Article
Cardiac & Cardiovascular Systems
Karen Sliwa, Johann Bauersachs, Zolt Arany, Timothy F. Spracklen, Denise Hilfiker-Kleiner
Summary: Peripartum cardiomyopathy is a global disease that should be suspected in peripartum women with symptoms of heart failure. Urgent cardiac investigations and referral to a cardiology team for expert management are crucial. Advances in genetics, pathophysiology, diagnostic approach, management, and outcome have been achieved in understanding PPCM.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Karen Sliwa, Johann Bauersachs, Zolt Arany, Timothy F. Spracklen, Denise Hilfiker-Kleiner
Summary: Peripartum cardiomyopathy is a globally occurring disease that should be suspected in women during the peripartum period. The disease has significant maternal and neonatal morbidity and mortality rates, with nearly half of patients experiencing myocardial recovery. Team efforts and expert management are crucial in the diagnosis and treatment of this condition.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ray E. Hershberger, Jason Cowan, Elizabeth Jordan, Daniel D. Kinnamon
Summary: Insights into the genetic architecture of dilated cardiomyopathy (DCM) are rapidly evolving, showing a complex and diverse nature. In addition to monogenic structures, oligogenic basis, rare variants, low-frequency, and common genetic variations may contribute to the complexity of DCM, along with gene-environment interactions.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Simon P. R. Romaine, Matthew Denniff, Veryan Codd, Mintu Nath, Andrea Koekemoer, Stefan D. Anker, John G. Cleland, Gerasimos Filippatos, Daniel Levin, Marco Metra, Ify R. Mordi, Wouter Ouwerkerk, Jozine M. ter Maaten, Dirk J. van Veldhuisen, Faiez Zannad, Leong L. Ng, Pim van der Harst, Chim C. Lang, Adriaan A. Voors, Christopher P. Nelson, Nilesh J. Samani
Summary: In patients with heart failure, shorter mean leukocyte telomere length (LTL) is independently associated with all-cause mortality. The association remains significant after adjusting for known prognostic factors, suggesting LTL can predict survival in heart failure patients.
Review
Biochemistry & Molecular Biology
Gianpaolo Palmieri, Maria Francesca D'Ambrosio, Michele Correale, Natale Daniele Brunetti, Rosa Santacroce, Massimo Iacoviello, Maurizio Margaglione
Summary: The relevance of genetics in cardiovascular diseases, especially in the context of cardiomyopathies, has expanded over the last decades. Genetic variants hold potential as therapeutic targets, but a comprehensive evaluation of the affected patients' family lineage is necessary. Collaboration between cardiologists specializing in cardiomyopathies and HF, and geneticists, is crucial in improving individual and family health outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Guoqi Li, Yihui Shao, Hong-Chang Guo, Ying Zhi, Bokang Qiao, Ke Ma, Jie Du, Yong-Qiang Lai, Yulin Li
Summary: miR-27b-3p induces pathological cardiac remodelling and inhibition of endogenous miR-27b-3p or administration of FGF1 might suppress cardiac remodelling.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Stephanie M. van der Voorn, Esmee van Drie, Virginnio Proost, Kristina Dimitrova, Robert F. Ernst, Cynthia A. James, Crystal Tichnell, Brittney Murray, Hugh Calkins, Ardan M. Saguner, Firat Duru, Patrick T. Ellinor, Connie R. Bezzina, Sean J. Jurgens, J. Peter van Tintelen, Toon A. B. van Veen
Summary: This study investigated the impact of the p.(Ser96Ala) polymorphism in the HRC gene on cardiomyopathy and found no association with life-threatening arrhythmias or heart failure-related events, suggesting a lack of evidence supporting its role as a modifier in cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Peripheral Vascular Disease
Maria Ercu, Stephan Walter, Enno Klussmann
Summary: Hypertension with brachydactyly (HTNB) is a rare autosomal dominant form of hypertension characterized by a significant rise in blood pressure. HTNB is caused by gain-of-function mutations in the PDE3A gene, resulting in hyperactive mutant enzymes. Despite decades of hypertension, HTNB is not associated with cardiac damage commonly seen in other hypertensive conditions. The cardioprotective effect of HTNB involves local changes in cAMP signaling and inhibition of Ca2+ reuptake. Understanding the molecular mechanisms underlying HTNB could lead to improved strategies for treating essential hypertension and preventing hypertension-induced cardiac damage.
