Article
Clinical Neurology
Shima Shahjouei, Georgios Tsivgoulis, Ghasem Farahmand, Eric Koza, Ashkan Mowla, Alireza Vafaei Sadr, Arash Kia, Alaleh Vaghefi Far, Stefania Mondello, Achille Cernigliaro, Annemarei Ranta, Martin Punter, Faezeh Khodadadi, Soheil Naderi, Mirna Sabra, Mahtab Ramezani, Ali Amini Harandi, Oluwaseyi Olulana, Durgesh Chaudhary, Aicha Lyoubi, Bruce C. Campbell, Juan F. Arenillas, Daniel Bock, Joan Montaner, Saeideh Aghayari Sheikh Neshin, Diana Aguiar de Sousa, Matthew S. Tenser, Ana Aires, Mercedes de Lera Alfonso, Orkhan Alizada, Elsa Azevedo, Nitin Goyal, Zabihollah Babaeepour, Gelareh Banihashemi, Leo H. Bonati, Carlo W. Cereda, Jason J. Chang, Miljenko Crnjakovic, Gian Marco De Marchis, Massimo Del Sette, Seyed Amir Ebrahimzadeh, Mehdi Farhoudi, Ilaria Gandoglia, Bruno Goncalves, Christoph J. Griessenauer, Mehmet Murat Hanci, Aristeidis H. Katsanos, Christos Krogias, Ronen R. Leker, Lev Lotman, Jeffrey Mai, Shailesh Male, Konark Malhotra, Branko Malojcic, Teresa Mesquita, Asadollah Mir Ghasemi, Hany Mohamed Aref, Zeinab Mohseni Afshar, Jusun Moon, Mika Niemela, Behnam Rezai Jahromi, Lawrence Nolan, Abhi Pandhi, Jong-Ho Park, Joao Pedro Marto, Francisco Purroy, Sakineh Ranji-Burachaloo, Nuno Reis Carreira, Manuel Requena, Marta Rubiera, Seyed Aidin Sajedi, Joao Sargento-Freitas, Vijay K. Sharma, Thorsten Steiner, Kristi Tempro, Guillaume Turc, Yasaman Ahmadzadeh, Mostafa Almasi-Dooghaee, Farhad Assarzadegan, Arefeh Babazadeh, Humain Baharvandat, Fabricio Buchadid Cardoso, Apoorva Dev, Mohammad Ghorbani, Ava Hamidi, Zeynab Sadat Hasheminejad, Sahar Hojjat-Anasri Komachali, Fariborz Khorvash, Firas Kobeissy, Hamidreza Mirkarimi, Elahe Mohammadi-Vosough, Debdipto Misra, Ali Reza Noorian, Peyman Nowrouzi-Sohrabi, Sepideh Paybast, Leila Poorsaadat, Mehrdad Roozbeh, Behnam Sabayan, Saeideh Salehizadeh, Alia Saberi, Mercedeh Sepehrnia, Fahimeh Vahabizad, Thomas Alexandre Yasuda, Mojdeh Ghabaee, Nasrin Rahimian, Mohammad Hossein Harirchian, Afshin Borhani-Haghighi, Mahmoud Reza Azarpazhooh, Rohan Arora, Saeed Ansari, Venkatesh Avula, Jiang Li, Vida Abedi, Ramin Zand
Summary: This multinational observational study found that SARS-CoV-2 infected patients had a higher rate of acute ischemic stroke, intracranial hemorrhage, and cerebral venous or sinus thrombosis. Compared to pre-pandemic population studies, these patients also had a significantly higher rate of large vessel occlusions, lower rate of small vessel occlusion, and lacunar infarction, as well as a considerable number of young stroke patients. Additionally, countries with lower health expenditures had a significantly lower rate of mechanical thrombectomy.
