Review
Chemistry, Multidisciplinary
Jinping Wang, Beilu Zhang, Jingyu Sun, Wei Hu, Hongjun Wang
Summary: Porous nanomaterials with high surface area, tunable porosity, and large mesopores have attracted attention in cancer therapy and imaging. Researchers have been working on fabricating various porous nanomaterials and exploring their potentials in oncology applications.
Review
Pharmacology & Pharmacy
Shubham Roy, Neelanjana Bag, Souravi Bardhan, Ikram Hasan, Bing Guo
Summary: Fluorescence imaging in the second near-infrared window (NIR-II) has many advantages, making it a popular choice for imaging-guided drug delivery (IGDD) paradigms. This review discusses the recent progress in NIR-II IGDD-mediated cancer therapeutics, including design approaches, different therapies, and updated platforms. The review also highlights the innovation directions for NIR-II IGDD platforms to improve theranostic outcomes and clinical translation. This review will contribute to the development of safe and efficient NIR-II fluorescence-mediated anticancer drug delivery.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Chemistry, Inorganic & Nuclear
Ying Zhao, Shi-Bin Wang, Ai-Zheng Chen, Ranjith Kumar Kankala
Summary: This review comprehensively introduces the applications of two-dimensional transition metal dichalcogenides (TMDCs)-based nanoarchitectures in cancer therapy. It discusses the chemistry and configuration of 2D TMDCs, explores different engineering strategies for the morphological features and physicochemical properties of these nanoarchitectures, and highlights their loading and transport capabilities as well as photothermal and photodynamic effects. The review concludes with the challenges of translating these innovative platforms into clinical practice.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Rajkumar Sekar, Nagaraj Basavegowda, Saktishree Jena, Santhoshkumar Jayakodi, Pandian Elumalai, Amballa Chaitanyakumar, Prathap Somu, Kwang-Hyun Baek
Summary: This review discusses the recent developments in doped CNDs for cancer therapy, including their preparations, properties, imaging, and therapeutic applications.
Review
Pharmacology & Pharmacy
Marjolein I. Priester, Timo L. M. ten Hagen
Summary: Significant advancements have been made in the development of solid tumor treatment, particularly through the implementation of nanosystems for drug delivery, which have reduced side effects and improved drug delivery to tumor regions. However, challenges still exist in clinical translation, and the development of smart drug delivery systems that can be actively manipulated to control drug release shows promise as a powerful strategy to improve drug activity at the target site.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Melgious Jin Yan Ang, Siew Yin Chan, Yi-Yiing Goh, Zichao Luo, Jun Wei Lau, Xiaogang Liu
Summary: The review focuses on recent developments of advanced nanomaterials and nanotheranostics in cancer treatment, particularly in the areas of stimulus-responsive nanomaterials and nanocarriers targeting the tumor microenvironment. The review also discusses the potential cytotoxicity and future prospects of next-generation nanomaterials for clinical implementation.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Medicinal
Jing Qian, Huang Wen, Konstantin Tamarov, Wujun Xu, Vesa-Pekka Lehto
Summary: In recent years, there has been an extensive increase in the number of studies on porous silicon (PSi) nanoparticles for biomedical applications, with a focus on its carrier properties and biotraceability. PSi has shown potential in both therapy and diagnosis, leading to the development of a nanotheranostics approach. This review paper discusses the progress in using PSi for various imaging modalities and highlights the gaps in knowledge that need to be addressed before PSi can be applied in clinical imaging.
Review
Chemistry, Multidisciplinary
Pavan Kumar Chintamaneni, Dasari Nagasen, Katta Chanti Babu, Atul Mourya, Jitender Madan, Dadi A. Srinivasarao, R. K. Ramachandra, P. Madhuri Santhoshi, Sai Kiran S. S. Pindiprolu
Summary: Breast cancer is the most common type of cancer in women, and early diagnosis and effective therapeutic interventions are crucial for improving survival and quality of life. Nanotheranostics, specifically rare earth metal-doped upconversion nanoparticles (UCNPs), show promise in providing both in vivo diagnosis and therapeutics in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Jie Zheng, Shi-Hui Chen, Biao Huang, Mingxi Zhang, Quan Yuan, Ran Cui
Summary: Malignant tumors are a major threat to human life. Precise theranostics using nanoprobes have emerged as a new method for diagnosing and treating tumors. This review introduces non-invasive tumor precise imaging and highlights the recent advances in using nanoprobes for anti-tumor drug delivery, tumor precise surgical navigation, chemodynamic therapy, and phototherapy.
