Article
Environmental Sciences
Yu Yu, Jason Su, Michael Jerrett, Kimberly C. Paul, Eunice Lee, I. -Fan Shih, Mary Haan, Beate Ritz
Summary: This study investigated the interactions between air pollution and noise on cognitive impairment in elderly Mexican Americans. The results showed that PM2.5 and NO2 air pollution have a negative impact on cognitive function in this population. Additionally, the study found that traffic-related noise exposure may exacerbate the effects of air pollution on cognitive function.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Clinical Neurology
Mingzhou Fu, Kelly M. Bakulski, Cesar Higgins, Erin B. Ware
Summary: Low blood HDL-C levels may be a potential causal risk factor for impaired cognition during aging in non-Hispanic whites of European ancestry. No significant associations were observed in the African ancestry sample.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Daniel Garbin Di Luca, Sheng Luo, Hongliang Liu, Melanie Cohn, Thomas L. Davis, Adoldo Ramirez-Zamora, Miriam Rafferty, Nabila Dahodwala, Anna Naito, Marilyn Neault, James Beck, Connie Marras
Summary: This study investigated the differences in health-related quality of life (HRQoL) and other outcomes in patients with Parkinson disease (PD) across different racial and ethnic groups. The findings showed that non-White patients had higher total PDQ-39 scores, indicating worse HRQoL, compared to White patients, and cognitive scores partially explained this difference.
Article
Neurosciences
Ann Abraham Daniel, Talisa Silzer, Jie Sun, Zhengyang Zhou, Courtney Hall, Nicole Phillips, Robert Barber
Summary: This study aimed to identify ethnicity-specific DNA methylation profiles that may be associated with cognitive impairment in Mexican American and non-Hispanic white populations. Through the analysis of DNA from participants, two significant differentially methylated sites and three suggestive sites were found. Most methylation sites were hypermethylated in the cognitive impairment group.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Jessica A. Katanga, Calum A. Hamilton, Lauren Walker, Johannes Attems, Alan J. Thomas
Summary: Age-related hearing loss often accompanies mild cognitive impairment and dementia, and it is unclear whether specific dementia-related neuropathologies are a cause or consequence of this association. This study found that neuritic plaques and Lewy body disease were associated with higher odds of hearing impairment, while nonspecific amyloid deposition, neurofibrillary tangle staging, overall AD neuropathology level, and cerebrovascular disease did not show clear associations. These results suggest that there may be a link between dementia-related neuropathology and hearing loss.
Article
Geriatrics & Gerontology
Megan A. Mullins, Julie P. W. Bynum, Suzanne E. Judd, Philippa J. Clarke
Summary: The study found that living in areas with low primary care supply and lack of regular medical care were associated with higher odds of cognitive impairment. This highlights the importance of primary care in preventing cognitive decline.
Article
Clinical Neurology
Beth K. Rush, Philip W. Tipton, Audrey Strongosky, Zbigniew K. Wszolek
Summary: The neuropsychological profile of CSF1R-related leukoencephalopathy (CRL) is characterized by impaired general cognitive function, processing speed, executive function, speeded visual problem solving, verbal fluency, and self-reported depression and anxiety. Confrontation naming and memory are preserved, distinguishing CRL from other dementia syndromes. Certain measures within cognitive domains show a higher frequency of impairment.
FRONTIERS IN NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Maria Isabel Cuartero, Alicia Garcia-Culebras, Carmen Nieto-Vaquero, Enrique Fraga, Cristina Torres-Lopez, Jesus Pradillo, Ignacio Lizasoain, Maria Angeles Moro
Summary: Increasing evidence suggests that commensal microbiota may have significant effects on both health and disease, including cerebrovascular disease. Gut microbes can impact physiology by metabolizing dietary factors and host-derived substrates, leading to the creation of active compounds such as toxins. This review highlights the complex interplay between microbiota, their metabolites, and essential functions for human health, including metabolism regulation, immune system modulation, and brain development. It also discusses the role of gut dysbiosis in cerebrovascular disease, specifically in stroke phases, and the potential involvement of intestinal microbiota in post-stroke cognitive impairment and dementia, as well as potential therapeutic opportunities in targeting microbiota in this context.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Yuting Qian, Xi Chen, Diwen Tang, Amy S. Kelley, Jing Li
Summary: The study found a low prevalence of early diagnosis, or a high rate of underdiagnosis, among older adults showing symptoms of cognitive impairment, especially among non-Whites and socioeconomically disadvantaged subgroups. These results call for targeted interventions to improve the rate of early diagnosis, especially among vulnerable populations.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Environmental Sciences
Teresa Urbano, Annalisa Chiari, Carlotta Malagoli, Andrea Cherubini, Roberta Bedin, Sofia Costanzini, Sergio Teggi, Giuseppe Maffeis, Marco Vinceti, Tommaso Filippini
Summary: Exposure to outdoor air pollutants, particularly PM10, may nonlinearly increase the risk of conversion from MCI to dementia. Higher PM10 levels were associated with increased concentrations of cerebrospinal fluid tau proteins and decreased beta-amyloid levels. The risk of dementia was positively associated with mean PM10 levels above 10 μg/m3 and maximum PM10 levels above 35 μg/m3.
ENVIRONMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Caterina Trevisan, Paola Siviero, Federica Limongi, Marianna Noale, Stefania Maggi
Summary: This study aims to identify modifiable health-related factors associated with changes in cognitive status among older people. The findings suggest that hypertension/bone and joint diseases cluster is the only predictor for conversion from preserved cognitive health to mild cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Hannah Gardener, Bonnie Levin, Janet DeRosa, Tatjana Rundek, Clinton B. Wright, Mitchell S. Elkind, Ralph L. Sacco
Summary: The study suggests that social connections may have a protective effect on cognitive health, especially in disadvantaged populations.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Environmental Sciences
Hengchuan Zhang, Yingying Chen, Ruyu Ni, Yawen Cao, Wenbin Fang, Wan Hu, Guixia Pan
Summary: The study aimed to investigate the joint effects of traffic-related air pollution (TRAP) and healthy lifestyles on cognition among the Chinese elderly. The results showed that participants living > 300 m from major roadways and adopting a healthy lifestyle had a significantly decreased risk of cognitive impairment compared to those living < 50 m from major roadways and adopting an unhealthy lifestyle. Stratified analysis indicated that the impact of TRAP on cognitive impairment was more pronounced among participants adopting an unhealthy lifestyle.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Clinical Neurology
Vijay K. Ramanan, Melissa J. Armstrong, Parichita Choudhury, Katherine A. Coerver, Roy H. Hamilton, Brad C. Klein, David A. Wolk, Scott R. Wessels, Lyell K. Jones Jr
Summary: This article provides practical guidance on logistic adaptations and decision making related to emerging antiamyloid mAbs in neurology, including patient selection, treatment monitoring, and communication. It emphasizes the importance of shared decision making, multidisciplinary collaboration, and future development.
Article
Clinical Neurology
Suman Dutta, Simon Hornung, Adira Kruayatidee, Katherine N. Maina, Irish del Rosario, Kimberly C. Paul, Darice Y. Wong, Aline Duarte Folle, Daniela Markovic, Jose-Alberto Palma, Geidy E. Serrano, Charles H. Adler, Susan L. Perlman, Wayne W. Poon, Un Jung Kang, Roy N. Alcalay, Miriam Sklerov, Karen H. Gylys, Horacio Kaufmann, Brent L. Fogel, Jeff M. Bronstein, Beate Ritz, Gal Bitan
Summary: The study found that measuring α-syn in exosomes from blood can effectively distinguish between patients with PD and MSA with high sensitivity and specificity. A multinomial logistic model combining α-syn concentration, exosome concentration, and a ratio between α-syn concentrations in specific exosomes showed promising results in separating PD from MSA.
ACTA NEUROPATHOLOGICA
(2021)
Article
Psychiatry
Jutta Lindert, Kimberley C. Paul, E. Lachman Margie, Beate Ritz, Teresa Seeman
Summary: Limited research has been done on the relationship between social stress and cognitive decline in aging individuals. The study found that lower subjective social status and discrimination stress had adverse effects on episodic memory, with women reporting lower social status and more discrimination stress than men. Marital risk had negative effects on episodic memory in men, while daily discrimination had adverse effects on executive functioning in all individuals. Strategies for public health should focus on reducing social stress, particularly subjective social status and discrimination stress.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Oncology
Kimberly C. Paul, Steve Horvath, Irish Del Rosario, Jeff M. Bronstein, Beate Ritz
Summary: This study found that PD patients had increased levels of DNAm biomarker for tibia-lead, suggesting that chronic and long-term lead exposure tracked via DNAm may contribute to the pathogenesis of PD.
CLINICAL EPIGENETICS
(2021)
Correction
Clinical Neurology
Suman Dutta, Simon Hornung, Adira Kruayatidee, Katherine N. Maina, Irish del Rosario, Kimberly C. Paul, Darice Y. Wong, Aline Duarte Folle, Daniela Markovic, Jose-Alberto Palma, Geidy E. Serrano, Charles H. Adler, Susan L. Perlman, Wayne W. Poon, Un Jung Kang, Roy N. Alcalay, Miriam Sklerov, Karen H. Gylys, Horacio Kaufmann, Brent L. Fogel, Jeff M. Bronstein, Beate Ritz, Gal Bitan
Summary: A correction to the paper has been published.
