Review
Biochemistry & Molecular Biology
Yujiro Matsuishi, Bryan J. Mathis, Nobutake Shimojo, Jesmin Subrina, Nobuko Okubo, Yoshiaki Inoue
Summary: The COVID-19 pandemic has captivated the medical world since December 2019. COVID-19 symptoms can range from mild to severe, and underlying chronic conditions can lead to excessive inflammatory responses, causing endothelial dysfunction. Maintaining endothelial integrity is crucial for favorable prognoses in COVID-19 patients, and therapeutic interventions supporting this may be beneficial.
Article
Biotechnology & Applied Microbiology
Geert Byttebier, Luc Belmans, Myriam Alexander, Bo E. H. Saxberg, Bart De Spiegeleer, Anton De Spiegeleer, Nick Devreker, Jens T. Van Praet, Karolien Vanhove, Reinhilde Reybrouck, Evelien Wynendaele, David S. Fedson
Summary: The COVID-19 pandemic has drastically impacted the world, but observational studies suggest that treating COVID-19 patients with statins and ACEI/ARB medications could reduce mortality rates. Combined treatment with these drugs may further decrease in-hospital mortality rates.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Antonio Desai, Giuseppe Voza, Silvia Paiardi, Francesca Ilaria Teofilo, Giuseppe Caltagirone, Marta Ripoll Pons, Monia Aloise, Maria Kogan, Tobia Tommasini, Victor Savevski, Giulio Stefanini, Claudio Angelini, Michele Ciccarelli, Salvatore Badalamenti, Ana Lleo De Nalda, Alessio Aghemo, Maurizio Cecconi, Filippo Martinelli Boneschi, Antonio Voza
Summary: The study found that chronic intake of ACE-I was associated with a trend in reduction of mortality in COVID-19 patients, while factors such as increased age and cardiovascular comorbidities were important risk factors for death. Timely treatment with low-molecular-weight heparin in the Emergency Department was also shown to decrease in-hospital mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Health Policy & Services
Dimitris Bertsimas, Alison Borenstein, Luca Mingardi, Omid Nohadani, Agni Orfanoudaki, Bartolomeo Stellato, Holly Wiberg, Pankaj Sarin, Dirk J. Varelmann, Vicente Estrada, Carlos Macaya, Ivan J. Nunez Gil
Summary: The study utilizes a machine learning framework to personalize the prescription of ACEIs and ARBs to hypertensive COVID-19 patients, improving patient outcomes by 1.0% compared to standard care. An interactive interface is developed for the algorithm to provide physicians with actionable treatment alternatives and inform clinical decisions. This work is the first to offer a personalized recommendation system evaluating the efficacy and risks of prescribing ACEIs and ARBs for hypertensive COVID-19 patients.
HEALTH CARE MANAGEMENT SCIENCE
(2021)
Letter
Gastroenterology & Hepatology
Arunkumar Krishnan, Carolin V. Schneider, Joern M. Schattenberg, Saleh A. Alqahtani
Summary: This study evaluated the hospitalization rates, severe disease, all-cause mortality, ICU requirement, and AKI risk in COVID-19 patients with Budd-Chiari syndrome (BCS). Compared to non-CLD patients, BCS patients had a higher risk of all-cause mortality, severe disease, hospitalization, and AKI, but no significant difference in ICU requirements. Compared to non-BCS CLD patients, BCS patients had a higher risk of all-cause mortality and hospitalization, but no statistically significant differences in ICU requirements, AKI, or severe disease.
LIVER INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Romil Singh, Sawai Singh Rathore, Hira Khan, Abhishek Bhurwal, Mack Sheraton, Prithwish Ghosh, Sohini Anand, Janaki Makadia, Fnu Ayesha, Kiran S. Mahapure, Ishita Mehra, Aysun Tekin, Rahul Kashyap, Vikas Bansal
Summary: The purpose of this systematic review is to assess the association between the use of ACEIs/ARBs and mortality or severity in COVID-19 patients. The findings indicate that there is no significant influence of ACEIs/ARBs on mortality or severity in COVID-19 patients. Multivariate meta-regression analysis suggests that age, gender, heart disease, and study country may contribute to the between-study variations.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Faisal Nabi, Owais Ahmad, Yawar Ali Khan, Anas Nabi, Hashmi Md Amiruddin, Faizan Abul Qais, Aiman Masroor, Malik Hisamuddin, Vladimir N. Uversky, Rizwan Hasan Khan
Summary: The study screened FDA-approved drugs against SARS-CoV-2 proteins and found potential interactions with anticancer, antipsychotic, and antiviral drugs. Molecular dynamics simulations revealed protein evolution upon drug interaction, and a phylogenetic analysis was conducted on 43 coronavirus strains infecting 12 mammalian species.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Medicine, Research & Experimental
Ankit Dhaundiyal, Puja Kumari, Snehal Sainath Jawalekar, Gaurav Chauhan, Sourav Kalra, Umashanker Navik
Summary: ACE 2 plays a crucial role in cleaving Ang II into Ang (1-7) and serving as a binding site for SARS-CoV-2. During pregnancy, ACE 2 is involved in fetal growth and development, as well as modulating maternal conditions, but more research is needed on the impact of SARS-CoV-2 on pregnancy and its interaction with fetal ACE 2.
