期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 63, 期 -, 页码 210-219出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2020.03.001
关键词
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资金
- PRIN
- AIRC
- Fondazione Cassa di Risparmio di Firenze
Environmental cues are essential in defining tumour malignancy, by promoting tumour initiation, progression and metastatic spreading. Stromal cells may metabolically cooperate or compete with cancer cells, playing a mandatory role in defining cancer metabolic plasticity, potentially dictating the final tumour outcome. Assessing shared nutrients between different tumoural or stromal compartments is essential to understand the impact of environmental nutrients on the metabolic plasticity of tumours. Here, we review analytical and computational approaches for studying the tumour metabolic microenvironment, the destiny of nutrients shared among tumour and stromal populations, as well as the molecular modules of these metabolic relationships.
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