Article
Chemistry, Multidisciplinary
Xue Li, Yongxin Zhang, Xiaohui Wu, Jiajing Chen, Menglin Yang, Feihe Ma, Linqi Shi
Summary: Personalized cancer vaccination using nanomaterials has great potential for cancer immunotherapy. A nanochaperone called PBA-nChap is designed to efficiently capture tumor-associated antigens (TAAs) in situ, protect TAAs from degradation, transport TAAs to antigen-presenting cells, and promote immune response.
Article
Oncology
Zeynep Eroglu, Kristy K. Broman, John F. Thompson, Amanda Nijhuis, Tina J. Hieken, Lisa Kottschade, Jeffrey M. Farma, Meghan Hotz, Jeremiah Deneve, Martin Fleming, Edmund K. Bartlett, Avinash Sharma, Lesly Dossett, Tasha Hughes, David E. Gyorki, Jennifer Downs, Giorgos Karakousis, Yun Song, Ann Lee, Russell S. Berman, Alexander van Akkooi, Emma Stahlie, Dale Han, John Vetto, Georgia Beasley, Norma E. Farrow, Jane Yuet Ching Hui, Marc Moncrieff, Jenny Nobes, Kirsten Baecher, Matthew Perez, Michael Lowe, David W. Ollila, Frances A. Collichio, Roger Olofsson Bagge, Jan Mattsson, Hidde M. Kroon, Harvey Chai, Jyri Teras, James Sun, Michael J. Carr, Ankita Tandon, Nalan Akgul Babacan, Younchul Kim, Mahrukh Naqvi, Jonathan Zager, Nikhil Khushalani
Summary: Most patients with SLN+ melanoma no longer undergo a completion lymph node dissection (CLND) prior to adjuvant systemic therapy. The omission of immediate CLND in these patients may increase the risk of nodal relapse, but salvage surgery with therapeutic lymph node dissection (TLND) at relapse may be a viable option for these patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Xiaofei Li, Jing Zhao, Said Movahedi Naini, Gianmarco Sabiu, Stefan G. Tullius, Su Ryon Shin, Jonathan S. Bromberg, Paolo Fiorina, George C. Tsokos, Reza Abdi, Vivek Kasinath
Summary: The study revealed that after unilateral ureteral obstruction in the kidney, fibroblastic reticular cells (FRCs) in the kidney-draining lymph node also become fibrogenic, contributing to fibrosis that closely mirrors changes in the kidney. Additionally, immune cell populations in the affected lymph node were significantly higher compared to the unaffected contralateral kidney-draining lymph node. This suggests a possible mechanism for fibrosis involving the TGF beta/TGF beta R signaling pathway, and future studies are needed to delve deeper into this connection between FRCs and lymph node fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Juliana Bernardi Aggio, Veronika Krmeska, Brian J. Ferguson, Pryscilla Fanini Wowk, Antonio Gigliotti Rothfuchs
Summary: Despite hindering skin DC migration, VACV can still access the draining lymph nodes to prime CD4(+) T cells. UV-inactivated or modified VACV can promote DC migration to the dLN, suggesting that replication-competent VACV is required to interfere with skin DC mobilization.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dante Alexander Patrick Louie, Darellynn Oo, Glory Leung, Yujia Lin, Matthew Stephens, Omar Alrashed, Marcus Tso, Shan Liao
Summary: Lymph node metastasis is closely related to tumor aggressiveness and poor prognosis. Research has shown that both anti-tumor and exhausted tumor-specific T cells can be induced in the tumor-draining lymph node (TDLN), but the activation and maturation of B cells in the TDLN have received less attention. In this study using mouse models, it was found that tumor growth promotes the entry of tumor-associated antigens into the B cell zone and facilitates access to follicular dendritic cells (FDCs) in the germinal centers (GCs), where antigen-specific B cell maturation occurs. Depletion of subcapsular sinus (SCS) macrophages in the TDLN increased GC formation and promoted tumor growth. These findings suggest that TDLN reconstruction creates a niche that favors B cell activation and maturation during tumor growth.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marieke F. Fransen, Thorbald van Hall, Ferry Ossendorp
Summary: Lymph nodes play a crucial role in immune responses, but the resection of tumor-draining lymph nodes needs to be reevaluated. Recent studies suggest that tumor-draining lymph nodes may play an important role in cancer immunotherapy, potentially changing the use of immune checkpoint therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Kelli A. Connolly, Manik Kuchroo, Aarthi Venkat, Achia Khatun, Jiawei Wang, Ivana William, Noah Hornick, Brittany L. Fitzgerald, Martina Damo, Moujtaba Y. Kasmani, Can Cui, Eric Fagerberg, Isabel Monroy, Amanda Hutchins, Julie F. Cheung, Gena G. Foster, Dylan L. Mariuzza, Mursal Nader, Hongyu Zhao, Weiguo Cui, Smita Krishnaswamy, Nikhil S. Joshi
Summary: Tumor-specific CD8(+) T cells in tumor-draining lymph nodes share similarities with T-SL from chronic infections, serving as developmental precursors for intratumoral TCF1(+) T cells, supporting a critical role in sustaining antitumor T cells during tumor development and protecting them from terminal differentiation in the tumor microenvironment.
SCIENCE IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
In-Cheol Sun, SeongHoon Jo, Diego Dumani, Wan Su Yun, Hong Yeol Yoon, Dong-Kwon Lim, Cheol-Hee Ahn, Stanislav Emelianov, Kwangmeyung Kim
Summary: Lymph node mapping is crucial in cancer immunotherapy, and new theragnostic glycol-chitosan-coated gold nanoparticles (GC-AuNPs) have been developed to highlight lymph nodes in ultrasound-guided photoacoustic imaging. These nanoparticles can also deliver tumor antigens to lymph node resident macrophages. In vitro studies have shown the strong performance of GC-AuNPs in imaging lymph nodes and their potential for cancer immunotherapy.
Review
Chemistry, Multidisciplinary
Qiu Wang, Zhe Wang, Xinxin Sun, Qikun Jiang, Bingjun Sun, Zhonggui He, Shenwu Zhang, Cong Luo, Jin Sun
Summary: Cancer immunotherapies using tumor vaccines and nanotechnology to target lymph nodes have shown promising results in enhancing antitumor immune response. The advancements in nanovaccines for lymph node targeting and the combination cancer immunotherapy show great potential in clinical translation and application.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Kavita Rawat, Anita Tewari, Xin Li, Arlind B. B. Mara, William T. T. King, Sophie L. L. Gibbings, Chinaza F. F. Nnam, Fred W. W. Kolling, Bart N. N. Lambrecht, Claudia V. V. Jakubzick
Summary: Dendritic cells and monocytes capture, transport, and present antigen to cognate T cells in the draining lymph nodes in a CCR7-dependent manner. It is unclear how monocytes reach the lymph nodes since only migratory dendritic cells express this chemokine receptor.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Engineering, Biomedical
Qiu-Ling Zhang, Sheng Hong, Xue Dong, Di-Wei Zheng, Jun-Long Liang, Xue-Feng Bai, Xia-Nan Wang, Zi-Yi Han, Xian-Zheng Zhang
Summary: This study presents a strategy for simplifying antigen presentation by extracellular degradation of antigen proteins into peptides, leading to improved utilization of cancer antigens and enhanced cancer immunity. The approach demonstrates potential for personalized anti-cancer therapy and has implications for expanding immunology fields and translational medicine.
Review
Oncology
Tomoya Katakai
Summary: The role of B cells in antitumor immunity is complex and dependent on the relationship between the tumor and B cells that recognize tumor antigens. Tumor cells, which originate from mutated autologous cells, are difficult for the immune system to eliminate. In tumor-draining lymph nodes, B cells may acquire immunoregulatory phenotypes, contributing to an immunosuppressive environment. However, B cell infiltration in tumors can be beneficial for antitumor immunity in mid- to late-stage tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jialu Xu, Qingle Ma, Yue Zhang, Ziying Fei, Yifei Sun, Qin Fan, Bo Liu, Jinyu Bai, Yue Yu, Jianhong Chu, Jingrun Chen, Chao Wang
Summary: This article discusses the research progress of microbe-based cancer immunotherapy, inducing anticancer immunity through the preparation of nanoparticles of different sizes. The study found that the size of the formulations inversely correlates with their accumulation ability in tumor-draining lymph nodes, showing potential therapeutic effects.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
V. S. Fear, C. A. Forbes, S. A. Neeve, S. A. Fisher, J. Chee, J. Waithman, S. K. Ma, R. A. Lake, A. K. Nowak, J. Creaney, M. D. Brown, C. Saunders, B. W. S. Robinson
Summary: Surgical resection of cancer, particularly complete lymph node removal, may shorten survival time for patients, while partial lymph node resection can partially restore it. Early administration of aPD-1/aCD40 therapy can counteract the detrimental effects of complete lymph node resection on survival.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Microbiology
Lina Daniel, Claudio Counoupas, Nayan D. Bhattacharyya, James A. Triccas, Warwick J. Britton, Carl G. G. Feng
Summary: Recruiting naive lymphocytes to lymph nodes is critical for an effective immune response. In this study, it was found that during pulmonary Mycobacterium tuberculosis infection, the homing of circulating lymphocytes to the draining mediastinal lymph node (mLN) was less efficient compared to non-draining lymph nodes. The recruitment of naive lymphocytes to mLN was partially dependent on L-selectin and lymphangiogenesis. Furthermore, mycobacterium-specific T cells entering the mLN through the L-selectin-independent route were readily activated. Overall, this study suggests that both L-selectin-dependent and -independent pathways contribute to naive lymphocyte entry into mLN during M. tuberculosis infection, with the latter pathway playing an important role in host defense in the lungs.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)