Review
Pharmacology & Pharmacy
Suvash Ghimire, Pritha Sarkar, Kasey Rigby, Aditya Maan, Santanu Mukherjee, Kaitlyn E. Crawford, Kausik Mukhopadhyay
Summary: Hemorrhage poses a significant threat to life on the battlefield, with a high percentage of combat deaths occurring within 30 minutes of injury. There is a pressing need for a unique and easy-to-use hemostatic treatment that can be applied by first responders to stop bleeding within 1 to 2 minutes at the point of injury.
Review
Biochemistry & Molecular Biology
Mateusz Mieczkowski, Beata Mrozikiewicz-Rakowska, Michal Kowara, Marcin Kleibert, Leszek Czupryniak
Summary: Chronic wounds are becoming more common due to aging population and conditions like diabetes, atherosclerosis, and venous insufficiency. Impaired blood circulation is a leading factor in delaying wound healing in diabetic patients. Various substances are being used to accelerate wound regeneration. The use of a correct animal model is crucial in studying diabetic chronic wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Quiterio, Sandra Simoes, Andreia Ascenso, Manuela Carvalheiro, Ana Paula Leandro, Isabel Correia, Ana Silveira Viana, Pedro Faisca, Lia Ascensao, Jesus Molpeceres, Maria Manuela Gaspar, Catarina Pinto Reis
Summary: Insulin, a peptide hormone, plays an important role in wound healing. Research shows that insulin-loaded nanoparticles exhibit controlled release characteristics in vitro, and demonstrate good safety in cell experiments and preliminary animal assays.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Cristiana Oliveira, Diana Sousa, Jose A. Teixeira, Pedro Ferreira-Santos, Claudia M. Botelho
Summary: Skin is an important indicator of health and greatly impacts a person's emotions and behavior. However, conventional wound healing materials often fail to provide sufficient healing, leading to scar formation. Therefore, the development of innovative biomaterials for wound healing is crucial. Both natural and synthetic polymers are extensively used for wound dressings and scaffold production, and their combination shows promising results in accelerating the healing process. This article describes commercially available solutions for skin wound management, explores the design of polymeric biomaterials, and addresses new directions and strategies for personalized care and faster healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Dermatology
Kohei Aoki, Yukiko Ida, Noritoshi Fukushima, Hajime Matsumura
Summary: The study investigated the usefulness of oxygen nano-bubble water as an oxygen-rich liquid for wound healing and found that it enhances the healing process of ischemic wounds.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Camila dos Santos Leite, Gabriel Alves Bonafe, Oscar Cesar Pires, Tanila Wood dos Santos, Geovanna Pacciulli Pereira, Jose Aires Pereira, Thalita Rocha, Carlos Augusto Real Martinez, Manoela Marques Ortega, Marcelo Lima Ribeiro
Summary: The study aimed to evaluate the anti-inflammatory effect of topical Dipotassium Glycyrrhizinate (DPG) on wound healing. Results showed that DPG treatment reduced inflammatory exudate, eliminated active hyperemia, increased granulation tissue, promoted tissue reepithelialization, and enhanced total collagen. In addition, DPG treatment decreased the expression of pro-inflammatory cytokines while increasing the expression of anti-inflammatory cytokine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Lizhi Xiao, Fang Hui, Tenghui Tian, Ruyue Yan, Jingwei Xin, Xinyu Zhao, Yingnan Jiang, Zhe Zhang, Yulan Kuang, Na Li, Yu Zhao, Quan Lin
Summary: Researchers have successfully developed a novel medical silver nanoparticle-doped hydrogel dressing with good antibacterial properties and biocompatibility for treating severely infected wounds.
FRONTIERS IN CHEMISTRY
(2021)
Review
Veterinary Sciences
Isa Ozaydin, Ugur Aydin
Summary: Studies on wound healing are crucial in both human and veterinary medicines as they determine the effects of new drugs on healing and provide insights into the mechanisms of wound repair. The development of new methods to intervene in natural wound healing and accelerate recovery is the primary objective of researchers in this field. However, wound healing research remains complex and requires careful planning and appropriate measurement techniques to evaluate the healing process.
