Somatic Gain of KRAS Function in the Endothelium is Sufficient to Cause Vascular Malformations that Require MEK but not PI3K Signaling

Ponatinib Combined With Rapamycin Causes Regression of Murine Venous Malformation

(2019) Xian Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor

(2019) Dong Li et al.   NATURE MEDICINE

Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

(2019) Ilya G. Serebriiskii et al.   Nature Communications

ShinyGO: a graphical gene-set enrichment tool for animals and plants

(2019) Steven Xijin Ge et al.   BIOINFORMATICS

Somatic NRAS mutation in patient with generalized lymphatic anomaly

(2018) Eugenia Manevitz-Mendelson et al.   ANGIOGENESIS

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

(2018) Sergey I. Nikolaev et al.   NEW ENGLAND JOURNAL OF MEDICINE

High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations

(2018) Tao Hong et al.   BRAIN

A somatic activating NRAS variant associated with kaposiform lymphangiomatosis

(2018) Sarah F. Barclay et al.   GENETICS IN MEDICINE

RASA1 regulates the function of lymphatic vessel valves in mice

(2017) Philip E. Lapinski et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues

(2017) Wade W. Sugden et al.   NATURE CELL BIOLOGY

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

(2017) Mark Merchant et al.   PLoS One

Alk1 controls arterial endothelial cell migration in lumenized vessels

(2016) Elizabeth R. Rochon et al.   DEVELOPMENT

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

(2015) Elisa Boscolo et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse Models of Cerebral Arteriovenous Malformation

(2015) Corinne M. Nielsen et al.   STROKE

Blood Vascular Abnormalities in Rasa1R780Q Knockin Mice

(2014) Beth A. Lubeck et al.   AMERICAN JOURNAL OF PATHOLOGY

Cell-specific translational profiling in acute kidney injury

(2014) Jing Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression

(2014) Simon Tual-Chalot et al.   PLoS One

Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration

(2014) L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De Novo Cerebrovascular Malformation in the Adult Mouse After Endothelial Alk1 Deletion and Angiogenic Stimulation

(2014) Wanqiu Chen et al.   STROKE

Endothelial RAF1/ERK activation regulates arterial morphogenesis

(2013) Y. Deng et al.   BLOOD

ETS Factors Regulate Vegf-Dependent Arterial Specification

(2013) Joshua D. Wythe et al.   DEVELOPMENTAL CELL

Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ

(2013) Matthew D. Shirley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse

(2012) Eun-Jung Choi et al.   CEREBROVASCULAR DISEASES

Coding exons function as tissue-specific enhancers of nearby genes

(2012) Ramon Y. Birnbaum et al.   GENOME RESEARCH

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

(2012) Walter J. Jessen et al.   JOURNAL OF CLINICAL INVESTIGATION

TAK1 in brain endothelial cells mediates fever and lethargy

(2011) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Computational Tool for Quantitative Analysis of Vascular Networks

(2011) Enrique Zudaire et al.   PLoS One

Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

(2010) Marwa Mahmoud et al.   CIRCULATION RESEARCH

Cranial vasculature in zebrafish forms by angioblast cluster-derived angiogenesis

(2010) Kira Proulx et al.   DEVELOPMENTAL BIOLOGY

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Transthoracic Echocardiography in Mice

(2010) Jonathan L. Respress et al.   Jove-Journal of Visualized Experiments

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas

(2009) Michael J. Parsons et al.   MECHANISMS OF DEVELOPMENT

Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused byRASA1 mutations

(2008) Nicole Revencu et al.   HUMAN MUTATION

Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations

(2008) Nisha Limaye et al.   NATURE GENETICS

Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice

(2008) P. A. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA