Review
Pharmacology & Pharmacy
Darija Cor Andrejc, Zeljko Knez, Masa Knez Marevci
Summary: Ganoderma lucidum is a medicinal mushroom with various biologically active compounds that have antioxidant, antitumor, anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Wenshuai Wang, Yaohan Zhang, Zhiying Wang, Jianjun Zhang, Le Jia
Summary: This study investigated the protective effects of Ganoderma lucidum polysaccharides (GLP) on high-fat diet-induced hyperlipidemia and explored the underlying mechanism. The results showed that GLP decreased body weight gain, reduced lipid levels, alleviated tissue injury, and improved oxidative stress and inflammation response. GLP also modulated bile acids synthesis, lipid regulatory factors, and promoted reverse cholesterol transport.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Integrative & Complementary Medicine
Ting Ye, Yang Ge, Xiaoying Jiang, Hang Song, Can Peng, Bin Liu
Summary: Gastrointestinal cancer is a common and deadly form of cancer, with surgical excision and chemotherapy as the main treatment methods. However, these methods often come with serious adverse reactions and drug toxicity. Ganoderma lucidum has been used medicinally and as a food source in China for a long time, and its bioactive compounds have shown potential anti-tumor activities. This review aims to compile the characteristics, anti-GI cancer mechanisms, and clinical applications of G. lucidum, providing a reference for further research on its role in the prevention and treatment of GI cancer from both traditional Chinese and western medicine perspectives.
Review
Pharmacology & Pharmacy
M. A. Oke, F. J. Afolabi, O. O. Oyeleke, T. A. Kilani, A. R. Adeosun, A. A. Olanbiwoninu, E. A. Adebayo
Summary: Ganoderma lucidum, also known as Lingzhi, is a medicinal mushroom used in traditional medicine for various health benefits. It contains a wide range of bioactive compounds, including triterpenoids and polysaccharides, which have been shown to possess numerous pharmacological activities. Studies have demonstrated the potential of Ganoderma lucidum in disease prevention and treatment, leading to the development of various formulations and products.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Shaodan Chen, Xiaoying Guan, Tianqiao Yong, Xiong Gao, Chun Xiao, Yizhen Xie, Diling Chen, Huiping Hu, Qingping Wu
Summary: In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have a protective effect on liver damage caused by restraint stress in mice by improving oxidative status. Two polysaccharides, including a neutral beta-glucan (GLPB2) and an acidic beta-glucan (GLPC2), were purified from GLP. GLPC2 exhibited a stronger hepatoprotective effect compared to GLPB2. The findings provide a theoretical basis for the potential application of G. lucidum polysaccharides as hepatoprotective agents in the food and pharmaceutical industry.
Article
Biochemistry & Molecular Biology
Jiaqi Jiao, Tianqiao Yong, Longhua Huang, Shaodan Chen, Chun Xiao, Qingping Wu, Huiping Hu, Yizhen Xie, Xiangmin Li, Yuancao Liu, Manjun Cai, Ruifang Zhang, Ting Xie, Rongjie Liu
Summary: In this paper, we revealed the hypoglycemic effect of Ganoderma lucidium polysaccharide F31, which showed efficacies between 45 and 54%, approaching that of liraglutide (52%). F31 reduced body weight gains and food intakes, protected kidney function, promoted apoptosis in epididymal fat, and induced early apoptosis in 3 T3-L1 preadipocyte cells. Molecular docking showed a possible cross-talk between kidney and epididymal fat through the glycerophosphorylcholine-Bax axis. Overall, F31 alleviated hyperglycemia through kidney protection and adipocyte apoptosis in db/db mice, providing novel insights into the hypoglycemic activity of polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Ruobing Liu, Jing Gan, Mengdi Du, Xiao Kong, Chunxia Xu, Yue Lue, Shengliang Cao, Ting Meng, Bo Wang, Tianying Yu
Summary: In this study, chitosan, sodium alginate, and sodium tripolyphosphate were used to prepare hydrogels as a stable polypeptide delivery system. The prepared M-SCT hydrogels showed excellent pH sensitivity and loading capacity for Ganoderma lucidum peptides (GLP). The characterization and evaluation of the hydrogels were performed, confirming their internal network structure, electrostatic interactions among the components, and improved stability. The hydrogels also demonstrated efficient peptide release and retained the antioxidant activity of GLP, suggesting their potential as a carrier for oral delivery.
