Rewired signaling network in T cells expressing the chimeric antigen receptor ( CAR )

Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differentiation

(2019) Iva Xhangolli et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

TCR–pMHC bond conformation controls TCR ligand discrimination

(2019) Dibyendu K. Sasmal et al.   Cellular & Molecular Immunology

Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency

(2019) David N. Nguyen et al.   NATURE BIOTECHNOLOGY

Capturing resting T cells: the perils of PLL

(2018) Ana Mafalda Santos et al.   NATURE IMMUNOLOGY

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

(2018) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chimeric antigen receptor T cell therapy for non-Hodgkin lymphoma

(2018) Armin Ghobadi   Current Research in Translational Medicine

Strategies to Address Chimeric Antigen Receptor Tonic Signaling

(2018) Adam Ajina et al.   MOLECULAR CANCER THERAPEUTICS

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

(2018) Eric Shifrut et al.   CELL

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

(2015) Kathrin Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE