Review
Biochemistry & Molecular Biology
Ruhua Luo, Mengmeng Liu, Tiantian Tan, Qian Yang, Yue Wang, Lianhui Men, Liping Zhao, Honghua Zhang, Shuling Wang, Tian Xie, Qingchang Tian
Summary: EVs are membrane-bound vesicles that offer advantages over traditional nanocarriers for drug and gene delivery, with therapeutic potential through chemical or biological modifications. Modified EVs can be used to load various therapeutic agents for disease intervention, providing new avenues for effective treatment strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell & Tissue Engineering
A. Ivica, M. Zehnder, F. E. Weber
Summary: Regenerative endodontic procedures involve two tissue engineering approaches, one using transplanted mesenchymal stem cells and the other relying on bioactive molecules. A potential third approach involves the application of MSC-derived exosomes for pulp regeneration. Future research should focus on investigating the therapeutic use of these exosomes in in-vivo and clinical studies.
EUROPEAN CELLS & MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Jagannath Mondal, Shameer Pillarisetti, Vijayabhaskarreddy Junnuthula, Monochura Saha, Seung Rim Hwang, In-kyu Park, Yong-kyu Lee
Summary: Exosomes are natural nanocarriers secreted by cells, which can be modified to load additional cargo for expanded biomedical applications. They have the potential to overcome the limitations of conventional nanoparticle-based techniques in targeted therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Shang Xian Bo, Wang Chen, Liu Chang, Yu Hao Ran, Guo Hui Hui, Zhu Ya Kun, Xie Wu Kun, Fan Hai Tao, Cheng Wen Dan
Summary: Exosomes play a role in the treatment of osteoarthritis by regulating the function of chondrocytes. However, research in this field is limited. This review summarizes the therapeutic properties of exosomes on chondrocytes in osteoarthritis and discusses the challenges and prospects of exosome-based treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Yujia Hao, Haoyue Song, Zilan Zhou, Xiaohang Chen, Huifei Li, Yuan Zhang, Jie Wang, Xiuyun Ren, Xing Wang
Summary: Extracellular vesicles (EVs) are important vehicles for intercellular communication, with different physiological and pathological effects, and can be used as biological therapeutic agents. In some cases, the release of EVs can exacerbate disease progression, while inhibition may delay disease development.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Susmita Sahoo, Marta Adamiak, Prabhu Mathiyalagan, Franziska Kenneweg, Sabine Kafert-Kasting, Thomas Thum
Summary: Exosomes are small membrane-bound vesicles actively secreted by cells. Research on the potential and challenges of exosomes in biological signaling in myocardial function highlights their significance in cardiac physiology and pathology, emphasizing the need for scientific innovations in isolation and characterization methodologies.
Review
Medicine, Research & Experimental
Majid Babaei, Jafar Rezaie
Summary: Ischemic diseases, characterized by insufficient blood flow leading to decreased oxygen and nutrient uptake, are a significant global contributor to disability and mortality. Up-regulation of angiogenesis, particularly through stem cell-derived exosomes, shows promise in treating these diseases by promoting blood vessel formation. Further research is needed to address limitations in exosome isolation and application, and to effectively translate preclinical findings into clinical practice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Peripheral Vascular Disease
Olga Martinez-Arroyo, Ana Ortega, Josep Redon, Raquel Cortes
Summary: Extracellular vesicles play a key role in hypertension and hypertension-related renal damage, serving as potential therapeutic agents and markers for kidney damage. The ability of exosomes to efficiently deliver various cargos to target cells makes them a promising drug delivery system for the treatment of renal diseases.
Review
Biotechnology & Applied Microbiology
Dao-Kun Deng, Jiu-Jiu Zhang, Dian Gan, Jie-Kang Zou, Rui-Xin Wu, Yi Tian, Yuan Yin, Xuan Li, Fa-Ming Chen, Xiao-Tao He
Summary: This review highlights the roles of extracellular vesicles (EVs) in periodontal homeostasis and their potential in periodontal regenerative strategies. The pathogenic roles of bacteria-derived EVs (BEVs) in plaque formation, immune evasion, inflammatory pathway activation, and tissue destruction are discussed, along with the multifunctional biological effects of cell-derived EVs (CEVs) on periodontal tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Huiling Deng, Jiecong Wang, Ran An
Summary: This article summarizes the important role of exosomes in bone regeneration and the problems in their clinical application. It then introduces the use of hydrogels as a solution to these problems, with a focus on the application prospects and challenges of hyaluronic acid-based hydrogels as exosome delivery devices in bone regeneration.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Tiantian Li, Hongchi Yu, Demao Zhang, Tang Feng, Michael Miao, Jianwei Li, Xiaoheng Liu
Summary: Vascular calcification is associated with increased risk of heart disease, stroke, and atherosclerotic plaque rupture. Extracellular vesicles, particularly matrix vesicles, play a crucial role in the early stages of vascular calcification. However, the underlying mechanism by which matrix vesicles drive vascular smooth muscle cells phenotype switching and calcification remains unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Max Piffoux, Jeanne Volatron, Kondareddy Cherukula, Kelly Aubertin, Claire Wilhelm, Amanda K. A. Silva, Florence Gazeau
Summary: Extracellular vesicles (EVs) have emerged as new drug delivery systems and regenerative cell-free effectors, with intrinsic biocompatibility and targeting capabilities, but clinical translation is still hindered by difficulties in production and loading of EVs.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Cell Biology
Katarzyna Nazimek, Krzysztof Bryniarski
Summary: EVs as a therapeutic approach face challenges in terms of clearance and distribution, but recent research suggests that utilizing antigen-specific antibodies and light chains can enhance their efficacy and targeting capability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Fanhua Kang, Yuanliang Yan, Yuanhong Liu, Qiuju Liang, Zhijie Xu, Wei Zhu, Abhimanyu Thakur
Summary: Exosomes, secreted by various cells, play a crucial role in cell-cell communication and have gained attention for their cargoes, including protein, lipids, DNA, and RNA. Among these cargoes, exosomal circular RNAs (circRNAs) have shown promising functional roles in cancer chemotherapeutic response by regulating gene expression. This review focuses on the important roles of exosomal circRNAs in cancer-associated signaling pathways and their potential effect on cancer therapeutic resistance.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jafar Rezaie, Tahereh Etemadi, Maryam Feghhi
Summary: This article presents the current understanding of how exosomes regulate innate immune responses and discusses their potential applications in cancer therapy and immunotherapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)