Article
Chemistry, Multidisciplinary
Fergus Imrie, Thomas E. Hadfield, Anthony R. Bradley, Charlotte M. Deane
Summary: This study presents a method that improves the performance of generative models by incorporating 3D structural information, allowing for greater control over the design process in molecular design. The method performs well in linker and R-group design, effectively generating molecules with high 3D similarity.
Article
Chemistry, Multidisciplinary
Yuxin Liu, Liwen Li, Ruoyu Zhang, Yonghua Guo, Hua Wang, Qingfeng Ge, Xinli Zhu
Summary: This study investigates the application of Pt-Re/SiO2 catalysts in the RWGS reaction. The results show that under suitable reaction conditions, PtRe/SiO2 catalyst exhibits higher turnover frequency and lower apparent activation energy compared to Pt/SiO2 catalyst. Additionally, Pt-Re/SiO2 catalyst maintains high CO selectivity and inhibits CH4 production.
JOURNAL OF CO2 UTILIZATION
(2022)
Article
Metallurgy & Metallurgical Engineering
Hisao Hori, Yuki Yonezato, Kei Ito
Summary: Platinum and rhenium can be selectively recovered as precipitates from aqueous solution using UV-Visible light irradiation in the presence of 2-propanol and acetone. Two-stage photochemical treatment achieved high recovery selectivity for both platinum and rhenium.
Review
Chemistry, Multidisciplinary
Shunzhe Zheng, Guanting Li, Jianbin Shi, Xinying Liu, Meng Li, Zhonggui He, Chutong Tian, Ken-ichiro Kamei
Summary: Due to the severe dose-dependent toxicity and drug resistance, platinum (Pt)-based chemotherapy has limitations. Pt(IV) prodrug nanotherapeutics have emerged as a promising approach to improve the antitumor performance of Pt drugs. This article summarizes the latest advances in Pt(IV) prodrug nano-therapeutics, including their potential for overcoming biological barriers and their synergistic effects with other therapies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Materials Science, Multidisciplinary
Natalia S. Veizaga, Gustavo Mendow, Andres Felipe Quintero-Jaime, Angel Berenguer-Murcia, Sergio de Miguel, Emilia Morallon, Diego Cazorla-Amoros
Summary: The study focuses on the synthesis of mono- and bimetallic Pt-based electrocatalysts for ethanol electrooxidation in acidic media. Incorporation of Re promotes bond breaking of intermediates, while addition of Ir reduces electroactive surface area and decreases electrocatalytic performance.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Ying Wang, Linxiang Cai, Hui Li, Hanhua Chen, Tao Yang, Yehong Tan, Zijian Guo, Xiaoyong Wang
Summary: Platinum anticancer drugs often face drug resistance, but platinum complexes with fenofibric acid can regulate cholesterol metabolism to overcome resistance and induce cancer cell death.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Pharmacology & Pharmacy
Ruizheng Sun, Chao Du, Jiaxin Li, Yanhong Zhou, Wei Xiong, Juanjuan Xiang, Jiheng Liu, Zhigang Xiao, Li Fang, Zheng Li
Summary: The study identified potential risk biomarkers and predictive biomarkers associated with platinum-based chemotherapy through analyzing the methylation patterns of 618 patients, as well as demonstrating the existence of a methylation-transcription axis in the complex biological mechanism of platinum resistance in various cancers. Six differentially methylated positions (DMPs) and four associated genes were proposed as promising epigenetic biomarkers for guiding clinical treatment selection.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Wei Liu, Xin Li, Ting Wang, Fei Xiong, Changrui Sun, Xikuang Yao, Wei Huang
Summary: Platinum (Pt) drugs are widely used in cancer therapy, but their efficacy is compromised by side effects and drug resistance. Precise delivery and release of Pt drugs have become important with the development of immunotherapy and imaging-guided therapy. Targeted delivery of Pt drugs increases accumulation at tumor sites and enhances antitumor efficacy. Combining Pt drugs with other theranostic agents in nanosystems achieves synergistic therapy and real-time monitoring.
Article
Chemistry, Multidisciplinary
Bingzheng Yu, Yushu Wang, Tiejun Bing, Yujing Tang, Jia Huang, Haihua Xiao, Chaoyong Liu, Yingjie Yu
Summary: Pyroptosis is an emerging mechanism of programmed cell death that can trigger a robust antitumor immune response. In this study, an amphiphilic polymer responsive to glutathione (GSH) was developed to overcome chemoresistance and enhance cisplatin-induced pyroptosis in pancreatic cancer. The polymer self-assembled into nanoparticles and released an inhibitor of cyclooxygenase-2 (COX-2) to inhibit COX-2 expression. In a pancreatic cancer mouse model, the nanoparticles significantly inhibited tumor growth and elicited adaptive immune responses. Furthermore, when combined with anti-programmed death ligand (alpha-PD-L1) treatment, the nanoparticles effectively suppressed metastatic tumors. Overall, this strategy holds great promise for enhancing the immune response and improving the effectiveness of platinum drugs in cancer immunotherapy.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Tugce Boztepe, Sebastian Scioli-Montoto, Rocio C. Gambaro, Maria Esperanza Ruiz, Silvia Cabrera, Jose Aleman, German A. Islan, Guillermo R. Castro, Ignacio E. Leon
Summary: Colorectal cancer, the second leading cause of cancer death, is referred to as colon or rectal cancer depending on the site of formation. The platinum-based compound 8-QO-Pt has shown promising anticancer activity. In this study, three different systems of 8-QO-Pt-encapsulated nanostructured lipid carriers (NLCs) with riboflavin (RFV) were investigated. The results demonstrated the higher cytotoxicity of the 8-QO-Pt-loaded NLC/RFV formulations compared to free 8-QO-Pt, indicating the potential of RFV-targeted NLC systems for colon cancer treatment.
Article
Geochemistry & Geophysics
Zhiwei Liu, Yuan Li
Summary: Highly siderophile elements such as Pt and Re play important roles in tracing Earth's crust-mantle differentiation. The behavior of Pt and Re in oxidized arc magmas is controlled by their strong partitioning into sulfides and/or magnetite. Experimental determination of the partition coefficients of Pt and Re between monosulfide-solid-solution (MSS) or magnetite and silicate melt helps to understand their behavior in magmatic systems and can reproduce their evolution trends in sulfide-saturated arc magmas.
EARTH AND PLANETARY SCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Brondwyn S. McGhie, Janice R. Aldrich-Wright
Summary: Cancer is responsible for over 9 million deaths worldwide each year. Current treatment options have low success rates, especially for late-stage cancers. Researchers globally are continuously searching for alternative treatment options. This study focuses on innovations in inorganic anticancer therapies with photoactive and luminescent properties. Transition metals offer advantages in both chemotherapeutics and luminescence. The study explores the effects of structural changes on the properties and the use of inherent luminescent properties for monitoring cellular localization in photodynamic therapy.
Article
Biochemistry & Molecular Biology
Giuseppe Floresta, Chiara Zagni, Davide Gentile, Vincenzo Patamia, Antonio Rescifina
Summary: The recent covid crisis has accelerated the adoption of data analytics and artificial intelligence, leading to remarkable achievements in drug research for COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Yaqi Zhang, Yaying Wang, Xiang Li, Di Nie, Chang Liu, Yong Gan
Summary: This review discusses the importance of LMNCs for enhanced oral drug delivery and the key factors influencing their design, including extracellular and cellular barriers, GI protein corona, and sequential transport barriers. It also highlights the key factors to consider in the rational design of LMNCs and the potential of orally administered LMNCs in disease therapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Medicinal
Laura Goracci, Alessandra Nurisso, Emile Roussel, Basile Peres, Vincent Chaptal, Pierre Falson, Christelle Marminon, Joachim Jose, Marc Le Borgne, Ahcene Boumendjel
Summary: Human breast cancer resistance protein (BCRP), also known as ABCG2, plays a crucial role in tumor cells' resistance to multiple drugs. In this study, the researchers used computer-aided drug design (CADD) to guide the design of effective ABCG2 inhibitors. The FLAPpharm method was employed to understand the pharmacological features of one of the ABCG2 binding sites involved in regulating the transporter's ATPase activity. The model was evaluated using three predicted compounds, which showed high inhibitory activity against BCRP in the nanomolar range for the best compound.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Marcel Annereau, Franck Martial, Jeremy Forte, Geoffrey Gontard, Sebastien Blanchard, Heloise Dossmann, Michele Salmain, Vincent Corce
Summary: A series of manganese(I) tricarbonyl complexes were synthesized and characterized, which could be easily obtained from a common dimeric structure. These complexes, when reacted with imidazole derivatives, led to the formation of monomeric complexes with various functional groups. Photoactivation of these complexes resulted in the release of CO, with the mechanism of CO release explored through spectroscopic and computational methods. A manganese complex containing a more elaborate imidazole ligand was successfully synthesized, allowing for its direct incorporation in peptides.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Jeannine Yang, Valerio Giuso, Min-Chih Hou, Edwyn Remadna, Jeremy Forte, Hai-Ching Su, Christophe Gourlaouen, Matteo Mauro, Benoit Bertrand
Summary: A series of ten cationic complexes with the formula [(C^C)Au-(P and P)]X have been synthesized and characterized. These complexes exhibit a switch-on of emission properties when transitioning from a fluid solution to a solid state, with long-lived emission in the green-yellow region. The use of gold(III) complexes as electroactive materials for light-emitting electrochemical cell (LEC) devices has been demonstrated, showing promising potential for these novel emitters.
