Review
Dermatology
Eva Anna Piros, Balint Szilveszter, Borbala Vattay, Pal Maurovich-Horvat, Klara Szalai, Edit Dosa, Bela Merkely, Peter Hollo
Summary: Psoriasis often coexists with other comorbidities, especially cardiovascular diseases, which contribute to the shortened life expectancy of severe psoriatic patients. Systemic inflammation plays a key role in the relationship between psoriasis and atherosclerotic plaque formation. Regular cardiac monitoring and biologic therapies are crucial for holistic care of severe psoriatic patients.
DERMATOLOGIC THERAPY
(2021)
Article
Food Science & Technology
Jinhyuk Na, Hye-Jeong Hwang, Mal-Soon Shin, Mingyu Kang, Jihye Lee, Geul Bang, Young Jun Kim, Yu-Jin Hwang, Kyung-A. Hwang, Youngja H. Park
Summary: White radish extract has the most beneficial effects on reducing triglycerides, while purple radish extract significantly reduces low-density lipoprotein cholesterol. Purple radish extract improves total cholesterol and high-density lipoprotein cholesterol levels, leading to a significant decrease in the atherogenic index and cardiac risk factor.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Maryam Darabi, Marie Lhomme, Veronica D. Dahik, Isabelle Guillas, Eric Frisdal, Emilie Tubeuf, Lucie Poupel, Mili Patel, Emmanuel L. Gautier, Thierry Huby, Maryse Guerin, Kerry-Anne Rye, Philippe Lesnik, Wilfried Le Goff, Anatol Kontush
Summary: Phosphatidylserine (PS) is a component of high-density lipoprotein (HDL) that exhibits potent anti-inflammatory activity. This study found that the incorporation of PS into reconstituted HDL enhanced its anti-inflammatory effects by modulating signaling pathways mediated by SR-BI.
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Dwaipayan Bharadwaj, Gauri Prasad, Andrey V. Grechko, Margarita A. Sazonova, Alexander N. Orekhov
Summary: Atherosclerosis is a well-known global health problem with unclear pathogenesis. Inflammation is considered the preferred target for its treatment, with studies showing efficacy in animal models but inconclusive results in clinical studies. Anti-inflammatory therapy could be part of a complex treatment for atherosclerosis prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Ana Maria Pello Lazaro, Luis M. Blanco-Colio, Juan Antonio Franco Pelaez, Jose Tunon
Summary: Inflammation plays a significant role in atherogenesis and plaque complications, with certain drugs showing anti-inflammatory effects. Inflammatory biomarkers can predict cardiovascular events. Some anti-inflammatory drugs have been successful in reducing the incidence of cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Chunping Liu, Huiqi Chen, Yanjiao Liu, Haiding Huang, Wanling Yu, Tingting Du, Xinyao Long, Xinming Chen, Zhijun Chen, Sien Guo, Jinxin Li, Zebo Jiang, Lei Wang, Chuanjian Lu
Summary: Psoriasis is a persistent inflammatory disease with a genetic predisposition, and it is often associated with the involvement of multiple organs. Atherosclerosis is a common complication in severe psoriasis patients. The specific pathogenesis of psoriasis is still unclear, but it is believed to be a polygenic genetic disease influenced by factors such as heredity and environment. Immune-mediated inflammatory pathways are involved in the proliferation of keratinocytes and the release of inflammatory factors. Psoriasis and atherosclerosis are closely related, and systemic inflammation may be a common feature of both conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carina A. Valenzuela, Ella J. Baker, Elizabeth A. Miles, Philip C. Calder
Summary: Conjugated linoleic acid (CLA) isomers, specifically cis-9, trans-11 (CLA9,11) and trans-10, cis-12 (CLA10,12), have shown modest anti-inflammatory effects on endothelial cells (ECs) at low concentrations. These CLAs decrease the concentrations of inflammatory factors such as MCP-1, IL-6, IL-8, and RANTES in the culture medium, but also upregulate some pro-inflammatory genes while downregulating others. The findings suggest that CLAs may have a role in preventing atherosclerosis by modulating inflammation in ECs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Mingming Zhao, Ke-Gang Linghu, Linxuan Xiao, Tianyi Hua, Guanding Zhao, Qiling Chen, Shihang Xiong, Liyu Shen, Jinyu Yu, Xiaotao Hou, Erwei Hao, Zhengcai Du, Jiagang Deng, Gang Bai, Xiaojia Chen, Ling Li, Peng Li, Hua Yu
Summary: In this study, the similarity and difference between Camellia nitidissima Chi (CC), C. euphlebia Merr. ex Sealy (CE), and C. insularis (CI) were comprehensively compared in terms of chemistry and pharmacology. A statistical model combining untargeted metabolomics and fingerprint analyses was developed for chemical pattern recognition and discrimination of the three yellow camellias species. The results showed that CC, CE, and CI could be distinguished based on specific chemical combinations and that they exhibited differences in anti-inflammation/anti-oxidation activities.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Rajeswari Gopal Geetha, Surya Ramachandran
Summary: Rhynchophylline (Rhy), a plant-derived indole alkaloid, possesses various protective properties such as anti-inflammatory, neuroprotective, anti-hypertensive, and anti-rhythmic effects. It is effective in protecting the central nervous system and cardiovascular system through modulation of calcium and potassium channels, as well as exhibiting anticoagulant and anti-platelet aggregation activity. While more research is needed, Rhy shows promise in preventing early atherosclerosis.