PAKISTAN VETERINARY JOURNAL
(2023)
Article
Polymer Science
Mahalakshmi Pandian, G. Reshma, C. Arthi, Mar Masson, Jayakumar Rangasamy
Summary: Wound healing is a complex process, and the presence of bacteria can hinder this process, resulting in infectious wounds. Numerous biomedical and biomaterial research efforts have been made over the past 20 years to address this issue. Polymeric scaffolds and hydrogels are the best candidates for developing effective drug-delivery biomaterials.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Martin Pfister, Kornelia Schuetzenberger, Bhavapriya J. Schafer, Stefan Puchner, Hannes Stegmann, Christine Hohenadl, Michael Mildner, Gerhard Garhoefer, Leopold Schmetterer, Rene M. Werkmeister
Summary: Optical coherence tomography angiography can provide biomarkers for vascular remodeling in preclinical wound healing studies. Analysis of high-resolution OCT angiograms reveals changes of microvasculature and allows identification of overlapping wound healing phases.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
Anna Froelich, Emilia Jakubowska, Monika Wojtylko, Barbara Jadach, Michal Gackowski, Piotr Gadzinski, Olga Napierala, Yulia Ravliv, Tomasz Osmalek
Summary: Alginate, a natural polysaccharide, is widely used in drug delivery, regenerative medicine, tissue engineering, and wound care due to its excellent biocompatibility and absorbing capacity. Incorporating nanoparticles into alginate-based wound dressings has proven to enhance wound healing process. Various types of nanoparticles, including antimicrobial inorganic nanoparticles, antibiotics, and growth factors, have been investigated. This review article focuses on the recent advancements in novel alginate-based materials loaded with nanoparticles and their potential use in the treatment of chronic wounds.
Article
Pharmacology & Pharmacy
Saibhargav Narisepalli, Shubham A. Salunkhe, Deepak Chitkara, Anupama Mittal
Summary: This study developed a gelatin-based biodegradable hydrogel embedded with Asiaticoside polymeric nanoparticles (AST PNP) to enable sustained release of AST and enhance its therapeutic effects. The AST PNP demonstrated sustained release profile and enhanced intra-cellular uptake in fibroblasts, leading to significant proliferation and migration of fibroblasts and improved collagen biosynthesis. The application of AST PNP gel also showed improved wound healing efficacy in diabetic rats.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Anna T. Hofmann, Paul Slezak, Sabine Neumann, James Ferguson, Heinz Redl, Rainer Mittermayr
Summary: In this study, the dose-dependent effects of rhVEGF(165) in fibrin sealant on ischemic and non-ischemic wounds were investigated. Lower doses of VEGF were found to promote angiogenesis and wound healing, and the use of fibrin sealant alone accelerated wound closure.
Article
Engineering, Biomedical
Sang Oon Baek, Uk Jang, Jeonghwan Shin, Jun Hyeok Kim, Jie Hyun Kim, Jun Yong Lee
Summary: The authors introduce a novel animal wound model using an internal splint made of nitinol, a shape memory alloy, to effectively impede wound contraction while not affecting the re-epithelialization rate, successfully mimicking the human wound healing mechanism. This model is robust, reliable, and easily reproducible.
BIOMEDICAL MATERIALS
(2021)
Review
Chemistry, Medicinal
Parisa Dehghani, Monireh Esmaeili Rad, Atefeh Zarepour, Ponnurengam Malliappan Sivakumar, Ali Zarrabi
Summary: Diabetes Mellitus is a chronic metabolic disease that affects millions of people worldwide and is characterized by a defect in insulin secretion or function. This review article introduces polymeric nanoparticles as a promising method for the management of diabetes. The use of these nanoparticles in diagnosis and treatment shows great potential for improving diabetes management and reducing long-term organ damage.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Thermodynamics
Amanda Naves Ferreira Moraes, Luis Antonio Dantas Silva, Maysa Aparecida de Oliveira, Eder Magno de Oliveira, Thais Leite Nascimento, Eliana Martins Lima, Ieda Maria Sapateiro Torres, Danielle Guimaraes Almeida Diniz
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2020)
Article
Veterinary Sciences
K. D. Ferreira, L. D. Cardoso, L. P. Oliveira, V. S. Franzo, A. Pancotti, M. P. Miguel, L. A. F. Silva, V. A. S. Vulcani
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2020)
Article
Chemistry, Physical
Angelica de Lima das Chagas, Leiny Paula de Oliveira, Mauricio Vicente Cruz, Renato Miranda de Melo, Marina Pacheco Miguel, Katia Flavia Fernandes, Liliana Borges de Menezes
Summary: Polymeric membranes prepared with cashew gum polysaccharide (CGP) associated with polyvinyl alcohol (PVA) were evaluated for their tissue response and biocompatibility in vivo. The results showed that the CGP/PVA membrane exhibited moderate tissue reaction, a thinner fibrous capsule, and a smaller amount of collagen compared to the positive control. At the cellular level, the membrane did not significantly increase the number of mast cells compared to the negative control. This study demonstrates the biocompatibility of the CGP/PVA membrane according to the ISO 10993-6 standard.
