Review
Nutrition & Dietetics
Jenifer F. Kruger, Elaine Hillesheim, Amanda C. S. N. Pereira, Carolina Q. Camargo, Estela Rabito
Summary: Probiotic supplementation did not show significant benefits on cognitive function in individuals with dementia, but did improve certain metabolic markers. The current evidence is insufficient to support the clinical application of probiotics and synbiotics for individuals with dementia.
Article
Biochemistry & Molecular Biology
Sandra Maria Barbalho, Rosa Direito, Lucas Fornari Laurindo, Ledyane Taynara Marton, Elen Landgraf Guiguer, Ricardo de Alvares Goulart, Ricardo Jose Tofano, Antonely C. A. Carvalho, Uri Adrian Prync Flato, Viviane Alessandra Capelluppi Tofano, Claudia Rucco Penteado Detregiachi, Patricia C. Santos Bueno, Raul S. J. Girio, Adriano Cressoni Araujo
Summary: Ginkgo biloba is associated with memory and cognitive improvement and has potential effects on preventing and treating aging-related diseases through its antiapoptotic, antioxidant, and anti-inflammatory actions.
Review
Geriatrics & Gerontology
Leonardo Santos Lopes da Silva, Marcio Fernando Tasinafo Junior, Leonardo da Silva Goncalves, Arthur Polveiro da Silva, Luis Felipe Pengo Almeida Leite, Laura Scatena Favero, Mateus do Carmo Bardella, Joao Gabriel Ribeiro de Lima, Carlos Roberto Bueno Junior, Camila de Moraes
Summary: This study conducted a systematic review and meta-analysis to examine the effects of multicomponent training on the cognitive function of older adults without cognitive impairment. The results showed that multicomponent training improves cognitive function in this population.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Plant Sciences
Han-Yang Lin, Wen-Hao Li, Chen-Feng Lin, Hao-Ran Wu, Yun-Peng Zhao
Summary: This article provides detailed information on the biology of Ginkgo biloba, covering its ecological characteristics, distribution, habitat, responses to environment and biotic factors, physiological structure, reproductive and seed characters, and the impact of diseases and pests. Ginkgo has a strong adaptability globally, with high tolerance to temperature variations, drought, and fire. Stem rot and leaf blight are common diseases in nursery seedlings and juvenile trees, which can be mitigated through shading and fertilization. Ginkgo biloba is one of the world's most distinctive trees, with significant importance in plant evolution and human society.
JOURNAL OF ECOLOGY
(2022)
Review
Medicine, General & Internal
Magdalena Sereda, Jun Xia, Polly Scutt, Malcolm P. Hilton, Amr El Refaie, Derek J. Hoare
Summary: This systematic review evaluated the effects of Ginkgo biloba for tinnitus in adults and children. The findings suggest that Ginkgo biloba may have little to no effect on reducing tinnitus symptoms compared to placebo. The evidence for other secondary outcomes was uncertain. The effectiveness and safety of Ginkgo biloba with concurrent interventions also remain unclear. Future research should use rigorous methodology and validated outcome measures.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Mei Cui, Tongyao You, Yuwu Zhao, Ruozhuo Liu, Yangtai Guan, Jianren Liu, Xueyuan Liu, Xin Wang, Qiang Dong
Summary: This study investigated the cognitive effects of EGb 761 (R) treatment in patients after acute ischemic stroke. The results showed that EGb 761 (R) treatment significantly improved overall cognitive function, especially in language learning and shape tracking. This suggests that EGb 761 (R) treatment has a positive effect on improving cognitive function in stroke patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Geriatrics & Gerontology
Dawei Li, Jinlong Ma, Baojian Wei, Shuang Gao, Yanmei Lang, Xueying Wan
Summary: This meta-analysis compared the efficacy and safety of ginkgo biloba preparations combined with donepezil hydrochloride vs. donepezil for the treatment of Alzheimer's disease. The results showed that ginkgo biloba preparations plus donepezil can improve clinical effectiveness rate and vocabulary memory outcomes. However, more relevant high-quality RCTs are needed in the future to validate these results.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Hantai Kim, Jungho Ha, Hun Yi Park, Yun-Hoon Choung, Jeong Hun Jang
Summary: This study investigated whether the co-administration of St. John's wort and Ginkgo biloba extracts can suppress tinnitus. The results showed that the combination did not improve the symptoms of subjective tinnitus compared to using Ginkgo biloba extract alone.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Plant Sciences
Marija Kovac Tomas, Iva Jurcevic, Dunja Samec
Summary: In this study, a HPLC-DAD method was developed to separate and determine five major biflavonoids in ginkgo. Tissue-specific profiling revealed that biflavonoids were not detected in plant parts not in direct contact with the environment. Leaves had the highest total biflavonoids content, with sciadopitysin being the predominant compound, while amentoflavone was the predominant biflavonoid in the bark.
