Article
Cell Biology
Jinsheng Zhu, Li Zhao, Yadan Hu, Guoqi Cui, Ang Luo, Changlei Bao, Ying Han, Tong Zhou, Wenju Lu, Jian Wang, Stephen M. Black, Haiyang Tang
Summary: This study elucidates the importance of HIF2 alpha in the pathogenesis of pulmonary arterial hypertension, demonstrating the potential of HIF2 alpha-mediated gene sets as a diagnostic tool for distinguishing PAH patients. The study also found significant differences in the expression profiles of HIF2 alpha-mediated gene sets in lung tissues and peripheral blood mononuclear cells between control subjects and PAH patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Essa M. Sabi, Anuja Singh, Ziyad M. Althafar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Hosam M. Alqahtani, Simona Bungau
Summary: Rheumatoid arthritis is a chronic disease that affects millions of people worldwide and is closely associated with factors such as hypoxia and angiogenesis. This review will examine how hypoxia activates molecular pathways and how other pathways involving inflammatory signals develop and sustain synovitis in rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yiqi Yang, Kai Huang, Minqi Wang, Qishan Wang, Haishuang Chang, Yakun Liang, Qing Wang, Jie Zhao, Tingting Tang, Shengbing Yang
Summary: The study presents an intelligent near-infrared-triggered nitric oxide nanogenerator that enhances angiogenesis, inhibits bacterial infection, and maintains the stability of HIF-1 alpha protein for treating diabetic ulcers.
ADVANCED MATERIALS
(2021)
Article
Multidisciplinary Sciences
Xin-Hua Wu, Yang-Yang He, Zhang-Rong Chen, Ze-Yuan He, Yi Yan, Yangzhige He, Guang-Ming Wang, Yu Dong, Ying Yang, Yi-Min Sun, Yong-Hong Ren, Qiu-Yan Zhao, Xiao-Dan Yang, Li-Ying Wang, Cai-Jun Fu, Miao He, Si-Jin Zhang, Ji-Fen Fu, Hong Liu, Zhi-Cheng Jing
Summary: Single cell transcriptomic sequencing reveals transcriptional differences in monocyte populations in patients with high-altitude pulmonary hypertension (HAPH), indicating the role of immune and inflammatory responses in the pathophysiology of HAPH.
NATURE COMMUNICATIONS
(2023)
Article
Dermatology
F. Toberer, H. A. Haenssle, M. Heinzel-Gutenbrunner, A. Enk, W. Hartschuh, P. Helmbold, H. Kutzner
Summary: The study highlights the crucial role of HIF-1α in MCC pathogenesis and suggests significant metabolic differences between McPyV(+) and McPyV(-) tumors.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Medicine, Research & Experimental
Tripti Singh, Pallabi Banerjee, Uditi, Sarita Kumari, Anita Chopra, Nagendra Singh, Imteyaz Qamar
Summary: Regucalcin regulates intracellular Ca2+ homeostasis and intracellular signaling pathways. Its expression in hypoxia is upregulated by HIF-1α through direct binding to the HRE binding motifs within the Regucalcin promoter.
Review
Oncology
Karolina Kozal, Anna Krzeslak
Summary: Hypoxia-inducible factors play an important role in breast cancer, affecting immune response, metabolism, angiogenesis, invasion, and metastasis. The study suggests that targeting hypoxia-inducible factors in breast cancer therapy should take into account multiple factors and requires a better understanding of their role in this type of cancer.
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Yiwei Liu, Qipeng Luo, Zhanhao Su, Junyue Xing, Jinlin Wu, Li Xiang, Yuan Huang, Haizhou Pan, Xie Wu, Xiaoling Zhang, Jun Li, Fuxia Yan, Hao Zhang
Summary: Cyanotic congenital heart disease (CCHD) leads to maladaptation of cardiac metabolism during puberty, accompanied by impaired cardiac function. The study identified HIF-1 alpha as the key regulator of cardiac metabolic adaptation in CH animal models, with pubertal insulin resistance potentially suppressing its expression.