INORGANIC CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Anthony Nina-Diogo, Benoit Bertrand, Serge Thorimbert, Geoffrey Gontard, Sehr Nassem-Kahn, Andrea Echeverri, Julia Contreras-Garcia, Clemence Allain, Gilles Lemercier, Eleonora Luppi, Candice Botuha
Summary: This report presents the design, synthesis, and photophysical study of two new series of promising fluorescent trisubstituted triazoles, PyOHTr and PyCOTr. The PyOHTr molecules were found to exhibit an excited state intramolecular proton transfer (ESIPT) fluorescence mechanism through ab initio theoretical calculations. These fluorescent dyes possess unique optical properties with potential applications in medicinal chemistry and materials science.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Sunyoung Hur, Christophe Methivier, Axel Wilson, Michele Salmain, Souhir Boujday, Ali Miserez
Summary: The protein MrCP20 in the calcareous base plate of the acorn barnacle Megabalanus rosa plays a role in regulating biomineralization and growth of the barnacle. It affects the kinetics of crystal nucleation and growth, as well as stabilizes a specific polymorph of calcium carbonate. The results provide insights into the molecular mechanisms of biomineralization and other functional roles of MrCP20.
ACS APPLIED BIO MATERIALS
(2023)
Review
Chemistry, Inorganic & Nuclear
Michele Salmain, Benoit Bertrand
Summary: The medicinal chemistry of gold has seen rapid progress since the 2000s, with new modes of action emerging for gold-based drug candidates. Previously, the mechanisms of gold complexes were limited to direct coordination or supramolecular interactions, but recent research has revealed additional modalities such as photo-induced cytotoxicity, selective protein modification, and in cellulo catalysis.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Valerio Giuso, Jeannine Yang, Jeremy Forte, Heloise Dossmann, Chantal Daniel, Christophe Gourlaouen, Matteo Mauro, Benoit Bertrand
Summary: A series of binuclear gold complexes have been synthesized and characterized. These complexes exhibit long-lived yellow-green phosphorescence in the solid state with high photoluminescence quantum yields. Two of the complexes show promising antiproliferative activity against lung adenocarcinoma cells.
Review
Oncology
Michele Salmain, Marie Gaschard, Milad Baroud, Elise Lepeltier, Gerard Jaouen, Catherine Passirani, Anne Vessieres
Summary: The identification of biological targets is crucial in understanding the mechanism of action of anticancer drugs. This review examines the relationship between the inhibition of thioredoxin reductase (TrxR), a key enzyme in maintaining cell redox balance, and the cytotoxic effects of two groups of organometallic complexes. The results show that these complexes interact differently with TrxR at the molecular level, and the majority of their antiproliferative activity stems from the interaction with multiple targets. The review also highlights the potential of a multi-targeting approach to treat multidrug-resistant (MDR) tumors.
Article
Chemistry, Organic
Anissa Beghennou, Geoffrey Gontard, Heloise Dossmann, Kevin Passador, Serge Thorimbert, Vincent Corce, Candice Botuha
Summary: Efficient synthesis of original 1,6-naphthyridin-7(6H)-ones and their optical properties, including dual fluorescence, solvatochromism, acidochromism, large Stokes shifts, and high quantum yields, are described in this study. These properties make them suitable for biological applications or as luminescent devices in materials science.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Physical
Dorian Rabaud, Paul Dussart, Guylaine Ducouret, Pierre-Antoine Albouy, Jeremy Forte, Benjamin Isare, Laurent Bouteiller
Summary: This study explores the possibility of designing FDCA-based organogelators and investigates their gel structure. The results show that these gelators are versatile and can be used in a wide variety of applications, especially in non-polar liquids.