Review
Oncology
Shangzhi Feng, Kecheng Lou, Cong Luo, Junrong Zou, Xiaofeng Zou, Guoxi Zhang
Summary: This review focuses on the relationship between obesity and prostate cancer, as well as the role of exosomes. It has been found that there is bidirectional communication between obesity-related adipose tissue and prostate cancer. This review provides new directions for understanding obesity as a risk factor for prostate cancer and highlights the potential use of adipose tissue and exosomes in cancer treatment.
Review
Pharmacology & Pharmacy
Ruping Pan, Jiadai Liu, Yong Chen
Summary: Diabetes mellitus is classified into four types, with type 2 diabetes mellitus (T2DM) having the highest incidence rate and being most associated with obesity. T2DM is characterized by high blood glucose due to insulin resistance and insufficient insulin secretion. Obesity causes insulin resistance, but it can potentially be treated by activating thermogenic adipose tissues.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuki Makino, Hayato Hikita, Seiya Kato, Masaya Sugiyama, Minoru Shigekawa, Tatsuya Sakamoto, Yoichi Sasaki, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Shogo Kobayashi, Hidetoshi Eguchi, Nobuyuki Takemura, Norihiro Kokudo, Hideki Yokoi, Masashi Mukoyama, Tomohide Tatsumi, Tetsuo Takehara
Summary: In hepatocellular carcinoma (HCC), CTGF-mediated tumor-stroma crosstalk activates STAT3 to promote HCC progression, and a positive feedback loop between STAT3 and CTGF is formed. This finding may serve as a potential therapeutic target for HCC treatment.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Haidong Zhao, Mingli Wu, Xiaoqin Tang, Qi Li, Xiaohua Yi, Wanxia Zhao, Xiuzhu Sun
Summary: This study reveals the metabolic mechanism of subcutaneous adipose tissue in chicks, demonstrates the crucial role of FFA-induced Ccl2 (chicken CCL26) secretion in lipid transportation, and identifies the significant involvement of macrophages in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Agnieszka Arthur, Stan Gronthos
Summary: Skeletal integrity is maintained through a tightly regulated bone remodeling process involving interactions between different cellular systems within the bone microenvironment. Disruption of these dynamic interactions can lead to poor bone health and an increased susceptibility to skeletal diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Marina Agueda-Oyarzabal, Brice Emanuelli
Summary: Brown adipose tissue and white adipose tissue are influenced by immune cells, which play a crucial role in maintaining and activating the adipose tissue through complex communication networks.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Sanil Patel, Njeri Z. R. Sparman, Douglas Arneson, Alexandra Alvarsson, Luis C. Santos, Samuel J. J. Duesman, Alessia Centonze, Ephraim Hathaway, In Sook Ahn, Graciel Diamante, Ingrid Cely, Chung Hwan Cho, Noble Kumar Talari, Abha K. K. Rajbhandari, Leigh Goedeke, Peng Wang, Atul J. J. Butte, Cedric Blanpain, Karthickeyan Chella Krishnan, Aldons J. J. Lusis, Sarah A. A. Stanley, Xia Yang, Prashant Rajbhandari
Summary: The mammary gland ductal epithelial cells regulate cold-induced adipocyte UCP1 expression and control adipose thermogenesis through the secretion of mammokines. These findings suggest that sympathetic nerve-activated glandular epithelium plays a crucial role in adipocyte UCP1 expression and has implications for energy expenditure and subcutaneous fat loss.
Article
Endocrinology & Metabolism
Junkun Jiang, Donglei Zhou, Anke Zhang, Wenjing Yu, Lei Du, Huiwen Yuan, Chuan Zhang, Zelin Wang, Xuyang Jia, Zhen-Ning Zhang, Bing Luan
Summary: The release of zinc from thermogenic adipocytes promotes sympathetic innervation of brown and white adipose tissue, establishing a positive feedback mechanism for thermogenesis and energy expenditure regulation. This mechanism plays a crucial role in adaptive thermogenesis and has potential implications for the treatment of obesity.
