Mechanisms of human embryo development: from cell fate to tissue shape and back

Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation

(2020) Sofiane Hamidi et al.   DEVELOPMENT

Integration of luminal pressure and signalling in tissue self-organization

(2020) Chii J. Chan et al.   DEVELOPMENT

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

(2020) Susanne C. van den Brink et al.   NATURE

Single-cell analysis of human embryos reveals diverse patterns of aneuploidy and mosaicism

(2020) Margaret R. Starostik et al.   GENOME RESEARCH

Embryonic stem cells become mechanoresponsive upon exit from ground state of pluripotency

(2019) C. M. Verstreken et al.   Open Biology

Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

(2019) Stefano Vianello et al.   DEVELOPMENTAL CELL

A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells

(2019) Iain Martyn et al.   DEVELOPMENT

Mechanochemical Feedback Loops in Development and Disease

(2019) Edouard Hannezo et al.   CELL

Hydraulic control of mammalian embryo size and cell fate

(2019) Chii Jou Chan et al.   NATURE

Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst

(2019) Julien G. Dumortier et al.   SCIENCE

Self-organization of stem cells into embryos: A window on early mammalian development

(2019) Marta N. Shahbazi et al.   SCIENCE

Reconstituting the transcriptome and DNA methylome landscapes of human implantation

(2019) Fan Zhou et al.   NATURE

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

Chromosome errors in human eggs shape natural fertility over reproductive life span

(2019) Jennifer R. Gruhn et al.   SCIENCE

Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm

(2019) Madeleine Linneberg-Agerholm et al.   DEVELOPMENT

Dynamics of trophoblast differentiation in peri-implantation–stage human embryos

(2019) Rachel C. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro culture of cynomolgus monkey embryos beyond early gastrulation

(2019) Huaixiao Ma et al.   SCIENCE

Dissecting primate early post-implantation development using long-term in vitro embryo culture

(2019) Yuyu Niu et al.   SCIENCE

Mouse embryo geometry drives formation of robust signaling gradients through receptor localization

(2019) Zhechun Zhang et al.   Nature Communications

Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation

(2019) Allyson Quinn Ryan et al.   DEVELOPMENTAL CELL

Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling

(2018) Mariya P. Dobreva et al.   DEVELOPMENT

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast

(2018) Giuliano G. Stirparo et al.   DEVELOPMENT

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

Deconstructing and reconstructing the mouse and human early embryo

(2018) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Geometrical confinement controls the asymmetric patterning of brachyury in cultures of pluripotent cells

(2018) Guillaume Blin et al.   DEVELOPMENT

Self-organization of a human organizer by combined Wnt and Nodal signalling

(2018) I. Martyn et al.   NATURE

Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells

(2018) Bruno Di Stefano et al.   NATURE METHODS

Human blastocysts of normal and abnormal karyotypes display distinct transcriptome profiles

(2018) Frederick Licciardi et al.   Scientific Reports

In Toto Imaging and Reconstruction of Post-Implantation Mouse Development at the Single-Cell Level

(2018) Katie McDole et al.   CELL

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

(2018) Neophytos Christodoulou et al.   NATURE CELL BIOLOGY

Selection of human blastocysts with a high implantation potential based on timely compaction

(2017) Yamato Mizobe et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Prediction of blastocyst development and implantation potential in utero based on the third cleavage and compaction times in mouse pre-implantation embryos

(2017) Jihyun KIM et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

(2017) Marta N. Shahbazi et al.   NATURE

Genome editing reveals a role for OCT4 in human embryogenesis

(2017) Norah M. E. Fogarty et al.   NATURE

Single-cell DNA methylome sequencing of human preimplantation embryos

(2017) Ping Zhu et al.   NATURE GENETICS

GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency

(2017) Christian Krendl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic review of worldwide trends in assisted reproductive technology 2004–2013

(2017) Vitaly A. Kushnir et al.   Reproductive Biology and Endocrinology

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

(2017) Meng Zhu et al.   Nature Communications

A pluripotent stem cell-based model for post-implantation human amniotic sac development

(2017) Yue Shao et al.   Nature Communications

Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF/MAPK pathway

(2017) M. Wigger et al.   Scientific Reports

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

(2016) Laralynne Przybyla et al.   Cell Stem Cell

Molecular Criteria for Defining the Naive Human Pluripotent State

(2016) Thorold W. Theunissen et al.   Cell Stem Cell

A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization

(2016) Fred Etoc et al.   DEVELOPMENTAL CELL

Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo

(2016) Guangdun Peng et al.   DEVELOPMENTAL CELL

The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion

(2016) Kotaro Sasaki et al.   DEVELOPMENTAL CELL

Correlation between aneuploidy, standard morphology evaluation and morphokinetic development in 1730 biopsied blastocysts: a consecutive case series study

(2016) Maria Giulia Minasi et al.   HUMAN REPRODUCTION

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Self-organization of the in vitro attached human embryo

(2016) Alessia Deglincerti et al.   NATURE

A developmental coordinate of pluripotency among mice, monkeys and humans

(2016) Tomonori Nakamura et al.   NATURE

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Neural tube morphogenesis in synthetic 3D microenvironments

(2016) Adrian Ranga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YAP Induces Human Naive Pluripotency

(2016) Han Qin et al.   Cell Reports

Hypomethylation and Genetic Instability in Monosomy Blastocysts May Contribute to Decreased Implantation Potential

(2016) Blair R. McCallie et al.   PLoS One

Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells

(2015) Yongchang Chen et al.   Cell Stem Cell

Selection and dynamics of embryonic stem cell integration into early mouse embryos

