Review
Polymer Science
Yedi Herdiana, Patihul Husni, Siti Nurhasanah, Shaharum Shamsuddin, Nasrul Wathoni
Summary: Breast cancer is a significant global cause of death, accounting for 13% of all deaths. Chemotherapy can generate reactive oxygen species (ROS) and oxidative stress, which can have adverse effects on the body. Antioxidants are crucial for cell health and immune system functionality, but their effectiveness when taken orally is limited due to poor solubility. Chitosan-based nanoparticle (CSNP) systems have been explored as a strategy to enhance oral bioavailability of natural antioxidants. This review focuses on the development of effective oral dosage forms for natural antioxidants using chitosan-based nanoformulation.
Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Yifeng Cao, Chuyang Chen, Yi Tao, Weifeng Lin, Ping Wang
Summary: Triple-negative breast cancer (TNBC) is characterized by extensive tumor heterogeneity at both the pathologic and molecular levels, leading to increased mortality of patients due to accelerated aggressiveness and terrible metastasis. Hindered by the negative expression of certain receptors, targeted therapy has been challenging, but the higher immune response in TNBC compared to other breast cancer types makes it suitable for immunotherapy.
Review
Nanoscience & Nanotechnology
Siyan Liu, Jing Li, Lin Gu, Kunzhe Wu, Hua Xing
Summary: Chemoimmunotherapy shows promise for treating TNBC, but challenges remain in improving efficacy and reducing side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yedi Herdiana, Nasrul Wathoni, Dolih Gozali, Shaharum Shamsuddin, Muchtaridi Muchtaridi
Summary: Despite recent advances, cancer remains the leading cause of death globally. Research has been conducted to find new and effective anticancer medications, with a focus on the complexity of breast cancer. Chitosan nanoparticles (CSNPs) have emerged as a promising drug delivery system, enhancing drug activity and minimizing harm to normal cells. The use of smart drug delivery systems (SDDs) to improve the bioactivity of CSNPs and understand breast cancer intricacies has gained significant interest. This review explores the potential of CSNPs as SDDs for targeted cancer therapy and stimulus response medication delivery.
Review
Chemistry, Medicinal
Parnian Baharlouei, Azizur Rahman
Summary: Chitin and chitosan, abundant polymers in nature, have gained attention for their favorable properties and enormous potential biomedical applications. They can be used in drug delivery systems, cancer treatment, wound dressings, and more, making them important in the medical field.
Review
Chemistry, Multidisciplinary
Qingqing Pan, Xi Fan, Li Xie, Di Wu, Rong Liu, Wenxia Gao, Kui Luo, Bin He, Yuji Pu
Summary: This review provides a cutting-edge summary of nanomedicine-based treatment in colorectal cancer, including drug delivery systems, therapeutic strategies, and efforts to address therapy resistance, metastasis, and recurrence. The potential of gut microbiota regulation in preventing and treating colorectal cancer is also discussed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Mohammad Arshad Javed Shaikh, Obaid Afzal, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Mohammed Jafar, Abdulmalik Saleh Alfawaz Altamimi, Vikash Jakhmola, Krishnan Anand, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Summary: Cancer is a complex disease influenced by genetics, environment, and lifestyle choices. The management of cancer relies on chemotherapy, surgery, and radiation therapy, but combination therapies are also utilized. Despite low success rates, chemotherapy remains the standard treatment. Drug delivery systems, such as chitosan liposomes, offer advantages in overcoming drug penetration and resistance challenges. This article explores the use of chitosan liposomes for cancer treatment through various routes, including immunotherapy and targeted therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhenhan Feng, Huan Meng
Summary: The article discusses the development of rationally designed mesoporous silica nanoparticles (MSNP) for more effective and well-tolerated chemotherapy and/or chemo-immunotherapy for gastrointestinal cancers. Through the use of the silicasome platform, single-drug or synergistic drug combinations have been successfully delivered to orthotopic PDAC tumors, with promising preclinical results. Additionally, enhancements in tumor microenvironment and the implementation of immunogenic cell death (ICD) in the silicasome platform have shown potential for generating a hot tumor microenvironment and long-lasting anticancer effects.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Nishant Kumar, Sajid Fazal, Eijiro Miyako, Kazuaki Matsumura, Robin Rajan
Summary: Cancer is a leading cause of death globally, causing physical, emotional, and financial strain on individuals, families, and healthcare systems. The development of nanoparticle-based drug delivery systems and synthetic biodegradable polypeptides and polymers offers new hope for cancer treatment, overcoming challenges such as harmful side effects and drug resistance. Additionally, immunotherapies and bacteria-based therapies show promising selectivity and efficacy in treating various cancers.
