Article
Chemistry, Multidisciplinary
Steffen Wolf, Benedikt Sohmen, Bjorn Hellenkamp, Johann Thurn, Gerhard Stock, Thorsten Hugel
Summary: The study investigates how ATP hydrolysis causes structural changes in proteins and the hierarchical dynamics process using Hsp90 as a model system.
The process involves timescales ranging from nanoseconds to milliseconds and length scales from angstroms to several nanometers, with conformational changes and structural information transfer leading to structural asymmetry in proteins.
The findings suggest that similar mechanisms may be fundamental for information transfer induced by ATP hydrolysis in many other proteins.
Article
Chemistry, Multidisciplinary
Elad Arad, Gal Yosefi, Sofiya Kolusheva, Ronit Bitton, Hanna Rapaport, Raz Jelinek
Summary: Glucagon amyloid fibrils have been found to catalyze important biological reactions, including dephosphorylation of ATP. The catalytic activity is located in an enzymatic pocket-like triad formed on the surface of the glucagon fibrils.
Article
Chemistry, Multidisciplinary
Sebastian Roth, Somayyeh Gandomkar, Federico Rossi, Melanie Hall
Summary: This study explores the biocatalytic potential of bacterial enzymes OplA and OplB for the hydrolysis of medium-sized lactams. By optimizing reaction conditions, improving protein expression and stability, and using a cheap recycling system for ATP, high conversion rates were achieved.
Article
Chemistry, Physical
Sriramvignesh Mani, Harshwardhan H. Katkar, Gregory A. Voth
Summary: The study presents an Ultra-Coarse-Grained model of actin filaments that can simulate ATP hydrolysis, inorganic phosphate release, and depolymerization reactions. The effects of compressive and tensile strains on the rates of reactions are analyzed, with compressive strains decreasing the rate of ATP hydrolysis and increasing the Pi release rate, while tensile strain has the opposite effect. Incorporating these predictions into a Markov State Model reveals that strains alter the steady-state distribution of subunits with ADPPi and ADP nucleotide, potentially impacting the binding of regulatory proteins to actin filaments.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2021)
Article
Cell Biology
Kaiming Cao, Shixuan Li, Yu Wang, Hongze Hu, Sijia Xiang, Qianling Zhang, Yangzhong Liu
Summary: Recently, it has been discovered that bacterial cells contain membrane-less organelles formed by liquid-liquid phase separation of proteins or nucleic acids. In this study, it was found that the bacterial nickel-responsive regulatory protein, NikR, exhibits liquid-liquid phase separation in both solution and cells. Furthermore, disrupting the phase separation promotes the expression of nickel transporter genes, suggesting that the formation of these membrane-less compartments is a regulatory mechanism in bacterial cells.
Article
Materials Science, Multidisciplinary
Francisco de Azambuja, Nele Steens, Tatjana N. Parac-Vogt
Summary: The reactivity of polyoxovanadates towards ATP hydrolysis was studied at different pH levels, showing significant acceleration in lower pH conditions. However, the effectiveness decreased as the pH of the reaction solution increased, with still observable rate increase at pH=7 compared to blank reactions. Interactions between vanadate species and ATP mainly occurred with phosphate groups rather than other regions of the ATP molecule, as revealed by NMR spectroscopy.
Article
Cell Biology
Bezia Lemma, Celeste M. Nelson
Summary: Biophysical signaling is crucial for tissue morphogenesis, requiring a significant amount of energy. Recent studies have shown spatial variations in energy metabolism, correlating with patterns of mechanical forces. This review defines and discusses the concept of energy metabolism during tissue morphogenesis, highlighting its spatial variations across different model systems and proposing methods for quantitative measurements of energy production and consumption.
