporal resolution.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Multidisciplinary Sciences
Matthew R. Lowerison, Nathiya Chandra Sekaran, Wei Zhang, Zhijie Dong, Xi Chen, Daniel A. Llano, Pengfei Song
Summary: Aging-related cognitive decline is a health crisis, with no established mechanism identified. This study used super-resolution ultrasound localization microscopy to image the vasculature of aged mice and found decreased blood velocity, increased vascular tortuosity, and reduced blood volume in the cerebral cortex. These findings provide novel insights into subcortical microvascular dynamics in the aging brain.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Multidisciplinary
Susanna S. Kwok, Xuan-Mai T. Nguyen, Diana D. Wu, Raksha A. Mudar, Daniel A. Llano
Summary: The association between age-related hearing loss (ARHL) and Alzheimer's Disease (AD) is still poorly understood. A meta-analysis study revealed that AD patients have significantly impaired hearing compared to controls, with a greater effect seen at higher sound frequencies.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Chemistry, Medicinal
Abdulhalim Serafi, Aisha Azmat, Muhammad Ahmed, Mohammed Bafail, Zahir Hussain
Summary: The ethanolic extract of Acacia tortilis leaves shows promising effects on hemodynamic activity and antidepressant effects in salt-induced hypertensive rats, indicating its potential as a valuable adjunct therapy for patients suffering from depression and hypertension.
NATURAL PRODUCTS JOURNAL
(2022)
Article
Geriatrics & Gerontology
Lydia T. Nguyen, Elizabeth A. Lydon, Shraddha A. Shende, Daniel A. Llano, Raksha A. Mudar
Summary: Individuals with mild cognitive impairment (MCI) show impaired value-directed strategic processing compared to cognitively normal older adults, as evidenced by behavioral and neural differences.
Article
Neurosciences
David Perez-Gonzalez, Thomas G. Schreiner, Daniel A. Llano, Manuel S. Malmierca
Summary: Age-related hearing loss is a common condition among the elderly, impacting their communication and social participation. Recent studies suggest a possible link between hearing loss and the development of Alzheimer's disease, with changes in acetylcholine playing a role in both hearing deviance detection and Alzheimer's disease. Further research is needed to explore this association.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Elizabeth A. L. Stine-Morrow, Giavanna S. McCall, Ilber Manavbasi, Shukhan Ng, Daniel A. Llano, Aron K. K. Barbey
Summary: Considerable evidence suggests that language processing depends on memory processes vulnerable to aging declines. This study found that sustained literacy engagement, such as leisure reading, had positive effects on memory and cognition in older adults. The experimental group showed improved verbal working memory, episodic memory, and conceptual integration in sentence processing, regardless of personality characteristics.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Qi You, Joshua D. Trzasko, Matthew R. Lowerison, Xi Chen, Zhijie Dong, Nathiya Vaithiyalingam ChandraSekaran, Daniel A. Llano, Shigao Chen, Pengfei Song
Summary: This study introduces a curvelet transform-based sparsity promoting (CTSP) algorithm that improves the imaging speed of ultrasound localization microscopy (ULM) by recovering missing microbubble localization signal from data with very short acquisition times. The results demonstrate that CTSP can facilitate fast and robust ULM imaging, especially when microbubble localizations are inadequate.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Review
Behavioral Sciences
Silvio Macias, Daniel A. Llano
Summary: This study takes a comparative approach to understand the top-down modulation mechanisms in the mammalian and amphibian inferior colliculus (IC). The key question addressed is whether the thalamotectal projections in mammals and amphibians are homologous and how they interact with projections from the cerebral cortex. The behavioral significance of these descending pathways is also considered, particularly in anurans' ability to navigate complex acoustic landscapes without a corticocollicular projection.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2023)
Article
Neurosciences
Ashwini G. Naik, Robert Kenyon, Aynaz Taheri, Tanya Y. BergerWolf, Baher A. Ibrahim, Yoshitaka Shinagawa, Daniel A. Llano
Summary: Understanding the functional correlations between neuron populations is crucial for studying neuronal networks. V-NeuroStack is a novel network visualization tool that allows visualization of large-scale neuronal activity data. It offers both 3D and 2D visualization modes to explore correlations between neurons and examine specific time steps in detail. It can handle large datasets and potentially support future advancements in data capturing techniques.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Editorial Material
Behavioral Sciences
Peter M. Narins, Daniel A. Llano, Gunther K. H. Zupanc
Summary: This special issue of the Journal of Comparative Physiology A commemorates the life and work of Albert (Al) S. Feng, a pioneer in the field of neuroethology of auditory systems. It includes 15 articles written by friends, students, and colleagues, many of whom have become leading experts themselves in this field. Their contributions provide a comprehensive overview of bioacoustics in amphibians and mammals (including bats) and aim to inspire a new generation of scientists to advance our understanding of brain mechanisms of acoustic perception.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Daniel A. Llano, Priya Devanarayan, Viswanath Devanarayan
Summary: This study proposes a framework for classifying and combining biomarkers for Alzheimer's Disease (AD). The researchers found that low levels of VGF in cerebrospinal fluid (CSF) can serve as a strong predictor for the conversion from mild cognitive impairment (MCI) to AD.
NEUROBIOLOGY OF AGING
(2023)
Article
Health Care Sciences & Services
Shalan Alaamri, Abdulhalim S. Serafi, Zahir Hussain, Munira M. Alrooqi, Mohammed A. Bafail, Sumera Sohail
Summary: This study investigated the association between blood pressure, body mass index (BMI), and serum leptin levels in young male Saudi students. The results showed significant differences in BMI, leptin, systolic blood pressure (SBP), and diastolic blood pressure (DBP) between the overweight and normal-weight groups. There was also a positive correlation between BMI, leptin, SBP, and DBP, except for the nonsignificant correlation between BMI and SBP in the normal-weight group. Other variables, such as interleukin-6, high sensitivity C-reactive protein, apelin, and resistin, also showed significant variations between the two groups.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Suzanna Kitten, Neel D. Jani, Daniel A. Llano
Summary: Functional neurological symptom disorder is a condition where neurological deficits cannot be explained by medical pathology, and auditory verbal agnosia is one of its manifestations. This case study demonstrates the effectiveness of a multi-pronged treatment approach in resolving conversion symptoms in a 19-year-old patient over several years.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