Article
Biochemistry & Molecular Biology
Je Lin Sieow, Hweixian Leong Penny, Sin Yee Gun, Ling Qiao Tan, Kaibo Duan, Joe Poh Sheng Yeong, Angela Pang, Diana Lim, Han Chong Toh, Tony Kiat Hon Lim, Edgar Engleman, Olaf Rotzschke, Lai Guan Ng, Jinmao Chen, Suet Mien Tan, Siew Cheng Wong
Summary: A large number of neutrophils infiltrate tumors and contribute to the inflammatory tumor microenvironment. The metabolic status of these neutrophils and their role in tumor progression were investigated in a mouse model of pancreatic ductal adenocarcinoma (PDAC). Tumor-infiltrating neutrophils showed enhanced glycolytic activity compared to neutrophils from the bone marrow and blood of the same mouse. Deletion of hypoxia-inducible factor 1-alpha (HIF-1 alpha) in neutrophils reduced tumor burden and improved survival in the mouse model, indicating a potential target for metabolic modulation in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chao Fang, Lei Dai, Cun Wang, Chuanwen Fan, Yongyang Yu, Lie Yang, Hongxin Deng, Zongguang Zhou
Summary: Research showed that SCG2 expression was associated with the survival of CRC patients, and it exhibited anti-tumor and anti-angiogenesis effects by inhibiting HIF-1 alpha/VEGF activity.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Article
Biochemistry & Molecular Biology
Jin-Woo Kim, Hyun-Ju An, HyunJeong Yeo, Yunhui Jeong, HyeonHae Lee, Jusung Lee, Kisik Nam, Jongheon Lee, Dong-Eun Shin, Soonchul Lee
Summary: Activation of the HIF-1α signaling pathway can protect intervertebral discs from degeneration and may serve as a potential therapeutic target in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Wenpeng Cao, Shan Lei, Zhirui Zeng, Chaolun Xiao, Baofei Sun, Peng Xie, Yumei Li, Daopeng Luo, Wenfeng Yu
Summary: This study identified TRAA2A as an important hypoxia-associated gene in pancreatic cancer, which is associated with tumor progression and metastasis. TRAA2A is regulated by hypoxia-inducible factor HIF1 alpha and promotes the proliferation and motility of pancreatic cancer cells via activation of the AKT pathway. Therefore, TRAA2A may serve as a novel molecular target for investigating the hypoxic response of pancreatic cancer cells.
Article
Biochemistry & Molecular Biology
Ji Young Kim, Eun Jung Lee, Yuri Ahn, Sujin Park, Yu Jeong Bae, Tae Gyun Kim, Sang Ho Oh
Summary: The study demonstrates that CTSL is a novel target gene of HIF-1 alpha and plays a role in melanosome degradation in melanocytes through lysosomal activity during autophagosome-lysosome fusion. Under autophagy-inducing starvation conditions, the expression of HIF-1 alpha and CTSL is upregulated in melan-a cells. Inhibition of conversion of pro-CTSL to mature CTSL leads to accumulation of certain proteins due to decreased lysosomal activity in the autophagic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Paola Locatelli, Mariano N. Belaich, Ayelen E. Lopez, Fernanda D. Olea, Martin Uranga Vega, Carlos S. Gimenez, Jorge Alejandro Simonin, Maria del Rosario Bauza, Marta G. Castillo, Luis A. Cuniberti, Alberto Crottogini, Carolina S. Cerrudo, Pablo D. Ghiringhelli
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Developmental Biology
Natalia Pascuali, Leopoldina Scotti, Gonzalo Oubina, Ignacio de Zuniga, Mariana Gomez Pena, Carlos Pomilio, Flavia Saravia, Marta Tesone, Dalhia Abramovich, Fernanda Parborell
MOLECULAR HUMAN REPRODUCTION
(2020)
Article
Surgery
Oscar A. Mendiz, Paul Gamboa, Maria F. Renedo, Gustavo A. Lev, Liliana E. Favaloro, Alejandro M. Bertolotti
Summary: Cardiac allograft vasculopathy (CAV) is a fibro-proliferative disease affecting coronary arteries post-heart transplantation. Despite often being clinically silent, IVUS is a reliable and safe technique for detecting angiographically silent CAV in heart transplant patients, with potential long-term clinical impact. Further large multicenter studies are needed to validate these findings.
CLINICAL TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Oscar A. Mendiz, Marko Noc, Carlos M. Fava, Luis Abel Gutierrez Jaikel, Matias Sztejfman, Ales Pleskovic, Paul Gamboa, Leon R. Valdivieso, Hemal Gada, Gilbert H. L. Tang
Summary: This study compared the incidence of LBBB and PPMI in patients undergoing TAVR with different implantation views, finding a significant reduction in LBBB and PPMI rates when using the COVL view. The TAVR outcomes were not compromised when using this view for implantation.
