Article
Toxicology
Julia R. Varshavsky, Joshua F. Robinson, Yan Zhou, Kenisha A. Puckett, Elaine Kwan, Sirirak Buarpung, Rayyan Aburajab, Stephanie L. Gaw, Saunak Sen, Songmei Gao, Sabrina Crispo Smith, June-Soo Park, Igor Zakharevich, Roy R. Gerona, Susan J. Fisher, Tracey J. Woodruff
Summary: This study investigated the impact of PFASs and OPFRs on maternal-fetal health and placental development, indicating that these chemicals may contribute to abnormal placentation and future health risks.
TOXICOLOGICAL SCIENCES
(2021)
Article
Engineering, Environmental
Shuang Wang, Chenglong Ji, Fei Li, Junfei Zhan, Tao Sun, Jianhui Tang, Huifeng Wu
Summary: The study evaluated the reproductive endocrine-disrupting effects of TBBPA on mussels, showing that TBBPA treatment promotes gametogenesis and alters vertebrate sex hormone levels in mussels, while also affecting the transcription levels of SULT1E1 and STS. These findings provide new insights into assessing the impact of TBBPA and monitoring TBBPA in the marine environment.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Sagi Enicole A. Gillera, William P. Marinello, Mason A. Nelson, Brian M. Horman, Heather B. Patisaul
Summary: The study investigated the effects of chemical exposure and social stressors on prosocial behavior, showing that these factors may have unique behavioral effects, particularly differing by sex. However, the combination of the two factors did not result in worse outcomes.
Review
Chemistry, Analytical
Parvaneh Hajeb, Argelia Castano, Enrique Cequier, Adrian Covaci, Marta Esteban Lopez, Ana Gonzalez Antuna, Line Smastuen Haug, Luis Alberto Henriquez-Hernandez, Lisa Melymuk, Octavio Perez Luzardo, Cathrine Thomsen, Katrin Vorkamp
Summary: Human biomonitoring is an important method for assessing exposure to environmental pollutants, and this article reviews studies on the chemical analysis of flame retardants (FRs) in human samples. The article discusses the different analytical methods used for FR biomarkers and highlights the challenges in analyzing low concentrations of FRs and limited sample materials. The development of universal analytical methods is also mentioned.
ANALYTICA CHIMICA ACTA
(2022)
Review
Environmental Sciences
Lola Bajard, Chander K. Negi, Vicente Mustieles, Lisa Melymuk, Stephane Jomini, Johanna Barthelemy-Berneron, Mariana F. Fernandez, Ludek Blaha
Summary: This review identified gaps in data on the endocrine disrupting potential of many replacement flame retardants, calling for further evaluation and potential regulation of these chemicals. It also highlighted potential endocrine disrupting chemicals associated with reproductive outcomes among these emerging chemicals, raising concerns for mixture effects as the population is co-exposed to several flame retardants and other chemicals.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Jillian Ashley-Martin, Susan MacPherson, Zhao Zhao, Eric Gaudreau, Gilles Provencher, Mandy Fisher, Michael M. Borghese, Maryse F. Bouchard, Linda Booij, Tye E. Arbuckle
Summary: In this study, urinary concentrations of 15 organophosphate ester (OPE) metabolites in 1865 pregnant women were measured using two analytical methods. The results indicate widespread exposure to OPEs and their metabolites, and identify subpopulations who may have higher exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Esther Smollich, Malte Bueter, Gerhard Schertzinger, Elke Dopp, Bernd Sures
Summary: The ecotoxicological effects of photolytic degradation mixtures of two brominated flame retardants, PolymericFR and TBBPA-BDBMPE, were studied in vitro and in vivo. The degradation of both substances under UV-exposure caused changes in their ecotoxicological potential. Short-term exposure to the degraded flame retardants resulted in physiological reactions of the annelid, while chronic exposure did not affect the growth, reproduction, fragmentation, and energy storage of the annelid.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Mary E. Ingle, Lidia Minguez-Alarcon, Courtney C. Carignan, Heather M. Stapleton, Paige L. Williams, Jennifer B. Ford, Molly B. Moravek, Marie S. O'Neill, Lu Wang, Russ Hauser, John D. Meeker
Summary: This study found that there were differences in PBDEs and OH-BDEs concentrations between males and females during IVF, with no clear patterns of adverse IVF outcomes associated with PBDEs and OH-BDEs, but some decreases in associations with IVF outcomes were observed in isolated quartiles.
ENVIRONMENTAL RESEARCH
(2021)
Article
Engineering, Environmental
Jessica Trowbridge, Roy Gerona, Michael McMaster, Katherine Ona, Cassidy Clarity, Vincent Bessonneau, Ruthann Rudel, Heather Buren, Rachel Morello-Frosch
Summary: This study investigated the exposure to flame retardants among female firefighters and office workers, finding a specific FR compound associated with thyroid hormone levels in firefighters. Additionally, it revealed that intermediate body mass index and a college education were associated with higher FR levels.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Matthew Ruis, Kate Hoffman, Heather M. Stapleton
Summary: This study examined temporal changes in the accumulation of persistent organic pollutants (POPs) in human placenta and their association with birth outcomes. The results showed a decrease in placental concentrations of polybrominated diphenyl ethers (PBDEs) over time, particularly BDE-47. Placental tissues associated with female infants had higher levels of BDE-100 compared to male infants, and placental BDE-47 concentrations were significantly associated with lower birthweight in male infants.