Article
Clinical Neurology
Michelle C. Johansen, Rebecca F. Gottesman, Brian G. Kral, Dhananjay Vaidya, Lisa R. Yanek, Lewis C. Becker, Diane M. Becker, Paul Nyquist
Summary: In healthy high-risk individuals, the presence and volume of coronary artery plaque are associated with larger WMH volumes, appearing the strongest for periventricular WMH. These findings in high-risk families suggest a disease relationship in 2 different vascular beds, possibly due to genetic predisposition.
Review
Clinical Neurology
Neal S. Parikh, Elora Basu, Mu Ji Hwang, Russel Rosenblatt, Lisa B. Vanwagner, Hana I. Lim, Santosh B. Murthy, Hooman Kamel
Summary: Chronic liver disease (CLD) is a prevalent condition that includes subclinical liver disease which may have an impact on stroke risk, mechanisms, and outcomes. However, there is limited synthesis of data and guidance on the relationship between CLD and stroke. Therefore, a multidisciplinary review is necessary to evaluate the correlation between CLD and stroke and provide treatment considerations.
Review
Hematology
Nathan W. Watson, Joseph J. Shatzel, Hanny Al-Samkari
Summary: CDK 4/6 inhibitors are important for hormone receptor-positive breast cancer, but they may increase the risk of thrombosis. This review summarizes the evidence of thrombosis risk for these agents, including clinical trials and real-world studies, and compares the risk among the three approved inhibitors for breast cancer. However, the need for prophylactic anticoagulation remains uncertain.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Biochemistry & Molecular Biology
Ming-Yee Sun, Sonu M. M. Bhaskar
Summary: This article provides an updated overview of the therapeutic and preventive strategies for strokes in cancer settings, emphasizing the distinct challenges and the need for individualized diagnostic and treatment approaches. The strategies discussed include acute reperfusion therapy, anticoagulant therapy, antiplatelet therapy, and lifestyle management options. The article highlights the limited guidelines and evidence-based clinical management for cancer-related strokes and thromboembolisms, and offers future recommendations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Katarzyna Kakareko, Alicja Rydzewska-Rosolowska, Edyta Zbroch, Tomasz Hryszko
Summary: TRAIL, a pro-apoptotic protein, may play a role in the pathophysiology of cardiovascular diseases, with evidence suggesting a link to all-cause mortality in patients. Further research is needed to clarify the exact association of TRAIL with cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Albert Youngwoo Jang, Jeongduk Seo, Yae Min Park, Yong Hoon Shin, Joonpyo Lee, Pyung Chun Oh, Woong Chol Kang, Wook-Jin Chung, Jeonggeun Moon
Summary: This study found that blood type of atrial fibrillation patients is associated with the occurrence of major adverse cerebrovascular events. AB blood type is associated with higher MACE rates compared to non-AB blood types.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Keri Callegari, Sabyasachi Dash, Hiroki Uchida, Yuto Shingai, Catherine Liu, Anne Khodarkovskaya, Yunkyoung Lee, Akira Ito, Amanda Lopez, Tuo Zhang, Jenny Xiang, Michael J. Kluk, Teresa Sanchez
Summary: Stroke-induced cerebral microvascular dysfunction aggravates neuronal injury and affects the efficacy of reperfusion therapies. Studying molecular changes in cerebral microvessels during stroke can lead to new therapeutic strategies. By analyzing mouse stroke microvessels and human stroke lesions, we identified common alterations and molecular features related to vascular disease, endothelial activation, and sphingolipid metabolism and signaling. Our study provides valuable insights for the development of neurovascular protection in stroke and other conditions with cerebral microvascular dysfunction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Nutrition & Dietetics
In Young Cho, Kyung Min Lee, Yoojin Lee, Chuel Min Paek, Ha Jin Kim, Ju Young Kim, Kiheon Lee, Jong Soo Han, Woo Kyung Bae
Summary: This study evaluated the dietary habits of CCVD patients using the Diet Quality Index-International and found that the quality of dietary habits of CCVD patients was lower than non-CCVD subjects. Evaluation and education of adequate dietary habits are needed in the management of CCVD patients.
Article
Clinical Neurology
Seung-Jae Lee, Seok Yoon, Yoon-Jong Bae, Cheryl D. Bushnell, Hyung Jun Kim, Dongwoo Kang
Summary: The study demonstrates the associations of migraine with cardio-cerebrovascular diseases, with stronger associations in females.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Article
Genetics & Heredity
Derralynn A. Hughes, Daniel G. Bichet, Roberto Giugliani, Robert J. Hopkin, Eva Krusinska, Kathleen Nicholls, Iacopo Olivotto, Ulla Feldt-Rasmussen, Norio Sakai, Nina Skuban, Gere Sunder-Plassmann, Roser Torra, William R. Wilcox
Summary: Fabry disease is a rare disorder caused by gene variants that results in enzyme deficiency and accumulation of lipids. This study evaluated the incidence of clinical events in Fabry patients treated with migalastat. The results showed that 17.5% of patients experienced 22 clinical events during long-term treatment, with a rate of 48.3 events per 1000 patient-years. Baseline characteristics such as gender, age, prior treatment, and kidney function were associated with the incidence of clinical events.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Clinical Neurology
Yuesong Pan, Runqi Wangqin, Hao Li, Aoming Jin, Jiejie Li, Jinxi Lin, Xia Meng, Ying Xian, Daniel T. Laskowitz, Yongjun Wang
Summary: This study found that elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischemic stroke among patients with minor ischemic stroke or TIA. For patients with LDL-C >= 2.6 mmol/L, lipid-lowering treatment was associated with a significantly reduced risk of ischemic stroke at 3 months.
STROKE AND VASCULAR NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Monika Szilveszter, Sandor Pal, Zsuzsanna Simon-Szabo, Orsolya-Zsuzsa Akacsos-Szasz, Mihaly Moldovan, Barbara Reger, Lorand Denes, Zsuzsanna Faust, Mariana Cornelia Tilinca, Eniko Nemes-Nagy
Summary: The course of COVID-19 is heavily influenced by cardiometabolic comorbidities, worsening the prognosis due to systemic inflammation, endothelium dysfunction, and thrombosis. A systematic review of recent literature was conducted in five languages to explore the management of high-risk COVID-19 patients with a focus on associated coagulopathy. The study presents special considerations for COVID-19 management based on underlying conditions and highlights the importance of a comprehensive approach to thromboembolic states. The article includes the latest findings on effective therapeutic approaches, offering guidance to medical professionals in severe cases of SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Peripheral Vascular Disease
Inbar Raber, Matthew J. Belanger, Rosemary Farahmand, Rahul Aggarwal, Nicholas Chiu, Mahmoud Al Rifai, Alan P. Jacobsen, Lewis A. Lipsitz, Stephen P. Juraschek
Summary: Orthostatic hypotension is a common complication affecting individuals with hypertension, leading to various adverse health outcomes. Predicting patterns of blood pressure dysregulation in hypertensive patients can help tailor treatment plans.
Review
Hematology
Ghadir Alkarithi, Cedric Duval, Yu Shi, Fraser L. Macrae, Robert A. S. Ariens
Summary: Thrombosis is a major complication of cardiovascular disease, with thrombi composed of fibrin, red blood cells, platelets, leukocytes, and neutrophil extracellular traps. Different diseases exhibit thrombi with varying compositions, highlighting the importance of further research on thrombus composition and function to enhance treatment and clinical outcomes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Psychiatry
Marie-Louise H. Rasmussen, Gry J. Poulsen, Poul Videbech, Jan Wohlfahrt, Mads Melbye
Summary: Previous research suggests that women with endocrine disease may have an increased risk of postpartum depression (PPD) due to their sensitivity to hormonal fluctuations. This nationwide cohort study aimed to investigate the association between endocrine disease history and PPD risk. The study included 888,989 deliveries and found that women with endocrine disease history had a 42% higher risk of PPD compared to those without. Interestingly, women with a history of PPD also had a 50% higher risk of endocrine disease. These findings highlight the importance of monitoring and providing support for pregnant women with endocrine disease to prevent and address PPD.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Infectious Diseases
Bertram Kjerulff, Kathrine A. Kaspersen, Khoa M. Dinh, Jens Boldsen, Susan Mikkelsen, Lise T. Erikstrup, Erik Sorensen, Kaspar R. Nielsen, Mie T. Bruun, Henrik Hjalgrim, Ole B. Pedersen, Lise W. Thorner, Henrik Ullum, Sisse R. Ostrowski, Klaus Rostgaard, Carsten B. Pedersen, Torben Sigsgaard, Christian Erikstrup
Summary: Through a study of more than 120,000 Danish blood donors, it was found that smoking is closely related to an increased risk of infection, especially respiratory tract infection, abscesses, and skin infection. These findings indicate that we should pay more attention to the infection risk among smokers.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Public, Environmental & Occupational Health
Signe Holst Soegaard, Maria Spanggaard, Klaus Rostgaard, Mads Kamper-Jorgensen, Lone Graff Stensballe, Kjeld Schmiegelow, Henrik Hjalgrim
Summary: Early childcare enrolment is associated with a modest increase in the cumulative number of antimicrobial-treated infections throughout childhood and adolescence, and this increase is not compensated by lower infection risk later in life.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Torsten Dahlen, Huiqi Li, Fredrik Nyberg, Gustaf Edgren
Summary: Individuals with blood groups A, AB, and B are at increased risk of contracting COVID-19 as well as developing more severe forms of the disease. However, this association is greatly attenuated in vaccinated individuals.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Environmental Sciences
Bertram Kjerulff, Henriette Thisted Horsdal, Kathrine Kaspersen, Susan Mikkelsen, Khoa Manh Dinh, Margit Horup Larsen, Sisse Rye Ostrowski, Henrik Ullum, Erik Sorensen, Ole Birger Pedersen, Mie Topholm Bruun, Kaspar Rene Nielsen, Jorgen Brandt, Camilla Geels, Lise M. Frohn, Jesper H. Christensen, Torben Sigsgaard, Clive Eric Sabel, Carsten Bocker Pedersen, Christian Erikstrup
Summary: Air pollution is a significant contributor to the global burden of disease, leading to inflammation and various health issues. However, studies on the impact of air pollution exposure on CRP levels in low to moderate pollution settings have yielded inconsistent results.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Hao Yu Chen, Christian Dina, Aeron M. Small, Christian M. Shaffer, Rebecca T. Levinson, Anna Helgadottir, Romain Capoulade, Hans Markus Munter, Andreas Martinsson, Benjamin J. Cairns, Linea C. Trudso, Mary Hoekstra, Hannah A. Burr, Thomas W. Marsh, Scott M. Damrauer, Line Dufresne, Solena Le Scouarnec, David Messika-Zeitoun, Dilrini K. Ranatunga, Rachel A. Whitmer, Amelie Bonnefond, Garoar Sveinbjornsson, Ragnar Danielsen, David O. Arnar, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hilma Holm, Jonas Ghouse, Morten Salling Olesen, Alex H. Christensen, Susan Mikkelsen, Rikke Louise Jacobsen, Joseph Dowsett, Ole Birger Vesterage Pedersen, Christian Erikstrup, Sisse R. Ostrowski, Christopher J. O'Donnell, Matthew J. Budoff, Vilmundur Gudnason, Wendy S. Post, Jerome Rotter, Mark Lathrop, Henning Bundgaard, Bengt Johansson, Johan Ljungberg, Ulf Naslund, Thierry Le Tourneau, J. Gustav Smith, Quinn S. Wells, Stefan Soderberg, Kari Stefansson, Jean-Jacques Schott, Daniel J. Rader, Robert Clarke, James C. Engert, George Thanassoulis
