Article
Oncology
Hafiz Muhammad Ishaq, Imran Shair Mohammad, Riaz Hussain, Rashida Parveen, Jafir Hussain Shirazi, Yang Fan, Muhammad Shahzad, Khezar Hayat, Huan Li, Ayesha Ihsan, Kiran Sher Muhammad, Muhammad Usman, Siruo Zhang, Lu Yuan, Shakir Ullah, Ana Claudia Paiva-Santos, Jiru Xu
Summary: This study investigated the changes in gut bacterial composition in thyroid cancer patients and found significant dysbiosis in the gut microbiota of euthyroid thyroid cancer patients. The results suggest that this study may propose new approaches to understanding the disease pathways, mechanisms, and treatment of thyroid cancer patients.
Review
Biochemistry & Molecular Biology
Angel Yun-Kuan Thye, Yi-Rou Bah, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Ya-Wen He, Sunny-Hei Wong, Sivakumar Thurairajasingam, Kok-Gan Chan, Learn-Han Lee, Vengadesh Letchumanan
Summary: Evidence suggests that the gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health, regulated through mechanisms such as inflammatory mediators and the immune system. Microbiota dysregulation has been observed in various inflammatory skin conditions, such as atopic dermatitis, rosacea, and psoriasis. Understanding the involvement of the gut microbiome in regulating skin health could lead to the development of novel therapies for these skin disorders, particularly psoriasis.
Review
Biochemistry & Molecular Biology
Ethan D. L. Brown, Barnabas Obeng-Gyasi, Janet E. Hall, Skand Shekhar
Summary: Thyroid function affects various aspects of the female HPG axis, and disruption of thyroid function is linked to reproductive dysfunction and gynecological conditions in women. The complex interplay between thyroid and reproductive hormones is further complicated by the association of certain autoimmune conditions with thyroid and HPG axis disorders. Minor disruptions in thyroid function during pregnancy and childbirth can have negative effects on maternal and fetal outcomes, and there are differing opinions on managing these conditions. This review provides a foundational understanding of thyroid hormone interactions with the female HPG axis and offers clinical insights on managing thyroid dysfunction in reproductive-aged women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Ilaria Testa, Oliviero Crescenzi, Susanna Esposito
Summary: Cystic fibrosis (CF) is a common autosomal recessive disease in Caucasians, and the features of gut microbiota in CF patients have been found to be altered, with reduced richness and diversity. The imbalanced gut microbial population, with a higher population of pro-inflammatory bacteria and scarcer immunomodulatory genera, may contribute to the development of systemic inflammation and affect clinical outcomes. Manipulation of gut microbiota could potentially be considered as an intervention to regulate the severity and progression of CF.
Review
Microbiology
Aditya Enjeti, Harindra Darshana Sathkumara, Andreas Kupz
Summary: Tuberculosis (TB) has been a global infectious disease problem for a long time. Efforts to eliminate TB have been hindered by factors such as the complexity of Mycobacterium tuberculosis (Mtb), the emergence of antibiotic resistant strains, and the impact of the COVID-19 pandemic. Studying the immunomodulatory role of gastrointestinal microbiota offers a new direction for TB research.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Mi Young Lim, Young-Do Nam
Summary: As the proportion of older people in the population increases, it is important to find ways to support healthy aging. The gut microbiome has been identified as a potential factor in aging-related diseases and is a target for improving health in older individuals. In this article, the relationship between the gut microbiome and chronological age in adults is discussed, as well as the features of the gut microbiome associated with unhealthy aging. The effects of microbiome-targeted interventions, such as dietary patterns and consumption of probiotics, prebiotics, and synbiotics, on modulating the gut microbiome composition and promoting healthy aging are also described. Further research is needed to understand the mechanisms of gut microbiome-induced aging complications and develop personalized microbiome-based strategies for reducing frailty severity or preventing frailty in older adults.