Review
Clinical Neurology
Meenakshi Dauwan, Marieke J. H. Begemann, Margot I. E. Slot, Edwin H. M. Lee, Philip Scheltens, Iris E. C. Sommer
Summary: Physical exercise as an add-on therapeutic intervention shows significant effects on quality of life and mood in patients with chronic brain disorders, as well as improvements in multiple cognitive domains with small but significant effects. Additionally, exercise is considered safe with a positive dose-response correlation.
JOURNAL OF NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Dingyi Yu, Pengli Zhang, Junying Li, Ting Liu, Yaodan Zhang, Qingqing Wang, Jianbing Zhang, Xiaoyan Lu, Xiaohui Fan
Summary: Parkinson's disease (PD) lacks effective and safe treatments, but Ginkgo biloba dropping pill (GBDP) shows potential as an alternative therapy with its antioxidant and neuroprotective effects. GBDP demonstrated higher levels of certain compounds compared to the G. biloba extract EGb 761, and showed greater neuroprotective effects in in vitro and in vivo PD models. The Akt/GSK3 beta pathway may be involved in the neuroprotective effects of GBDP.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Taizen Nakase, Yasuko Tatewaki, Izumi Matsudaira, Kouki Kobayashi, Hikari Iki, Haruka Asaoka, Radiztia Ekayantri, Michiho Muranaka, Hiroyuki Murata, Tatsushi Mutoh, Yasuyuki Taki
Summary: This study aims to compare the changes in memory and executive functions in participants consuming GBE/MST, GBE alone, and placebo for 24 weeks through a double-blind randomized assignment. The alterations in the default mode network will be evaluated by comparing the rs fMRI findings between baseline and 24 weeks in different groups. These results will clarify the impact of GBE on cognitive function and the functional mechanism behind altered cognitive function induced by GBE components.
Review
Pharmacology & Pharmacy
Anna Nowak, Klaudyna Kojder, Joanna Zielonka-Brzezicka, Jacek Wrobel, Mateusz Bosiacki, Marta Fabianska, Mariola Wrobel, Joanna Solek-Pastuszka, Adam Klimowicz
Summary: Alzheimer's disease is a common neurodegenerative disease characterized by memory degradation and disorientation. In recent years, there has been increasing focus on using natural bioactive compounds for the treatment of neurodegenerative diseases, including Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Allison Mak, Kim Delbaere, Kathryn Refshauge, Timothy Henwood, Stephen Goodall, Lindy Clemson, Jennifer Hewitt, Morag E. Taylor
Summary: The study aimed to analyze the subgroup of the Sunbeam trial and determine whether the intervention was effective in reducing falls among LTC residents with mild-moderate cognitive impairment/dementia. The results showed that the Sunbeam program significantly reduced falls and improved physical performance in cognitively impaired LTC residents. Progressive resistance and balance exercise was found to be a safe and effective fall prevention intervention in this population.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Review
Plant Sciences
Dunja Samec, Erna Karalija, Sabina Dahija, Sherif T. S. Hassan
Summary: Ginkgo is a distinctive plant with excellent resistance to environmental conditions. It is used as an ornamental plant and a medicinal plant, and its bioactive potential is associated with flavonoids and terpene trilactones. Biflavonoids are important constituents of ginkgo and have various bioactivities and potential health benefits.
Article
Construction & Building Technology
Miaomiao Zhang, Hongren Gong, Rui Xiao, Xi Jiang, Yuetan Ma, Baoshan Huang
Summary: This study evaluated the cost-effectiveness of different overlay strategies using life-cycle cost analysis and probabilistic pavement performance models based on survival analysis. The results showed that there was a significant difference in survival probabilities between thin and thick overlays, while the overlay material type or milling had no significant impact on pavement service life. Thin overlays were more cost-effective in terms of life-cycle cost when traffic was not considered, while thick overlays were more cost-effective for pavements in wet areas with high traffic volumes.
