Article
Cell Biology
Cong Cao, Jun Li, Guangzhi Li, Gaoyu Hu, Zhihua Deng, Bing Huang, Jing Yang, Jiequn Li, Song Cao
Summary: The study found that TMEM220-AS1 is significantly downregulated in HCC, promoting proliferation and metastasis of HCC cells through the miR-484/MAGI1 axis, demonstrating an important biological function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jinjun Ye, Jidong Liu, Tao Tang, Le Xin, Xing Bao, Yukuang Yan
Summary: The study revealed that FoxD2-AS1 functions as an oncogene in CRC progression, while miR-4306 can inhibit the malignant behaviors of CRC by regulating FoxD2-AS1. The findings provide a promising therapeutic target for CRC treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Mahafujul Islam Quadery Tonmoy, Atqiya Fariha, Ithmam Hami, Kumkum Kar, Hasan Al Reza, Newaz Mohammed Bahadur, Md Shahadat Hossain
Summary: This study characterized the epigenetic landscape and expression profiles of lncRNAs in prostate cancer and identified potential prognostic biomarkers related to patient survival. These findings provide new insights into the understanding of lncRNA regulation by aberrant DNA methylation and the underlying epigenetic mechanisms in prostate cancer.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Hongbo Jiao, Geng Ji, Binjie Luo, Chuanjun Chen
Summary: This study revealed the important role of circCOL5A1 in keloid formation. Inhibition of circCOL5A1 was found to suppress the proliferation, migration, and invasion of keloid fibroblasts and promote apoptosis. Furthermore, circCOL5A1 exerted its effects by regulating the expression of miR-877-5p and EGR1.
Article
Surgery
Xiaoguang Su, Yaohui Ma, Qing Wang, Yanjun Gao
Summary: The study identified that the HOXA11-AS-miR-205-5p-FOXM1 pathway plays a role in the progression of keloid, indicating a potential mechanism for therapeutic intervention in keloid management.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Cell Biology
Yun Liu, Lei Li, Jia-Yao Wang, Fei Gao, Xia Lin, Shi-Shuai Lin, Zhi-Yang Qiu, Zun-Hong Liang
Summary: This study investigates the mechanism and function of GNAS antisense-1 (GNAS-AS1) in keloids. GNAS-AS1 is found to be upregulated in keloid clinical tissues and promotes cell proliferation, migration, and invasion. miR-188-5p and RUNX2 expression are negatively regulated by GNAS-AS1, and their inhibition or overexpression affects keloid cell growth and migration. These findings suggest that GNAS-AS1 could be a potential therapeutic target for keloid prevention and treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Qi Zhou, Yuan Li, Lujun Chen, Xiao Zheng, Tianwei Jiang, Juan Liu, Yuanyuan Fu, Liping Guan, Jingfang Ju, Changping Wu
Summary: This study identified the regulatory relationship between lncRNA GRIK1-AS1 and the miR-375/IFIT2 axis in gastric cancer. It demonstrated that GRIK1-AS1 acts as a sponge for miR-375, impacting the progression of gastric cancer by modulating target mRNA IFIT2 translation. These findings provide a novel strategy for future therapeutic development based on GRIK1-AS1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Qiqi Zhou, Yan Zhang, Meiqing Zhao, Xia Zhao, Hongwei Xue, Shuxin Xiao
Summary: This study confirmed the expression of CACNA1G-AS1 in DLBCL and its association with clinical staging. The study revealed that knockdown of CACNA1G-AS1 increased cytotoxicity and facilitated apoptosis in DLBCL cells, while overexpression of miR-3160-5p had similar effects. The findings suggest that CACNA1G-AS1 and miR-3160-5p may serve as novel therapeutic targets for DLBCL.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Dermatology
Yu Guo, Mengjuan Li, Jianhong Long, Pengju Fan, Chenchen Zuo, Yongjie Wang
Summary: This study discovers that lncRNA-ZNF252P-AS1 plays a role in keloid formation and verifies its high expression in clinical and cellular experiments. Further analysis and experiments indicate that lncRNA-ZNF252P-AS1 affects keloid formation by regulating the miR-15b-5p/BTF3 signaling pathway. Therefore, lncRNA-ZNF252P-AS1 may serve as a potential target for keloid treatment.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Qing Chen, Lin Zhou, De Ma, Juan Hou, Yuxin Lin, Jie Wu, Min Tao
Summary: In this study, GAS6-AS1 was found to be highly expressed in colorectal cancer and associated with poor prognosis. GAS6-AS1 upregulated TRIM14 expression by competitively binding to miR-370-3p and miR-1296-5p, and interacted with FUS to stabilize TRIM14 mRNA. GAS6-AS1 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition in colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Junpeng Feng, Jianhang Li, Peng Qie, Zhenhua Li, Yanzhao Xu, Ziqiang Tian
Summary: This study identified a new lncRNA PGM5P4-AS1, which was lower expressed in lung cancer tissues and could inhibit the proliferation, migration, and invasion abilities of lung cancer cells when overexpressed. PGM5P4-AS1 positively regulated the expression of LZTS3 by sponging miR-1275.
Article
Cell Biology
Jun Huang, Qiuhua Yu, Yanjuan Zhou, Ying Chu, Feng Jiang, Qiang Wang
Summary: Our study demonstrated that FAM201A was significantly upregulated in LUAD tissues and cells, and its knockdown suppressed cell proliferation, migration, and invasion while promoting apoptosis. FAM201A was shown to affect LUAD progression by targeting miR-7515 to promote GLO1 expression. Additionally, FAM201A downregulation also suppressed LUAD development in vivo, indicating its potential as a novel therapeutic target for LUAD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Lei Wang, Ying Tan, Ziyu Zhu, Jun Chen, Qiang Sun, Zhibin Ai, Chunqi Ai, Yu Xing, Guohou He, Yong Liu
Summary: The study demonstrates that ATP2B1-AS1 is upregulated in cerebral ischemia/reperfusion injury, and regulates cell survival, apoptosis, and inflammation through miR-330-5p and TLR4. Additionally, ATP2B1-AS1 affects neurological function in rats and their performance in the Morris water maze test.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xinyu Tang, YiHe Wu, Jie Yang, Wenyu Zhu
Summary: The COX10-AS1/miR-142-5p/PAICS axis, identified as a ceRNA regulatory network, influences the apoptosis and proliferation of non-small cell lung cancer cells by activating the glycolysis pathway.