期刊
CHEMBIOCHEM
卷 21, 期 21, 页码 3071-3076出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202000262
关键词
chemoselectivity; cyclometallated gold complexes; cysteine arylation; mass spectrometry; peptides
资金
- EPSRC [EP/L016443/1, EP/L027240/1]
- CDT in Catalysis [EP/L016443/1]
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [663830]
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- BBSRC [BB/T015799/1]
- Leverhulme Trust [RPG-2017-195]
- Royal Society [RG170187]
- Austrian Science Fund (FWF) [P33238-N]
- Projekt DEAL
- Austrian Science Fund (FWF) [P33238] Funding Source: Austrian Science Fund (FWF)
- EPSRC [EP/L027240/1] Funding Source: UKRI
To gain more insight into the factors controlling efficient cysteine arylation by cyclometallated Au(III)complexes, the reaction between selected gold compounds and different peptides was investigated by high-resolution liquid chromatography electrospray ionization mass spectrometry (HR-LC-ESI-MS). The deduced mechanisms of C-S cross-coupling, also supported by density functional theory (DFT) and quantum mechanics/molecular mechanics (QM/MM) calculations, evidenced the key role of secondary peptidic gold binding sites in favouring the process of reductive elimination.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据