Article
Pharmacology & Pharmacy
Qing-Hai Xia, Cui-Tao Lu, Meng-Qi Tong, Meng Yue, Rui Chen, De-Li Zhuge, Qing Yao, He-Lin Xu, Ying-Zheng Zhao
Summary: Photothermal immunotherapy, combining photothermal therapy and immunotherapy, shows promise in treating hepatocellular carcinoma. Indocyanine Green and Ganoderma lucidum polysaccharides play important roles in inhibiting tumor growth, inducing cell apoptosis, and enhancing immunity in the treatment, leading to improved survival time for liver cancer patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fang Kou, Yunfei Ge, Weihao Wang, Yuxia Mei, Longkui Cao, Xuetuan Wei, Hang Xiao, Xian Wu
Summary: Ganoderma lucidum polysaccharides have unique functional properties and various processing technologies have been used to improve their yield and utilization. This review summarizes the structure and health benefits of G. lucidum polysaccharides, and discusses factors that may affect their quality, including chemical modifications. These modifications improve the physicochemical characteristics and utilization of G. lucidum polysaccharides, making them more stable and suitable for encapsulating active substances. Ultimately, G. lucidum polysaccharide-based nanoparticles are designed to deliver functional ingredients for better health-promoting effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Organic
Zhiyuan Chen, Guozhi Xiao
Summary: The highly branched tetradecasaccharide repeating unit and shorter sequences of GLSWA-1 from Ganoderma lucidum, which possess immune-enhancing activities, were prepared using a one-pot glycan assembly strategy that features orthogonal one-pot glycosylation, one-pot assembly of oligosaccharides, and modular and convergent [4+5+5] assembly of the highly branched tetradecasaccharide.
Article
Polymer Science
Wei-Lun Qiu, Wei-Hung Hsu, Shu-Ming Tsao, Ai-Jung Tseng, Zhi-Hu Lin, Wei-Jyun Hua, Hsin Yeh, Tzu-En Lin, Chien-Chang Chen, Li-Sheng Chen, Tung-Yi Lin
Summary: The study investigated the effects of WSG, a polysaccharide from Ganoderma lucidum, in combination with cisplatin on lung cancer treatment. It found that WSG enhanced the inhibitory effect of cisplatin on tumor growth and metastasis in mice, as well as increased their survival rate. Additionally, WSG reduced the cytotoxic effects of cisplatin on macrophages and normal lung fibroblasts.
Article
Food Science & Technology
Ming Cai, Hua Mu, Haoyong Xing, Zhenhao Li, Jing Xu, Wei Liu, Kai Yang, Peilong Sun
Summary: The study found that Ganoderma lucidum spores with the sporoderm removed showed stronger metabolic promotion effects and better anti-inflammatory properties after in vitro digestion.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Plant Sciences
Marcela Rodrigues de Camargo, Talita Fonseca Frazon, Kelly Karina Inacio, Fhernanda Ribeiro Smiderle, Nadia Ghinelli Amor, Thiago Jose Dionisio, Carlos Ferreira Santos, Camila Oliveira Rodini, Vanessa Soares Lara
Summary: The polysaccharides of Ganoderma lucidum have the potential to be an important ally for tongue squamous cell carcinoma treatment, as they can alter the behavior and morphology of tumor cells, as well as downregulate cancer stem cells and EMT markers.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Ming Cai, Haoyong Xing, Baoming Tian, Jing Xu, Zhenhao Li, Hua Zhu, Kai Yang, Peilong Sun
Summary: The study revealed that Ganoderma lucidum polysaccharides can extend swimming time, enhance endurance, and promote fatigue recovery, especially polysaccharides with molecular weights above 10 kDa. These GLPs may reduce the activities of SUN and CK, decrease the levels of MDA and BLA, increase the level of Gly, accelerate fat transformation, and improve the activities of GPx, SOD, and LDH in all treated mice. Therefore, GLPs above 10 kDa could be potential agents with antifatigue activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Chung-Hsiung Huang, Tzu-Yu Chen, Guo-Jane Tsai
Summary: This study investigated the hypouricemic effects of submerged culture of Ganoderma lucidum. The results demonstrated the stronger hypouricemic effect of the submerged culture's mycelium, as well as the effectiveness of the extracellular polysaccharides in improving renal and hepatic function.