Article
Hematology
Sean P. Heffron, Ada Weinstock, Bianca Scolaro, Shiyu Chen, Brian E. Sansbury, Greg Marecki, Christina C. Rolling, Hanane El Bannoudi, Tessa Barrett, James W. Canary, Matthew Spite, Jeffrey S. Berger, Edward A. Fisher
Summary: Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. This effect is partially mediated by prostaglandin E2 stimulating the EP4 receptor on macrophages, leading to altered gene expression and function.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Cardiac & Cardiovascular Systems
Lucia Scisciola, Vittoria Cataldo, Fatemeh Taktaz, Rosaria Anna Fontanella, Ada Pesapane, Puja Ghosh, Martina Franzese, Armando Puocci, Antonella De Angelis, Liberata Sportiello, Raffaele Marfella, Michelangela Barbieri
Summary: Atherosclerosis is an inflammatory disease that leads to cardiovascular mortality and morbidity. Type 2 diabetes mellitus is a known risk factor for atherosclerosis. Sodium-glucose co-transporter 2 inhibitors have been found to have anti-inflammatory effects and can potentially slow down the progression of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Hematology
Heiko Bugger, Andreas Zirlik
Summary: Atherosclerosis, a chronic inflammatory disease triggered by inflammation, can be effectively reduced in terms of cardiovascular events and mortality through anti-inflammatory interventions. Managing risk factors plays a crucial role in attenuating and preventing atherosclerosis and its complications. Promising therapeutic approaches include traditional anti-inflammatory drugs, specific immunomodulation, and vaccination development against atherosclerotic disease.
Article
Pharmacology & Pharmacy
Dan Huang, Xindong Wang, Yunhong Zhu, Juexiao Gong, Junqing Liang, Yanfei Song, Yiyan Zhang, Linsheng Liu, Cong Wei
Summary: The study demonstrated the anti-atherosclerotic effect of Bazi Bushen capsule through experiments with Ovx/ApoE(-/-) mice and human umbilical vein endothelial cells, indicating a potential mechanism involving GPER1-dependent anti-inflammatory and anti-apoptotic actions.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tomoko Tashiro, Yu Sawada
Summary: Psoriasis is not only a skin disease but can also cause systemic inflammatory diseases. Clinical and experimental studies have shown that there is an important interaction between psoriasis and systemic inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Xin-Fang Leong, Ker Woon Choy, Aspalilah Alias
Summary: Atherosclerosis poses serious health problems and requires long-term medication for prevention. Thymoquinone, a bioactive compound from Nigella sativa L., shows potential anti-inflammatory effects in atherosclerosis, but further studies are needed to determine its effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Patrick R. Lawler, Ole F. Norheim
AMERICAN JOURNAL OF CARDIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Virginie Beausejour Ladouceur, Patrick R. Lawler, Michelle Gurvitz, Louise Pilote, Mark J. Eisenberg, Raluca Ionescu-Ittu, Liming Guo, Ariane J. Marelli
Article
Cardiac & Cardiovascular Systems
Patrick R. Lawler, David A. Silver, Benjamin M. Scirica, Gregory S. Couper, Gerald L. Weinhouse, Phillip C. Camp
Article
Cardiac & Cardiovascular Systems
Patrick R. Lawler, Akintunde O. Akinkuolie, Paulette D. Chandler, M. Vinayaga Moorthy, Martin J. Vandenburgh, Debra A. Schaumberg, I-Min Lee, Robert J. Glynn, Paul M. Ridker, Julie E. Buring, Samia Mora
CIRCULATION RESEARCH
(2016)
Article
Cardiac & Cardiovascular Systems
Pranoti Hiremath, Patrick R. Lawler, Jennifer E. Ho, Andrew W. Correia, Siddique A. Abbasi, Raymond Y. Kwong, Michael Jerosch-Herold, Carolyn Y. Ho, Susan Cheng
CIRCULATION-HEART FAILURE
(2016)
Editorial Material
Medical Laboratory Technology
Patrick R. Lawler, Brendan M. Everett
CLINICAL CHEMISTRY
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Virginie Beausejour Ladouceur, Patrick R. Lawler
Article
Cardiac & Cardiovascular Systems
Patrick R. Lawler, Jonathan Afilalo, Mark J. Eisenberg, Louise Pilote
AMERICAN JOURNAL OF CARDIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Patrick R. Lawler, Brian A. Bergmark, Jacob P. Laubach, Neal K. Lakdawala
Editorial Material
Medical Laboratory Technology
Patrick R. Lawler, Samia Mora
CLINICAL CHEMISTRY
(2014)
Article
Peripheral Vascular Disease
Patrick R. Lawler, Pranoti Hiremath, Susan Cheng
CURRENT HYPERTENSION REPORTS
(2014)
Article
Multidisciplinary Sciences
Paulette D. Chandler, Akintunde O. Akinkuolie, Deirdre K. Tobias, Patrick R. Lawler, Chungying Li, M. Vinayaga Moorthy, Lu Wang, Daniel A. Duprez, David R. Jacobs, Robert J. Glynn, James Otvos, Margery A. Connelly, Wendy S. Post, Paul M. Ridker, Joann E. Manson, Julie E. Buring, I-Min Lee, Samia Mora
Article
Cardiac & Cardiovascular Systems
George Thanassoulis, Ken Williams, Keying Ye, Robert Brook, Patrick Couture, Patrick R. Lawler, Jacqueline de Graaf, Curt D. Furberg, Allan Sniderman
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2014)
Article
Medical Laboratory Technology
Patrick R. Lawler, Akintunde O. Akinkuolie, Paul M. Ridker, Allan D. Sniderman, Julie E. Buring, Robert J. Glynn, Daniel I. Chasman, Samia Mora
CLINICAL CHEMISTRY
(2017)