Article
Cell Biology
Wai-Yin Cheng, Yuen-Shan Ho, Raymond Chuen-Chung Chang
Summary: Emerging evidence suggests a close relationship between disruption of circadian rhythms, gut dysbiosis, and aging-associated neurodegenerative diseases. The microbiota-gut-brain axis has revolutionized research in neurological disorders and offers new perspectives on pathology, diagnosis, and treatment. The crosstalk between the brain and gut microbiota occurs through multiple systems, including endocrine, immune, and nervous. Recent studies have shown that host circadian rhythms influence the composition and diurnal oscillation of gut microbiota, highlighting the importance of investigating the microbiome-gut-brain axis. This article aims to review current research on the interaction between circadian rhythms and the microbiome-gut-brain axis, as well as the potential contribution to neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2022)
Review
Microbiology
Samradhi Singh, Poonam Sharma, Namrata Pal, Manoj Kumawat, Swasti Shubham, Devojit Kumar Sarma, Rajnarayan R. Tiwari, Manoj Kumar, Ravinder Nagpal
Summary: In recent years, the microbiome has become a high-priority research area for uncovering the connection between brain health and gut dysbiosis. Through metabolites produced by the microbiome and the involvement of various systems, the gut microbiome plays a crucial role in regulating the gut-brain axis. Environmental pollutants may impact the communication between gut microbes and the brain, potentially leading to neurological and psychiatric disorders.
Review
Medicine, General & Internal
Dora C. Moldovan, Abdulrahman Ismaiel, Sharmila Fagoonee, Rinaldo Pellicano, Ludovico Abenavoli, Dan L. Dumitrascu
Summary: This article summarizes the pathways linking gut microbiota with cardiovascular diseases, including metabolic endotoxemia, alteration of pattern recognition receptors, and changes in various metabolite levels.
Article
Food Science & Technology
Cantao Yang, Jian Xue, Qizhong Qin, Yinyin Xia, Shuqun Cheng, Xuejun Jiang, Shanshan Zhang, Zhaohong Lu, Xia Qin, Jun Zhang, Lejiao Mao, Shangcheng Xu, Jingfu Qiu, Zhen Zou, Chengzhi Chen
Summary: This study found that gestational exposure to titanium dioxide nanoparticles may cause persistent neurobehavioral impairments in maternal mice and may be associated with disruption of the gut-brain axis. These findings provide a new insight for the prevention of neurotoxicity of titanium dioxide nanoparticles in pregnant women.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Skand Shekhar, Raven McGlotten, Sunyoung Auh, Kristina Rother, Lynnette K. Nieman
Summary: The study revealed that abnormal thyroid function, likely mediated by subnormal nocturnal TSH levels, is prevalent in patients with Cushing syndrome. This abnormality can be reversed after cure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Inaki Robles-Vera, Nestor de la Visitacion, Marta Toral, Manuel Sanchez, Manuel Gomez-Guzman, Rosario Jimenez, Miguel Romero, Juan Duarte
Summary: The study suggests that MMF reduces gut dysbiosis in SHR by improving gut integrity, reducing neuroinflammation, and enhancing aortic endothelial function, ultimately leading to lower blood pressure in hypertensive rats.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Infectious Diseases
Dan Zhou, Qiu Wang, Hanmin Liu
Summary: The gut-lung axis may play a role in SARS-CoV-2 infection and the development of COVID-19, influencing disease severity through regulating microbiota, microbiota metabolites, common mucosal immunity, and ACE2 pathways.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Pedram Honarpisheh, Robert M. Bryan, Louise D. McCullough
Summary: The microbiota-gut-brain-axis (MGBA) is a communication network between gut microbes and the host, and dysbiosis disrupts this network, affecting the host's immune, metabolic, and nervous systems. Dysbiosis is linked to aging and stroke, and is associated with stroke risk factors such as obesity and diabetes. The article summarizes the role of MGBA signaling in the development of stroke risk factors and discusses current understanding of microbiota-based therapies for stroke.
CIRCULATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Takashi Kobayashi, Michihiro Iwaki, Atsushi Nakajima, Asako Nogami, Masato Yoneda
Summary: Global lifestyle changes have led to an increased incidence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). High-fat and high-fructose diets increase intestinal permeability, exposing the liver to endotoxins. The intestinal axis, including dysbiosis of the gut microbiome and leaky-gut syndrome, is linked to these liver diseases. This review summarizes recent research on the gut microbiome and liver diseases, providing new research directions for understanding the mechanisms and developing novel treatment targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shizhan Ma, Shudong Liu, Qi Wang, Lijuan Chen, Ping Yang, Huihuan Sun
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2020)
Article
Chemistry, Multidisciplinary
Wen-kai Bi, Shan-shan Shao, Zhi-wei Li, Yong-wei Ruan, Si-si Luan, Zhen-hua Dong, Jing Wang, Shan-shan Wu, Tian Guo, Shi-zhan Ma, Ling Gao, Jia-jun Zhao, Zhao He
ACTA PHARMACOLOGICA SINICA
(2020)
Article
Endocrinology & Metabolism
S. Ma, S. Shao, C. Yang, Z. Yao, L. Gao, W. Chen
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Yang Li, Xinhuan Su, Ying Gao, Chenxiao Lv, Zhiwei Gao, Yipeng Liu, Yan Wang, Shujuan Li, Zunsong Wang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Letter
Endocrinology & Metabolism
Yupeng Wang, Qingbo Guan, Xu Hou, Xu Zhang, Haiqing Zhang, Chao Xu, Fei Jing, Shizhan Ma, Shanshan Shao, Meng Zhao, Qingling Guo, Fang Zhong, Ling Gao, Jiajun Zhao
JOURNAL OF DIABETES
(2020)
Article
Immunology
Qingqing Yin, Jian Chen, Shizhan Ma, Chuanfang Dong, Yue Zhang, Xunyao Hou, Shangbin Li, Bin Liu
JOURNAL OF INFLAMMATION RESEARCH
(2020)
Article
Endocrinology & Metabolism
Yupeng Wang, Qihang Li, Zhongshang Yuan, Shizhan Ma, Shanshan Shao, Yafei Wu, Zhixiang Wang, Qiu Li, Ling Gao, Meng Zhao, Jiajun Zhao
Summary: This study aimed to assess the association between statin use and thyroid function, and found that statin use was associated with lower thyroid-stimulating hormone levels and improved thyroid function. Changes in total cholesterol served as a mediator of the association between statin use and thyroid-stimulating hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Urology & Nephrology
Kai Wei, Gesheng Song, Linhe Xi, Juan Chen, Chuancai Sun, Ping Chen, Yong Wei, Li Wang, Xianglei Kong, Yang Li, Dongmei Xu, Xiaoyan Jia
Summary: The study revealed positive correlations among plasma NGAL, serum Ca, and ARC in MHD patients without diabetes, suggesting that NGAL might be involved in cardiovascular calcification in this non-diabetic population.
Article
Peripheral Vascular Disease
Jing Du, Yang Li, Xiaoyan Jia, Xianglei Kong, Liming Liang, Dongmei Wang, Anzhuang Li, Qinlan Chen, Hong Su, Wenbin Li, Dongmei Xu
Summary: This study found that c-kit and related proteins associated with the PI3K/Akt pathway were elevated in failed AVFs among ESRD patients, and the expression level of c-kit in the intima correlates with the degree of AVF stenosis.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Medicine, Research & Experimental
Yang Li, Min Han, Jia Song, Shijin Liu, Yongjun Wang, Xinhuan Su, Kai Wei, Zhen Xu, Hui Li, Zunsong Wang
Summary: This study showed that dietary fiber may improve renal anemia in ESRD patients by regulating the gut microbiota and SCFAs, leading to increases in Hb, Fe2+, and SF levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Wen Liu, Xiangyu Hou, Yang Li, Zunsong Wang
Summary: This study examines the application value of hyperspectral imaging in predicting the efficacy of cyclophosphamide treatment in primary membranous nephropathy. Using a one-dimensional convolutional neural network model to analyze renal pathological images, the study successfully classified patients into remission and non-remission groups.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Xiangyu Hou, Chongxuan Tian, Wen Liu, Yang Li, Wei Li, Zunsong Wang
Summary: A non-invasive fluid biopsy assisted diagnosis model for glomerular diseases based on hyperspectral was developed to improve the early diagnosis rate. The model achieved an accuracy rate of 96% for early diagnosis of four glomerular diseases.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Endocrinology & Metabolism
Jianmei Zhang, Huixiao Wu, Shizhan Ma, Ling Gao, Chunxiao Yu, Fei Jing, Jiajun Zhao