期刊
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
卷 271, 期 6, 页码 1035-1051出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00406-020-01159-2
关键词
Longitudinal; Resilience; Modern-life stressors; Deep phenotyping
资金
- Projekt DEAL
- German Research Foundation [DFG CRC 1193]
- Stiftung Rheinland-Pfalz fur Innovation (MARP program) [961-386261/1080]
- Ministry of Science of the state of Rhineland-Palatinate (DRZ program)
- European Union's Horizon 2020 research and innovation program [777084, 667302, 728018]
Resilience is the ability to maintain and quickly recover mental health during and after periods of adversity, resulting from successful adaptation to stressors. The mechanisms underlying resilience are not yet understood, and the Longitudinal Resilience Assessment (LORA) study aims to shed light on the complex processes that lead to positive long-term outcomes in the face of adversity. The study involves longitudinal tracking of healthy participants over 4.5 years, with assessments of mental health, sociodemographic and lifestyle variables, resilience factors, life history, neuropsychological assessments, and biomaterials.
Resilience is the maintenance and/or quick recovery of mental health during and after periods of adversity. It is conceptualized to result from a dynamic process of successful adaptation to stressors. Up to now, a large number of resilience factors have been proposed, but the mechanisms underlying resilience are not yet understood. To shed light on the complex and time-varying processes of resilience that lead to a positive long-term outcome in the face of adversity, the Longitudinal Resilience Assessment (LORA) study has been established. In this study, 1191 healthy participants are followed up at 3- and 18-month intervals over a course of 4.5 years at two study centers in Germany. Baseline and 18-month visits entail multimodal phenotyping, including the assessment of mental health status, sociodemographic and lifestyle variables, resilience factors, life history, neuropsychological assessments (of proposed resilience mechanisms), and biomaterials (blood for genetic and epigenetic, stool for microbiome, and hair for cortisol analysis). At 3-monthly online assessments, subjects are monitored for subsequent exposure to stressors as well as mental health measures, which allows for a quantitative assessment of stressor-dependent changes in mental health as the main outcome. Descriptive analyses of mental health, number of stressors including major life events, daily hassles, perceived stress, and the ability to recover from stress are here presented for the baseline sample. The LORA study is unique in its design and will pave the way for a better understanding of resilience mechanisms in humans and for further development of interventions to successfully prevent stress-related disorder.
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