Review
Pharmacology & Pharmacy
Minshan Guo, Xiaojie Sun, Jiahui Chen, Ting Cai
Summary: Pharmaceutical cocrystals are multicomponent systems where at least one component is an active pharmaceutical ingredient. Cocrystallization with a coformer is a promising approach to enhance pharmaceutical performance. This review provides a comprehensive overview of pharmaceutical cocrystals, their preparation methods, properties, and applications, offering guidance for more efficient design and manufacturing.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Hematology
Maggie A. Stanislawski, Leslie A. Lange, Laura M. Raffield, Neil A. Zakai, Mariah Meyer, Kendra Ferrier, Mindy D. Szeto, Colton Leavitt, Jonathan A. Shortt, Timothy A. Thornton, Russell P. Tracy, Paul L. Auer, Alex P. Reiner, Ethan M. Lange, Nels C. Olson
Summary: This study identified a significant association between sCD14 levels and cardiovascular disease outcomes and mortality in a cohort of Black participants from the JHS. Adjusting for cardiovascular disease risk factors and C-reactive protein, higher sCD14 levels were significantly associated with increased risk of mortality, incident coronary heart disease, and incident heart failure. The study also found genetic associations with sCD14, highlighting the importance of genetic factors in these relationships.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sarah Abou Alaiwi, Thomas M. Roston, Peter Marstrand, Brian Lee Claggett, Victoria N. Parikh, Adam S. Helms, Jodie Ingles, Rachel Lampert, Neal K. Lakdawala, Michelle Michels, Anjali T. Owens, Joseph W. Rossano, Sara Saberi, Dominic J. Abrams, Euan A. Ashley, Christopher Semsarian, John C. Stendahl, James S. Ware, Erin Miller, Thomas D. Ryan, Mark W. Russell, Sharlene M. Day, Iacopo Olivotto, Christoffer R. Vissing, Carolyn Y. Y. Ho
Summary: A study on children diagnosed with hypertrophic cardiomyopathy (HCM) found that they have a higher risk of developing left ventricular systolic dysfunction (LVSD) compared to adult patients. This study highlights the importance of careful surveillance for LVSD in children with HCM, especially during their transition to adult care.
Article
Agricultural Engineering
Jessica Fagionato Masiero, Eduardo Jose Barbosa, Luiza de Oliveira Macedo, Aline de Souza, Megumi Nishitani Yukuyama, Geraldo Jose Arantes, Nadia Araci Bou-Chacra
Summary: Research on the application of vegetable oils in lipid-based nanocarriers has shown superior efficacy compared to commercial therapy, indicating their promising use in nanotechnology for developing safer and more effective pharmaceutical and cosmetic products.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Cardiac & Cardiovascular Systems
Avni Madhani, Natalia Sabogal, Daniel Massillon, Ludwine D. Paul, Carlos Rodriguez, Denise Fine, Stephen Helmke, Morgan Winburn, Damian Kurian, Farbod Raiszadeh, Sergio Teruya, Elizabeth Cohn, Andrew J. Einstein, Edward J. Miller, Lawreen H. Connors, Mathew S. Maurer, Frederick L. Ruberg
Summary: In this study, it was found that 3.4% of self-identified Black individuals carry the V122I variant, and 39% of them exhibit hereditary ATTR-CM. The study also suggests that serum prealbumin concentration may be helpful in diagnosing ATTR-CM in V122I carriers.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Chemistry, Medicinal
Anastasia Stella Perpinia, Nikolaos Kadoglou, Maria Vardaka, Georgios Gkortzolidis, Apostolos Karavidas, Theodoros Marinakis, Chrysostomi Papachrysostomou, Panagiotis Makaronis, Charikleia Vlachou, Marina Mantzourani, Dimitrios Farmakis, Konstantinos Konstantopoulos
Summary: Modern treatment modalities in hematology have improved clinical outcomes of patients with hematological malignancies, but some anticancer drugs may have adverse effects on the cardiovascular system, leading to various cardiac disorders. Therefore, it is crucial to understand all aspects of cardiotoxicity and provide appropriate care promptly to patients.
Article
Cardiac & Cardiovascular Systems
A. J. Marian
Summary: Hypertrophic cardiomyopathy (HCM) is a genetic disease characterized by left ventricular hypertrophy and may lead to heart failure or sudden cardiac death. Pathogenic variants in genes encoding myocardial protein constituents, especially MYH7 and MYBPC3 genes, are the main causes of HCM. Advances in genetic testing and drug development have improved the therapeutic prospects for HCM.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jessica C. Garbern, Jason Williams, Amy C. Kristl, Alyyah Malick, Inbal Rachmin, Benjamin Gaet, Nafis Ahmed, Ana Vujic, Peter Libby, Richard T. Lee
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Multidisciplinary Sciences