Review
Cell Biology
Graciano da Nadyellem Silva, Angelica Amorim Amato
Summary: Adipose tissue undergoes significant changes with aging, leading to an increased risk of metabolic diseases. These changes include defective adipogenesis, dysfunctional adipokine secretion, inflammation, and impaired thermogenesis. Brown and beige adipocytes play a role in regulating energy homeostasis. Age-related reduction in thermogenic adipocyte mass and function can be attributed to diminished adipose precursor cell pool size and adipogenic potential, mitochondrial dysfunction, decreased sympathetic signaling, and altered paracrine and endocrine signals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras, Emilio P. Mottillo
Summary: Metabolic diseases have negative health outcomes and are associated with dysregulated energy metabolism. Adipose tissue plays a crucial role in energy homeostasis and utilizes redox reactions for metabolism. Non-shivering thermogenesis, a highly oxidative process, can enhance energy expenditure and may have beneficial effects on metabolic health. However, targeting the redox mechanisms of adipose tissue as a therapeutic approach for metabolic disease remains understudied.
Article
Endocrinology & Metabolism
Kristin E. Cla, Kyle H. Flippo, Andrew I. Sullivan, Meghan C. Naber, Bolu Zhou, Tate J. Neff, Sharon O. Jensen-Cody, Matthew J. Potthoff
Summary: UCP1 is expressed not only in thermogenic adipose tissues, but also in various other tissues such as the kidneys, adrenal glands, thymus, and hypothalamus. Active expression of UCP1 is also observed in the central nervous system of mice.
MOLECULAR METABOLISM
(2022)
Article
Multidisciplinary Sciences
Morten Lundh, Ali Altintas, Marco Tozzi, Odile Fabre, Tao Ma, Farnaz Shamsi, Zachary Gerhart-Hines, Romain Barres, Yu-Hua Tseng, Brice Emanuelli
Summary: The scaffold protein Afadin is dynamically regulated by cold in brown adipose tissue (BAT) and plays a role in supporting the adrenergic response in brown adipocytes. Afadin depletion leads to decreased enrichment of gene sets controlling essential metabolic functions in BAT at thermoneutrality, and alters the reprogramming response to cold with enhanced enrichment of pathways related to metabolism and remodeling.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xin Liu, Chunhua Huang, Tingting Jiang, Xueliang Sun, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Dinghui Dai, Yan Wang, Li Li, Hongping Zhang, Linjie Wang
Summary: This study identified a cold-induced long noncoding RNA (lncRNA) called lncDGAT2 in the brown adipose tissue (BAT) of newborn goats. Functional studies showed that lncDGAT2 promotes the differentiation of brown and white adipocytes as well as the expression of thermogenic genes. Additionally, the transcription factor PRDM4 directly binds to the lncDGAT2 promoter to activate its transcription, and the PRDM4-lncDGAT2 axis is crucial for the brown adipocyte thermogenic gene program.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Briana K. Shimada, Ligia M. Watanabe, Sydonie Swanson, Pamela Toh, Lucia A. Seale
Summary: Selenium plays a role in energy metabolism, particularly in brown and beige adipocytes. The selenoprotein DIO2 is crucial for activating adaptive thermogenesis, and other selenoproteins may also be involved. This review discusses the involvement of selenium metabolism and selenoproteins in the mechanisms of adaptive thermogenesis in brown and beige adipocytes, highlighting the gaps in knowledge.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Oncology
Inge Oudaert, Arne Van der Vreken, Anke Maes, Elke De Bruyne, Kim De Veirman, Karin Vanderkerken, Eline Menu
Summary: This article discusses the metabolic adaptations of Multiple Myeloma (MM) cells in a hypoxic environment and how targeted treatments can block tumor progression.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kang-Yun Lu, Kingsley Theras Primus Dass, Shinn-Zong Lin, Yu-Hua Tseng, Shih-Ping Liu, Horng-Jyh Harn
Summary: Our study demonstrated that N-butylidenephthalide (BP) derived from Angelica sinensis can improve the metabolic profiles of mice with high fat diet-induced obesity (DIO) by preventing weight gain, improving serum blood parameters, enhancing energy expenditure, stimulating white fat browning, and reversing hepatic steatosis. BP treatment upregulated the mRNA expression of beige and brown fat selected genes in white adipose tissues, and promoted AMPK signaling and oxygen consumption in murine differentiated beige adipocytes, suggesting its potential utility for clinical use in the treatment of obesity and related diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Anushka Gupta, Farnaz Shamsi, Nicolas Altemose, Gabriel F. Dorlhiac, Aaron M. Cypess, Andrew P. White, Nir Yosef, Mary Elizabeth Patti, Yu-Hua Tseng, Aaron Streets
Summary: Single-nucleus RNA sequencing (snRNA-seq) is applicable for characterizing cellular diversity in adipose tissue, but it has inherent biases and limitations compared to whole-cell RNA sequencing (scRNA-seq).