Article
Veterinary Sciences
D. P. Araujo, G. H. M. Araujo, L. P. Oliveira, L. B. M. Leite, V. S. Franzo, G. P. Santos, T. R. Souza, V. A. S. Vulcani
Summary: This study confirmed the improved biocompatibility of bovine elastic cartilage decellularized with alkaline solution when implanted in rats.
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2022)
Article
Veterinary Sciences
V. M. Freitas, R. E. Rabelo, B. M. Assis, S. N. Bao, A. F. Garcia Neto, L. P. Oliveira, L. O. Jesus, K. K. Helfenstein, V. A. S. Vulcani
Summary: This study aimed to establish morphometric parameters and histological characteristics of the external genitalia of the bull, comparing between Aberdeen Angus and Nellore breeds. The results showed that Nellore bulls have a larger internal preputial leaflet and free part of the penis, as well as more preputial sebaceous glands than Aberdeen Angus bulls.
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2022)
Article
Thermodynamics
Barbara Cristina Campos Ribeiro, Emilio Ramos Cintra, Eliana Martins Lima, Luis Antonio Dantas Silva, Danielle Guimaraes Almeida Diniz
Summary: Testosterone, a poorly water-soluble cholesterol-derived hormone, was formulated into a liquid self-emulsifying drug delivery system (L-SEDDS) to improve its bioavailability. Pre-formulation studies were conducted to investigate the compatibility of testosterone with oils and surfactants, and the selection of excipients for the development of L-SEDDS.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Anatomy & Morphology
Evelyn de Oliveira, Eduardo de Paula Nascente, Leiny Paula Oliveira, Jair Martins Santiago Neto, Bruna Siqueira Gomes de Lima, Julio Roquete Cardoso, Veridiana Maria Brianezi Dignani de Moura
Summary: The giant anteater, an endangered species residing in Latin America, is experiencing habitat loss, particularly in the Cerrado biome. This study aimed to describe the pharynx and larynx of the giant anteater macroscopically and histomorphologically. The anatomical location of these structures and the larynx differed significantly from other species, and the pharynx and soft palate of these animals were extensive. Histologically, the epithelium of the pharynx and larynx varied between pseudostratified ciliated columnar and non-keratinized stratified squamous epithelium.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2023)
Article
Engineering, Biomedical
Leiny Paula de Oliveira, Angelica de Lima Chagas, Tainara Ribeiro de Souza, Isabela Rodrigues Araujo, Liliana Borges de Menezes, Marina Pacheco Miguel, Valcinir Aloisio Scalla Vulcani
Summary: The study aimed to evaluate the effects of low-power laser in the healing of skin wounds in rats. The results showed that laser treatment could reduce inflammatory cell infiltration and promote collagen deposition, with a better anti-inflammatory effect at a dosage of 1 J/cm(2). In comparison, a dosage of 3 J/cm(2) resulted in higher total collagen after ten days of treatment. Therefore, low-power laser can be used as an auxiliary tool in wound healing.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Veterinary Sciences
Evelyn Oliveira, Eduardo P. Nascente, Leiny P. Oliveira, Jair M. Santiago Neto, Julio C. Roquete, Ana Paula I. Santin, Veridiana M. B. D. Moura
PESQUISA VETERINARIA BRASILEIRA
(2020)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