Review
Medicine, General & Internal
Ihtisham Ul Haq, Katarzyna Krukiewicz, Hamnah Tayyab, Imran Khan, Mehtab Khan, Galal Yahya, Simona Cavalu
Summary: The genetic variants of HLAs play a crucial role in virus-host interaction and pathology of COVID-19, influencing both T and B cell immune responses. Certain HLA alleles, such as HLA-C*01 and HLA-B*44, increase susceptibility to COVID-19, while others like HLA-A*02:01, HLA-DR*03:01, and HLA-Cw*15:02 show resistance to SARS infection. Understanding the genetic association of HLA with COVID-19 is important for studying transmission and pathogenesis, and integrating HLA testing can help identify highly susceptible populations and aid in vaccine development.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
B. Buchmann, L. K. Engelbrecht, P. Fernandez, F. P. Hutterer, M. K. Raich, C. H. Scheel, A. R. Bausch
Summary: The authors estimated COVID-19 mortality in Italy using a counterfactual time series analysis, finding that the actual deaths were approximately 1.5 times higher than official statistics. The proportion of population deaths and infection rates were also calculated for the most affected regions, showing significant differences from reported numbers.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Pan, Alexi Vasbinder, Elizabeth Anderson, Toniemarie Catalan, Husam R. Shadid, Hanna Berlin, Kishan Padalia, Patrick O'Hayer, Chelsea Meloche, Tariq U. Azam, Ibrahim Khaleel, Erinleigh Michaud, Pennelope Blakely, Abbas Bitar, Yiyuan Huang, Lili Zhao, Rodica Pop-Busui, Sven H. Loosen, Athanasios Chalkias, Frank Tacke, Evangelos J. Giamarellos-Bourboulis, Jochen Reiser, Jesper Eugen-Olsen, Salim S. Hayek
Summary: The study found that the use of ACEi/ARB in hospitalized COVID-19 patients is associated with lower levels of inflammation and a reduced risk of in-hospital outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
David Varillas-Delgado, Carmen Jimenez-Antona, Angel Lizcano-Alvarez, Roberto Cano-de-la-Cuerda, Alberto Molero-Sanchez, Sofia Laguarta-Val
Summary: Long COVID-19 syndrome, present in 5-10% of SARS-CoV-2 infected patients, is still poorly understood in terms of predisposing factors. This study aimed to evaluate the role of early symptoms, clinical features, and ACE-2 gene polymorphisms in the susceptibility to developing Long COVID-19 syndrome. The study found that early symptoms such as fatigue, myalgia, and headache, as well as clinical features including emergency care, SARS-CoV-2 reinfection, previous diseases, respiratory disease, and brain fog, were associated with a higher risk of developing Long COVID-19. Additionally, certain ACE-2 gene polymorphisms were also linked to an increased susceptibility to Long COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Bhagat Singh, Dheer Singh, Vinod Verma, Ramakant Yadav, Raj Kumar
Summary: As of August 16, 2021, there have been over 207 million confirmed cases and 4.36 million deaths worldwide due to COVID-19. Effective drugs for treating COVID-19 are still lacking, but ACE2 has been identified as a potential target for therapeutic interventions. Researchers are investigating different strategies to block ACE2 or neutralize the virus through competitive binding with hrsACE2.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Editorial Material
Multidisciplinary Sciences
Enrique Acosta
Summary: Estimating global deaths caused by COVID-19 is a complex task, as demonstrated by the attempt to measure global excess mortality in 2020 and 2021.
