Loss of gene function and evolution of human phenotypes

The acquisition of novel N-glycosylation sites in conserved proteins during human evolution

(2015) Dong Seon Kim et al.   BMC BIOINFORMATICS

Always follow your nose: The functional significance of social chemosignals in human reproduction and survival

(2015) Katrin T. Lübke et al.   HORMONES AND BEHAVIOR

Insights into hominin phenotypic and dietary evolution from ancient DNA sequence data

(2015) George H. Perry et al.   JOURNAL OF HUMAN EVOLUTION

The Evolution and Functional Impact of Human Deletion Variants Shared with Archaic Hominin Genomes

(2015) Yen-Lung Lin et al.   MOLECULAR BIOLOGY AND EVOLUTION

Identification of a large set of rare complete human knockouts

(2015) Patrick Sulem et al.   NATURE GENETICS

Human knockout research: new horizons and opportunities

(2015) Fowzan S. Alkuraya   TRENDS IN GENETICS

Host Adaptation of a Bacterial Toxin from the Human Pathogen Salmonella Typhi

(2014) Lingquan Deng et al.   CELL

N-Glycolylneuraminic Acid on Human Epithelial Cells Prevents Entry of Influenza A Viruses That Possess N-Glycolylneuraminic Acid Binding Ability

(2014) T. Takahashi et al.   JOURNAL OF VIROLOGY

Frequent Expansions of the Bitter Taste Receptor Gene Repertoire during Evolution of Mammals in the Euarchontoglires Clade

(2014) Takashi Hayakawa et al.   MOLECULAR BIOLOGY AND EVOLUTION

Comparative primate genomics: emerging patterns of genome content and dynamics

(2014) Jeffrey Rogers et al.   NATURE REVIEWS GENETICS

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction

(2014) Dong Seon Kim et al.   PLoS One

The Hunt for Missing Genes

(2014) J. Kaiser   SCIENCE

Humans Can Discriminate More than 1 Trillion Olfactory Stimuli

(2014) C. Bushdid et al.   SCIENCE

Gains of ubiquitylation sites in highly conserved proteins in the human lineage

(2012) Dong Seon Kim et al.   BMC BIOINFORMATICS

Human-specific protein isoforms produced by novel splice sites in the human genome after the human-chimpanzee divergence

(2012) Dong Seon Kim et al.   BMC BIOINFORMATICS

Olfactory Receptor Multigene Family in Vertebrates: From the Viewpoint of Evolutionary Genomics

(2012) Yoshihito Niimura   CURRENT GENOMICS

ENDURANCE RUNNING AND ITS RELEVANCE TO SCAVENGING BY EARLY HOMININS

(2012) Graeme D. Ruxton et al.   EVOLUTION

Metabolism of Vertebrate Amino Sugars withN-Glycolyl Groups

(2012) Anne K. Bergfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Major taste loss in carnivorous mammals

(2012) P. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomedical Differences Between Human and Nonhuman Hominids: Potential Roles for Uniquely Human Aspects of Sialic Acid Biology

(2011) Nissi M. Varki et al.   Annual Review of Pathology-Mechanisms of Disease

Linkage analysis of plasma dopamine β-hydroxylase activity in families of patients with schizophrenia

(2011) Joseph F. Cubells et al.   HUMAN GENETICS

Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners

(2011) N. Roudnitzky et al.   HUMAN MOLECULAR GENETICS

Loss-of-Function Mutation in a Repressor Module of Human-Specifically Activated Enhancer HACNS1

(2011) K. Sumiyama et al.   MOLECULAR BIOLOGY AND EVOLUTION

Human-specific loss of regulatory DNA and the evolution of human-specific traits

(2011) Cory Y. McLean et al.   NATURE

Identification of human-specific transcript variants induced by DNA insertions in the human genome

(2010) Dong Seon Kim et al.   BIOINFORMATICS

The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

(2010) Onofre Combarros et al.   BMC Medical Genetics

Loss-of-function variants in the genomes of healthy humans

(2010) D. G. MacArthur et al.   HUMAN MOLECULAR GENETICS

Characterization of TRPC2, an Essential Genetic Component of VNS Chemoreception, Provides Insights into the Evolution of Pheromonal Olfaction in Secondary-Adapted Marine Mammals

(2010) Li Yu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Degeneration of Olfactory Receptor Gene Repertories in Primates: No Direct Link to Full Trichromatic Vision

(2010) A. Matsui et al.   MOLECULAR BIOLOGY AND EVOLUTION

Pseudogenization of the Umami Taste Receptor Gene Tas1r1 in the Giant Panda Coincided with its Dietary Switch to Bamboo

(2010) H. Zhao et al.   MOLECULAR BIOLOGY AND EVOLUTION

Origin of the human malaria parasite Plasmodium falciparum in gorillas

(2010) Weimin Liu et al.   NATURE

The craniomandibular mechanics of being human

(2010) S. Wroe et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Genome-wide Survey of the Prevalence and Evolutionary Forces Acting on Human Nonsense SNPs

(2009) Bryndis Yngvadottir et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human-specific transcriptional regulation of CNS development genes by FOXP2

(2009) Genevieve Konopka et al.   NATURE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human-specific evolution of sialic acid targets: Explaining the malignant malaria mystery?

(2009) A. Varki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The origin of malignant malaria

(2009) S. M. Rich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinctive structures between chimpanzee and humanin a brain noncoding RNA

(2008) A. Beniaminov et al.   RNA

Human-Specific Gain of Function in a Developmental Enhancer

(2008) S. Prabhakar et al.   SCIENCE

The Vestigial Olfactory Receptor Subgenome of Odontocete Whales: Phylogenetic Congruence between Gene-Tree Reconciliation and Supermatrix Methods

(2008) Michael R. McGowen et al.   SYSTEMATIC BIOLOGY