ACTA NEUROPATHOLOGICA
(2021)
Article
Public, Environmental & Occupational Health
Kosuke Inoue, Elizabeth Rose Mayeda, Roch Nianogo, Kimberly Paul, Yu Yu, Mary Haan, Beate Ritz
Summary: Diabetes and depression are risk factors for cardiovascular disease. This study found that the joint presence of diabetes and depressive symptoms is associated with an increased risk of cardiovascular mortality among older Latinos.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Environmental Sciences
Yu Yu, Michael Jerrett, Kimberly C. Paul, Jason Su, I-Fan Shih, Jun Wu, Eunice Lee, Kosuke Inoue, Mary Haan, Beate Ritz
Summary: The study found that ambient ozone exposure may increase the risk of developing type 2 diabetes, especially among elderly Mexican Americans. Physical activity can reduce the risk of diabetes, and individuals who engage in outdoor physical activity are more susceptible to the effects of ozone.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Environmental Sciences
Thanh T. Hoang, Cancan Qi, Kimberly C. Paul, Mikyeong Lee, Julie D. White, Marie Richards, Scott S. Auerbach, Stuart Long, Srishti Shrestha, Tianyuan Wang, Laura E. Beane Freeman, Jonathan N. Hofmann, Christine Parks, Cheng-Jian Xu, Beate Ritz, Gerard H. Koppelman, Stephanie J. London
Summary: This study investigated the relationship between DNA methylation and several pesticide active ingredients in European ancestry male farmers, finding differential methylation patterns which may serve as biomarkers of chronic exposure and help understand the mechanisms of long-term health outcomes from pesticide exposure.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Clinical Neurology
Cynthia D. J. Kusters, Kimberly C. Paul, Aline Duarte Folle, Adrienne M. Keener, Jeff M. Bronstein, Lars Bertram, Johnni Hansen, Steve Horvath, Janet S. Sinsheimer, Christina M. Lill, Beate R. Ritz
Summary: The study found that a later age at menopause in women was associated with a decreased risk of PD, indicating that sex hormones or other factors related to late menopause may have neuroprotective effects on PD.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Jodi Maple-Grodem, Kimberly C. Paul, Ingvild Dalen, Kathie J. Ngo, Darice Wong, Angus D. Macleod, Carl E. Counsell, David Backstrom, Lars Forsgren, Ole-Bjorn Tysnes, Cynthia D. J. Kusters, Brent L. Fogel, Jeff M. Bronstein, Beate Ritz, Guido Alves
Summary: This study found no association between GBA carrier status and the risk of developing motor complications in Parkinson's disease patients. It is important to publish studies with null results to accurately summarize the clinical features of GBA-associated PD.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Psychiatry
Jutta Lindert, Kimberley C. Paul, Margie E. Lachman, Beate Ritz, Teresa E. Seeman
Summary: This study aimed to investigate the effects of depression, anxiety, and anger symptoms on cognition and cognition changes, particularly on episodic memory and executive functioning. The results showed that these symptoms were associated with declines in episodic memory and executive functioning.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biotechnology & Applied Microbiology
Kimberly C. Paul, Alexandra M. Binder, Steve Horvath, Cynthia Kusters, Qi Yan, Irish Del Rosario, Yu Yu, Jeff Bronstein, Beate Ritz
Summary: The study reveals a clear separation of epigenetic mitotic age by blood cell lineage, with PD patients showing accelerated mitotic aging and a correlation with extrinsic epigenetic age acceleration. These findings suggest a potential link between immune system imbalances and motor/cognitive progression in early PD.
Article
Clinical Neurology
Katherine A. Fu, Kimberly C. Paul, Ake T. Lu, Steve Horvath, Adrienne M. Keener, Yvette Bordelon, Jeff M. Bronstein, Beate Ritz
Summary: The study found that certain blood DNA methylation markers are associated with Parkinson's disease risk, which may provide insights into factors that are affected differently in early Parkinson's disease patients compared to controls.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Gary K. Chen, Qi Yan, Kimberly C. Paul, Cynthia D. J. Kusters, Aline Duarte Folle, Melissa Furlong, Adrienne Keener, Jeff Bronstein, Steve Horvath, Beate Ritz
Summary: The accumulation of stochastic epigenetic mutations (SEM), known as epigenetic mutation load (EML), is associated with the risk and progression of Parkinson's disease (PD). Specifically, PD-related genes show a significant association with EML, indicating their importance in the development and progression of the disease.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Cynthia D. J. Kusters, Kimberly C. Paul, Aline Duarte Folle, Adrienne M. Keener, Jeff M. Bronstein, Lars Bertram, Johnni Hansen, Steve Horvath, Janet S. Sinsheimer, Christina M. Lill, Beate R. Ritz
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Kimberly C. Paul, Frooi Debes, Eina Eliasen, Pal Weihe, Maria Skaalum Petersen
Summary: In the Faroese Septuagenarian cohort study, researchers found that 9.1% of participants were diagnosed with dementia within 10 years, with a higher incidence rate in women compared to men. After selection, gender and six neuropsychological tests were chosen to distinguish between those who would and would not develop dementia. Overall, the model was able to accurately identify 82% of non-dementia participants (specificity) and 71% of dementia participants (sensitivity).
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
