Review
Oncology
Xingkai Liu, Ping Zhang, Jing Xu, Guoyue Lv, Yan Li
Summary: Bioactive lipid molecules play important roles in linking obesity/metabolic syndrome and cancers. Controlling lipid metabolism can be a potential strategy for cancer prevention and therapy. Comprehensive understanding of the regulatory role of lipid metabolism in cellular entities and their tumor microenvironment will provide a new direction for further studies and development of novel anti-cancer strategies.
CANCER CELL INTERNATIONAL
(2022)
Review
Immunology
Daniella Cesar-Silva, Filipe S. Pereira-Dutra, Ana Lucia Moraes Giannini, Clarissa M. Maya-Monteiro, Cecilia Jacques G. de Almeida
Summary: Lipids play important roles in cellular functions and disruptions in lipid metabolism can be associated with diseases, including viral infections. This review discusses how coronaviruses utilize cellular lipids and explores the potential of targeting lipid metabolism as a strategy to combat viral infections. The review also provides insights into pharmacological approaches targeting lipid metabolism to impair and treat coronavirus infections.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shi-Feng Huang, Xiao-Fei Peng, Lianggui Jiang, Ching Yuan Hu, Wen-Chu Ye
Summary: Lipid metabolism is crucial for biological processes, and dysregulation can lead to lipid-related diseases. lncRNAs play essential roles in the regulation of lipid-related diseases, and understanding their functions can help identify potential biomarkers and therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei-Lun Tsai, Chih-Yang Wang, Yu-Cheng Lee, Wan-Chun Tang, Gangga Anuraga, Hoang Dang Khoa Ta, Yung-Fu Wu, Kuen-Haur Lee
Summary: The development and progression of colorectal cancer involves changes in genetic and epigenetic levels of oncogenes and tumor suppressors, and more research is needed to discover effective biomarkers and targets for diagnosis and treatment. Long non-coding RNAs may play a role in tumor development. The upregulation of CRNDE in CRC patients at an advanced stage is associated with poor outcomes, and knocking down CRNDE can reduce lipid accumulation and induce autophagy in CRC cells through the miR-29b-3p/ANGPTL4 axis.
Article
Multidisciplinary Sciences
Cora N. Betsinger, Connor S. R. Jankowski, William A. Hofstadter, Joel D. Federspiel, Clayton J. Otter, Pierre M. Jean Beltran, Ileana M. Cristea
Summary: The study reveals how the prevalent pathogen HCMV increases mitochondrial metabolism and cellular respiration through the viral protein pUL13, promoting virus replication. Interaction of pUL13 with the MICOS complex alters mitochondrial structure and affects oxidative phosphorylation process in cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Amin Javadifar, Sahar Rastgoo, Maciej Banach, Tannaz Jamialahmadi, Thomas P. Johnston, Amirhossein Sahebkar
Summary: This study focuses on the role of foam cells in the development of atherosclerosis, with a special emphasis on non-coding RNAs and their regulation of lipid metabolism, inflammatory pathways, and foam cell formation. Important preclinical evidence is reviewed regarding therapeutic targeting of non-coding RNAs in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Tianren Wang, Yuan Xiao, Zhe Hu, Jingkai Gu, Renwu Hua, Zhuo Hai, Xueli Chen, Jian V. Zhang, Zhiying Yu, Ting Wu, William S. B. Yeung, Kui Liu, Chenxi Guo
Summary: This study investigates the impact of MFN2 deficiency on spermatogenesis and meiosis. The results show that depletion of MFN2 disrupts the development of spermatocytes and affects mitochondrial functions. Furthermore, the study reveals alterations in the PPAR pathway and lipid metabolism in Mfn2 deficient spermatocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Henriette Berg Andersen, Renata Ialchina, Stine Falsig Pedersen, Dominika Czaplinska
Summary: PDAC is a deadly cancer with limited therapeutic options, characterized by an acidic tumor microenvironment and metabolic rewiring. Metabolic crosstalk with nonmalignant cells and resistance to conventional treatments contribute to treatment failure. Increasing research focuses on targeting pro-tumorigenic metabolic pathways for potential therapeutic opportunities.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Immunology
Serena Shunmugam, Nyamekye Quansah, Ansgar Flammersfeld, Md Muzahidul Islam, Juliane Sassmannshausen, Sandra Bennink, Yoshiki Yamaryo-Botte, Gabriele Pradel, Cyrille Y. Botte
Summary: Plasmodium falciparum, the parasite responsible for malaria, lacks an efficient vaccine and is becoming increasingly resistant to drugs. Recent research has shown the importance of lipid synthesis and trafficking for the survival and pathogenesis of the parasite, highlighting them as potential targets for new drugs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Medicine, Research & Experimental
Jia Gu, Ya-Ning Shi, Neng Zhu, Hong-Fang Li, Chan-Juan Zhang, Li Qin
Summary: Lipid metabolism disorders play a crucial role in the development of various lipid-related diseases. Celastrol, extracted from the Chinese herb Tripterygium wilfordii Hook F, has shown promising therapeutic effects for these diseases. It can ameliorate lipid metabolism disorders by regulating lipid profiles and related processes. This review provides an overview of celastrol's lipid-regulating properties and its underlying molecular mechanisms, as well as suggesting potential strategies for enhancing its effects and overcoming limitations in clinical applications.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Chao-Yi Wu, Huang-Yu Yang, Jenn-Haung Lai
Summary: Synovial inflammation and destruction of articular cartilage and bone are key characteristics of autoimmune arthritis. Current treatments targeting proinflammatory cytokines and Janus kinases have shown promise, but many patients still lack adequate disease control. Recent advances in understanding the imbalance of immune cells and bone cells in autoimmune arthritis have highlighted new therapeutic targets, particularly focused on synovial fibroblasts. This commentary comprehensively reviews the interactions between synovial fibroblasts, bone cells, and immune cells and their contributions to the immunopathogenesis of autoimmune arthritis, providing insights into novel treatment approaches.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nannan Sun, Chuangpeng Shen, Lei Zhang, Xiaojie Wu, Yuanyuan Yu, Xiaoying Yang, Chen Yang, Chong Zhong, Zhao Gao, Wei Miao, Zehong Yang, Weihang Gao, Ling Hu, Kevin Williams, Changhui Liu, Yongsheng Chang, Yong Gao
Summary: The transcription factor KLF16 plays a crucial role in hepatic lipid metabolism by regulating fatty acid oxidation and improving mitochondrial stress and oxidative stress, thus reducing hepatic steatosis and insulin resistance.
Review
Cardiac & Cardiovascular Systems
Yi Luan, Kai-Di Ren, Ying Luan, Xing Chen, Yang Yang
Summary: Vascular diseases, particularly atherosclerosis, are associated with high morbidity and mortality. Mitochondrial dynamics, including fusion and fission, have been shown to influence vascular diseases and may be a potential target for treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Hematology
Sushanta Kumar Mishra, Scott E. Millman, Lingbo Zhang
Summary: Metabolic rewiring and cellular reprogramming are characteristic features of neoplastic initiation and progression in AML. Targeting abnormal metabolic activities provides therapeutic opportunities with improved efficacy and wider therapeutic windows.
Article
Oncology
Suman Mohajan, Praveen Kumar Jaiswal, Mousa Vatanmakarian, Hassan Yousefi, Saikolappan Sankaralingam, Suresh K. Alahari, Sweaty Koul, Hari K. Koul
Summary: The Hippo pathway serves as a master regulator of various cellular processes and its deregulation is associated with cancer. Despite the importance, the detailed functions of the components of the mammalian Hippo pathway in tumor biology are still unclear.