期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2020, 期 29, 页码 4494-4498出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202000863
关键词
C-H activation; Rh-catalysis; Cascade reactions; Redox-neutral; Isoquinolinones
资金
- SERB, India [CRG/2019/005059]
- University Grants Commission (U.G.C.)
- Council for Scientific and Industrial Research (C.S.I.R.)
Herein, we demonstrate a [RhCp*Cl-2](2)catalyzed synthesis of isoindolo[2,1-b]isoquinolin-5(7H)-one derivatives fromN-(pivaloyloxy)benzamides andp-quinone methides under redox neutral conditions.p-Quinone methide derivatives were engaged for the first time as precursors in C-H activation reactions and the cascade sequence consists of Rh(III)-catalyzed C-H activation, alkyne insertion followed by an intramolecular 1,6-conjugate addition. This novel tandem reaction strategy offers a rapid and straightforward access to complex fused isoquinolinone derivatives in an efficient manner.
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