An anti‐siglec‐8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells

Eosinophil and mast cell Siglecs: From biology to drug target

(2020) Jeremy A. O'Sullivan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge

(2018) Mats W. Johansson et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids

(2018) Michael C. Peters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Randomized, Double-Blind, Placebo-Controlled, Ascending Dose Phase 1 Study of AK002, a Novel Siglec-8 Selective Monoclonal Antibody, in Healthy Subjects

(2018) Henrik S. Rasmussen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sialic acid–binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β 2 -integrin–dependent function in human eosinophils

(2018) Daniela J. Carroll et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma

(2018) Michael C Peters et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

(2018) Fanny Legrand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma

(2013) Michael C. Peters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ex VivoSputum Analysis Reveals Impairment of Protease-dependent Mucus Degradation by Plasma Proteins in Acute Asthma

(2009) Anh L. Innes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-5 Priming of Human Eosinophils Alters Siglec-8–Mediated Apoptosis Pathways

(2007) Esra Nutku-Bilir et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of FcεRI-dependent mediator release and calcium flux from human mast cells by sialic acid–binding immunoglobulin-like lectin 8 engagement

(2007) Hidenori Yokoi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY