期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 62, 期 -, 页码 50-57出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2020.05.024
关键词
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资金
- Burroughs Wellcome Fund Career Award at the Scientific Interface
- Searle Scholarship
- Pew Biomedical Scholarship
- Alfred P. Sloan Fellowship
- Fred Hutchinson Cancer Research Center Translational Data Science Postdoctoral Fellowship
- NIH NIAID F-31 Predoctoral Fellowship
There are many possible failure points in the transmission of genetic information that can produce heritable germline mutations. Once a mutation has been passed from parents to offspring for several generations, it can be difficult or impossible to identify its root cause; however, sometimes the nature of the ancestral and derived DNA sequences can provide mechanistic clues about a genetic change that happened hundreds or thousands of generations ago. Here, we review evidence that the sequence context 'spectrum' of germline mutagenesis has been evolving surprisingly rapidly over the history of humans and other species. We go on to discuss possible causal factors that might underlie rapid mutation spectrum evolution.
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