Article
Chemistry, Multidisciplinary
Rajesh Kumar, Dinesh Pratap Singh, Romina Munoz, Mongi Amami, Rajesh Kumar Singh, Shipra Singh, Vinod Kumar
Summary: This review article introduces the potential and research progress of graphene and its derivatives in biomedical applications, and summarizes their effects on human health and the environment.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Bhushan Phafat, Sankha Bhattacharya
Summary: The use of quantum technology for drug delivery has the potential to enhance the effectiveness of treatments for rare diseases. Semiconductor nanoparticles known as quantum dots have unique properties that make them suitable for applications as medication carriers and biosensors. Recent advancements in research and clinical domains have enabled in-depth exploration of quantum dots. Notable progress has been made in the fluorescence bioimaging research of quantum dots, where they can be applied for gene transport, drug delivery, and improving the biocompatibility of other medications.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Deyu Yi, Jian Zhao, Lele Li
Summary: Li et al. achieved cell-selective imaging of metal ions using an enzyme-activatable DNAzyme sensor technology, allowing differentiation of metal-ion signals in tumor cells from healthy cells both in vitro and in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Ceramics
Ganji Lakshmi Varaprasad, Hoomin Lee, Suheon Kim, Eunsu Kim, Eluri Pavitra, Neeraja Valluru, Young-Kyu Han, Ganji Seeta Rama Raju, Yun Suk Huh
Summary: This study aimed to develop a fast and eco-friendly synthesis method for creating urchin-like GdPO4·xH(2)O:5Eu(3+) nanoparticles with excellent photoluminescence properties. The nanoparticles showed effective penetration in lung cancer cells and exhibited efficient antitumor activity when conjugated with doxorubicin.
CERAMICS INTERNATIONAL
(2022)
Review
Chemistry, Multidisciplinary
Seokhwan Chung, Richard A. Revia, Miqin Zhang
Summary: Graphene quantum dots (GQDs) have excellent properties for various applications in nanomedicine. Recent research focuses on their physicochemical, electronic, magnetic, and biological properties, discussing their use in bioimaging and therapy, as well as technical progress in GQDs synthesis.
ADVANCED MATERIALS
(2021)
Article
Polymer Science
Benjamin J. Carberry, Juan J. Hernandez, Adam Dobson, Christopher N. Bowman, Kristi S. Anseth
Summary: This study characterizes the thiol-thioester exchange reaction in cross-linked poly(ethylene glycol) (PEG) hydrogels and identifies the significant role of network thiols liberated from exchanged thioester cross-links in hydrogel degradation, resulting in predictable changes in the storage modulus and nonideal mass loss profiles. These findings enable the design of on-demand degradable hydrogels with uniquely tunable degradation and mass loss.
Review
Chemistry, Multidisciplinary
Abhinandan Gupta, Shringika Soni, Nidhi Chauhan, Manika Khanuja, Utkarsh Jain
Summary: This article reviews the applications of nanobots in environmental sciences and robotics, and introduces the propulsion strategies and recent developments in biomedical sciences. It highlights the challenges and prospects of nanobots in biomedical applications, and predicts the future direction of research in this field.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Engineering, Environmental
Xinyu Wang, Yeli Fan, Junjie Yan, Min Yang
Summary: Polyphenols, compounds found in natural plants, have various beneficial effects such as anti-tumor, anti-inflammatory, and antibacterial capacities. Polyphenol-based polymeric nanoparticles have emerged as promising drug carriers in biomedical engineering.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell Biology
Mengping Liu, Lin Wang, Young Lo, Simon Chi-Chin Shiu, Andrew B. Kinghorn, Julian A. Tanner
Summary: The interdisciplinary field of nanomaterials and aptamer science has significant potential for biomedical applications in drug delivery, imaging, and therapy. However, there are challenges to be addressed for their future development.
Article
Engineering, Biomedical
Aqsa Qambrani, Fawad Ur Rehman, Tanziela Tanziela, Sana Shaikh, Farouk Semcheddine, Tianyu Du, Weiwei Liu, Hui Jiang, Xuemei Wang
Summary: Exosomes have shown potential as an effective tool for cancer diagnosis and treatment, due to their unique characteristics in generating from all types of cells and their ability to enter targeted cancer cells with high efficiency.
BIOMEDICAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Dana A. Ali, Mohammed M. Mehanna
Summary: Lignin is a biopolymer that has drawn significant interest due to its high content of phenolic compounds, ecofriendly feature, and cost-efficiency. Recent efforts have focused on utilizing lignin on the nanoscale, as lignin nanoparticles exhibit unique properties such as notable absorption capacity, fluorescence emission, biodegradability, and non-toxicity. These nanoparticles have shown promising therapeutic effects, including anticancer, antimicrobial, and antioxidant properties. This review highlights the recent development of lignin nanoparticles as drug carriers and diagnostic tools for anticancer applications, while discussing the impact of surface properties on the final product characteristics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Jin-Xu Qin, Xi-Gui Yang, Chao-Fan Lv, Yi-Zhe Li, Kai-Kai Liu, Jin-Hao Zang, Xun Yang, Lin Dong, Chong-Xin Shan
Summary: Nanodiamonds have excellent properties for various potential applications in nanomedicine, with significant progress being made in recent years, especially in bioimaging, drug delivery, and biosensing. There is a promising outlook for their future developments and applications.
MATERIALS & DESIGN
(2021)
Article
Materials Science, Multidisciplinary
Gulshakhar Kudaibergen, Zhanar Akhmetkarimova, Ertan Yildirim, Murat Baidarbekov
Summary: Cryogels based on biopolymers have exceptional properties and are suitable for various applications in tissue engineering and drug delivery. The injectable formation of cryogels, combined with their biocompatibility, has great potential in developing innovative systems for the human body. Our study focuses on synthesizing advanced generation cryogels using UV radiation and thiolene chemistry, using gelatin and hyaluronic acid as starting materials. We characterized the properties of these cryogels and found that they exhibited larger pore structures and greater swelling capacities compared to conventional hydrogels.
JOURNAL OF MATERIALS SCIENCE
(2023)
Review
Biochemical Research Methods
Rui Wang, Hui-Da Li, Ying Cao, Zi-Yi Wang, Ting Yang, Jian-Hua Wang
Summary: Viruses, specifically M13 phage, are being utilized in biosensing and biomedicine due to their versatility, specific reactivities, and responsiveness to genetic modifications. M13 phages can be engineered and modified to create a multifunctional analysis platform, with different functional regions performing their tasks without interference. The unique filamentous morphology and flexibility of M13 phages enhance target affinity and signal amplification in analytical applications.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Jinping Wang, Beilu Zhang, Jingyu Sun, Wei Hu, Hongjun Wang
Summary: Porous nanomaterials with high surface area, tunable porosity, and large mesopores have attracted attention in cancer therapy and imaging. Researchers have been working on fabricating various porous nanomaterials and exploring their potentials in oncology applications.
Article
Chemistry, Multidisciplinary
Tao Yan, Linlin Ren, Fengyan Li, Feng Tian, Chengfang Jiang, Qi Wang, Xinyue Song, Shusheng Zhang
Summary: This sequentially responsive nanocarrier integrates bio-imaging, tumor microenvironment responsive chemotherapy, and cascade activation of upconversion photodynamic therapy. It shows site-specific degradation in the designed DNA outer nanoshell, leading to high cell apoptosis ratios and significant tumor inhibition.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Yilin Wang, Xuefan Xiong, Yanxi Zhu, Xinyue Song, Qiong Li, Shusheng Zhang
Summary: In this study, a pH-responsive nanoplatform was developed to combine gene therapy and chemotherapy for cancer treatment. Results showed that the combination therapy achieved better therapeutic efficacy in tumor inhibition compared to monotherapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Huimin Zhou, Yao Jiang, Wenjing Zhao, Shusheng Zhang
Summary: In this study, a light-activated nanodevice based on DNA nanotechnology was constructed for high precision detection of low-abundance miRNA. The nanodevice enabled on-demand imaging of miRNA in living cells with high spatial and temporal control.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Feifei Xu, Qing Wang, Ling Jiang, Fawei Zhu, Lei Yang, Shusheng Zhang, Xiangzhi Song
Summary: IPF is a chronic and fatal lung disease. The DCM-NO probe can quickly detect IPF by monitoring changes in NO concentration, showing good response properties in vitro and ability to evaluate treatment effects.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yao Jiang, Huimin Zhou, Wenjing Zhao, Shusheng Zhang
Summary: This study presents a self-assembled three-dimensional (3D) DNA nanostructure drug delivery system that utilizes ATP-triggered drug release for tumor fluorescence imaging and targeted therapy. The Dox@3D DNA nanostructures are assembled through a simple annealing reaction and can release drugs rapidly in tumor cells induced by high concentrations of ATP, providing efficient accumulation of drugs in tumors and minimizing damage to normal tissues.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiaoru Zhang, Yonghao Ge, Minghui Liu, Yujiao Pei, Peng He, Weiling Song, Shusheng Zhang