Summary: This study conducted a genome-wide meta-analysis and discovered 17 loci associated with calcific aortic stenosis. The integration of functional, expression, and cross-phenotype data revealed the mechanisms of this disease. Dyslipidemia, inflammation, calcification, and adiposity were identified as important factors in the etiology of calcific aortic stenosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Andreas Roos, Eva Sedin, Gustaf Edgren
Summary: This study in Sweden found that patients with psychiatric disorders who present with chest pain receive different management and have different outcomes compared to those without psychiatric disorders. Patients with affective or psychotic disorders had a reduced risk of myocardial infarction, but were less likely to receive cardiovascular medications or undergo percutaneous coronary intervention. On the other hand, patients with psychiatric disease had an increased risk of being diagnosed with a myocardial infarction within 30 days after the visit.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Arnor Sigurdsson, Ioannis Louloudis, Karina Banasik, David Westergaard, Ole Winther, Ole Lund, Sisse Rye Ostrowski, Christian Erikstrup, Ole Birger Vesterager Pedersen, Mette Nyegaard, Soren Brunak, Bjarni J. Vilhjalmsson, Simon Rasmussen
Summary: We developed a deep learning framework for polygenic risk score (PRS) prediction that can handle large-scale genomics data, support multi-task learning, and automatically integrate clinical and biochemical data. The framework demonstrated competitive performance and improved predictions for complex genetic relationships and non-additive genetic effects and epistasis. The model also outperformed traditional linear PRS methods for Type 1 Diabetes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Health Care Sciences & Services
M. A. S. Henning, M. Didriksen, K. S. Ibler, S. R. Ostrowski, C. Erikstrup, K. Nielsen, S. G. Saekmose, T. F. Hansen, H. Ullum, L. W. Thorner, K. A. Kaspersen, S. Mikkelsen, G. B. E. Jemec, O. B. Pedersen
Summary: This study compared the health-related quality of life and stress levels between individuals with and without hyperhidrosis, hidradenitis suppurativa, or psoriasis during the COVID-19 pandemic. The findings suggest that individuals with hyperhidrosis or hidradenitis suppurativa experienced worse mental or physical well-being, and individuals with hyperhidrosis also had higher stress levels during the pandemic compared to healthy individuals.
QUALITY OF LIFE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Asmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny M. Arnadottir, Valgerdur Steinthorsdottir, Gisli Halldorsson, Bjarni O. Atlason, Gudjon Oskarsson, Hannes Helgason, Henriette Svarre Nielsen, David A. Westergaard, Juha Karjalainen, Hildigunnur Katrinardottir, Run B. Fridriksdottir, Brynjar Jensson, Vinicius A. Tragante, Egil Ferkingstad, Hakon Jonsson, Sigurjon Gudjonsson, Doruk Beyter, Kristjan H. S. Moore, Helga Thordardottir, Snaedis Kristmundsdottir, Olafur Stefansson, Solbritt Rantapaa-Dahlqvist, Ida Elken Sonderby, Maria A. Didriksen, Pernilla Stridh, Jan Haavik, Laufey Tryggvadottir, Oleksandr Frei, G. Bragi Walters, Ingrid Kockum, Henrik Hjalgrim, Thorunn Olafsdottir, Geir Selbaek, Mette Nyegaard, Christian Erikstrup, Thorsten Brodersen, Saedis Saevarsdottir, Tomas Olsson, Kaspar Rene Nielsen, Asgeir Haraldsson, Mie Topholm Bruun, Thomas Folkmann Hansen, Thora Steingrimsdottir, Rikke Louise T. Jacobsen, Rolv Lie, Srdjan Djurovic, Lars Alfredsson, Aitzkoa Lopez de Lapuente Portilla, Soren Brunak, Pall V. Melsted, Bjarni Halldorsson, Jona Saemundsdottir, Olafur Th. Magnusson, Leonid Padyukov, Karina Banasik, Thorunn Rafnar, Johan Askling, Lars Klareskog, Ole Birger Pedersen, Gisli Masson, Alexandra Havdahl, Bjorn A. Nilsson, Ole Andreassen, Mark Daly, Sisse Rye Ostrowski, Ingileif Jonsdottir, Hreinn Stefansson, Hilma Holm, Agnar Helgason, Unnur Thorsteinsdottir, Kari F. Stefansson, Daniel Gudbjartsson
