Article
Gastroenterology & Hepatology
Lyvianne Decourtye-Espiard, Parry Guilford
Summary: Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer (LBC). It is caused by germline mutations in the CDH1 and CTNNA1 genes. This article discusses the genetics, clinical phenotype, pathology, tumor initiation mechanism, natural history, and clinical management of HDGC.
Editorial Material
Oncology
Huocong Huang, Rolf A. Brekken
Summary: Spatial single-cell transcriptomics of primary diffuse type gastric cancer revealed distinct cancer and stromal cell differences based on location. The expression of CCL2 by stromal cells in deep tumor regions may drive the immunosuppressive microenvironment and enhance the invasive capacity of tumor cells.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alexander M. M. Minikes, Yu Song, Yan Feng, Changhwan Yoon, Sam S. S. Yoon, Xuejun Jiang
Summary: Gastric cancer, particularly the aggressive subtype diffuse-type gastric cancer (DGC), is difficult to detect and treat. In this study, it was found that DGC cells with loss-of-function mutation of E-cadherin are more sensitive to ferroptosis, a non-apoptotic, iron-dependent form of cell death. E-cadherin suppresses ferroptosis through activation of the Hippo pathway. Mutations in E-cadherin that reduce its homophilic binding capacity reverse its ability to suppress ferroptosis. Additionally, circulating DGC cells lacking E-cadherin have lower metastatic ability due to their susceptibility to ferroptosis. This study suggests E-cadherin as a biomarker for predicting ferroptosis sensitivity in DGC cells and guiding future therapeutic usage.
Article
Multidisciplinary Sciences
Wenhao Shi, Yushen Wang, Chen Xu, Yan Li, Sai Ge, Bin Bai, Kecheng Zhang, Yunzhi Wang, Nairen Zheng, Juan Wang, Shiqi Wang, Gang Ji, Jipeng Li, Yongzhan Nie, Wenquan Liang, Xiaosong Wu, Jianxin Cui, Yi Wang, Lin Chen, Qingchuan Zhao, Lin Shen, Fuchu He, Jun Qin, Chen Ding
Summary: This research utilizes multilevel proteomic analyses to investigate the molecular differences between diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC) in Chinese patients. The analyses reveal an ARIDIA mutation with opposite prognostic effects, identify three subtypes for DGC and IGC based on distinct protein expression patterns, and demonstrate that disease progressions are regulated by specific transcription factor complexes. Furthermore, immune cell infiltration is shown to be an indicator for immunotherapeutic effectiveness. These results contribute to a better understanding of gastric cancer and have implications for precision medicine.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Ken Namikawa, Norio Tanaka, Yuki Ota, Manabu Takamatsu, Mayuko Kosugi, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Sayuri Amino, Rie Furuya, Osamu Gotoh, Tomoko Kaneyasu, Izuma Nakayama, Yu Imamura, Tetsuo Noda, Junko Fujisaki, Seiichi Mori
Summary: This study compared the genomic differences between HP-exposed and HP-naive diffuse-type gastric cancer (DGC) and found that they develop along different molecular pathways. This finding provides a basis for early detection strategies in high incidence settings.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Paul Girot, Nicolas Chapelle, Laetitia Aymeric, Anne Bessard, Alice Prigent, Yann Touchefeu, Christine Varon, Michel Neunlist, Emilie Duchalais, Tamara Matysiak-Budnik
Summary: Gastric cancer is a leading cause of cancer-related deaths globally. This study investigated the adhesion of gastric cancer cells to enteric neurons, and found that enteric neurons are a privileged site for gastric cancer cell adhesion, especially in diffuse-type gastric cancer. The adhesion was partially mediated by N-Cadherin, and blocking N-Cadherin significantly decreased the adhesion ability. These findings suggest a potential role of enteric neurons in the dissemination of gastric cancer cells.
Review
Oncology
Akira Ooki, Kensei Yamaguchi
Summary: Gastric cancer is a common malignancy with distinct subtypes. Diffuse-type gastric cancer (DGC) is aggressive and has limited response to systemic chemotherapy. CLDN18.2 and FGFR2-IIIb have been identified as potential therapeutic targets for DGC, and recent clinical trials have shown promising results with anti-CLDN18.2 and FGFR2-IIIb antibodies.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Oncology
Koichi Takiguchi, Katsutoshi Shoda, Takashi Nakayama, Kazunori Takahashi, Ryo Saito, Atsushi Yamamoto, Shinji Furuya, Hidenori Akaike, Naohiro Hosomura, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Shingo Inoue, Hiroshi Kono, Hirotaka Konishi, Eigo Otsuji, Daisuke Ichikawa
Summary: This study focused on cancer-associated fibroblasts (CAFs) in gastric cancer and examined their potential as a blood biomarker. The results showed that plasma soluble PDPN may serve as a marker for diffuse gastric cancer and reflect the prognosis of the disease.
Article
Multidisciplinary Sciences
Long Qin, Long Wang, Junchang Zhang, Huinian Zhou, Zhiliang Yang, Yan Wang, Weiwen Cai, Fei Wen, Xiangyan Jiang, Tiansheng Zhang, Huili Ye, Bo Long, Junjie Qin, Wengui Shi, Xiaoying Guan, Zeyuan Yu, Jing Yang, Qi Wang, Zuoyi Jiao
Summary: This study identifies urokinase-type plasminogen activator receptor (uPAR) as a potential therapeutic target for diffuse-type gastric cancer (DGC), a subtype of gastric cancer with low HER2 positivity rate and insensitivity to chemotherapy and immune checkpoint inhibitors. The combination of anti-uPAR and anti-Programmed cell death protein 1 (PD-1) is shown to effectively inhibit tumor growth and prolong survival through multiple mechanisms. Furthermore, uPAR chimeric antigen receptor-expressing T cells demonstrate the ability to kill DGC cells and improve survival in preclinical models, especially when combined with PD-1 blockade therapy.
Article
Oncology
Haojie Li, Xuhong Fu, Junjie Zhao, Chen Li, Lingmeng Li, Peiyan Xia, Jianping Guo, Wenyi Wei, Rong Zeng, Jiarui Wu, Yihong Sun, Liyu Huang, Xuefei Wang
Summary: In this study, the researchers found that compared to intestinal-type gastric cancer, diffuse-type gastric cancer (DGC) has a higher recurrence rate, metastasis rate, and poorer clinical outcomes. They identified that exocyst complex component 4 (EXOC4) is significantly upregulated in DGC with recurrence. High expression of EXOC4 is associated with tumor metastasis and poor prognosis in DGC patients. Moreover, EXOC4 promotes cell migration and invasion, as well as tumor metastasis in DGC cells. The researchers also discovered that EXOC4 regulates the phosphorylation of focal adhesion kinase (FAK) and affects the migration and tumor metastasis of DGC cells.
MOLECULAR CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Masayuki Komatsu, Hitoshi Ichikawa, Fumiko Chiwaki, Hiromi Sakamoto, Rie Komatsuzaki, Makoto Asaumi, Kazuhisa Tsunoyama, Takeo Fukagawa, Hiromichi Matsushita, Narikazu Boku, Keisuke Matsusaki, Fumitaka Takeshita, Teruhiko Yoshida, Hiroki Sasaki
Summary: Frequent gene fusions of ARHGAP6/ARHGAP26 are found in peritoneally-metastasized gastric and pancreatic cancer, leading to downregulation of RhoA-ROCK-MLC2 signaling and cell death. The findings suggest the tumor-suppressive nature of ARHGAP-RhoA signaling and may provide a new avenue for drug discovery against this refractory cancer.
Article
Medicine, General & Internal
Chao-Tao Tang, Si-Hai Chen
Summary: The study comprehensively analyzed early-onset early-stage gastric cancer, identifying intestinal type as a risk factor for lymph node metastasis and survival compared to the diffuse type. The oncogenic expression promoting the occurrence of LNM was different between intestinal and diffuse types, suggesting clinicians should focus more attention on intestinal-type EEGC.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Kazuhiro Togasaki, Shinya Sugimoto, Yuki Ohta, Kosaku Nanki, Mami Matano, Sirirat Takahashi, Masayuki Fujii, Takanori Kanai, Toshiro Sato
Summary: In diffuse gastric cancer, signet-ring cell carcinoma (SRCC) and poorly cohesive carcinoma not otherwise specified (PCC-NOS) were found to be clonally identical, with their morphology regulated by external Wnt and R-spondin expression. The study results decoded how genetic mutations and the tumor microenvironment shape pathohistologic and biologic phenotypes in human diffuse gastric cancers.
Article
Oncology
Shingo Miyamoto, Yoshiko Nagano, Makoto Miyazaki, Yuko Nagamura, Kazuki Sasaki, Takeshi Kawamura, Kazuyoshi Yanagihara, Toshio Imai, Rieko Ohki, Masakazu Yashiro, Masato Tanaka, Ryuichi Sakai, Hideki Yamaguchi
Summary: The study revealed that integrin alpha 5 plays a crucial role in mediating the heterotypic cancer cell-fibroblast interaction during peritoneal dissemination of DGC, suggesting it may be a potential therapeutic target.
Review
Health Care Sciences & Services
Christo Kole, Nikolaos Charalampakis, Stratigoula Sakellariou, George Papaxoinis, Konstantinos G. Apostolou, Nikolaos Machairas, Ioannis S. Papanikolaou, Dimitrios Schizas
Summary: Gastric cancer is a common malignancy, with the majority being sporadic and only a small percentage being hereditary. Hereditary diffuse gastric cancer (HDGC) is a rare early-onset disease primarily caused by genetic alterations in the E-cadherin gene and beta-catenin gene. This study provides an overview of the molecular basis of HDGC, outlines essential elements of genetic counseling and surveillance, and offers a practical summary of current guidelines for the clinical management and treatment of high-risk individuals and patients with early-stage disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Thiago Pereira Diniz, Wilson L. da Costa Jr, Camila Couto Gomes, Victor Hugo F. de Jesus, Tiago C. Felismino, Silvio Melo Torres, Heber S. C. Ribeiro, Alessandro L. Diniz, Andre Luis de Godoy, Igor Correia de Farias, Emmanuel Dias-Neto, Maria Paula Curado, Felipe J. F. Coimbra
Summary: Early diagnosis of disease recurrence among asymptomatic patients did not affect the overall survival of gastric cancer patients treated with curative intent. Additional evidence is needed to support the use of intensive surveillance strategies in this context.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Enbo Ma, Taichi Shimazu, Minkyo Song, Hadrien Charvat, Norie Sawada, Taiki Yamaji, Manami Inoue, M. Constanza Camargo, Troy J. Kemp, Ruth M. Pfeiffer, Ligia A. Pinto, Charles S. Rabkin, Shoichiro Tsugane
Summary: This study found no significant associations between 62 inflammatory markers and pancreatic cancer risk, but further investigation is warranted for the suggestive association with circulating levels of leukocyte recruiting cytokine CCL8/MCP2.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Genetics & Heredity
Gabriela E. de Albuquerque, Bruno S. Moda, Marianna S. Serpa, Gabriela P. Branco, Alexandre Defelicibus, Isabella K. T. M. Takenaka, Maria G. de Amorim, Elizabeth C. Miola, Valquiria C. A. Martins, Katia L. Torres, Stephania M. Bezerra, Laura C. L. Claro, Adriane G. Pelosof, Claudia Z. Sztokfisz, Lais L. S. Abrantes, Felipe J. F. Coimbra, Luiz P. Kowalski, Fabio A. Alves, Stenio C. Zequi, Klas I. Udekwu, Israel T. Silva, Diana N. Nunes, Thais F. Bartelli, Emmanuel Dias-Neto
Summary: This study presents a targeted qPCR approach to determine the absolute and relative abundance of bacteria and fungi in different human tissue types. The results show that fungi are more abundant in stool and skin samples, while bacteria are more prevalent in stool, skin, oral swabs, saliva, and gastric fluids.
Article
Oncology
Minkyo Song, M. Constanza Camargo, Hormuzd A. Katki, Stephanie J. Weinstein, Satu Mannisto, Demetrius Albanes, Helja-Marja Surcel, Charles S. Rabkin
Summary: The cohort study showed that autoantibody positivity may indicate subclinical autoimmune gastritis in younger women, particularly in H pylori-seronegative individuals. The findings among young females and corpus subsite align with increasing cancer incidence trends for these groups, suggesting autoimmune gastritis may be replacing H pylori as the driving factor.
Article
Oncology
Vinicius Ferreira da Paixao, Omar Julio Sosa, Diogo Vieira da Silva Pellegrina, Bianca Dazzani, Thalita Bueno Correa, Ester Riserio Bertoldi, Luis Bruno da Cruz e Alves-de-Moraes, Diogo de Oliveira Pessoa, Victoria de Paiva Oliveira, Ricardo Alberto Chiong Zevallos, Lilian Cristina Russo, Fabio Luis Forti, Joao Eduardo Ferreira, Helano Carioca Freitas, Jose Jukemura, Marcel Cerqueira Cesar Machado, Maria Dirlei Begnami, Joao Carlos Setubal, Daniela Sanchez Basseres, Eduardo Moraes Reis
Summary: Transcriptome analysis of PDAC identified numerous lncRNAs, with some showing significant associations with patient outcomes. Knockdown of certain lncRNAs led to reduced cell proliferation, migration, and invasion. Gene co-expression network analysis revealed associations between deregulated lncRNAs and various biological processes, such as cell adhesion and DNA repair, with potential implications for therapeutic development.
Article
Gastroenterology & Hepatology
Lusheng Song, Minkyo Song, Charles S. Rabkin, Yunro Chung, Stacy Williams, Javier Torres, Alejandro H. Corvalan, Robinson Gonzalez, Enrique Bellolio, Mahasish Shome, Joshua LaBaer, Ji Qiu, M. Constanza Camargo
Summary: Our study provides a comprehensive assessment of anti-H. pylori antibody profiles in gastric intestinal metaplasia (IM). The identified novel antibodies against target antigens, in addition to CagA, may play a role in the progression of IM. Specific H. pylori antibodies, along with other biomarkers, can help identify IM patients for surveillance.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Parneet Cheema, Byoung Chul Cho, Helano Freitas, Mariano Provencio, Yuh Min Chen, Sang-We Kim, Yi-Long Wu, Antonio Passaro, Claudio Martin, Marcello Tiseo, Gee-Chen Chang, Keunchil Park, Benjamin Solomon, Otto Burghuber, Janessa Laskin, Ziping Wang, Sung Yong Lee, Yanping Hu, Johan Vansteenkiste, He-long Zhang, Emer Hanrahan, Thomas Geldart, Rosemary Taylor, Leslie Servidio, Jingyi Li, Filippo de Marinis
Summary: This study reports the final analysis from ASTRIS, the largest real-world study of osimertinib in patients with advanced/metastatic EGFR T790M NSCLC. The results demonstrate the clinical benefit and safety of osimertinib in this patient population.
Letter
Gastroenterology & Hepatology
M. Blanca Piazuelo, Fatima Carneiro, M. Constanza Camargo
Article
Biochemistry & Molecular Biology
Manohar Prasad Bhandari, Inese Polaka, Reinis Vangravs, Linda Mezmale, Viktors Veliks, Arnis Kirshners, Pawel Mochalski, Emmanuel Dias-Neto, Marcis Leja
Summary: This study investigated the correlation between volatile organic compounds (VOCs) in exhaled breath and the fecal microbiota in gastric cancer patients and healthy controls. The results showed that this correlation differs between cancer patients and healthy controls. The volatile metabolites in exhaled breath were highly correlated with fecal bacterial taxa in cancer patients, while the correlation was lower in healthy controls.
Article
Nutrition & Dietetics
Giulia Collatuzzo, Eva Negri, Claudio Pelucchi, Rossella Bonzi, Federica Turati, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Domenico Palli, Monica Ferraroni, Lizbeth Lopez-Carrillo, Nuno Lunet, Samantha Morais, Demetrius Albanes, Stephanie J. Weinstein, Dominick Parisi, David Zaridze, Dmitry Maximovitch, Trinidad Dierssen-Sotos, Jose Juan Jimenez-Moleon, Jesus Vioque, Manoli Garcia de la Hera, Maria Paula Curado, Emmanuel Dias-Neto, Raul Ulises Hernandez-Ramirez, Malaquias Lopez-Cervantes, Mary H. Ward, Shoichiro Tsugane, Akihisa Hidaka, Areti Lagiou, Pagona Lagiou, Zuo-Feng Zhang, Antonia Trichopoulou, Anna Karakatsani, Maria Constanza Camargo, Carlo La Vecchia, Paolo Boffetta
Summary: A meta-analysis of 16 studies found no significant association between yoghurt consumption and gastric cancer risk.
Article
Oncology
Michele Sassano, Marco Mariani, Claudio Pelucchi, Nuno Lunet, Samantha Morais, Vicente Martin, Victor Moreno, Maria Paula Curado, Emmanuel Dias-Neto, Marcis Leja, Evita Gasenko, Carlo La Vecchia, Stefania Boccia, Roberta Pastorino
Summary: This study found a potential association between proton-pump inhibitors (PPI) and gastric cancer, which may be mainly due to reverse causality. The results showed that short-term use of PPIs may increase the risk of gastric cancer, but this association becomes non-significant after using PPIs for more than 3 years.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Editorial Material
Health Care Sciences & Services
Arnoldo Riquelme, Christian C. Abnet, Karen J. Goodman, M. Blanca Piazuelo, Erika Ruiz-Garcia, Paulo Pimentel de Assumpcao, M. Constanza Camargo
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Oncology
Minkyo Song, Harindra Jayasekara, Claudio Pelucchi, Charles S. Rabkin, Kenneth C. Johnson, Jinfu Hu, Domenico Palli, Monica Ferraroni, Linda M. Liao, Rossella Bonzi, David Zaridze, Dmitry Maximovitch, Nuria Aragones, Vicente Martin, Gemma Castano-Vinyals, Marcela Guevara, Shoichiro Tsugane, Gerson Shigueaki Hamada, Akihisa Hidaka, Eva Negri, Mary H. Ward, Rashmi Sinha, Areti Lagiou, Pagona Lagiou, Paolo Boffetta, Maria Paula Curado, Nuno Lunet, Jesus Vioque, Zuo-Feng Zhang, Carlo La Vecchia, M. Constanza Camargo
Summary: This study aims to investigate and quantify the relationship between reproductive factors, menopausal hormone therapy (MHT), and gastric cancer risk in women. The results suggest a lower risk of gastric cancer in women with a longer duration of fertility and those who have used MHT after menopause.
CANCER CAUSES & CONTROL
(2023)
Meeting Abstract
Oncology
D. F. Chamorro, A. Ruiz-Patino, G. Recondo, C. Martin, L. Raez, S. Samtani, J. N. Minata, J. B. Blaquier, D. Enrico, M. Burotto, C. Ordonez-Reyes, J. B. Garcia-Robledo, L. Corrales, L. Zatarain-Barron, L. Mas, C. Sotelo, L. Ricaurte, N. Santoyo, M. Cuello, S. Mejia, E. Jaller, C. Vargas, H. Carranza, J. Otero, J. Rodriguez, P. Archila, M. Bermudez, T. Gamez, V. Cordeiro de Lima, H. Freitas, A. Russo, C. Polo, U. Malapelle, D. de Miguel-Perez, C. Rolfo, L. Viola, R. Rossell, O. Arrieta, A. F. Cardona
JOURNAL OF THORACIC ONCOLOGY
(2022)
