期刊
CANCER CELL
卷 38, 期 1, 页码 44-+出版社
CELL PRESS
DOI: 10.1016/j.ccell.2020.06.004
关键词
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资金
- Anniversary Fund of the Oesterreichische Nationalbank, Vienna, Austria [16152]
- Medical Scientific Fund of the Mayor of the City of Vienna, Austria [14015]
- Austrian Science Fund, Vienna, Austria [P30105, J-4311]
- German Research Foundation, Bonn, Germany [LI-3486]
- Andruzzi Foundation, North Attleborough, United States
- Ryan Richards Foundation, United States
- Solving Kids' Cancer, New York, United States/The Bibi Fund
- Verein unser Kind'', Vienna, Austria
- Innovative Medicines Initiative 2 Joint Undertaking, Brussels, European Union [116064]
- European Union's Horizon 2020 research and innovation program
- EFPIA, Brussels
- European Union
- American Cancer Society, Atlanta, United States [PF-17-042-01-LIB]
- NIH education loan repayment program, Bethesda, United States (NCI) [L30 CA231679-01]
- Burroughs Wellcome Fund, Research Triangle, United States
- Sontag Foundation, Ponte Vedra Beach, United States
- Alex's Lemonade Stand Foundation, Bala Cynwyd, United States
Ependymoma is a heterogeneous entity of central nervous system tumors with well-established molecular groups. Here, we apply single-cell RNA sequencing to analyze ependymomas across molecular groups and anatomic locations to investigate their intratumoral heterogeneity and developmental origins. Ependymomas are composed of a cellular hierarchy initiating from undifferentiated populations, which undergo impaired differentiation toward three lineages of neuronal-glial fate specification. While prognostically favorable groups of ependymoma predominantly harbor differentiated cells, aggressive groups are enriched for undifferentiated cell populations. The delineated transcriptomic signatures correlate with patient survival and define molecular dependencies for targeted treatment approaches. Taken together, our analyses reveal a developmental hierarchy underlying ependymomas relevant to biological and clinical behavior.
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