Article
Biochemistry & Molecular Biology
Wei-Jin Zhang, Shuwei Li, Yong-Zhu Yan, Sung Soo Park, Anandhu Mohan, Ildoo Chung, Suk-kyun Ahn, Jung Rae Kim, Chang-Sik Ha
Summary: In this study, a novel MXene-based nanocarrier was developed for drug delivery, which exhibited excellent drug-loading capacity and encapsulation efficiency. The MXene nanosheets also demonstrated outstanding dual-responsive properties and exhibited excellent antibacterial activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tamer M. Tamer, Hongyan Zhou, Mohamed A. Hassan, Marwa M. Abu-Serie, Sergey Shityakov, Smaher M. Elbayomi, Mohamed S. Mohy-Eldin, Yongcheng Zhang, Tuckyun Cheang
Summary: This study aimed to synthesize a functionalized chitosan, Cs-TMB, by coupling the amine groups of chitosan with 2,4,6-Trimethoxybenzaldehyde. Cs-TMB showed improved antioxidant and antibacterial activities compared to native chitosan. It also exhibited a safe profile against normal fibroblast cells and demonstrated prominent anticancer properties against human skin cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Liu Cui, Xi Wang, Zhaoyun Liu, Ziqi Li, Ziwei Bai, Kui Lin, Jian Yang, Yuanlu Cui, Fei Tian
Summary: Stimulus-responsive nanomaterials have shown promise in controllable drug delivery systems for cancer therapy. In this study, iron (III) carboxylate metal-organic framework nanoparticles coated with glycyr- rhetinic acid-chitosan conjugate were successfully fabricated as a pH-responsive and target-selective system for delivering doxorubicin to hepatocellular carcinoma cells. The nanocarriers exhibited uniform size, high drug loading efficiency, and pH-dependent controlled drug release. In vitro experiments demonstrated their excellent inhibitory effects on cancer cells and targeted delivery ability. The results suggest that these nanoparticles have potential applications in cancer therapy as a pH-responsive controlled drug delivery system.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zeming Zhu, Jianfeng Hu, Zicheng Zhong
Summary: Encapsulation technology improves stability and preservation of volatile active substances in plant essential oils. In this study, tree essential oil was encapsulated with modified polylactic acid chitosan to form antibacterial microcapsules that respond to pH changes. The microcapsules showed high encapsulation efficiency and drug loading efficiency, and released the essential oil at different pH levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Wei Xia, Xiao-Yi Wei, Yuan-Yuan Xie, Tao Zhou
Summary: A novel thioether chitosan oligosaccharide (COS-All-Tio) with enhanced antioxidant and antibacterial activities was synthesized, and it showed no toxicity to cells.
CARBOHYDRATE POLYMERS
(2022)
Article
Multidisciplinary Sciences
Sepideh Asadi, Tayyebeh Madrakian, Mazaher Ahmadi, Miguel Angel Aguirre, Abbas Afkhami, Seyed Sepehr Uroomiye, Fatemeh Ghaffari, Akram Ranjbar
Summary: This study developed an aerosol-assisted method for the synthesis of smart nanocarriers. The method allows for controlled release of the polymeric nanocarrier by responding to the environment. Characterization and cytotoxicity evaluation of the synthesized nanocarrier revealed its potential application in drug delivery.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Qingli Qu, Anquan Yang, Jing Wang, Min Xie, Xiaoli Zhang, Dan Huang, Ranhua Xiong, Dong Pei, Chaobo Huang
Summary: Chitosan-phytate (CS-PA) microparticles with various morphologies were prepared using gas-shearing microfluidics. The size of the microparticles was controlled by the gas flow rate, and their morphology was influenced by the concentration of CS and PA. These microparticles exhibited stability during storage, rehydration after lyophilization, pH-responsive behavior, antibacterial properties, and biocompatibility, making them promising carriers for active ingredient encapsulation in pharmaceutical, food, and cosmetic industries.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Food Science & Technology
Jiawei Lin, Hecheng Meng, Xiaobing Guo, Zhongsheng Tang, Shujuan Yu
Summary: The present work aimed to fabricate Schiff base compounds between chitosan and aldehydes and utilize them for broccoli preservation. The aldehyde-chitosan Schiff bases exhibited acidic sensitivity and released aldehydes upon hydrolysis in a pH range of 4-6. The release of aldehydes endowed the Schiff bases with enhanced antibacterial activity, and their application significantly extended the shelf life of broccoli.
