Intestinal stromal cells play key roles in the regulation of intestinal stem cell biology, injury-induced intestinal epithelial regeneration, and tumorigenesis. Roulis and colleagues present evidence indicating that PGE(2) secreted from PTGS2-expressing fibroblasts induces expansion of Sca-1(+) reserve stem-like cells and accelerates intestinal adenoma formation via an EP4-YAP1 pathway.
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