Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing

High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing

(2020) Morgane Macheret et al.   CELL RESEARCH

Dynamics of DNA replication in a eukaryotic cell

(2019) Thomas Kelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HumCFS: a database of fragile sites in human chromosomes

(2019) Rajesh Kumar et al.   BMC GENOMICS

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

(2019) Tatiana N. Moiseeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AT-dinucleotide rich sequences drive fragile site formation

(2019) Michal Irony-Tur Sinai et al.   NUCLEIC ACIDS RESEARCH

Visualizing locus-specific sister chromatid exchange reveals differential patterns of replication stress-induced fragile site breakage

(2019) Irina Waisertreiger et al.   ONCOGENE

Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide

(2019) Olivier Brison et al.   Nature Communications

Genome-wide analysis of replication timing by next-generation sequencing with E/L Repli-seq

(2018) Claire Marchal et al.   Nature Protocols

Replication stress induces accumulation of FANCD2 at central region of large fragile genes

(2018) Yusuke Okamoto et al.   NUCLEIC ACIDS RESEARCH

Pathways for maintenance of telomeres and common fragile sites during DNA replication stress

(2018) Özgün Özer et al.   Open Biology

Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse

(2018) Anthony Tubbs et al.   CELL

Poly(dA:dT) make it and break it

(2018) Eytan Zlotorynski   NATURE REVIEWS MOLECULAR CELL BIOLOGY

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

The FRA14B common fragile site maps to a region prone to somatic and germline rearrangements within the large GPHN gene

(2018) Diana Zheglo et al.   GENES CHROMOSOMES & CANCER

BLM prevents instability of structure-forming DNA sequences at common fragile sites

(2018) Hailong Wang et al.   PLoS Genetics

Common Chromosomal Fragile Sites—Conserved Failure Stories

(2018) Vasileios Voutsinos et al.   Genes

Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines

(2017) Heather M. Walline et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Synthethic biology: A fully designed yeast genome

(2017)   NATURE METHODS

FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells

(2017) Constanze Pentzold et al.   NUCLEIC ACIDS RESEARCH

Mitotic transcription and waves of gene reactivation during mitotic exit

(2017) Katherine C. Palozola et al.   SCIENCE

Design of a synthetic yeast genome

(2017) Sarah M. Richardson et al.   SCIENCE

BMAL1 regulates transcription initiation and activates circadian clock gene expression in mammals

(2016) Wei Xiong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma

(2016) S. Del Mare et al.   CANCER RESEARCH

Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

(2016) Pei-Chi Wei et al.   CELL

Nucleoporin-mediated regulation of cell identity genes

(2016) Arkaitz Ibarra et al.   GENES & DEVELOPMENT

Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma

(2016) Ge Gao et al.   GENES CHROMOSOMES & CANCER

DNA Breaks and End Resection Measured Genome-wide by End Sequencing

(2016) Andres Canela et al.   MOLECULAR CELL

FANCD2 Facilitates Replication through Common Fragile Sites

(2016) Advaitha Madireddy et al.   MOLECULAR CELL

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization

(2016) Yating Wang et al.   NUCLEIC ACIDS RESEARCH

Formation of Chromosomal Domains by Loop Extrusion

(2016) Geoffrey Fudenberg et al.   Cell Reports

The interplay of histone modifications - writers that read

(2015) T. Zhang et al.   EMBO REPORTS

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

Large transcription units unify copy number variants and common fragile sites arising under replication stress

(2014) Thomas E. Wilson et al.   GENOME RESEARCH

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Common chromosome fragile sites in human and murine epithelial cells andFHIT/FRA3Bloss-induced global genome instability

(2013) Seyed Ali Hosseini et al.   GENES CHROMOSOMES & CANCER

Use of Bru-Seq and BruChase-Seq for genome-wide assessment of the synthesis and stability of RNA

(2013) Michelle T. Paulsen et al.   METHODS

MUS81 promotes common fragile site expression

(2013) Songmin Ying et al.   NATURE CELL BIOLOGY

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

(2013) Nicola Crosetto et al.   NATURE METHODS

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

(2012) Arkarachai Fungtammasan et al.   GENOME RESEARCH

A DNA hypermethylation module for the stem/progenitor cell signature of cancer

(2012) H. Easwaran et al.   GENOME RESEARCH

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

Determinants and dynamics of genome accessibility

(2011) Oliver Bell et al.   NATURE REVIEWS GENETICS

Molecular profiling of common fragile sites in human fibroblasts

(2011) Benoî Le Tallec et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication dynamics at common fragile site FRA6E

(2010) Elisa Palumbo et al.   CHROMOSOMA

Relicensing of Transcriptionally Inactivated Replication Origins in Budding Yeast

(2010) Marko Lõoke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breakpoint regions and homologous synteny blocks in chromosomes have different evolutionary histories

(2009) D. M. Larkin et al.   GENOME RESEARCH

Impaired replication dynamics at the FRA3B common fragile site

(2009) Aparna Palakodeti et al.   HUMAN MOLECULAR GENETICS

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

Epigenetic inheritance during the cell cycle

(2009) Aline V. Probst et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Replication timing of two human common fragile sites: FRA1H and FRA2G

(2008) F. Pelliccia et al.   CYTOGENETIC AND GENOME RESEARCH