Article
Biochemistry & Molecular Biology
Wangli Dai, Lin Zhou, Saiqi Gu, Wenjie Wang, Zheng Xu, Xuxia Zhou, Yuting Ding
Summary: Novel chitosan films incorporating epigallocatechin gallate (EGCG) were developed with improved physical and mechanical properties compared to traditional chitosan films. The addition of EGCG increased thickness, tensile strength, water solubility, and decreased elongation at break, moisture content, degree of swelling, and water contact angles. The films also exhibited enhanced UV-vis barrier capability and opacity, and had a rougher surface structure. EGCG improved the thermal stability of chitosan films by intermolecular hydrogen bonding. Furthermore, EGCG significantly enhanced the antioxidant and antibacterial activity of chitosan films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Ahmed M. Omer, Abdelazeem S. Eltaweil, Esmail M. El-Fakharany, Eman M. Abd El-Monaem, Magda M. F. Ismail, Mohamed S. Mohy-Eldin, Mohammed S. Ayoup
Summary: This study developed a novel bioactive chitosan Schiff base (CTS-SB) derivative by coupling chitosan (CTS) with 4-((5, 5-dimethyl-3-oxocyclohex-1-en-1-yl) amino) benzene-sulfonamide. The CTS-SB derivative exhibited enhanced antibacterial, anticancer, and antidiabetic activities compared to pure CTS. It showed improved ion exchange capacity, increased antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria, higher inhibitory values of alpha-amylase and alpha-glucosidase, and potential anticancer activity.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Applied
Ke Zhang, Qing Chen, Jie Xiao, Lijun You, Siming Zhu, Chao Li, Xiong Fu
Summary: In this study, a novel nano-polysaccharide based edible film (nSPP/CH) was developed by blending Sargassum pallidum polysaccharide nanoparticles (nSPP) with chitosan (CH). The compatibility, physicochemical, and fruit preservation properties of nSPP/CH were investigated. The results showed that nSPP/CH exhibited excellent mechanical properties, good compatibility between nSPP and CH, and a great cherry preservation ability.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Bingren Tian, Wanrong Li, Jie Wang, Yumei Liu
Summary: In this study, beta-acids/chitosan complex films were successfully prepared and characterized. The films showed improved mechanical strength, antimicrobial properties, and excellent UV barrier capability, making them a promising alternative for active packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Eunhye Yang, Ho-Sup Jung, Pahn-Shick Chang
Summary: In this study, a stimulus-responsive polymer complex called capsosomes containing trilaurin-based solid lipid nanoparticles (SLNs) known as CSLNs was prepared for the oral delivery of hydrophilic molecules. The capsosomes showed improved stability and prolonged retention time under small intestinal conditions and bypassed the gastrointestinal tract. These findings demonstrate the potential application of pH-sensitive capsosomes for the oral delivery of food nutraceuticals.
FOOD HYDROCOLLOIDS
(2022)
Article
Polymer Science
Sreelekha Ediyilyam, Mahesh M. Lalitha, Bini George, Sarojini Sharath Shankar, Stanislaw Waclawek, Miroslav Cernik, Vinod Vellora Thekkae Padil
Summary: This study investigates the combined effect of glycerol, tween 80, and silver nanoparticles on the physicochemical properties of lyophilized chitosan scaffolds. The incorporation of biogenic nanoparticles enhances the biochemical properties of the polymer composites, increasing their demand in the medical and biological sectors.
Article
Chemistry, Multidisciplinary
Evelyn Osehontue Uroro, Richard Bright, Jing Yang Quek, Krasimir Vasilev
Summary: A novel approach for drug administration using stimulus-responsive carriers is introduced in this study to minimize drug dosage and frequency, thereby reducing cytotoxicity levels. Nanocomposites loaded with rifampicin (RFP) were prepared using lipases-sensitive polycaprolactone (PCL) and showed responsive behavior and improved biocompatibility compared to the free drug.
Article
Chemistry, Multidisciplinary
Jiayun Xu, Hao Zhou, Yong Zheng, Chenyu Li, Lin Dai, Chunlin Xu, Chuanling Si
Summary: A simple and rapid approach for the fabrication of lignin nanoparticles (LNPs) was provided by switching pH environments, allowing for repeated generation and dissolution of LNPs. This method not only reduces solvent consumption for LNPs production but also improves LNPs concentration in solution compared to conventional methods.