Article
Chemistry, Multidisciplinary
Quan Liu, Yanhong Duo, Jianye Fu, Meng Qiu, Zhe Sun, Dickson Adah, Jianlong Kang, Zhongjian Xie, Taojian Fan, Shiyun Bao, Han Zhang, Li-Ping Liu, Yihai Cao
Summary: Therapeutic targeting of the immune system, including immunotherapy and nanotechnology, presents a promising approach for treating various cancers. While immunotherapeutics have limitations, nanotechnology offers unique opportunities to enhance therapeutic efficacy through precision targeting and controlled drug release. Combining these two modalities could provide synergistic efficacy in cancer treatment.
Review
Biotechnology & Applied Microbiology
Yazid Zaiki, Athirah Iskandar, Tin Wui Wong
Summary: Chitosan, as a biotechnological derivative of chitin, has various pharmaceutical and biomedical applications. It can encapsulate and deliver cancer therapeutics with specific drug targeting at the tumor microenvironment, enhancing cancer cytotoxic drug actions. To minimize off-target effects and drug-related adverse reactions, it is clinically necessary to achieve highly targeted drug delivery at the lowest possible drug doses.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Instruments & Instrumentation
Isra Rana, Jaeeun Oh, Juwon Baig, Jeong Hyun Moon, Sejin Son, Jutaek Nam
Summary: The immune system can target and kill cancer cells, and nanocarriers offer a promising approach to enhance cancer immunotherapy by boosting immune activity and improving drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Mostafa Saeedi, Omid Vahidi, Mohammad Reza Moghbeli, Sepideh Ahmadi, Mohsen Asadnia, Omid Akhavan, Farzad Seidi, Mohammad Rabiee, Mohammad Reza Saeb, Thomas J. Webster, Rajender S. Varma, Esmaeel Sharifi, Ali Zarrabi, Navid Rabiee
Summary: This article reviews the importance of chitosan in drug delivery applications, discussing different types and functionalities of cross-linkers and fabrication methods for chitosan hydrogels. It also explores recent advances in advanced chitosan hydrogels for oral drug delivery, transdermal drug delivery, and cancer therapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Applied
Xiaoyan Liang, Min Mu, Rangrang Fan, Bingwen Zou, Gang Guo
Summary: Chitosan, with its biodegradable, biocompatible, nonimmunogenic and nontoxic properties, has shown great potential as a delivery material in cancer immunotherapy, improving drug effectiveness and offering broad application prospects.
CARBOHYDRATE POLYMERS
(2022)
Article
Endocrinology & Metabolism
Abbas Samadi-Khouzani, Payam Kheirmand Parizi, Fatemeh Ghafari, Seyed-Alireza Esmaeili, Maryam Peymani, Amir Abbas Momtazi-Borojeni
Summary: The study did not find an association between the rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 and susceptibility to T2DM in the Isfahan population.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2022)
Article
Biochemistry & Molecular Biology
Hassan Doulabi, Elham Masoumi, Maryam Rastin, Afsaneh Foolady Azarnaminy, Seyed-Alireza Esmaeili, Mahmoud Mahmoudi
Summary: CD4(+) T helper (Th) cells play a significant role in modulating host defense. Th22 cells, a recently identified subset of CD4(+) T cells, participate in mucosal defense, tissue repair, and wound healing. However, overexpression of IL-22 can lead to inflammation and tumor progression.