Article
Environmental Sciences
Flavia Renata Abe, Andreia Avila Soares de Oliveira, Renan Vieira Marino, Taisa Carla Rizzi Rialto, Danielle Palma Oliveira, Daniel Junqueira Dorta
Summary: This study evaluated the toxicity of BDEs and HFFR on zebrafish early development. Results showed that at the highest concentration, BDE-47 induced edemas while HFFR ALPI had a lesser impact on development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Ishfaq Ahmad Sheikh, Mohd Amin Beg, Taha Abo-Almagd Abdel-Meguid Hamoda, Hammam Mahmoud Siraj Mandourah, Erdogan Memili
Summary: Polybrominated diphenyl ethers (PBDEs) are widely used fire-retardant chemicals in consumer products and have the potential to bioaccumulate in the environment, including wildlife and humans, leading to adverse health effects such as neurodevelopmental deficits and reproductive dysfunction. In this study, the structural interactions of four PBDEs with the thyroid hormone receptor (TR alpha) were investigated. The results showed that all four PBDEs bound tightly to TR alpha and disrupted the thyroid signaling, which could have implications in reproductive function and infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Bin Zou, Shuilai Qiu, Yifan Zhou, Ziyan Qian, Zhoumei Xu, Jingwen Wang, Yuling Xiao, Can Liao, Wenhao Yang, Longfei Han, Fukai Chu, Lei Song, Zhou Gui, Yuan Hu
Summary: Inspired by plant cell walls, a life-cycle safe multifunctional nanocomposite with properties of photothermal-healing, thermal stability, and fire safety has been developed. Through studying the chemical responses and gas-phase analysis, the self-assembly behavior and pyrolysis product capturing ability of the material have been revealed. In addition, the material effectively reduces the release of phosphorus compounds that may be detrimental to human health and the ecological environment.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Water Resources
Jiawen Yang, Wenjin Zhao, Yu Li
Summary: The study demonstrated that a recommended complementary food scheme (CFS) significantly reduced the joint toxicity of organophosphorus flame retardants (OPFRs) in pregnant women, with a focus on reproductive toxicity. The nutrients in the recommended CFS competed with OPFRs for binding to the joint toxic receptor (JTR), effectively reducing the toxicity. Simulation of OPFRs molecular metabolic pathways in pregnant women also showed a decrease in binding affinity with metabolic kinases, indicating a reduced inhibition effect on biochemical reactions in the body.
EXPOSURE AND HEALTH
(2021)
Article
Environmental Sciences
Michiel Bastiaensen, Celine Gys, Ann Colles, Veerle Verheyen, Gudrun Koppen, Eva Govarts, Liesbeth Bruckers, Bert Morrens, Ilse Loots, Annelies De Decker, Vera Nelen, Tim Nawrot, Stefaan De Henauw, Nik Van Larebeke, Greet Schoeters, Adrian Covaci
Summary: European adolescents are commonly exposed to organophosphate flame retardants and plasticizers, with some metabolites frequently detected in urine samples. These metabolite concentrations show seasonal variations. Although estimated daily intakes were generally low and below oral reference doses, individual differences in exposure levels may exist in certain circumstances.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Toxicology
Joshua F. Robinson, Mirhan Kapidzic, Emily G. Hamilton, Hao Chen, Kenisha W. Puckett, Yan Zhou, Katherine Ona, Emily Parry, Yunzhu Wang, June-Soo Park, Joseph F. Costello, Susan J. Fisher
TOXICOLOGICAL SCIENCES
(2019)
Review
Reproductive Biology
Julia Varshavsky, Anna Smith, Aolin Wang, Elizabeth Hom, Monika Izano, Hongtai Huang, Amy Padula, Tracey J. Woodruff
REPRODUCTIVE TOXICOLOGY
(2020)
Review
Obstetrics & Gynecology
