Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes

Critical evaluation of the DNA-methylation markers ABCG1 and SREBF1 for Type 2 diabetes stratification

(2019) Christin Krause et al.   Epigenomics

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

(2019) Jun Liu et al.   Nature Communications

GWAS Central: a comprehensive resource for the discovery and comparison of genotype and phenotype data from genome-wide association studies

(2019) Tim Beck et al.   NUCLEIC ACIDS RESEARCH

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers

(2018) Midori Honma et al.   INTERNATIONAL JOURNAL OF OBESITY

A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver

(2018) Tobias Strunz et al.   Scientific Reports

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis

(2018) Christin Krause et al.   Endocrine Connections

Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma

(2017) Wenxia Shi et al.   MEDICINE

DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions

(2017) Dimitra Karagkouni et al.   NUCLEIC ACIDS RESEARCH

JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework

(2017) Aziz Khan et al.   NUCLEIC ACIDS RESEARCH

Impact of cytosine methylation on DNA binding specificities of human transcription factors

(2017) Yimeng Yin et al.   SCIENCE

Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies

(2017) Tsuyoshi Hachiya et al.   npj Genomic Medicine

The epigenetic signature of systemic insulin resistance in obese women

(2016) Peter Arner et al.   DIABETOLOGIA

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

(2016) Naoto Kubota et al.   Nature Communications

Miravirsen dosing in chronic hepatitis C patients results in decreased microRNA-122 levels without affecting other microRNAs in plasma

(2015) M. H. van der Ree et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain

(2014) Ryan L. Boudreau et al.   NEURON

The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells

(2014) Yuan Gao et al.   NUCLEIC ACIDS RESEARCH

Transcriptional Control of Hepatic Lipid Metabolism by SREBP and ChREBP

(2013) Xu Xu et al.   SEMINARS IN LIVER DISEASE

Role of DNA Methylation in the Regulation of Lipogenic Glycerol-3-Phosphate Acyltransferase 1 Gene Expression in the Mouse Neonatal Liver

(2012) T. Ehara et al.   DIABETES

Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects

(2012) R Rametta et al.   INTERNATIONAL JOURNAL OF OBESITY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

Factorbook.org: a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium

(2012) J. Wang et al.   NUCLEIC ACIDS RESEARCH

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

High density DNA methylation array with single CpG site resolution

(2011) Marina Bibikova et al.   GENOMICS

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Targeting microRNA-122 to Treat Hepatitis C Virus Infection

(2010) Catherine L. Jopling   Viruses-Basel

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of Genes

(2008) Brian D. Reed et al.   PLoS Genetics