Review
Endocrinology & Metabolism
Farnaz Shamsi, Chih-Hao Wang, Yu-Hua Tseng
Summary: Obesity and metabolic disorders are highly related to adipose tissue, and activating and expanding BAT and beige adipose tissue can increase energy expenditure and potentially treat obesity.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Matthew D. Lynes, Diana L. Carlone, Kristy L. Townsend, David T. Breault, Yu-Hua Tseng
Summary: In this study, researchers used a mouse model to track mTert-expressing cells in live animals for over a year. They identified a rare population of stem cells in adipose tissue that have the ability to self-renew and differentiate into adipocytes. The study also showed that a high-fat diet can initiate differentiation of these cells in vivo.
Article
Cell Biology
Marco Rosina, Veronica Ceci, Riccardo Turchi, Li Chuan, Nicholas Borcherding, Francesca Sciarretta, Maria Sanchez-Diaz, Flavia Tortolici, Keaton Karlinsey, Valerio Chiurchi, Claudia Fuoco, Rocky Giwa, Rachael L. Field, Matteo Audano, Simona Arena, Alessandro Palma, Federica Riccio, Farnaz Shamsi, Giovanni Renzone, Martina Verri, Anna Crescenzi, Salvatore Rizza, Fiorella Faienza, Giuseppe Filomeni, Sander Kooijman, Stefano Rufini, Antoine A. F. de Vries, Andrea Scaloni, Nico Mitro, Yu-Hua Tseng, Andre's Hidalgo, Beiyan Zhou, Jonathan R. Brestoff, Katia Aquilano, Daniele Lettieri-Barbato
Summary: Recent findings show that mitochondria can be transferred between cells to control metabolic homeostasis. This study reveals that thermogenically stressed brown adipocytes release extracellular vesicles (EVs) containing damaged mitochondrial parts to avoid failure of the thermogenic program. The efficient removal of these EVs by tissue-resident macrophages is crucial for preserving the function of brown adipose tissue (BAT) and its response to cold exposure.
Article
Cardiac & Cardiovascular Systems
Kyoungmin Park, Qian Li, Matthew D. Lynes, Hisashi Yokomizo, Ernesto Maddaloni, Takanori Shinjo, Ronald St-Louis, Qin Li, Sayaka Katagiri, Jialin Fu, Allen Clermont, Hyunseok Park, I-Hsien Wu, Marc Gregory Yu, Hetal Shah, Yu-Hua Tseng, George L. King
Summary: This study found that activation of endothelial cells and eNOS by insulin can promote differentiation of PPCs into BAT, improving systemic bioenergetics and reducing atherosclerosis. This suggests that endothelial dysfunction is a major contributor of energy disequilibrium in obesity.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tadataka Tsuji, Valerie Bussberg, Allison M. MacDonald, Niven R. Narain, Michael A. Kiebish, Yu-Hua Tseng
Summary: A balanced omega-6/omega-3 polyunsaturated fatty acids (PUFAs) ratio in brown adipose tissue (BAT) can have a positive impact on metabolic health. In this study, mice receiving Fat-1 BAT transplants showed improved glucose tolerance and higher energy expenditure. The targeted lipidomic analysis revealed significant changes in omega-6 oxylipins in the circulation of these mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Kristy L. Townsend, Eleanor Pritchard, Jeannine M. Coburn, Young Mi Kwon, Magdalena Blaszkiewicz, Matthew D. Lynes, David L. Kaplan, Yu-Hua Tseng
Summary: Delivery of bone morphogenetic protein 7 (BMP7) via silk scaffolds directly into subcutaneous white adipose tissue (scWAT) can induce the differentiation of progenitor cells into brown adipocytes, increasing energy expenditure and reducing weight gain. This method shows promise as a potential therapeutic avenue for metabolic treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Yu-Hua Tseng
Summary: Several exciting discoveries in 2022 shed light on the cellular composition and cell-cell communication within the adipose tissue, as well as its interaction with other organs and its role in metabolism.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Cell Biology
Tadataka Tsuji, Yu-Hua Tseng
Summary: Adipose tissue is important for metabolism regulation, producing bioactive molecules that communicate with and modulate other organs. Lipid metabolites, or lipokines, have been found to play a key role in various metabolic processes. This review discusses the latest advances in adipose tissue-derived lipokines and their cellular and molecular functions, as well as potential therapeutic implications for obesity and its associated complications.
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2023)
Article
Multidisciplinary Sciences
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi
Summary: Mitochondrial morphology, regulated by fission and fusion, plays a crucial role in the thermogenic capacity of brown adipocytes. TMEM135 has been identified as a critical mediator in the regulation of mitochondrial fission and thermogenesis, providing a potential target for therapeutic activation of brown adipose tissue.
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Matthew D. Lynes, Qian Huang, Carolina Cora, Sheng-Chiang Su, Peng Yi, Yu-Hua Tseng
Summary: This study reveals the complexity of genetic regulation of brown adipogenesis and glucose metabolism. The E3-ubiquitin ligase Rfwd2 was found to suppress glucose uptake in brown adipocytes.
Article
Biology
Farnaz Shamsi, Rongbin Zheng, Li-Lun Ho, Kaifu Chen, Yu-Hua Tseng
Summary: Brown adipose tissue (BAT) regulates body temperature through thermogenesis. Cold exposure enhances intercellular interactions among major cell types in BAT, leading to remodeling of the extracellular matrix, inflammatory response, angiogenesis, and neurite growth.
COMMUNICATIONS BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Elena Kempf, Kathrin Landgraf, Robert Stein, Martha Hanschkow, Anja Hilbert, Rami Abou Jamra, Paula Boczki, Gunda Herberth, Andreas Kuehnapfel, Yu-Hua Tseng, Claudia Staeubert, Torsten Schoeneberg, Peter Kuehnen, N. William Rayner, Eleftheria Zeggini, Wieland Kiess, Matthias Blueher, Antje Koerner
Summary: We report a heterozygous tandem duplication in the ASIP gene locus that causes widespread ectopic expression of ASIP in a female patient with extreme childhood obesity. Our data indicate that this ubiquitous ectopic ASIP expression is likely a monogenic cause of human obesity.
Article
Endocrinology & Metabolism
Satoru Sugimoto, Hebe Agustina Mena, Brian E. Sansbury, Shio Kobayashi, Tadataka Tsuji, Chih-Hao Wang, Xuanzhi Yin, Tian Lian Huang, Joji Kusuyama, Sean D. Kodani, Justin Darcy, Gerson Profeta, Nayara Pereira, Rudolph E. Tanzi, Can Zhang, Thomas Serwold, Efi Kokkotou, Laurie J. Goodyear, Aaron M. Cypess, Luiz Osorio Leiria, Matthew Spite, Yu-Hua Tseng
Summary: The study found that cold exposure can improve obesity-induced inflammation and insulin resistance, and enhance glucose tolerance. The beneficial effects are dependent on brown adipose tissue (BAT) and liver. The researchers discovered that cold and beta 3-adrenergic stimulation promote the production of MaR2 from BAT, which reduces inflammation in obesity, particularly targeting macrophages in the liver.