CHINESE CHEMICAL LETTERS
(2024)
Article
Cell Biology
Mengping Liu, Lin Wang, Young Lo, Simon Chi-Chin Shiu, Andrew B. Kinghorn, Julian A. Tanner
Summary: The interdisciplinary field of nanomaterials and aptamer science has significant potential for biomedical applications in drug delivery, imaging, and therapy. However, there are challenges to be addressed for their future development.
Article
Engineering, Biomedical
Aqsa Qambrani, Fawad Ur Rehman, Tanziela Tanziela, Sana Shaikh, Farouk Semcheddine, Tianyu Du, Weiwei Liu, Hui Jiang, Xuemei Wang
Summary: Exosomes have shown potential as an effective tool for cancer diagnosis and treatment, due to their unique characteristics in generating from all types of cells and their ability to enter targeted cancer cells with high efficiency.
BIOMEDICAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Lu Liu, Hongjun Li, Jinqiang Wang, Jinchao Zhang, Xing-Jie Liang, Weisheng Guo, Zhen Gu
Summary: Macrophages play a dual role in cancer development and are being explored as targets and tools for cancer theranostics. This article provides an overview of the mixed roles of macrophages in cancer pathogenesis and highlights the latest progress in macrophage-based cancer theranostic strategies, focusing on targeting tumor-associated macrophages and engineering adoptive macrophages to enhance immunosuppression and improve therapeutic efficacy.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Natalia Lopuszynska, Wladyslaw P. Weglarz
Summary: Poor pharmacokinetics and low aqueous solubility combined with rapid clearance from the circulation of drugs result in their limited effectiveness and generally high therapeutic doses. The use of nanocarriers for drug delivery can prevent the rapid degradation of the drug, improve its solubility and stability, enhance distribution and targeting, ensure sustained release, and reduce drug resistance. Nanotechnology enables the combination of therapeutics with biomedical imaging agents to overcome the challenges of disease diagnosis and therapy. This paper presents scientific reports on polymeric nanocarriers for MRI-guided drug delivery, focusing on their contrasting properties and categorizing them into three main groups based on the type of contrast agents.
Review
Nanoscience & Nanotechnology
Arindam Mal, Huimin Ding, Mengsi Li, Weixu Li, Cheng Wang
Summary: Covalent organic frameworks (COFs) are functional nanoporous materials with potential applications in biomedical research, such as drug delivery, bioimaging, phototherapy, and antibacterial properties, due to their robust covalent connectivity and chromophoric networks.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Inorganic & Nuclear
Hardev Singh, Divya Sareen, Jiya Mary George, Vineet Bhardwaj, Saehee Rha, Suk Joong Lee, Sheetal Sharma, Amit Sharma, Jong Seung Kim
Summary: Mitochondria, as the most critical target in cell physiology, have attracted substantial attention in cancer therapy due to their structural and functional discrepancies between normal and cancerous cells. Various synthetic strategies are used to deliver cytotoxins exclusively to mitochondria, achieving significant mitochondrial accumulations by proper selection of cell types and targeting unit. This review article addresses different strategies for targeting cancerous mitochondria with small molecule-based theranostics for diagnostic and potential therapeutic purposes since 2015.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Applied
Dang Ngoc Quang, Chung Thanh Pham, Linh Thi Khanh Le, Quynh Ngoc Ta, Ngoc Kim Dang, Nhung Thi Hoang, Dien Huu Pham
NATURAL PRODUCT RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Yong Kyun Kim, Thanh Chung Pham, Jaewon Kim, Chaeeon Bae, Yeonghwan Choi, Min Hee Jo, Songyi Lee
Summary: This study enhanced the sensing ability of polydiacetylene-based chemosensors for Cd2+ by improving the chelate structure, resulting in a novel PDA-MP sensor with a low detection limit. The interaction between PCDA-MP and Cd2+ was confirmed using Raman spectroscopy, Field Emission Scanning Electron Microscopes (FE-SEM), and Proton nuclear magnetic resonance (H-1 NMR).