Article
Materials Science, Biomaterials
Yanxue Liu, Dan Zheng, Yunyun Ma, Juan Dai, Chunxiao Li, Shangzhen Xiao, Kefeng Liu, Jing Liu, Luying Wang, Jiandu Lei, Jing He
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Yanxue Liu, Dan Zheng, Yunyun Ma, Juan Dai, Chunxiao Li, Shangzhen Xiao, Kefeng Liu, Jing Liu, Luying Wang, Jiandu Lei, Jing He
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Chunxiao Li, Juan Dai, Dan Zheng, Jingyang Zhao, Yinghua Tao, Jiandu Lei, Xingjun Xi, Jing Liu
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Biotechnology & Applied Microbiology
Jingyang Zhao, Dan Zheng, Yinghua Tao, Yucheng Li, Luying Wang, Jing Liu, Jing He, Jiandu Lei
BIOCHEMICAL ENGINEERING JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Yinghua Tao, Dan Zheng, Jingyang Zhao, Kefeng Liu, Jing Liu, Jiandu Lei, Luying Wang
Summary: The use of nanoparticle drug delivery systems based on pectin has shown promising results in quickly releasing drugs and inhibiting tumor growth, demonstrating the potential of pectin in biomedical applications.
Article
Materials Science, Biomaterials
Dan Zheng, Jingyang Zhao, Yucheng Li, Liyu Zhu, Mengchen Jin, Luying Wang, Jing Liu, Jiandu Lei, Zhonglong Li
Summary: A novel pH-sensitive nanoparticle drug delivery system based on Ganoderma lucidum polysaccharides was designed for efficient delivery of MTX and HCPT to tumor cells, exhibiting synergistic anti-tumor effects. These irregularly spherical nanoparticles with uniform size demonstrated high drug-loading capacity and excellent biocompatibility. The loaded drugs were rapidly released within tumor cells under acidic conditions, showing better tumor suppression and fewer side effects in vivo compared to free drugs.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Food Science & Technology
Huaming Hou, Lanping Shu, Zhihui Yu, Dan Zheng, Yisheng Chen
Summary: This study found that magnetic field-assisting germination can significantly increase the content of bioactive substances and antioxidant activities in quinoa. The bioactive substance content and antioxidant activity of magnetic field-assisted germinated quinoa were higher than ordinary germinated quinoa, providing theoretical guidance for the processing and application of quinoa.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Chemistry, Multidisciplinary
Qifei Chen, Huaming Hou, Dan Zheng, Xueming Xu, Xingjun Xi, Yisheng Chen
Summary: In this study, a fast and reliable analytical method combining HPTLC with densitometry and surface enhanced Raman spectroscopy was established for the screening of saccharin in various beverages. The method showed good linearity, accuracy, and precision, with a limit of detection and quantification equivalent to 6 and 20 mg kg(-1), respectively. The study also demonstrated the versatility and cost-efficiency of HPTLC as a platform for food analysis.