Article
Psychology, Biological
Jonas Schoeley, Jose Manuel Aburto, Ilya Kashnitsky, Maxi S. Kniffka, Luyin Zhang, Hannaliis Jaadla, Jennifer B. Dowd, Ridhi Kashyap
Summary: In 2021, there were diverging impacts of the COVID-19 pandemic on life expectancies in different regions, with vaccination rates negatively correlated with life expectancy deficits. Generally, countries in western Europe saw improvements in life expectancy, while those in eastern Europe and the United States experienced sustained deficits.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Peripheral Vascular Disease
Tufan Cinar, Faysal Saylik, Tayyar Akbulut, Yetkin Korkmaz, Vedat Cicek, Suha Asal, Almina Erdem, Murat Selcuk, Mert Ilker Hayiroglu
Summary: This study aimed to evaluate the Intermountain Risk Score (IMRS) in predicting short- and long-term mortality in ST elevation myocardial infarction (STEMI) patients and compare it with other well-known risk scores. The results showed that IMRS had similar predictive capability for mortality compared to the Thrombolysis in Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) risk scores in STEMI patients.
Article
Peripheral Vascular Disease
Faysal Saylik, Tufan Cinar, Tayyar Akbulut, Murat Selcuk
Summary: Contrast-induced nephropathy (CIN) is a common complication following primary percutaneous coronary intervention (pPCI) in ST-elevation myocardial infarction (STEMI) patients. A novel marker, serum uric acid to albumin ratio (UAR), has been found to be associated with acute kidney injury in intensive care unit patients. This study investigated the predictive value of UAR for the development of CIN in STEMI patients after pPCI and found that UAR was an independent predictor of CIN.
Article
Peripheral Vascular Disease
Tufan Cinar, Faysal Saylik, Mert Ilker Hayiroglu, Suha Asal, Murat Selcuk, Vedat Cicek, Ibrahim Halil Tanboga
Summary: This study aimed to explore the relationship between serum uric acid/albumin ratio (UAR) and no-reflow (NR) in ST elevation myocardial infarction patients who underwent primary percutaneous coronary intervention. The study found that a high UAR was an independent risk factor for NR, and the AUC value of UAR in detecting NR was higher than that of its components, albumin and serum uric acid.
Article
Cardiac & Cardiovascular Systems
Faysal Saylik, Tufan Cinar, Tayyar Akbulut, Mert Ilker Hayiroglu
Summary: This meta-analysis demonstrates that catheter ablation (CA) has lower all-cause mortality risk, greater improvement in left ventricular ejection fraction (LVEF), longer walking distances, and better quality of life compared to medical therapy (MT) in heart failure patients with atrial fibrillation (AF).
Review
Cardiac & Cardiovascular Systems
Faysal Saylik, Tufan Cinar, Murat Selcuk, Vedat Cicek, Mert Ilker Hayiroglu, Ahmet Lutfullah Orhan
Summary: This meta-analysis compared the outcomes of treating diffuse coronary artery lesions with a single long stent (SLS) versus overlapping two or more stents (OLS). The results showed that individuals who received OLS had higher rates of cardiac mortality and target lesion revascularization (TLR) compared to those who received SLS, as well as longer fluoroscopy times.
Article
Medicine, General & Internal
Faysal Saylik, Tufan Cinar, Mert Ilker Hayiroglu
Summary: The protective effect of obesity, known as the obesity paradox, in acute coronary syndrome patients undergoing percutaneous coronary intervention or bypass surgery was investigated in this comprehensive meta-analysis. Overweight patients had a lower mortality risk compared to normal-weight patients for both short-term and long-term mortality. Additionally, low-weight patients had a higher risk of mortality than normal-weight patients.
BALKAN MEDICAL JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Mert Ilker Hayiroglu, Tufan Cinar, Selin Cilli Hayiroglu, Faysal Saylik, Mehmet Uzun, Ahmet Ilker Tekkesin
Summary: This study aimed to assess the influence of mobile application and smart devices on cardiopulmonary exercise testing in individuals with high risk for cardiovascular disease over a one-year period. The results showed that the smart device and mobile application technologies increased VO2 measurements in individuals with high cardiovascular risk compared to conventional treatment alone during the one-year follow-up.