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Thanh Chung Pham, Hyun Sung Kim, Songyi Lee
Summary: The novel polydiacetylene-linked ligand PDA-CB exhibits excellent selectivity and sensitivity for Cd2+ ions over other metal ions, including Zn2+, with a noticeable color change visible to the naked eye. The Cd2+-responsive color change of PDA-CB is attributed to the coordination between Cd2+ and CB ligand units, and has been characterized through H-1 NMR titration.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Thanh Chung Pham, Seongman Lee, Dongwon Kim, Ok-Sang Jung, Myung Won Lee, Songyi Lee
Article
Nanoscience & Nanotechnology
Thanh Chung Pham, Seonye Heo, Van-Nghia Nguyen, Myung Won Lee, Juyoung Yoon, Songyi Lee
Summary: In this study, we designed and synthesized new heavy-atom-free photosensitizers BS and NS, which efficiently generate a triplet excited state with high singlet oxygen quantum yield and showed low dark cytotoxicity against cells at working concentrations. These photosensitizers rapidly induced cell death under blue light irradiation and demonstrated potential dual functions as a fluorescent imaging agent and anti-cancer therapeutic through photophysical changes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Danghui Ma, Shumin Hou, Chaeeon Bae, Thanh Chung Pham, Songyi Lee, Xin Zhou
Summary: In this study, a novel photoacoustic probe AZB-1 was developed for in vivo imaging of ONOO-, and successfully applied in inflammatory mice models. By shutting the ICT effect, the output of its photoacoustic signal can be controlled, providing a potential platform for novel PA chemosensors.
CHINESE CHEMICAL LETTERS
(2021)
Article
Energy & Fuels
Mi-Ra Kim, Thanh Chung Pham, Yeonghwan Choi, Seah Yang, Hyun-Seock Yang, Sung Heum Park, Mijeong Kang, Songyi Lee
Summary: Three novel pyrazine-based organic photosensitizers were synthesized and characterized for dye-sensitized solar cell studies. The effects of their molecular structures on the photovoltaic performances of the solar cells were investigated. The interfacial charge transfer resistances were also studied to further understand the photovoltaic behaviors.
Article
Polymer Science
Mi-Ra Kim, Thanh Chung Pham, Hyun-Seock Yang, Sung Heum Park, Songyi Lee
Summary: A new type of polymer matrix electrolyte based on modified polybutadiene has been developed to improve the stability of dye-sensitized solar cells. The DSSC device using the modified PB matrix electrolyte showed improved conductivity and charge transfer ability, leading to outstanding stability.
Article
Chemistry, Analytical
Thanh Chung Pham, Thi Thuy Hang Hoang, Yeonghwan Choi, Seongman Lee, Sang-Woo Joo, Gun Kim, Dongwon Kim, Ok-Sang Jung, Songyi Lee
Summary: This study developed a lysosome-targeted heavy-metal-free photosensitizer for hypoxic cancer photodynamic therapy. By studying the action of the photosensitizer in lysosome and aggregate state, and examining the photophysical properties, important information for improving photodynamic therapy is provided.
Article
Nanoscience & Nanotechnology
Thanh Chung Pham, Thi Thuy Hang Hoang, Dung Ngoc Tran, Gun Kim, Trang Van Nguyen, Thong Van Pham, Sondavid Nandanwar, Dai Lam Tran, Myeongkee Park, Songyi Lee
Summary: This study presents a molecular design strategy for hydrophilic heavy-atom-free photosensitizers (PSs) based on imidazolium salts, and comprehensively investigates the photophysical properties of these PSs through a combination of experimental and theoretical analyses. Among the synthesized PSs, the ethylcarbazole-naphthoimidazolium (NI-Cz) conjugate exhibits efficient fluorescence emission and singlet oxygen generation, even in highly aqueous environments. The performance of NI-Cz is validated through its application in fluorescence bioimaging and photodynamic therapy (PDT) treatment in HeLa cells, suggesting its potential for expanding the design of heavy-atom-free PSs and phototheranostic applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Thanh Chung Pham, Dong Joon Lee, Do Hun Kim, Juyoung Yoon, Tran Dai Lam, Hwan Myung Kim, Songyi Lee
Summary: A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Thanh Chung Pham, Yeonghwan Choi, Chaeeon Bae, Cong So Tran, Dongwon Kim, Ok-Sang Jung, Yong-Cheol Kang, SungYong Seo, Hyun Sung Kim, Hwayoung Yun, Xin Zhou, Songyi Lee
Summary: A fluorescent probe, BDP-1, was developed for selective detection of cysteine, enabling early diagnosis of diseases. This probe exhibited color change and fluorescence enhancement upon reaction with cysteine, with a low detection limit.
Article
Materials Science, Multidisciplinary
Thanh Chung Pham, Seongman Lee, Ye Rim Son, Minseok Kwak, Hyun Sung Kim, Songyi Lee
JOURNAL OF MATERIALS CHEMISTRY C
(2020)
Article
Chemistry, Physical
Thanh Chung Pham, Yong Kyun Kim, Jung Bin Park, Sumin Jeon, Juhyeon Ahn, Yubin Yim, Juyoung Yoon, Songyi Lee
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)