Summary: In this study, stable Janus nanoparticles (JNPs) were successfully prepared and used for in situ SERS detection and imaging analysis of cancer cells. The results showed that this method can improve the accuracy and sensitivity of cancer diagnosis and achieve a synergistic antitumor effect of chemotherapy and photodynamic therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Jiaju Shi, Chunqin Zhao, Meiqi Shen, Zichao Chen, Jinhua Liu, Shusheng Zhang, Zhen Zhang
Summary: This article discusses the advantages and disadvantages of label-free and label-based methods commonly used in the isolation of CTCs, and systematically reviews the most recent advances in the combination of microfluidic chips and biosensing for the enrichment of circulating tumor cells, proposing the current barriers and developmental trends in CTCs research.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Cheng Tian, Lei Zhao, Jin Zhu, Shusheng Zhang
Summary: In this study, a new SERS aptasensor was developed to simultaneously detect Hg2+ and Ag+ using cascade nucleic acid amplification strategy, which greatly improved the sensitivity. It can be widely applied for the detection of multiple heavy metal ions or other toxic substances in environmental water.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Yingnan Sun, Yuhan Song, Haohan Sun, Qingqing Tian, Qian Wang, Yongshu Liu, Shusheng Zhang
Summary: This study develops a strategy to transform superhydrophobic surfaces into large label-free SERS substrates with uniform and dense hot spots, enabling sensitive and high-throughput detection.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Wenxiu Han, Zizhen Wei, Lu Feng, Mei Yao, Huairong Zhang, Shusheng Zhang
Summary: The study developed a therapeutic platform by wrapping doxorubicin in mesoporous CNTs/Fe-N-C with the cell membrane, showing high antitumor activity due to efficient catalytic ability, increased drug release rates, and significant photothermal effect.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Inorganic & Nuclear
Jiaju Shi, Zichao Chen, Chunqin Zhao, Meiqi Shen, Han Li, Shusheng Zhang, Zhen Zhang
Summary: Tumor metastasis is a leading cause of patient mortality. Tumor markers play a crucial role in improving the treatment success rate by reflecting tumor progression and prognosis. Recently, photoelectrochemical (PEC) sensors have emerged as a highly promising strategy for tumor marker analysis due to their high sensitivity and cost-effectiveness. Combining PEC technique with biosensing strategies offers higher specificity and sensitivity compared to conventional sensing methods. The development of novel PEC nanosensors using nanotechnology holds great potential for building more powerful signal amplification systems. This review focuses on the signal amplification strategies of PEC biosensors for tumor marker detection in the past 5 years, and discusses the future prospects and challenges in PEC biosensor development.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Engineering, Environmental
Xinyue Song, Fengyan Li, Tao Yan, Feng Tian, Linlin Ren, Chengfang Jiang, Qi Wang, Shusheng Zhang
Summary: The wide use of pesticides has led to serious environmental pollution and health hazards. Developing feasible, fast, and accurate analysis methods for pesticide residues detection is of great importance. Sample pretreatment techniques play a key role in solving the challenges of detecting pesticide residues in complex sample matrices.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Chemistry, Analytical
Cheng Tian, Lei Zhao, Guoliang Qi, Jin Zhu, Shusheng Zhang
Summary: In this study, a SERS aptasensor was developed for fast and sensitive detection of SARS-CoV-2 virus. The sensor has the advantages of convenience, speed, sensitivity, and selectivity, making it a promising tool for analyzing viral particles in the environment and monitoring virus sources.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Xiaoru Zhang, Yonghao Ge, Minghui Liu, Yujiao Pei, Peng He, Weiling Song, Shusheng Zhang
Summary: This study developed stable Janus nanoparticles for in situ SERS detection and imaging analysis of cancer cells, which can improve the accuracy and sensitivity of diagnosis by monitoring ATP and acid conditions. Additionally, these nanoparticles can also achieve a synergistic antitumor effect through chemotherapy/photodynamic therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xinran Sun, Guoda Zhang, Xilai Ding, Yingyan Liu, Kaixiu Chen, Pengfei Shi, Shusheng Zhang
Summary: This study presents a metal-organic framework combined with magnesium peroxide nanoparticles, functionalized with an aptamer, for enhanced photodynamic therapy. The platform generates sufficient oxygen to address tumor hypoxia and performs targeted therapy.
MATERIALS CHEMISTRY FRONTIERS
(2022)