Summary: Using genetic data from 1.52 million individuals, the authors identified 25 genes with protein-altering variants that are essential for successful early development. It is challenging to find genotypes causing pregnancy loss and perinatal mortality, as they are depleted among living individuals.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Bo L. Honge, Morten N. Andersen, Mikkel S. Petersen, Sanne Jespersen, Candida Medina, David D. S. Te, Bertram Kjerulff, Alex L. Laursen, Holger J. Moller, Christian Wejse, Henrik Krarup, Bjarne K. Moller, Christian Erikstrup
Summary: AIDS-defining illness develops at higher CD4+ T-cell counts in individuals infected with HIV-2 compared with HIV-1-infected, which suggests that the two types of HIV may have different effects on other compartments of the immune system. This study investigated monocyte phenotype, activation, and macrophage-derived extracellular vesicles in individuals with different HIV types. The results showed that HIV-2-positive participants had a less deviated monocyte phenotype from healthy controls and a lower concentration of extracellular CD206 vesicles compared with HIV-1-positive participants.
Article
Gastroenterology & Hepatology
Simon M. D. Baunwall, Mette M. Hansen, Sara E. Andreasen, Marcel K. Eriksen, Nina Ragard, Jens Kelsen, Anne K. Grosen, Susan Mikkelsen, Christian Erikstrup, Jens F. Dahlerup, Christian L. Hvas
Summary: Background: Fecal microbiota transplantation (FMT) is effective for recurrent Clostridioides difficile infection (rCDI), but its effect varies. This study aimed to optimize the effectiveness of FMT for rCDI and identify determinants for effect. The results showed that a single FMT achieved resolution in 69% of patients at week 8, while repeated FMT achieved resolution in 91% of patients. Patient age, post-FMT antibiotics, and donor were associated with the effect. Standardizing processing and increasing microbial dosages did not improve outcomes.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Niklas Worm Andersson, Giulia Corn, Tine Lovso Dohlmann, Mads Melbye, Jan Wohlfahrt, Marie Lund
Summary: Reducing LDL cholesterol through lipid-lowering therapy has been shown to effectively lower the risk of cardiovascular disease in individuals under 70 years old, but the evidence is less clear for older individuals. This study compared the clinical effectiveness of lowering LDL cholesterol through lipid-lowering therapy for primary prevention of cardiovascular disease in older and younger individuals, and found that the risk reduction effect was similar between the two age groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Hematology
Louise Ornskov Drechsler, Jens Kjaergaard Boldsen, Lotte Hindhede, Bitten Aagaard, Lene Holm Harritshoj, Christina Mikkelsen, Thorsten Brodersen, Nanna Brons, Michael Schwinn, Henrik Hjalgrim, Klaus Rostgaard, Mie Topholm Bruun, Sisse Rye Ostrowski, Ole Birger Pedersen, Susan Mikkelsen, Christian Erikstrup
Summary: This study examines the effects of ferritin-guided iron supplementation on Danish female first-time blood donors. The intervention resulted in a significant decrease in the risk of low hemoglobin levels and an increase in the number of donations per donor.
Article
Hematology
Jenny Ryden, Mark Clements, Agneta Wikman, Eva Hellstrom-Lindberg, Gustaf Edgren, Petter Hoglund
Summary: This study found that alloimmunization against blood group antigens is associated with sex, DAT-positivity, increased transfusion needs, and lower post-transfusion hemoglobin increments in patients with myelodysplastic syndromes (MDS). Further investigation is needed to evaluate the clinical significance of up-front typing and prophylactic antigen matching in these patients.