4.5 Review

Tc17 biology and function: Novel concepts

期刊

EUROPEAN JOURNAL OF IMMUNOLOGY
卷 50, 期 9, 页码 1257-1267

出版社

WILEY
DOI: 10.1002/eji.202048627

关键词

CD8(+)T cells; IL-17; inflammation; plasticity; Tc17

资金

  1. DFG [HU 1824/5-1, HU 1824/7-1]
  2. Fresenius Stiftung [2015_A232]

向作者/读者索取更多资源

Research over the past years has provided increasing understanding about IL-17-producing CD8(+)T cells termed Tc17 or IL-17(+)CD8(+)T cells, their distribution and role in a range of diverse immune processes. These comprise resistance to pathogens and tissue homeostasis, but also contribution to autoimmunity and cancer, as well as involvement in gut inflammation, lung diseases and graft-versus-host-disease. Tc17 cells are regulated by unique differentiation mechanisms distinguishing them from other IL-17-producing T cells, including Th17, mucosal-associated invariant T cells, and gamma delta 17 T cells, thus ensuring their specific function in immune responses. Here, we review recent advances in understanding Tc17 cell differentiation and function, and highlight experimental evidence from human studies on patients suffering from organ-specific autoimmunity including psoriasis, spondyloarthritis and MS as well as from ulcerative colitis and gastrointestinal tract-associated cancers. We also discuss mouse models analyzing Tc17 characteristics and indicate mechanisms of cross-talk between Tc17 cells and immune or nonimmune cells, enabling their effector function in both protective as well as pathologic immune responses.

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