期刊
EXPERIMENTAL CELL RESEARCH
卷 391, 期 1, 页码 -出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2020.111940
关键词
Long non-coding RNA; Transcriptomics; Ribosome profiling; sORF; de novo gene
资金
- Programa Estatal de Generacion de Conocimiento (Spanish Government) [BFU2015-65235-P, PGC2018094091-B-I00]
- Programa Estatal de Generacion de Conocimiento (FEDER, EU) [BFU2015-65235-P, PGC2018094091-B-I00]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR, Generalitat de Catalunya) [2014SGR1121, 2017SGR01020]
High throughput RNA sequencing techniques have revealed that a large fraction of the genome is transcribed into long non-coding RNAs (lncRNAs). Unlike canonical protein-coding genes, lncRNAs do not contain long open reading frames (ORFs) and tend to be poorly conserved across species. However, many of them contain small ORFs (sORFs) that exhibit translation signatures according to ribosome profiling or proteomics data. These sORFs are a source of putative novel proteins; some of them may confer a selective advantage and be maintained over time, a process known as de novo gene birth. Here we review the mechanisms by which randomly occurring sORFs in lncRNAs can become new functional proteins.
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