ROAD MATERIALS AND PAVEMENT DESIGN
(2023)
Article
Materials Science, Multidisciplinary
Youqing Wang, Baoping Li, Peiling Ren, Menghan Liu, Zilin Gong, Miaomiao Zhang, Hao Zhao, Yu Zhang, Yanqing Zhang, Jianke Liu
Summary: An Ag nanowire network was prepared by electrospinning and magnetron sputtering, and transferred to a quartz substrate to obtain a UV-visible TCE with high transmittance. The addition of an ITO functional layer further improved electron conductivity and inhibited electronic recombination. The PEC UV detector based on this new electrode system showed excellent self-powered response performance and an extended response range.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Oncology
Jiannan Chen, Jianhua Hu, Lili Gu, Feng Ji, Fan Zhang, Miaomiao Zhang, Jun Li, Zhengliang Chen, Longwei Jiang, Yan Zhang, Ruifang Shi, Lihua Ma, Shaochang Jia, Ying Zhang, Qi Zhang, Junqing Liang, Shunyu Yao, Zhigang Hu, Zhigang Guo
Summary: This study demonstrates the efficacy of anti-MSLN CAR-T treatment for ovarian cancer through the screening and design of antibodies and CAR-T cells, and successful clinical trials have been conducted to preliminarily evaluate the safety and effectiveness.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Engineering, Environmental
Miaomiao Zhang, Yibo Gao, Yanpeng Mao, Wenlong Wang, Jian Sun, Zhanlong Song, Jing Sun, Xiqiang Zhao
Summary: Efficient syngas production can be achieved through the use of lanthanum nickelate catalyst and deposited carbon under microwave irradiation, enhancing catalytic performance and process stability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Zhuoxin Li, Lingyi Zhou, Yuyan Qin, Xin Sun, Qianzhe Li, Mengyu Yang, Beibei Yu, Fengyi Du, Miaomiao Zhang
Summary: In this study, a NIR responsive nano-immunostimulant was developed, which could induce immunogenic cell death of tumor cells through photothermal conversion and promote the maturation and antigen cross-presentation ability of dendritic cells. The multifunctional nano-immunostimulant provided a combined treatment strategy for tumor therapy, integrating photothermal therapy, chemo-dynamic therapy, and immune activation.
Article
Agronomy
Bing Wang, Xiang Zhou, Jun-Le Ren, Miao-Miao Zhang, Qing-Feng Wu, Shan Yuan, Wei Liu, Dong Lu
Summary: In this study, molasses was pretreated to meet the requirements of Clostridium tyrobutyricum fermentation. Through microbial adaptive laboratory evolution, C. tyrobutyricum was able to convert fructose and glucose in the treated molasses into butyric acid.
Article
Genetics & Heredity
Long Chen, Miaomiao Zhang, Xue Li, Qimin Wu, Xingfan Xue, Tingting Zhang, Renfei Lu, Yiquan Zhang
Summary: The study elucidated the regulatory mechanism of AphA on the colony morphology variation of Vibrio parahaemolyticus biofilm, which was achieved through its regulation of EPS gene expression.
Article
Immunology
Juan He, Yu Li, Jian Chen, Qi Wu, Hongying Shan, Xiaocheng Wang, Miaomiao Zhang, Liping Nie, Qingwen Wang
Summary: Different subsets of CD8+ T cells are associated with clinical features and serological parameters in rheumatoid arthritis (RA). Naive CD8+ T cells are negatively correlated with disease activity, while CD8+ CD28-T cells and CD8+ CD27-T cells are positively correlated with disease activity. Activated CD8+ T cells and TCR gamma E+ CD8+ T cells may be involved in inflammation and lipid metabolism in RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Polymer Science
Jun Li, Miaomiao Zhang, Gaolei Ni, Hao-Yang Mi, BinBin Dong, Chuntai Liu, Changyu Shen
Summary: This research proposes a method to fabricate thermoplastic polyurethane foams with surface wrinkly structures using a dynamic supercritical carbon dioxide foaming technique. The surface wrinkled TPU film paired with a surface structured polydimethylsiloxane film in a TENG showed enhanced output voltage, current, and maximum transfer charge. The flexible TENG demonstrated outstanding stability in long-term continuous operation and can be used for charging, power supply, and self-powered sensing.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Meteorology & Atmospheric Sciences
Miaomiao Zhang, Wenxiong Jia, Guofeng Zhu, Fuhua Zhang, Hui Xiong, Le Yang, Yue Zhang, Xin Lan
Summary: This study analyzes the stable isotopes of hydrogen and oxygen in the Shiyang River Basin to investigate the moisture sources and transport processes in this arid area. The results show that westerly winds and monsoons play important roles in moisture flux, and there is spatial variation in the isotopic values of precipitation. Precipitation from maritime sources is depleted in oxygen-18 compared to continental sources, while enrichment of oxygen-18 is associated with continental sources affected by evapotranspiration and secondary evaporation.
