Rapid Neuronal Ultrastructure Disruption and Recovery during Spreading Depolarization-Induced Cytotoxic Edema

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis

(2018) Homa Sadeghian et al.   ANNALS OF NEUROLOGY

The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex

(2018) Janos Lückl et al.   BRAIN

Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke

(2018) Jens P. Dreier et al.   NEUROPHARMACOLOGY

Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex

(2017) Yury M. Morozov et al.   NEUROBIOLOGY OF AGING

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Transient global cerebral ischemia induces rapid and sustained reorganization of synaptic structures

(2016) Lirui Zhu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal pannexin-1 channels are not molecular routes of water influx during spreading depolarization-induced dendritic beading

(2016) Jeremy Sword et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

(2016) Jens P Dreier et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

(2016) Jed A Hartings et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reversible Disruption of Neuronal Mitochondria by Ischemic and Traumatic Injury Revealed by Quantitative Two-Photon Imaging in the Neocortex of Anesthetized Mice

(2016) Mikhail Kislin et al.   JOURNAL OF NEUROSCIENCE

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

(2016) Liang Zhang et al.   Scientific Reports

The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema

(2015) Ravi L. Rungta et al.   CELL

Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading

(2015) A. B. Steffensen et al.   JOURNAL OF NEUROSCIENCE

The Stroke-Migraine Depolarization Continuum

(2015) Jens P. Dreier et al.   NEURON

Prolonged Deficits in Parvalbumin Neuron Stimulation-Evoked Network Activity Despite Recovery of Dendritic Structure and Excitability in the Somatosensory Cortex following Global Ischemia in Mice

(2014) Y. Xie et al.   JOURNAL OF NEUROSCIENCE

Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo

(2014) Michael O Breckwoldt et al.   NATURE MEDICINE

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Dynamics from Seconds to Hours in Hodgkin-Huxley Model with Time-Dependent Ion Concentrations and Buffer Reservoirs

(2014) Niklas Hübel et al.   PLoS Computational Biology

Mitochondrial morphology transitions and functions: implications for retrograde signaling?

(2013) Martin Picard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

New insights into the function and regulation of mitochondrial fission

(2013) Hidenori Otera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Evolution of neuronal and astroglial disruption in the peri-contusional cortex of mice revealed by in vivo two-photon imaging

(2013) Jeremy Sword et al.   BRAIN

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

Blood–brain barrier opening to large molecules does not imply blood–brain barrier opening to small ions

(2013) E.J. Kang et al.   NEUROBIOLOGY OF DISEASE

Propagation of cortical spreading depolarization in the human cortex after malignant stroke

(2013) J. Woitzik et al.   NEUROLOGY

Physiological Roles of the Permeability Transition Pore

(2012) Catherine Brenner et al.   CIRCULATION RESEARCH

Mitochondrial quality control: a matter of life and death for neurons

(2012) Elena I Rugarli et al.   EMBO JOURNAL

Persistent astroglial swelling accompanies rapid reversible dendritic injury during stroke-induced spreading depolarizations

(2012) W. Christopher Risher et al.   GLIA

Is Spreading Depolarization Characterized by an Abrupt, Massive Release of Gibbs Free Energy from the Human Brain Cortex?

(2012) Jens P. Dreier et al.   NEUROSCIENTIST

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Dibucaine Mitigates Spreading Depolarization in Human Neocortical Slices and Prevents Acute Dendritic Injury in the Ischemic Rodent Neocortex

(2011) W. Christopher Risher et al.   PLoS One

Transient Swelling, Acidification, and Mitochondrial Depolarization Occurs in Neurons but not Astrocytes during Spreading Depression

(2010) Ning Zhou et al.   CEREBRAL CORTEX

Experimental and Preliminary Clinical Evidence of an Ischemic Zone with Prolonged Negative DC Shifts Surrounded by a Normally Perfused Tissue Belt with Persistent Electrocorticographic Depression

(2010) Ana I Oliveira-Ferreira et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic Penumbra

(2010) W. C. Risher et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke

(2010) M. D. Budde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible Cyclosporin A-sensitive Mitochondrial Depolarization Occurs within Minutes of Stroke Onset in Mouse Somatosensory Cortexin Vivo

(2009) Ran R. Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simple and cost-effective hardware and software for functional brain mapping using intrinsic optical signal imaging

(2009) Thomas C. Harrison et al.   JOURNAL OF NEUROSCIENCE METHODS

Water transport between CNS compartments: contributions of aquaporins and cotransporters

(2009) N. MacAulay et al.   NEUROSCIENCE

Real-time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices andin vivorevealed by two-photon microscopy

(2008) W. Christopher Risher et al.   GLIA

Two-Photon Imaging of Stroke Onset In Vivo Reveals That NMDA-Receptor Independent Ischemic Depolarization Is the Major Cause of Rapid Reversible Damage to Dendrites and Spines

(2008) T. H. Murphy et al.   JOURNAL OF NEUROSCIENCE

Zn2+ Influx Is Critical for Some Forms of Spreading Depression in Brain Slices

(2008) R. M. Dietz et al.   JOURNAL OF NEUROSCIENCE

Hardware and methodology for targeting single brain arterioles for photothrombotic stroke on an upright microscope

(2008) Albrecht Sigler et al.   JOURNAL OF NEUROSCIENCE METHODS

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE