Review
Immunology
Huili Liu, Jun Wang, Yan Zhang, Jing Gu, Yu Wang, Yongxing Yan, Dongli Pan, Zeyu Sun
Summary: The study found that proteins (CXCL10, ELANE, IL-1RN, MPO, PRTN3, etc.) related to inflammation and immune cell activation were significantly upregulated in the cerebrospinal fluid (CSF) of patients with varicella zoster virus (VZV) meningitis compared to patients with herpes zoster (HZ) (p < .01). Proteins related to nerve function and energy metabolism (CKMT1B, SLITRK3, Synaptotagmin-3, KIF5B, etc.) were significantly downregulated (p < .05). The levels of a pro-inflammatory factor, IL-18, in CSF were significantly higher in patients with unfavorable outcome compared to patients with favorable outcome (p < .05).
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Microbiology
Xin Hong, Youqi Ji, Mengyuan Chen, Fang Su, Yongze Zhu, Yumei Ge
Summary: We report a rare case of acute varicella zoster viral encephalitis in an immunocompetent adult patient without cutaneous herpes, diagnosed through metagenomic next-generation sequencing of cerebrospinal fluid.
FUTURE MICROBIOLOGY
(2023)
Article
Behavioral Sciences
Tiphaine Lenfant, Anne-Sophie L'Honneur, Brigitte Ranque, Benoit Pilmis, Caroline Charlier, Mathieu Zuber, Jacques Pouchot, Flore Rozenberg, Adrien Michon
Summary: Neurological complications of VZV infection can vary in prognosis, with aseptic meningitis having a better outcome compared to CNS and PNS involvement. This retrospective study found that a higher prior disability score and the presence of CNS or PNS manifestations were significantly associated with a higher risk of unfavorable outcome (including mortality and incomplete recovery).
BRAIN AND BEHAVIOR
(2022)
Review
Immunology
Zheng-Bing Xiang, Er-Ling Leng, Wen-Feng Cao, Shi-Min Liu, Yong-Liang Zhou, Chao-Qun Luo, Fan Hu, An Wen
Summary: mNGS has good specificity and moderate sensitivity in diagnosing TBM. A more sensitive test should be developed to assist in the diagnosis of TBM.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Madjid Morsli, Christine Zandotti, Aurelie Morand, Philippe Colson, Michel Drancourt
Summary: In this case report, metagenomic next-generation sequencing successfully identified Echovirus 12 as an etiological agent of acute meningitis in pediatric population, highlighting the potential of this method in improving the accuracy of viral diagnosis.
Article
Public, Environmental & Occupational Health
Yunqi Zhu, Miaomiao Xu, Chengyuan Ding, Zhihang Peng, Weixiao Wang, Binghu Sun, Jian Cheng, Chen Chen, Wei Chen, Hongxia Wei, Zhiliang Hu
Summary: This study suggests that CSF mNGS may have higher sensitivity for VZV detection than CSF VZV PCR and antibody tests, and has the advantage of identifying unexpected pathogens.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Yirui Xie, Bing Ruan, Guanjing Lang, Biao Zhu
Summary: This report described a case of a HIV-infected patient with meningitis of multipathogenic infections. Streptococcus suis was detected using next-generation sequencing (NGS) in cerebrospinal fluid (CSF). Early stage NGS is recommended for immunocompromised patients with meningitis and negative CSF culture results.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Yukang Dong, Yingying He, Xia Zhou, Xia Lv, Jia Huang, Yaqi Li, Xin Qian, Fangfang Hu, Jiaying Zhu
Summary: This case report highlights the use of metagenomic next-generation sequencing (mNGS) in diagnosing Mycoplasma hominis meningitis, which is a rare postoperative complication of neurosurgery. mNGS showed high sensitivity and specificity in identifying the pathogen, enabling targeted clinical treatment. Combination with polymerase chain reaction (PCR) is recommended for early identification of pathogens and targeted medication.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Xiaobo Zhang, Chao Jiang, Chaojun Zhou
Summary: MNGS technology plays a crucial role in the diagnosis of E. faecalis meningitis, assisting in confirming the diagnosis and treatment plan even when CSF culture is negative.