THEORETICAL AND APPLIED CLIMATOLOGY
(2023)
Article
Engineering, Civil
Miaomiao Zhang, Hongren Gong, Yuetan Ma, Xi Jiang, Baoshan Huang
Summary: This study establishes a predictive model for post-treatment pavement roughness using data from the LTPP program. A nomogram is provided to help highway agencies obtain predicted post-treatment roughness values. Results show that post-treatment roughness is significantly higher in dry and non-freeze areas, and the effect of pavement structure is time-dependent.
TRANSPORTATION RESEARCH RECORD
(2023)
Article
Physics, Multidisciplinary
Tinggui Wang, Guilin Liu, Zhenyi Cai, Jinjun Geng, Min Fang, Haoning He, Ji-an Jiang, Ning Jiang, Xu Kong, Bin Li, Ye Li, Wentao Luo, Zhizheng Pan, Xuefeng Wu, Ji Yang, Jiming Yu, Xianzhong Zheng, Qingfeng Zhu, Yi-Fu Cai, Yuanyuan Chen, Zhiwei Chen, Zigao Dai, Lulu Fan, Yizhong Fan, Wenjuan Fang, Zhicheng He, Lei Hu, Maokai Hu, Zhiping Jin, Zhibo Jiang, Guoliang Li, Fan Li, Xuzhi Li, Runduo Liang, Zheyu Lin, Qingzhong Liu, Wenhao Liu, Zhengyan Liu, Wei Liu, Yao Liu, Zheng Lou, Han Qu, Zhenfeng Sheng, Jianchun Shi, Yiping Shu, Zhenbo Su, Tianrui Sun, Hongchi Wang, Huiyuan Wang, Jian Wang, Junxian Wang, Daming Wei, Junjie Wei, Yongquan Xue, Jingzhi Yan, Chao Yang, Ye Yuan, Yefei Yuan, Hongxin Zhang, Miaomiao Zhang, Haibin Zhao, Wen Zhao
Summary: The Wide Field Survey Telescope (WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China (USTC) and the Purple Mountain Observatory (PMO). It is equipped with a 2.5-meter diameter primary mirror and a mosaic CCD camera, and it will scan the northern sky in four optical bands to detect transient phenomena and study the variability of Galactic and extragalactic objects.
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
(2023)
Article
Geochemistry & Geophysics
Heping Sun, Xiaoming Cui, Jianqiao Xu, Hao Ding, Miaomiao Zhang, Hang Li, Zhenyu Wang, Jiangcun Zhou, Xiaodong Chen
Summary: This paper briefly introduces the recent important research progress in background noise analysis, gravity tides, liquid core dynamics, hum signal, and normal mode detection based on China's gravity network and its cooperation with the international gravity network.
PURE AND APPLIED GEOPHYSICS
(2023)
Article
Chemistry, Analytical
Xinyue Guo, Weiqi Zhou, Yanxue Guan, Juan Qin, Bailin Zhang, Miaomiao Zhang, Jilin Tang
Summary: This study synthesized biocompatible bovine serum albumin-modified manganese-based nanozymes and found that they possess the ability to scavenge reactive oxygen species. These nanozymes can effectively reduce cellular damage caused by oxidative stress by inhibiting F-actin depolymerization, helping cells maintain their normal morphology, and reducing the decrease in cellular Young's modulus.
Article
Materials Science, Biomaterials
Jingjin Liu, Suwan Liu, Yunchao Wu, Xiao Xu, Qianzhe Li, Mengyu Yang, Aihua Gong, Miaomiao Zhang, Rongzhu Lu, Fengyi Du
Summary: In this study, researchers developed a novel nanoplatform for tumor therapy using curcumin doped zeolitic imidazolate framework nanoparticles (Cur-ZIF NPs). The Cur-ZIF NPs exhibited uniform nanosize, good stability and high drug-loading capacities. They were capable of controlled release of curcumin in response to pH and redox stimuli and could be used for tumor-targeted delivery.
BIOMATERIALS SCIENCE
(2022)
