Studies on DNA-related enzymes to elucidate molecular mechanisms underlying genetic information processing and their application in genetic engineering

Activation of the mismatch-specific endonuclease EndoMS/NucS by the replication clamp is required for high fidelity DNA replication

(2018) Sonoko Ishino et al.   NUCLEIC ACIDS RESEARCH

Engineering the Delivery System for CRISPR-Based Genome Editing

(2018) Zachary Glass et al.   TRENDS IN BIOTECHNOLOGY

Direct visualization of DNA baton pass between replication factors bound to PCNA

(2018) Kouta Mayanagi et al.   Scientific Reports

Elucidating functions of DP1 and DP2 subunits from the Thermococcus kodakarensis family D DNA polymerase

(2018) Natsuki Takashima et al.   EXTREMOPHILES

A longer finger-subdomain of family A DNA polymerases found by metagenomic analysis strengthens DNA binding and primer extension abilities

(2016) Takeshi Yamagami et al.   GENE

Origins of Programmable Nucleases for Genome Engineering

(2016) Srinivasan Chandrasegaran et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea

(2016) Sonoko Ishino et al.   NUCLEIC ACIDS RESEARCH

Structure of the EndoMS-DNA Complex as Mismatch Restriction Endonuclease

(2016) Setsu Nakae et al.   STRUCTURE

EndoQ and EndoV work individually for damaged DNA base repair in Pyrococcus furiosus

(2015) Sonoko Ishino et al.   BIOCHIMIE

A novel endonuclease that may be responsible for damaged DNA base repair in Pyrococcus furiosus

(2015) Miyako Shiraishi et al.   NUCLEIC ACIDS RESEARCH

Biochemical characterization of endonuclease V from the hyperthermophilic archaeon, Pyrococcus furiosus

(2014) S. Kiyonari et al.   JOURNAL OF BIOCHEMISTRY

Multiple Interactions of the Intrinsically Disordered Region between the Helicase and Nuclease Domains of the Archaeal Hef Protein

(2014) Sonoko Ishino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant Taq DNA polymerases with improved elongation ability as a useful reagent for genetic engineering

(2014) Takeshi Yamagami et al.   Frontiers in Microbiology

DNA polymerases as useful reagents for biotechnology – the history of developmental research in the field

(2014) Sonoko Ishino et al.   Frontiers in Microbiology

Archaeal DNA Polymerase D but Not DNA Polymerase B Is Required for Genome Replication in Thermococcus kodakarensis

(2013) L. Cubonova et al.   JOURNAL OF BACTERIOLOGY

Genome-scale analysis of gene function in the hydrogenotrophic methanogenic archaeon Methanococcus maripaludis

(2013) F. Sarmiento et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

(2012) G. Gasiunas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Rapid progress of DNA replication studies in Archaea, the third domain of life

(2012) Yoshizumi Ishino et al.   Science China-Life Sciences

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

(2011) Rimantas Sapranauskas et al.   NUCLEIC ACIDS RESEARCH

Architecture of the DNA polymerase B-proliferating cell nuclear antigen (PCNA)-DNA ternary complex

(2011) Kouta Mayanagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas, the Immune System of Bacteria and Archaea

(2010) P. Horvath et al.   SCIENCE

Studies on the base excision repair (BER) complex inPyrococcus furiosus

(2009) Shinichi Kiyonari et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus

(2009) Shinichi Kiyonari et al.   NUCLEIC ACIDS RESEARCH

Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex

(2009) H. Nishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of replication machinery assembly as revealed by the DNA ligase-PCNA-DNA complex architecture

(2009) K. Mayanagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical and Functional Interactions between Uracil-DNA Glycosylase and Proliferating Cell Nuclear Antigen from the EuryarchaeonPyrococcus furiosus

(2008) Shinichi Kiyonari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

(2008) S. J. J. Brouns et al.   SCIENCE

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

(2008) Luciano A. Marraffini et al.   SCIENCE

Virus Population Dynamics and Acquired Virus Resistance in Natural Microbial Communities

(2008) A. F. Andersson et al.   SCIENCE