BMC INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Aiqing Lin, Baotao Cheng, Xiaochun Han, Hong Zhang, Xiaoli Liu, Xueping Liu
Summary: The study aimed to evaluate the application of next-generation sequencing (NGS) technology in the early diagnosis of TBM patients. The results showed that NGS technology combined with MTB culture could increase the detection rate of TBM.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Yong Liu, Xichao Mo, Ye Feng, Rodney E. Willoughby, Xing Weng, Yuyang Wang, Xing Li, Junling Gao, Jinfei Tian, Jie Peng
Summary: Rabies is a lethal disease for which an accurate diagnostic assay is highly desirable. This study found that metagenomic next-generation sequencing can successfully identify the rabies virus, making it a useful screening tool for diagnosing rabies, especially in cases without timely laboratory testing or exposure history.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Ye-Won Lee, Byunghoon Yoo, Yun Hee Lim
Summary: Headache is a common complication of regional anesthesia, and it can be caused by meningitis. Clinicians should consider multiple causes when diagnosing post spinal anesthesia headache.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Microbiology
P. Pancholi, R. F. Relich, S. Chandrasekaran, J. J. Dunn, P. A. Granato, A. T. Harrington, G. T. Hansen, N. A. Ledeboer, Q. Li, M. D. Sims, T. S. Uphoff, W. Greene, S. Young, N. Dhiman
Summary: This study evaluated the performance of two different molecular assays for detecting Varicella-zoster virus (VZV) and found that the Simplexa assays showed near perfect agreement with the composite reference methods. Comparison with standard molecular assays used at the site of specimen collection also showed excellent agreement. The Simplexa assays offer rapid and reliable alternatives for VZV detection in certain clinical specimens.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Oncology
Daiquan Gao, Yongqiang Hu, Xuebin Jiang, Hao Pu, Zhendong Guo, Yunzhou Zhang
Summary: ptNGS showed higher positivity rate and sensitivity in pathogen detection in cerebrospinal fluid compared to mNGS. It also had higher positive predictive value and negative predictive value for diagnosing infectious diseases. Additionally, ptNGS required less time and lower costs for pathogen diagnosis than mNGS.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Zhouqing Gan, Jia Liu, Yijie Wang, Lu Yang, Zheng Lou, Han Xia, Min Li, Zhuolin Chen, Ying Jiang, Fuhua Peng
Summary: This study demonstrates that cerebrospinal fluid (CSF) metagenomic next-generation sequencing (mNGS) can be considered as a supplementary test for the diagnosis of cryptococcal meningitis (CM) and for directly distinguishing Cryptococcus gattii from Cryptococcus neoformans in clinical specimens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Neurosciences
Lingling Zhang, Kangping Song, Mengting Zhu, Jinling Shi, Huijuan Zhang, Liang Xu, Yingzhu Chen
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2016)
Article
Clinical Neurology
Jianping Jia, Cuibai Wei, Junhua Liang, Aihong Zhou, Xiumei Zuo, Haiqing Song, Liyong Wu, Xiaochun Chen, Shengdi Chen, Junjian Zhang, Jiang Wu, Kai Wang, Lan Chu, Dantao Peng, Peiyuan Lv, Hongzhi Guo, Xiaoyuan Niu, Yingzhu Chen, Wanli Dong, Xiujie Han, Boyan Fang, Mao Peng, Dan Li, Qian Jia, Liyuan Huang
ALZHEIMERS & DEMENTIA
(2016)
Article
Virology
Shuai Lu, Yanqun Wang, Yingzhu Chen, Bingjie Wu, Kun Qin, Jincun Zhao, Yongliang Lou, Wenjie Tan
Correction
Immunology
Yingzhu Chen, Shuai Lu, Hao Jia, Yao Deng, Jianfang Zhou, Baoying Huang, Yueyang Yu, Jiaming Lan, Wenling Wang, Yongliang Lou, Kun Qin, Wenjie Tan
EMERGING MICROBES & INFECTIONS
(2017)
Article
Immunology
Yingzhu Chen, Shuai Lu, Hao Jia, Yao Deng, Jianfang Zhou, Baoying Huang, Yueyang Yu, Jiaming Lan, Wenling Wang, Yongliang Lou, Kun Qin, Wenjie Tan
EMERGING MICROBES & INFECTIONS
(2017)
Article
Neurosciences
Yingzhu Chen, Lingling Zhang, Hailong Yu, Kangping Song, Jinling Shi, Linlin Chen, Jian Cheng
Article
Immunology
Yao Deng, Jiaming Lan, Linlin Bao, Baoying Huang, Fei Ye, Yingzhu Chen, Yanfeng Yao, Wenling Wang, Chuan Qin, Wenjie Tan
EMERGING MICROBES & INFECTIONS
(2018)
Article
Neurosciences
Yingzhu Chen, Liangzhu Wang, Lingling Zhang, Beilei Chen, Liu Yang, Xiaobo Li, Yuping Li, Hailong Yu
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Beilei Chen, Liu Yang, Jian Chen, Yingzhu Chen, Lingling Zhang, Liangzhu Wang, Xiaobo Li, Yuping Li, Hailong Yu
BRAIN RESEARCH BULLETIN
(2019)
Article
Neurosciences
Zhiyong Yang, Sisi Dong, Qiuyue Zheng, Lingling Zhang, Xinmei Tan, Jun Zou, Bingchun Yan, Yingzhu Chen
Article
Cell Biology
Kangping Song, Xiaojie Liu, Qiuyue Zheng, Lingling Zhang, Hongying Zhang, Hailong Yu, Yan Zhu, Li-An Huang, Yingzhu Chen
Review
Cell Biology
Haili Wang, Xiaojia Tang, Hongyang Fan, Yuhan Luo, Yuxia Song, Yao Xu, Yingzhu Chen
Review
Clinical Neurology
Haili Wang, Juan Lu, Xia Zhao, Rongyin Qin, Kangping Song, Yao Xu, Jun Zhang, Yingzhu Chen
Summary: Elderly COVID-19 patients are at higher risk of developing neurodegenerative conditions like AD due to systemic inflammation and neurological symptoms. Preventive measures such as anti-inflammatory therapies, antioxidants, nutritional intervention, physical activity, blood glucose control, and vaccination are proposed to reduce the risk of AD in COVID-19 patients, as multiple risk factors may intersect during severe SARS-CoV-2 infection.
NEUROLOGICAL SCIENCES
(2021)
Correction
Clinical Neurology
Haili Wang, Juan Lu, Xia Zhao, Rongyin Qin, Kangping Song, Yao Xu, Jun Zhang, Yingzhu Chen
NEUROLOGICAL SCIENCES
(2021)