Article
Agricultural Engineering
Weihua Zhang, Luyao Wang, Ermei Makila, Stefan Willfor, Chunlin Xu
Summary: In this study, a novel ultralight aerogel-based adsorbent with a highly porous structure and good mechanical integrity was developed. It showed excellent water stability, fast shape recovery, and ultra-fast water transport. Additionally, the adsorbent exhibited excellent selective adsorption and separation performance. This research provides a new strategy for the development of low-cost and highly efficient adsorbents for wastewater treatment.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Agricultural Engineering
Yongchao Zhang, Shuzhen Ni, Ruijie Wu, Yingjuan Fu, Menghua Qin, Stefan Willfor, Chunlin Xu
Summary: This review highlights the importance of lignocellulosic biomass fractionation and discusses the latest technologies, including autohydrolysis, organosolv fractionation, ionic liquid, and deep eutectic solvent treatment. The challenges and future development directions in this field are also addressed.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Forestry
Veikko Mottonen, Samuli Helama, Andrey Pranovich, Ekaterina Korotkova, Chunlin Xu, Hannu Herva, Henrik Herajarvi, Harri Makinen, Pekka Nojd, Tuula Jyske
Summary: This study investigated the properties of stem wood and knot wood from two subfossil Scots pine trunks. The younger trunk had lower moisture content, density, and strength properties compared to the older trunk. The chemical composition of both stem wood samples was similar to recently grown wood, except for a slight decrease in cellulose and hemicellulose in the subfossil samples. The SWOT analysis highlighted the potential for commercial niche uses of subfossil wood due to its branding value as an ancient material.
Editorial Material
Biotechnology & Applied Microbiology
Caoxing Huang, Chunlin Xu, Xianzhi Meng, Lei Wang, Xin Zhou
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Weihua Zhang, Chunlin Xu, Xinpeng Che, Ting Wang, Stefan Willfoer, Mingjie Li, Chaoxu Li
Summary: Continuous filtering adsorption using nanowood membranes shows great potential in uranium resource exploration and wastewater treatment, providing a sustainable and efficient route for extracting aqueous uranium.
Article
Chemistry, Applied
Liqiu Hu, Wenyang Xu, Jan Gustafsson, Rajesh Koppolu, Qingbo Wang, Emil Rosqvist, Anna Sundberg, Jouko Peltonen, Stefan Willfor, Martti Toivakka, Chunlin Xu
Summary: This study establishes a method of water-redispersible nanocellulose production by adding water-soluble polysaccharides, which saves energy consumption. The addition of carboxymethylated-galactoglucomannan improves fiber fibrillation and enhances the water redispersibility and film properties of nanocellulose.
CARBOHYDRATE POLYMERS
(2022)
Article
Green & Sustainable Science & Technology
Jelena Ivic, Andreas Petritz, Cristian Vlad Irimia, Bilge Kahraman, Yasin Kanbur, Mateusz Bednorz, Cigdem Yumusak, Muhammad Awais Aslam, Aleksandar Matkovic, Klara Saller, Clemens Schwarzinger, Wolfgang Schuehly, Annika Smeds, Yolanda Salinas, Manuela Schiek, Felix Mayr, Chunlin Xu, Christian Teichert, Mariana Osiac, Niyazi Serdar Sariciftci, Barbara Stadlober, Mihai Irimia-Vladu
Summary: Natural dielectrics are becoming more popular for their biocompatibility and biodegradability in electronics and sensors. Silver fir and Rocky mountain fir demonstrate robust dielectric properties without traps, and the inclusion of inorganic nanofillers opens up possibilities for high dielectric constant insulating layers in low voltage OFETs.
ADVANCED SUSTAINABLE SYSTEMS
(2022)
Article
Chemistry, Multidisciplinary
Luyao Wang, Qingbo Wang, Emil Rosqvist, Jan-Henrik Smatt, Qiwen Yong, Lippo Lassila, Jouko Peltonen, Thomas Rosenau, Martti Toivakka, Stefan Willfoer, Patrik Eklund, Chunlin Xu, Xiaoju Wang
Summary: Fabricating bio-latex colloids with core-shell nanostructure is an effective method for obtaining films with enhanced mechanical characteristics. Nano-sized lignin is rising as a class of sustainable nanomaterials that can be incorporated into latex colloids. The correlation between surface chemistry of lignin nanoparticles (LNPs) and integration efficiency in latex colloids and from it thermally processed latex films is explored.
