Article
Virology
Qutaiba A. Al Khames Aga, Waseem H. Alkhaffaf, Tagreed H. Hatem, Kawthar F. Nassir, Yazan Batineh, Abdullah T. Dahham, Dimah Shaban, Luma A. Al Khames Aga, Manhal Y. R. Agha, Muaamar Traqchi
Summary: This study investigated the adverse effects associated with three different COVID-19 vaccines and found that local reactions were more common with Pfizer and AstraZeneca vaccines, while systemic events were more prevalent with AstraZeneca and Pfizer vaccines. There was no correlation between age or gender and the duration of adverse effects, and some participants reported unusual symptoms like swelling of eyelids and severe allergic reactions. Overall, Pfizer, AstraZeneca, and Sinopharm vaccines were deemed safe, with Sinopharm showing lower prevalence of adverse effects compared to the others.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiyue He, Xiaoyan Chen, Hairui Wang, Guangsheng Du, Xun Sun
Summary: Exploring novel routes of immunization, particularly respiratory immunization, has become a prominent area of study in recent years. However, the development of respiratory vaccines is challenging due to physiological barriers and technical constraints.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Immunology
Jang Hyun Park, Heung Kyu Lee
Summary: The development of COVID-19 vaccines includes various types such as subunit vaccines, inactivated vaccines, and nucleic acid vaccines, but currently only intramuscular vaccination is available. Research suggests that mucosal vaccination may enhance local immune responses, but the lack of understanding of mucosal immunity combined with the urgent need for a COVID-19 vaccine has resulted in the limited delivery options available at present.
Review
Virology
Aleksandra Anna Zasada, Aniela Darlinska, Aldona Wiatrzyk, Katarzyna Woznica, Kamila Forminska, Urszula Czajka, Malgorzata Glowka, Klaudia Lis, Paulina Gorska
Summary: The development of COVID-19 vaccines has been unprecedented in terms of speed, with various vaccine platforms receiving approval for human application.
Review
Medicine, General & Internal
Mai N. Vu, Hannah G. Kelly, Stephen J. Kent, Adam K. Wheatley
Summary: COVID-19 has caused massive health and economic disruptions globally, and mass vaccination is the most efficient way to end the pandemic. Nanoparticle-based vaccines are becoming increasingly important in extending or improving vaccination outcomes against COVID-19, with over 26 candidates in clinical testing and around 60 more in pre-clinical development. The emerging promise of nanotechnology in vaccine design and manufacturing to combat SARS-CoV-2 presents both opportunities and challenges.
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt, Ishan Kamat, Peter J. Hotez
Summary: Myocarditis is a rare complication of COVID-19 mRNA vaccines, predominantly affecting young adult and adolescent males, with most patients showing improvement in symptoms. Possible mechanisms include molecular mimicry between viral proteins and self-antigens, dysregulated immune pathways, immune response to mRNA, and dysregulated cytokine expression.
Article
Immunology
Deepak Subedi, Saurav Pantha, Sanju Subedi, Anil Gautam, Asmita Gaire, Deepak Sapkota, Sachin Sapkota, Milan Kandel, Aabishkar Parajuli, Harishchandra Ghimire, Shristi Ghimire, Janardan Devkota, Santosh Dhakal
Summary: The study found that the majority of residents in Nepal perceive COVID-19 vaccines as safe and effective, and support prioritizing vaccine distribution to older adults and healthcare workers. Over 60% of participants have received at least one dose of the vaccine, and nearly 93% of the unvaccinated individuals are willing to get vaccinated when their turn comes.
Review
Cardiac & Cardiovascular Systems
Runyu Liu, Junbing Pan, Chunxiang Zhang, Xiaolei Sun
Summary: Vaccination against COVID-19 has become crucial in controlling the pandemic, but it comes with potential cardiovascular complications such as myocarditis and immune thrombocytopenia. Accurate reporting and monitoring of vaccine safety are essential to address public concerns and ensure effective vaccine administration.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Santiago Grau, Elena Martin-Garcia, Olivia Ferrandez, Raquel Martin, Sonia Tejedor-Vaquero, Ramon Gimeno, Giuliana Magri, Rafael Maldonado
Summary: Evaluated the integrity and immunogenicity of COVID-19 mRNA vaccines after re-freezing vials, finding that the vaccines can be re-frozen under specific freezing conditions without losing their effectiveness.
Review
Environmental Sciences
Diksha Nagpal, Shakti Nagpal, Deepak Kaushik, Himanshu Kathuria
Summary: This review summarizes the clinical status of COVID-19 and available treatment approaches, discusses the negative impacts of the pandemic on the economy and the strategies against new variants, providing insights into the current status and upcoming vaccines and therapies for COVID-19 management.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
Azure Tariro Makadzange, Patricia Gundidza, Charles Lau, Norest Beta, Nellie Myburgh, Nyasha Elose, Wilmot James, Lawrence Stanberry, Chiratidzo Ndhlovu
Summary: This study evaluated the adverse events following vaccination with whole inactivated COVID-19 vaccines in an African population and found that the vaccines were well tolerated with mostly mild symptoms, and no hospitalizations were required. Participants who perceived the vaccines as safe or had a personal experience with COVID-19 were less likely to report adverse events.
Review
Virology
Shahab Falahi, Azra Kenarkoohi
Summary: The efficacy of vaccines can vary due to individual and population differences and can be influenced by various factors, including host factors. Previous studies have shown that host factors can affect vaccine effectiveness, including those for COVID-19 vaccines.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Li-Ping Wong, Hai-Yen Lee, Haridah Alias, Sazaly AbuBakar
Summary: This study conducted in Malaysia found that parents' willingness to vaccinate their children against COVID-19 is influenced by their perceived susceptibility to the disease and their concerns about vaccines. A significant number of parents showed a preference for traditional vaccines over mRNA vaccines, citing concerns about mRNA technology and potential side effects. Public education campaigns are needed to address these concerns and increase vaccine acceptance among hesitant parents.
Article
Immunology
Azure Tariro Makadzange, Patricia Gundidza, Charles Lau, Janan Dietrich, Norest Beta, Nellie Myburgh, Nyasha Elose, Chiratidzo Ndhlovu, Wilmot James, Lawrence Stanberry
Summary: Despite sufficient vaccine supply, less than 25% of the population in sub-Saharan Africa has received a COVID-19 vaccine. This study surveyed individuals who were late-adopters of vaccination in Zimbabwe to understand their attitudes towards vaccine mandates and vaccines for children. The findings suggest that vaccine mandates can help mitigate vaccine hesitancy and increase vaccine coverage in Africa.
Review
Medicine, General & Internal
Aqu Alu, Li Chen, Hong Lei, Yuquan Wei, Xiaohe Tian, Xiawei Wei
Summary: Currently licensed COVID-19 vaccines are administered intramuscularly and fail to activate mucosal immunity, which contributes to the inability to prevent upper respiratory tract infection. The demand for the next generation of COVID-19 vaccines that can induce both mucosal and systemic immune responses has led to the investigation of intranasal vaccination. Several intranasal vaccines against SARS-CoV-2 are currently under intensive investigation, with 12 candidates in clinical trials at different phases.
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)