Amy M. Padula, Catherine Monk, Patricia A. Brennan, Ann Borders, Emily S. Barrett, Cindy T. McEvoy, Sophie Foss, Preeya Desai, Akram Alshawabkeh, Renee Wurth, Carolyn Salafia, Raina Fichorova, Julia Varshavsky, Amii Kress, Tracey J. Woodruff, Rachel Morello-Frosch, D. K. Benjamin, P. B. Smith, K. L. Newby, L. P. Jacobson, C. B. Parker, R. Gershon, D. Cella, S. L. Teitelbaum, R. O. Wright, K. M. Aldous, T. Fennell, S. S. Hecht, L. Peterson, B. O'Brien, J. Y. Lee, J. Snowden, J. L. Aschner, A. A. Litonjua, F. P. Perera, M. R. Karagas, C. J. Newschaffer, A. L. Dunlop, P. A. Brennan, E. J. Corwin, P. K. Gregersen, B. Diamond, E. Oken, K. P. Kleinman, A. Ferrara, L. A. Croen, C. A. Camargo, J. E. Vena, R. Wapner, S. Deoni, H. G. Mueller, N. Paneth, C. Barone, G. E. Copeland, M. R. Elliott, D. M. Ruden, C. S. Duarte, G. J. Canino, C. E. Monk, J. E. Posner, C. B. Blair, L. Trasande, C. T. McEvoy, E. R. Spindel, A. N. Alshawabkeh, A. J. Elliott, B. Eskenazi, I Hertz-Picciotto, D. H. Bennett, J. B. Schweitzer, E. C. Claud, D. Dabelea, S. L. Schantz, L. D. Leve, J. L. Lewis, D. MacKenzie, M-G Begay, M. O'Shea, R. Fry, A. E. Hipwell, K. E. Keenan, T. G. O'Connor, C. Buss, R. K. Miller, P. D. Wadhwa, F. D. Gilliland, C. Breton, J. B. Stanford, E. B. Clark, C. Porucznik, C. Karr, N. R. Bush, K. Z. Lewinn, J. Gern, B. Lester, D. Gold, S. T. Weiss, R. T. Schultz, N. Hershey, R. Miller, J. B. Herbstman, C. J. Marsit, J. M. Ganiban, C. Johnson, D. Ownby, E. Zoratti, A. Stroustrup, K. Huddleston, H. E. Volk, R. J. Landa, K. Hunt, J. M. Neiderhiser, S. Sathyanarayana, F. Martinez, A. Wright, R. Keller, T. J. Woodruff, R. J. Schmidt, S. Ozonoff, B. Andrews, D. S. Messinger, V Padma-nabhan, J. Piven, H. N. Simhan, G. Pryhuber, F. A. Tylaysky, S. R. Dager, D. Maycock, W. L. Stone, D. Jackson, C. Seroogy, T. Hartert, P. Moore, L. Bacharier, K. N. Botteron
JOURNAL OF PERINATOLOGY
(2020)
Article
Obstetrics & Gynecology
Daisy Leon-Martinez, Joshua F. Robinson, Tamara Zdravkovic, Olga Genbacev, Matthew Gormley, Michael Mcmaster, Susan J. Fisher, Katherine Bianco
REPRODUCTIVE SCIENCES
(2020)
Article
Environmental Sciences
Julia R. Varshavsky, Rachel Morello-Frosch, Suhash Harwani, Martin Snider, Syrago-Styliani E. Petropoulou, June-Soo Park, Myrto Petreas, Peggy Reynolds, Tuan Nguyen, Thu Quach
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Developmental Biology
Sara K. Taylor, Sahar Houshdaran, Joshua F. Robinson, Matthew J. Gormley, Elaine Y. Kwan, Mirhan Kapidzic, Birgit Schilling, Linda C. Giudice, Susan J. Fisher
Article
Multidisciplinary Sciences
Leah McNally, Yan Zhou, Joshua F. Robinson, Guangfeng Zhao, Lee-may Chen, Hao Chen, M. Yvonne Kim, Mirhan Kapidzic, Matthew Gormley, Roberta Hannibal, Susan J. Fisher
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Julia R. Varshavsky, Saunak Sen, Joshua F. Robinson, Sabrina Crispo Smith, Julie Frankenfield, Yunzhu Wang, Greg Yeh, June-Soo Park, Susan J. Fisher, Tracey J. Woodruff
SCIENTIFIC REPORTS
(2020)
Article
Reproductive Biology
Hao Chen, Megan A. Chidboy, Joshua F. Robinson
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Toxicology
Julia R. Varshavsky, Joshua F. Robinson, Yan Zhou, Kenisha A. Puckett, Elaine Kwan, Sirirak Buarpung, Rayyan Aburajab, Stephanie L. Gaw, Saunak Sen, Songmei Gao, Sabrina Crispo Smith, June-Soo Park, Igor Zakharevich, Roy R. Gerona, Susan J. Fisher, Tracey J. Woodruff
Summary: This study investigated the impact of PFASs and OPFRs on maternal-fetal health and placental development, indicating that these chemicals may contribute to abnormal placentation and future health risks.
TOXICOLOGICAL SCIENCES
(2021)
Article
Developmental Biology
Hao Chen, Katherine E. Williams, Elaine Y. Kwan, Mirhan Kapidzic, Kenisha A. Puckett, Rayyan K. Aburajab, Joshua F. Robinson, Susan J. Fisher
Summary: During pregnancy, cytotrophoblasts from the placenta differentiate into specialized subpopulations, with some following an invasive pathway crucial for proper fetal development. The ability of these cells to migrate, invade and remodel arteries is essential for ensuring adequate blood flow to nourish the fetus. Advances in understanding the molecular features regulating the differentiation of these cells are ongoing, with a mass spectrometry-based approach providing new insights into their differentiation dynamics.
Review
Public, Environmental & Occupational Health
Nida Ozarslan, Joshua F. Robinson, Stephanie L. Gaw
JOURNAL OF TROPICAL MEDICINE
(2019)