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Ayelen Emilce Lopez, Maria del Rosario Bauza, Luis Cuniberti, Alberto Jose Crottogini, Fernanda Daniela Olea, Paola Locatelli
Summary: Adult mammalian cardiomyocytes have limited division ability, making it difficult to replace lost contractile cells. Gene therapy can stimulate and enhance the endogenous division ability of cardiomyocytes for regeneration. Success in therapy depends on the selection of target, vector, and animal model.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Cell Biology
Gonzalo Oubina, Natalia Pascuali, Leopoldina Scotti, Silvia Bianchi, Maria May, Jorge Esteban Martinez, Clariana Marchese Ragona, Javier Higuera, Dalhia Abramovich, Fernanda Parborell
Summary: The study evaluated the potential of low level laser therapy (LLLT) in protecting ovaries from chemotherapy-induced gonadotoxicity using a mice model. The results showed that LLLT could effectively increase the number of antral follicles, decrease atretic follicles, and have positive effects on ovarian weight and hormonal levels, indicating a promising protocol in preserving female fertility in cancer survivors.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yamila Herrero, Natalia Pascuali, Candela Velazquez, Gonzalo Oubina, Vanesa Hauk, Ignacio de Zuniga, Mariana Gomez Pena, Gustavo Martinez, Mariano Lavolpe, Florencia Veiga, Fernando Neuspiller, Dalhia Abramovich, Leopoldina Scotti, Fernanda Parborell
Summary: The study revealed that SARS-CoV-2 infection may have adverse effects on ovarian function, leading to increased IgG antibodies in follicular fluid and alterations in key gene and protein expressions.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Lucila Gallino, Vanesa Hauk, Lara Castagnola, Daiana Vota, Natalia Pascuali, Fernanda Parborell, Maria May, Vanina Fontana, Fatima Merech, Zaira Naguila, James Waschek, Claudia Perez Leiros, Rosanna Ramhorst
Summary: VIP plays a crucial role in immune regulation during pregnancy by promoting a tolerogenic maternal microenvironment. VIP deficiency leads to dysfunctional ovaries, including difficulty in ovulation and follicular atresia. Moreover, VIP KO mice exhibit premature ovarian aging and a pro-inflammatory milieu.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Physiology
Daniel Bia, Yanina Zocalo, Ramiro Sanchez, Gustavo Lev, Oscar Mendiz, Franco Pessana, Agustin Ramirez, Edmundo Cabrera-Fischer
Summary: This study evaluated the agreement between invasively and non-invasively obtained aoSBP and aoPP values using different recording techniques, sites, waveform analysis algorithms, and calibration schemes. Overall, non-invasive methods yielded lower aoSBP and aoPP levels compared to invasive methods. CCA recordings provided values closest to invasive recordings, followed by BA recordings. The 033HR and 0412 calibration schemes showed the lowest mean error, while the 033 method had the highest error. Most non-invasive methods overestimated and underestimated aoSBP at low and high invasive aoSBP values, respectively. The higher the invasively measured aoPP, the greater the underestimation by non-invasive methods. Therefore, the recording method and site, the mathematical method/model used to quantify aoSBP and aoPP, and the calibration method for waveforms are essential for accurate estimation of aoBP. This study highlights the importance of methodological transparency and consensus for non-invasive aoBP assessment.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yamila Herrero, Candela Velazquez, Natalia Pascuali, Maria May, Dalhia Abramovich, Leopoldina Scotti, Fernanda Parborell
Summary: The aim of this study was to analyze whether Resveratrol treatment can protect ovarian function from Doxorubicin-induced gonadotoxicity. The results showed that Res increased the percentage of primary and antral follicles, reduced atretic follicles, and preserved the number of primordial follicles. Res also increased proliferation and reduced DNA damage and apoptosis in the follicles. Moreover, Res improved microvasculature stability and restored the architecture of uterine tissue. Therefore, Res administration could serve as a noninvasive and low-cost protocol to preserve ovarian function in female cancer survivors.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Bia, Yanina Zocalo, Ramiro Sanchez, Juan F. Torrado, Gustavo Lev, Oscar Mendiz, Franco Pessana, Agustin Ramirez, Edmundo I. Cabrera-Fischer
Summary: The use of oscillometry to determine brachial blood pressure can result in underestimation of invasively measured systolic and pulse pressure levels, as well as overestimation of diastolic pressure. There is no consensus on the most accurate approach to estimate brachial mean blood pressure non-invasively.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Cristian N. Nunez Pedrozo, Tomas M. Peralta, Fernanda D. Olea, Paola Locatelli, Alberto J. Crottogini, Mariano N. Belaich, Luis A. Cuniberti
Summary: This study aimed to compare the performance of CRISPick and CHOP CHOP platforms in designing sgRNAs for angiogenic genes. The study found that although there were no significant differences in DNA curvature between the two platforms, sgRNA on-target efficiency was higher when using CRISPick.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