Article
Peripheral Vascular Disease
Faysal Saylik, Tufan cinar, Murat Selcuk, Tayyar Akbulut, Mert Ilker Hayiroglu, Ibrahim Halil Tanboga
Summary: The Naples score (NS), a composite of cardiovascular adverse event predictors, has been proven to be a prognostic risk score in cancer patients. This study aimed to investigate the predictive value of NS for long-term mortality in ST-segment elevation myocardial infarction patients. The results showed that NS was independently associated with long-term mortality, and adding NS to a baseline model improved the prediction and discrimination of long-term mortality. NS could be used for risk stratification of long-term mortality in STEMI patients undergoing primary percutaneous coronary intervention.
Article
Peripheral Vascular Disease
Suleyman Karakoyun, Metin Cagdas, Aziz Inan Celik, Tahir Bezgin, Ibrahim H. Tanboga, Ali Karagoz, Tufan Cinar, Remziye Dogan, Mehmet Saygi, Vecih Oduncu
Summary: The purpose of this study was to investigate the association between the Naples prognostic score and the development of acute kidney injury (AKI) in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI). A total of 2901 consecutive STEMI patients who underwent pPCI were included in the study. The Naples prognostic score was found to be the most significant predictor of AKI occurrence after considering factors such as admission creatinine, age, and contrast volume. The continuous Naples prognostic score model provided the best prediction performance and discriminative ability. The study suggests that the Naples prognostic score may be useful in predicting the risk of AKI in STEMI patients undergoing pPCI.
Article
Cardiac & Cardiovascular Systems
Faysal Saylik, Tufan Cinar, Murat Selcuk, Ibrahim Halil Tanboga
Summary: The uric acid to albumin ratio (UAR) is associated with carotid intima-media thickness (CIMT) in hypertensive patients, and it can be used as a marker for predicting high CIMT and risk stratification.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Article
Peripheral Vascular Disease
Muammer Karakayali, Inanc Artac, Timor Omar, Ibrahim Rencuzogullari, Yavuz Karabag, Tufan Cinar, Mehmet Altunova, Serif Hamideyin
Summary: This study investigated the association between the fQRS-T angle and reverse dipper hypertension in newly diagnosed hypertensive patients without LVH. The results showed that individuals with reverse dipper hypertension had significantly higher fQRS-T angles compared to those with normal and non-reverse dipper hypertension. Multivariate analysis also showed an independent association between the fQRS-T angle and reverse dipper hypertension.
BLOOD PRESSURE MONITORING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Akin Torun, Almina Erdem, Mustafa Oguz, Tufan Cinar
KARDIOLOGIA POLSKA
(2023)
Article
Cardiac & Cardiovascular Systems
Almina Erdem, Akin Torun, Sahhan Kilic, Tufan Cinar, Mehmet Uzun, Ahmet Lutfullah Orhan
Summary: If a permanent pacemaker lead is misplaced in the left ventricle (LV), it can cause complications such as heart rhythm problems and blood clots. In this case, a 78-year-old patient presented with an embolic stroke caused by an LV lead passing through a patent foramen ovale and being misplaced in the LV. Thrombus regression was achieved with anticoagulation and lead extraction was planned. Lead extraction is a priority in acute cases, but not the primary approach for long-term leads misplaced in the LV. A patient-based individual approach should be preferred in such cases.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mert Ilker Hayiroglu, Tufan Cinar, Goeksel Cinier, Gizem Yuksel, Gokcem Ayan, Levent Pay, Cahit Coskun, Kivanc Keskin, Vedat Cicek, Ahmet Ilker Tekkesin
Summary: This study analyzed the influence of pre-implantation left ventricular mass index (LVMI) on pacing-induced cardiomyopathy (PICM) in patients with dual chamber permanent pacemakers (PPMs) due to complete AV block. The findings showed that higher LVMI was associated with an increased risk of long-term PICM. Overall, this study highlights the prognostic role of LVMI in predicting PICM.
ACTA CARDIOLOGICA SINICA
(2023)
Article
Medicine, General & Internal
Levent Pay, Ahmet Cagdas Yumurtas, Ozan Tezen, Tugba Cetin, Kivanc Keskin, Semih Eren, Gokse Cinier, Mert Ilker Hayiro, Tufan Cinar, Ahmet Ilker Tekkesin
Summary: This study investigated the effect of ivabradine on life-threatening arrhythmias and long-term mortality in heart failure patients with reduced ejection fraction. The results showed a lower likelihood of ventricular tachycardia in patients using ivabradine, as well as a lower presence of premature ventricular contractions and ventricular tachycardias. Additionally, ivabradine users had fewer appropriate implantable cardioverter-defibrillator shocks, and long-term mortality did not differ between the groups.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)