Article
Nanoscience & Nanotechnology
Chunxiao Li, Zhenyu Chen, Dan Zheng, Jingyang Zhao, Jiandu Lei
Summary: A tumor-penetrating peptide, iRGD, was successfully combined with PEG to create nanoparticles for efficient drug delivery, resulting in high drug loading efficiency, controlled release rate, good pH response, and active and passive tumor targeting. These features indicated that the iRGD-modified drug delivery system could significantly improve tumor therapy efficacy compared to non-targeted nanoparticles.
ACS APPLIED BIO MATERIALS
(2021)
Article
Engineering, Environmental
Xinping Zhang, Yuxin Guo, Xiaoyang Liu, Shun-Yu Wu, Ya-Xuan Zhu, Shao-Zhe Wang, Qiu-Yi Duan, Ke-Fei Xu, Zi-Heng Li, Xiao-Yu Zhu, Guang-Yu Pan, Fu-Gen Wu
Summary: This study develops a nanotrigger HCFT for simultaneous photodynamic therapy and light-triggered ferroptosis therapy. The nanotrigger can relieve tumor hypoxia, induce enhanced photodynamic reaction, and facilitate the continuation of Fenton reaction, ultimately leading to lethal ferroptosis in tumor cells.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Olumide Bolarinwa Ayodele, Toyin Daniel Shittu, Olayinka S. Togunwa, Dan Yu, Zhen-Yu Tian
Summary: This study focused on the semihydrogenation of acetylene in an ethylene-rich stream using two alloyed Pt catalysts PtCu and PtCo. The PtCu catalyst showed higher activity and ethylene yield compared to PtCo due to its higher unoccupied Pt d-orbital density. This indicates that alloying Pt with Cu is more promising for industrial relevant SHA catalyst.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Guowei Chen, Wen-Cheng Chen, Yaozu Su, Ruicheng Wang, Jia-Ming Jin, Hui Liang, Bingxue Tan, Dehua Hu, Shaomin Ji, Hao-Li Zhang, Yanping Huo, Yuguang Ma
Summary: This study proposes an intramolecular dual-locking design for organic luminescent materials, achieving high luminescence efficiency and performance for deep-blue organic light-emitting diodes. The material also exhibits unique mechanochromic luminescence behavior and strong fatigue resistance.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Joren van Stee, Gregory Hermans, Jinu Joseph John, Koen Binnemans, Tom Van Gerven
Summary: This work presents a continuous solvent extraction method for the separation of cobalt and nickel in a millifluidic system using Cyphos IL 101 (C101) as the extractant. The optimal conditions for extraction performance and solvent properties were determined by investigating the effects of channel length, flow rate, and temperature. The performance of a developed manifold structure was compared to a single-channel system, and excellent separation results were achieved. The continuous separation process using the manifold structure resulted in high purity cobalt and nickel products.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Yan Xu, Jingai Jiang, Xinyi Lv, Hui Li, Dongliang Yang, Wenjun Wang, Yanling Hu, Longcai Liu, Xiaochen Dong, Yu Cai
Summary: A programmed gas release nanoparticle was developed to address the challenges in treating diabetic infected wounds. It effectively removes drug-resistant pathogens and remodels the wound microenvironment using NO and H2S. The nanoparticle can eliminate bacteria and promote wound healing through antibacterial and anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Tong Xia, Zhilin Xi, Lianquan Suo, Chen Wang
Summary: This study investigated a highly efficient coal dust suppressant with low initial viscosity and high adhesion-solidification properties. The results demonstrated that the dust suppressant formed a network of multiple hydrogen bonding cross-linking and achieved effective adhesion and solidification of coal dust through various chemical reactions.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jinzhi Cai, Zhenshan Li
Summary: A density functional theory-based rate equation was developed to predict the gas-solid reaction kinetics of CaO carbonation with CO2 in calcium looping. The negative activation energy of CaO carbonation close to equilibrium was accurately predicted through experimental validation.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jianxiong Chen, Fuhao Ren, Ningning Yin, Jie Mao
Summary: This study presents an economically efficient and easily implementable surface modification approach to enhance the high-temperature electrical insulation and energy storage performance of polymer dielectrics. The self-assembly of high-insulation-performance boron nitride nanosheets (BNNS) on the film surface through electrostatic interactions effectively impedes charge injection from electrodes while promoting charge dissipation and heat transfer.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Zijian Li, Zhaohui Yang, Shao Wang, Hongxia Luo, Zhimin Xue, Zhenghui Liu, Tiancheng Mu
Summary: This study reports a strategy for upgrading polyester plastics into value-added chemicals using electrocatalytic methods. By inducing the targeted transfer of *OH species, polyethylene terephthalate was successfully upgraded into potassium diformate with high purity. This work not only develops an excellent electrocatalyst, but also provides guidance for the design of medium entropy metal oxides.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Navneet Singh Shekhawat, Surendra Kumar Patra, Ashok Kumar Patra, Bamaprasad Bag
Summary: This study primarily focuses on developing a sulphur dyeing process at room temperature using bacterial Lysate, which is environmentally friendly, energy and cost effective, and sustainable. The process shows promising improvements in dye uptake and fastness properties.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Dengjia Shen, Hongyang Ma, Madani Khan, Benjamin S. Hsiao
Summary: This study developed cationic PVC nanofibrous membranes with high filtration and adsorption capability for the removal of bacteria and hexavalent chromium ions from wastewater. The membranes demonstrated remarkable performance in terms of filtration efficiency and maximum adsorption capacity. Additionally, modified nanofibrous membranes were produced using recycled materials and showed excellent retention rates in dynamic adsorption processes.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Xiaoyan Wang, Zhikun Wang, Ben Jia, Chunling Li, Shuangqing Sun, Songqing Hu
Summary: Inspired by photosystem II, self-supported Fe-doped NiCoP nanowire arrays modified with carboxylate were constructed to boost industrial-level overall water splitting by employing the concerted proton-coupled electron transfer mechanism. The introduction of Fe and carboxyl ligand led to improved catalytic activity for HER and OER, and NCFCP@NF exhibited long-term durability for overall water splitting.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Pengyao Yu, Ge Yang, Yongming Chai, Lubomira Tosheva, Chunzheng Wang, Heqing Jiang, Chenguang Liu, Hailing Guo
Summary: Thin LTA zeolite membranes were prepared through secondary growth of nano LTA seeds in a highly reactive gel, resulting in membranes with superior permeability and selectivity in gas separation applications.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Baiqin Zhou, Huiping Li, Ziyu Wang, Hui Huang, Yujun Wang, Ruichun Yang, Ranran Huo, Xiaoyan Xu, Ting Zhou, Xiaochen Dong
Summary: The use of machine learning to predict the performance of specific adsorbents in phosphate adsorption shows great promise in saving time and revealing underlying mechanisms. However, the small size of the dataset and insufficient detailed information limits the model training process and the accuracy of results. To address this, the study employs a fuzzing strategy that replaces detailed numeric information with descriptive text messages on the physiochemical properties of adsorbents. This strategy allows the recovery of discarded samples with limited information, leading to accurate prediction of adsorption amount, capacity, and kinetics. The study also finds that phosphate uptake by adsorbents is generally through physisorption, with some involvement of chemisorption. The framework established in this study provides a practical approach for quickly predicting phosphate adsorption performance in urgent scenarios, using easily accessible information.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Paula Alejandra Lamprea Pineda, Joren Bruneel, Kristof Demeestere, Lisa Deraedt, Tex Goetschalckx, Herman Van Langenhove, Christophe Walgraeve
Summary: This study evaluates the use of four esterified fatty acids and three vegetable oils as absorption liquids for hydrophobic VOCs. The experimental results show that isopropyl myristate is the most efficient liquid for absorbing the target VOCs.
CHEMICAL ENGINEERING JOURNAL
(2024)