(2015) Stoyana Alexandrova et al.   DEVELOPMENT

Positional information and reaction-diffusion: two big ideas in developmental biology combine

(2015) J. B. A. Green et al.   DEVELOPMENT

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

(2015) P. Blakeley et al.   DEVELOPMENT

An interview with Lewis Wolpert

(2015) Catarina Vicente   DEVELOPMENT

Epiblast morphogenesis before gastrulation

(2015) Guojun Sheng   DEVELOPMENTAL BIOLOGY

Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo

(2015) Chaminda R. Samarage et al.   DEVELOPMENTAL CELL

Collapse of blastocysts is strongly related to lower implantation success: a time-lapse study

(2015) Julian Marcos et al.   HUMAN REPRODUCTION

Hallmarks of pluripotency

(2015) Alejandro De Los Angeles et al.   NATURE

Pulsatile cell-autonomous contractility drives compaction in the mouse embryo

(2015) Jean-Léon Maître et al.   NATURE CELL BIOLOGY

Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts

(2015) Ermanno Greco et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos

(2015) Hiroshi Sasaki   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study

(2015) Laila Noli et al.   Stem Cell Reports

Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells

(2015) Kenichiro Taniguchi et al.   Stem Cell Reports

Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

(2014) Ivan Bedzhov et al.   CELL

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo

(2014) Shihadeh Anani et al.   DEVELOPMENT

Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst

(2014) Teresa Rayon et al.   DEVELOPMENTAL CELL

A Molecular Switch for the Orientation of Epithelial Cell Polarization

(2014) David M. Bryant et al.   DEVELOPMENTAL CELL

Rebirth of human embryology

(2014) Raymond F. Gasser et al.   DEVELOPMENTAL DYNAMICS

Analysis of compaction initiation in human embryos by using time-lapse cinematography

(2014) Kyoko Iwata et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Role of cell-cell adhesion complexes in embryonic stem cell biology

(2014) T. Pieters et al.   JOURNAL OF CELL SCIENCE

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

(2014) Yubing Sun et al.   NATURE MATERIALS

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Mapping the route from naive pluripotency to lineage specification

(2014) T. Kalkan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo

(2014) M. J. Stower et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Timing of developmental events in the early mouse embryo

(2014) Yoji Kojima et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

3D niche microarrays for systems-level analyses of cell fate

(2014) A. Ranga et al.   Nature Communications

New insights into mechanisms behind miscarriage

(2013) Elisabeth Clare Larsen et al.   BMC Medicine

Forces in Tissue Morphogenesis and Patterning

(2013) Carl-Philipp Heisenberg et al.   CELL

Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

(2013) Yoshikazu Hirate et al.   CURRENT BIOLOGY

Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst

(2013) N. Saiz et al.   DEVELOPMENT

The origin and impact of embryonic aneuploidy

(2013) Elpida Fragouli et al.   HUMAN GENETICS

Cadherin-dependent filopodia control preimplantation embryo compaction

(2013) Juan Carlos Fierro-González et al.   NATURE CELL BIOLOGY

High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias

(2013) Emanuel J P Nazareth et al.   NATURE METHODS

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells

(2013) Liying Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4

(2013) M. Amita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In-vitro model systems for the study of human embryo–endometrium interactions

(2013) Charlotte H.E. Weimar et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms

(2013) Chuen Yan Leung et al.   Nature Communications

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

(2013) Thibaut Brunet et al.   Nature Communications

Molecular origin of mitotic aneuploidies in preimplantation embryos

(2012) Eleni Mantikou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Generation of Chimeric Rhesus Monkeys

(2012) Masahito Tachibana et al.   CELL

Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse

(2012) Kathy K. Niakan et al.   DEVELOPMENTAL BIOLOGY

Human trophectoderm cells are not yet committed

(2012) C. De Paepe et al.   HUMAN REPRODUCTION

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment

(2012) P. Home et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pluripotency in the Embryo and in Culture

(2012) J. Nichols et al.   Cold Spring Harbor Perspectives in Biology

BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages

(2011) Andreia S. Bernardo et al.   Cell Stem Cell

Prediction of human blastocyst development from morulas with delayed and/or incomplete compaction

(2011) Martin Ivec et al.   FERTILITY AND STERILITY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Polarization of PAR Proteins by Advective Triggering of a Pattern-Forming System

(2011) N. W. Goehring et al.   SCIENCE

Cell Polarity Regulator PARD6B Is Essential for Trophectoderm Formation in the Preimplantation Mouse Embryo1

(2010) Vernadeth B. Alarcon   BIOLOGY OF REPRODUCTION

Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2

(2010) A. Ralston et al.   DEVELOPMENT

On the origin of amniotic stem cells: of mice and men

(2010) Mariya P. Dobreva et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage

(2010) Connie C Wong et al.   NATURE BIOTECHNOLOGY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment

(2009) M. Carmen Martínez et al.   FERTILITY AND STERILITY

Integrins are required for the differentiation of visceral endoderm

(2009) J. Liu et al.   JOURNAL OF CELL SCIENCE

Chromosome instability is common in human cleavage-stage embryos

(2009) Evelyne Vanneste et al.   NATURE MEDICINE

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

(2008) Nicolas Desprat et al.   DEVELOPMENTAL CELL

From cells to organs: building polarized tissue

(2008) David M. Bryant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of Human Embryonic Stem Cell Colony and Aggregate Size Heterogeneity Influences Differentiation Trajectories

(2008) Céline Liu Bauwens et al.   STEM CELLS

Selection of embryos by morphology is less effective than by a combination of aneuploidy testing and morphology observations

(2007) Santiago Munné et al.   FERTILITY AND STERILITY