Article
Engineering, Biomedical
Qingbo Wang, Ozge Karadas, Oskar Backman, Luyao Wang, Tuomas Nareoja, Jessica M. Rosenholm, Chunlin Xu, Xiaoju Wang
Summary: In this study, a ternary-component aqueous emulsion was used to fabricate microgel assembly for 3D bioprinting. The emulsion consisted of methacrylated gelatin (GelMA) microgels, methacrylated galactoglucomannan (GGMMA), and dextran (Dex). The GGMMA and Dex provided stability to the emulsion, while GGMMA also facilitated the adhesion of GelMA microgels to form a porous hydrogel construct that supported cell growth and colonization.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yidong Zhang, Wangfang Deng, Chao Liu, Fei Yan, Meiyan Wu, Qiu Cui, Stefan Willfoer, Chunlin Xu, Bin Li
Summary: A sustainable and cost-effective method for the preparation of dialdehyde nanocellulose (DANC) was developed through LiBr·3H2O (LBTH) non-dissolving pretreatment, which shortened the oxidation time and reduced the oxidant consumption. LBTH transformed the cellulose Iβ structure into an amorphous structure, reducing crystallinity and increasing aldehyde group content of DANC. The fabricated DANC exhibited strong antibacterial activity. LBTH could be recovered and reused, maintaining its effectiveness. This study provides a sustainable and clean approach for the preparation of DANC and promotes the application of cellulose nanomaterials.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Yidong Zhang, Wangfang Deng, Meiyan Wu, Mehdi Rahmaninia, Chunlin Xu, Bin Li
Summary: Nanocellulose (NC), including cellulose nanofibril (CNF) and cellulose nanocrystal (CNC), has gained attention for its unique physical and chemical properties. This review summarizes various chemical modifications, such as silanization, esterification, oxidation, and grafting, applied to NC in order to introduce new functionalities. The incorporation of NC in functional materials and the challenges in the preparation process are also discussed. Overall, NC is considered a promising green nanomaterial for large-scale applications in the future.
Article
Biochemistry & Molecular Biology
Yury Brusentsev, Peiru Yang, Alistair W. T. King, Fang Cheng, Maria F. Cortes Ruiz, John E. Eriksson, Ilkka Kilpela''inen, Stefan Willfo''r, Chunlin Xu, Lars Wagberg, Xiaoju Wang
Summary: In the field of 3D cell culture and tissue engineering, 3D printing is a useful tool for creating customized in vitro models to study cell-matrix and cell-cell interactions. Cellulose nanofibril (CNF) hydrogels have emerged as a promising material for tissue-like scaffolds. This study presents a multi-step approach to modify CNF with a photocross-linkable building block, which allows for the formulation of printable bioinks. The resulting hydrogel shows good printability and cytocompatibility with different cell lines.
Article
Biochemistry & Molecular Biology
Shujun Liang, Wenyang Xu, Liqiu Hu, Ville Yrjana, Qingbo Wang, Emil Rosqvist, Luyao Wang, Jouko Peltonen, Jessica M. M. Rosenholm, Chunlin Xu, Rose-Marie Latonen, Xiaoju Wang
Summary: One-dimensional nanomaterials of conductive polypyrrole (PPy) synthesized using lignocellulose nanofibrils (LCNF) as a template show high electrical conductivity and low cytotoxicity, making them promising for constructing bioelectronics. The PPy@LCNFs can be easily processed into thin coatings, flexible membranes, and three-dimensional cryogels. The dynamic control of doping/undoping process through an electric field enables both electronic and ionic conductivity. This study demonstrates the potential of PPy@LCNFs as a smart platform nanomaterial for interfacing bioelectronics.
Article
Chemistry, Applied
Maria F. Cortes Ruiz, Yury Brusentsev, Stefan B. Lindstrom, Chunlin Xu, Lars Wagberg
Summary: The development of strong cellulose nanofibril (CNF) networks is crucial for advanced applications, especially in the biomedical field, due to their biocompatible nature and plant-based origin. However, the lack of mechanical strength and complex synthesis methods restrict their application in areas that require both toughness and manufacturing simplicity. This study presents a simple method for synthesizing a low solid content (<2 wt%) covalently crosslinked CNF hydrogel using Poly (N-isopropylacrylamide) (NIPAM) chains as crosslinks. The resulting networks can fully recover their shape after various drying and rewetting cycles. X-ray scattering, rheological investigations, and compression testing were conducted to characterize the hydrogel and its components. The influence of covalent crosslinks was compared to networks crosslinked by the addition of CaCl2. Furthermore, a mathematical model was developed to describe and predict the large-deformation, elastoplastic behavior, and fracture of these networks to a considerable extent.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)