期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 63, 期 -, 页码 34-40出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2019.11.008
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资金
- Deutsche Forschungsgemeinschaft (DFG) [CRC 969]
The ability to control gene expression via small molecule effectors is important in basic research as well as in future gene therapy applications. Although transcription factor-based systems are widely used, they are not well suited for certain applications due to a lack of functionality, limited available coding space, and potential immunogenicity of the regulatory proteins. RNA-based switches fill this gap since they can be designed to respond to effector compounds utilizing ligand-sensing aptamers. These systems are very modular since the aptamer can be combined with a variety of different expression platforms. RNA-based switches have been constructed that allow for controlling gene expression in diverse contexts. Here we discuss latest developments and applications of aptamer-based gene expression switches in eukaryotes.
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