Article
Immunology
Bita Mohammadi, Mohammadreza Saghafi, Tola Abdulsattar Faraj, Ramiar Kamal Kheder, Hadi Sajid Abdulabbas, Seyed-Alireza Esmaeili
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by an imbalance between effector and regulatory immune responses. Inflammatory dendritic cells (inflDC) play a role in promoting inflammation in SLE, while tolerogenic dendritic cells (tolDC) suppress immune cell overreaction in SLE. Recent studies show the potential of tolDC therapy in treating autoimmune diseases including SLE, by inducing regulatory T cells and maintaining self tolerance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Akram Hoseinzadeh, Zahra Rezaieyazdi, Mahmoud Mahmoudi, Jalil Tavakol Afshari, Fahimeh Lavi Arab, Seyed-Alireza Esmaeili, Arezoo Faridzadeh, Amin Rezaeian, Sara Hoseini, Mehdi Barati, Ali Mahmoudi, Nafiseh Sadat Tabasi
Summary: This study investigated the potential of MSCs in the treatment of refractory SLE. The results showed that MSCs can reduce inflammation, modulate immune function, and repair damaged tissues. Animal experiments demonstrated that MSCs transplantation can decrease proteinuria and anti-dsDNA antibody levels, reduce serum creatinine levels, and attenuate lupus renal pathology.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Parisa Ahmadi, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh Mollazadeh, Hadi Sajid Abdulabbas, Seyed-Alireza Esmaeili
Summary: In patients with rheumatoid arthritis (RA), certain citrullinated proteins can be targeted by ACCPAs in the synovial sites. Extra-articular sites may be the origin of primary auto-immunization against these proteins. There is a significant association between P. gingivalis periodontitis, anti-P. gingivalis antibodies, and RA. P. gingivalis can degrade proteins such as fibrin and alpha-enolase into citrullinated peptides, and induce inflammation and immune cell attraction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Gholamreza Karimi, Sina Fatemi, Bahram Memar, Mohammad-Bagher Khorrami, Arian Amali, Mahmood Sadeghi, Seyed-Alireza Esmaeili, Bamdad Riahi-Zanjani
Summary: Our study showed that melittin had no significant pathological effects on the spleen and bone marrow, as well as no impact on hematological parameters. Additionally, melittin did not affect proliferation response of splenocytes, spleen cellularity, DTH response, and the production of anti-SRBC antibodies in the mice immune system.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Obstetrics & Gynecology
Malihe Soltani, Maryam Moghimian, Seyed-Hosein Abtahi-Evari, Seyed-Alireza Esmaeili, Ramin Mahdipour, Majid Shokoohi
Summary: This study aimed to determine whether clove could help PCOS rats. The results showed that clove improved oxidative stress, apoptosis, and excessive autophagy in PCOS rats, thereby improving pathological parameters and hormone levels.
INTERNATIONAL JOURNAL OF FERTILITY & STERILITY
(2023)
Review
Medicine, Research & Experimental
Davood Bahadorian, Samaneh Mollazadeh, Hosein Mirazi, Tola Abdulsattar Faraj, Ramiar Kamal Kheder, Seyed-Alireza Esmaeili
Summary: NK cells play a vital role in defending against tumors and viral infections and regulating innate and adaptive immunity. They can be divided into CD56dim NK and CD56bright NK subsets, with CD56bright NK cells known as regulatory NK cells. Their activation can suppress autologous CD4+ T cells and prevent the initiation of autoimmunity. This review summarizes the roles of regulatory NK cells in autoimmune diseases and suggests targeting NK cells as a promising therapeutic approach.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Review
Oncology
Seyed Hossein Abtahi Eivary, Ramiar Kamal Kheder, Soran K. Najmaldin, Nahid Kheradmand, Seyed-Alireza Esmaeili, Jafar Hajavi
Summary: Cancer, a deadly disease, is a recent global dilemma. The use of cytokine IL-21 shows potential in manipulating the immune system to fight solid tumors, as it enhances NK and CTL functions and stimulates IgG antibody production. Combining IL-21 with other agents is found to further enhance its antitumor activity. Promising preclinical results have led to the initiation of clinical trials in cancer patients. This review focuses on the function of IL-21 in solid tumor immunotherapy.