Amir H. Ameri, Sara Moradi Tuchayi, Anniek Zaalberg, Jong Ho Park, Kenneth H. Ngo, Tiancheng Li, Elena Lopez, Marco Colonna, Richard T. Lee, Mari Mino-Kenudson, Shadmehr Demehri
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Cardiac & Cardiovascular Systems
Jessica Garbern, Amy C. Kristl, Vinicius Bassaneze, Ana Vujic, Henk Schoemaker, Rebecca Sereda, Liming Peng, Elisabeth M. Ricci-Blair, Jill M. Goldstein, Ryan G. Walker, Shalender Bhasin, Amy J. Wagers, Richard T. Lee
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Review
Cardiac & Cardiovascular Systems
Filippos Triposkiadis, Javed Butler, Francois M. Abboud, Paul W. Armstrong, Stamatis Adamopoulos, John J. Atherton, Johannes Backs, Johann Bauersachs, Daniel Burkhoff, Robert O. Bonow, Vijay K. Chopra, Rudolf A. de Boer, Leon de Windt, Nazha Hamdani, Gerd Hasenfuss, Stephane Heymans, Jean-Sebastien Hulot, Marvin Konstam, Richard T. Lee, Wolfgang A. Linke, Ida G. Lunde, Alexander R. Lyon, Christoph Maack, Douglas L. Mann, Alexandre Mebazaa, Robert J. Mentz, Petros Nihoyannopoulos, Zoltan Papp, John Parissis, Thierry Pedrazzini, Giuseppe Rosano, Jean Rouleau, Petar M. Seferovic, Ajay M. Shah, Randall C. Starling, Carlo G. Tocchetti, Jean-Noel Trochu, Thomas Thum, Faiez Zannad, Dirk L. Brutsaert, Vincent F. Segers, GillesW. De Keulenaer
EUROPEAN HEART JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Jessica C. Garbern, Aharon Helman, Rebecca Sereda, Mohsen Sarikhani, Aishah Ahmed, Gabriela O. Escalante, Roza Ogurlu, Sean L. Kim, John F. Zimmerman, Alexander Cho, Luke MacQueen, Vassilios J. Bezzerides, Kevin Kit Parker, Douglas A. Melton, Richard T. Lee
Review
Cell Biology
Ana Vujic, Niranjana Natarajan, Richard T. Lee
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Jessica C. Garbern, Gabriela O. Escalante, Richard T. Lee
Summary: Cell replacement therapy using pluripotent stem cell-derived cardiomyocytes (PSC-CMs) is still in the research phase, with various challenges that need to be addressed before successful clinical translation can be achieved.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Jason D. Roh, Nicholas Houstis, Andy Yu, Bliss Chang, Ashish Yeri, Haobo Li, Ryan Hobson, Carolin Lerchenmueller, Ana Vujic, Vinita Chaudhari, Federico Damilano, Colin Platt, Daniel Zlotoff, Richard T. Lee, Ravi Shah, Michael Jerosch-Herold, Anthony Rosenzweig
Article
Multidisciplinary Sciences
Thiago M. Batista, Sezin Dagdeviren, Shannon H. Carroll, Weikang Cai, Veronika Y. Melnik, Hye Lim Noh, Suchaorn Saengnipanthkul, Jason K. Kim, C. Ronald Kahn, Richard T. Lee
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Ryan G. Walker, Ornella Barrandon, Tommaso Poggioli, Sezin Dagdeviren, Shannon H. Carroll, Melanie J. Mills, Kourtney R. Mendello, Yanet Gomez, Francesco S. Loffredo, James R. Pancoast, Claudio Macias-Trevino, Colin Marts, Katherine B. LeClair, Hye-Lim Noh, Taekyoon Kim, Alexander S. Banks, Jason K. Kim, David E. Cohen, Amy J. Wagers, Douglas A. Melton, Richard T. Lee
SCIENTIFIC REPORTS
(2020)
Article
Cell & Tissue Engineering
Mohsen Sarikhani, Jessica C. Garbern, Sa Ma, Rebecca Sereda, Jeffrey Conde, Guido Krahenbuhl, Gabriela O. Escalante, Aishah Ahmed, Jason D. Buenrostro, Richard T. Lee
Article
Multidisciplinary Sciences
Anu Shah, Sezin Dagdeviren, Jordan P. Lewandowski, Angela B. Schmider, Elisabeth M. Ricci-Blair, Niranjana Natarajan, Henna Hundal, Hye Lim Noh, Randall H. Friedline, Charles Vidoudez, Jason K. Kim, Amy J. Wagers, Roy J. Soberman, Richard T. Lee
Review
Cell & Tissue Engineering
Jessica C. Garbern, Richard T. Lee
Summary: Current methods to differentiate cardiomyocytes from human pluripotent stem cells inadequately recapitulate complete development, resulting in cardiomyocytes with an immature or fetal-like phenotype. Metabolic changes and mitochondrial dynamics play key roles in the maturation of cardiomyocytes, with the transitions in mitochondria responding to metabolic signals throughout development.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Jacob P. Keller, Jonathan S. Marvin, Haluk Lacin, William C. Lemon, Jamien Shea, Soomin Kim, Richard T. Lee, Minoru Koyama, Philipp J. Keller, Loren L. Looger
Summary: A family of highly sensitive glucose sensors was described to study glucose transport and metabolism in cells. Differential glucose kinetics were observed in different cell types, revealing the existence of specific transport pathways for intracellular glucose flux.
Article
Medicine, Research & Experimental
Niranjana Natarajan, Ana Vujic, Jishnu Das, Annie C. Wang, Krystal K. Phu, Spencer H. Kiehm, Elisabeth M. Ricci-Blair, Anthony Y. Zhu, Kelli L. Vaughan, Ricki J. Colman, Julie A. Mattison, Richard T. Lee