Article
Immunology
Maryam Rastin, Mahmoud Mahmoudi, Nafiseh Tabasi, Nadia Kia, Jafar Hajavi, Seyed-Alireza Esmaeili
Summary: The immunomodulatory effect of Lactobacillus rhamnosus and Lactobacillus delbrueckii on the differentiation and maturation of myeloid dendritic cells was evaluated. The probiotic-treated dendritic cells exhibited significant immunomodulatory properties, indicating their potential for immune response regulation.
IRANIAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Oncology
Vahideh Keyvani, Nahid Kheradmand, Zahra Nasrpour Navaei, Samaneh Mollazadeh, Seyed-Alireza Esmaeili
Summary: Gynecological cancers, the most common among women worldwide, have a significant impact on reproductive system function and quality of life. The epidemiological patterns of these cancers vary across regions and change over time. Improving patient outcomes requires addressing the challenges and evaluating reported risk factors in gynecological cancers. Preventive measures, modifiable lifestyles, and early detection in high-risk groups are effective strategies for reducing mortality rates. This review provides a summary of the epidemiology, global risk factors, and management approaches for gynecological cancers to improve the quality of life in affected patients.
Review
Biochemistry & Molecular Biology
Zahra Darvish, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Soran K. Najmaldin, Samaneh Mollazadeh, Reza Nosratabadi, Seyed-Alireza Esmaeili
Summary: Autoimmune diseases are caused by disturbed regulatory mechanisms of the immune response, and investigating the CTLA4-CD80/86 axis may provide insights for treatment strategies.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Cell & Tissue Engineering
Akram Hoseinzadeh, Zahra Rezaieyazdi, Jalil Tavakol Afshari, Ali Mahmoudi, Sahar Heydari, Reza Moradi, Seyed-Alireza Esmaeili, Mahmoud Mahmoudi
Summary: The breakdown of self-tolerance in the immune response can cause autoimmune diseases like systemic lupus erythematosus (SLE), which is more prevalent in women of childbearing age and influenced by ethnicity. Dysregulation in B cell subsets and hyperactive T helper cells play a major role in SLE's pathogenesis. New treatment strategies using mesenchymal stem cells (MSCs) as immune modulators show promise in controlling autoimmune responses without suppressing the immune system.
STEM CELL REVIEWS AND REPORTS
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Darshan Chakrabarti, John P. Dickerson, Seyed A. Esmaeili, Aravind Srinivasan, Leonidas Tsepenekas
Summary: This paper introduces a novel definition of individual fairness for clustering problems and answers questions regarding the combinatorial structure and Price of Fairness (PoF) behavior. Efficient and easily-implementable approximation algorithms are provided for the well-defined region of alpha, with bounded-PoF guarantees in certain cases. Extensive experiments validate the effectiveness of the theoretical results.
INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE AND STATISTICS, VOL 151
(2022)
Article
Biotechnology & Applied Microbiology
Vahid Bagheri, Seyed-Alireza Esmaeili, Mehran Gholamin, Mohammad Reza Abbaszadegan
Summary: This study successfully generated spherical colonies from cancerous cell suspensions isolated from patients with GC under serum-free conditions, which were able to form xenograft tumors in immunodeficient nude mice. The spheroid-forming single cells upregulated stemness transcription factors associated with pluripotency and self-renewal, as well as CD44 isoforms, indicating their stem-like properties. The rapid isolation of cancer cells with certain stem-like properties may be important for targeted CSC therapy, especially in advanced disease patients.
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2022)