CURRENT OPINION IN CELL BIOLOGY
(2023)
Article
Behavioral Sciences
Yonatan M. Kupchik, Asheeta A. Prasad
Summary: The ventral pallidum plays a crucial role in drug seeking and relapse, with complex neurobiology involving neural anatomical subregions, cellular heterogeneity, circuitry, neurotransmitters, and peptides. Targeting the VP can reduce relapse rates and alleviate addiction symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Chemistry, Physical
Meredith M. Rickard, Haolin Luo, Ashley De Lio, Martin Gruebele, Taras V. Pogorelov
Summary: The cytoplasm affects the conformation of ATP, with ATP molecules bound to proteins in cells forming specific pitched conformations. These interactions may play functional roles when ATP interacts with protein surfaces.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Neurosciences
Xiao-Jing Yu, Tong Xiao, Xiao-Jing Liu, Ying Li, Jie Qi, Nianping Zhang, Li-Yan Fu, Kai-Li Liu, Yanjun Li, Yu-Ming Kang
Summary: Knocking down Nrf1 suppresses sympathoexcitation in hypertension by reducing PVN transcription of NMDAR subunits (GluN1, GluN2A, and GluN2B), rebalancing PVN excitatory and inhibitory neurotransmitters, inhibiting PVN neuronal activity and oxidative stress, and attenuating sympathetic activity.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Physics, Multidisciplinary
Solange Flatt, Daniel Maria Busiello, Stefano Zamuner, Paolo de los Rios
Summary: ATP-binding cassette (ABC) transporters are biological machines that perform crucial import or export of substrates across membranes, driven by ATP hydrolysis. We propose a model that shows ABC transporters are molecular realizations of autonomous Maxwell Demons, which use information to drive systems out of equilibrium. Our framework provides a bridge between the molecular-level description and the language of information theory for ABC transporters.
COMMUNICATIONS PHYSICS
(2023)
Article
Multidisciplinary Sciences
Yusuke Kanematsu, Akihiro Narita, Toshiro Oda, Ryotaro Koike, Motonori Ota, Yu Takano, Kei Moritsugu, Ikuko Fujiwara, Kotaro Tanaka, Hideyuki Komatsu, Takayuki Nagae, Nobuhisa Watanabe, Mitsusada Iwasa, Yuichiro Maeda, Shuichi Takeda
Summary: This study reveals the reaction mechanism of ATP hydrolysis by actin. Through structural analysis and calculations, the researchers have identified a specific reaction path, explaining the slow rate and irreversibility of actin ATP hydrolysis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biotechnology & Applied Microbiology
Mengchen Shi, Yu Tian, Lingyuan He, Jingdan Zhang, Xiangling Yang, Huanliang Liu
Summary: This study evaluated the serum levels of nucleotide-metabolizing enzymes in patients with colorectal cancer and found that ATPase and AMPase activities were significantly higher in colorectal cancer patients, providing considerable diagnostic significance. The combination of CEA, ATPase, and AMPase could be a novel approach for colorectal cancer screening.
Review
Cell Biology
Donnell White, Qinglin Yang
Summary: ATP is the primary molecule for storing and transferring energy in cells, produced by mitochondria and cytosolic glycolysis. Mitochondria produce most cellular ATP under normal oxygen conditions, while cytosolic glycolysis plays a major role in proliferating cells or hypoxic conditions. Under pathological conditions, ATP demand increases, affecting the function and communication of mitochondria and cytosolic glycolysis.
Article
Pharmacology & Pharmacy
Qing Su, Xiao-Jing Yu, Xiao-Min Wang, Hong-Bao Li, Ying Li, Juan Bai, Jie Qi, Nianping Zhang, Kai-Li Liu, Yan Zhang, Guo-Qing Zhu, Yu-Ming Kang
Summary: Long-term high salt diet induces oxidative stress and increases blood pressure in the paraventricular nucleus (PVN), while extracellular superoxide dismutase (Ec-SOD) can reduce hypertension by inhibiting oxidative stress and improving excitatory neurotransmitter release.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Solomon E. Owumi, Michael A. Gbadegesin, Oyeronke A. Odunola, Ayodeji M. Adegoke, Anthony O. Uwaifo
ENVIRONMENTAL TOXICOLOGY
(2015)
Article
Chemistry, Applied
Aliyu Muhammad, Oyeronke A. Odunola, Michael A. Gbadegesin, Ayodeji M. Adegoke, J. Olorunjuwon Olugbami, Ndidi S. Uche
NATURAL PRODUCT RESEARCH
(2015)
Article
Nutrition & Dietetics
John O. Ige, Michael A. Gbadegesin, Jeremiah O. Olugbami, Ayodeji M. Adegoke, Oyeronke A. Odunola, Gloria O. Anetor, John I. Anetor
Summary: The study found that exposure to Baygon(R) led to significantly increased levels of arsenic and selenium, while zinc levels decreased significantly in rats. Histologically, rats treated with SA showed moderate fibrous hyperplasia in the liver and thickened alveolar walls in the lung; while those treated with Baygon(R) exhibited mild hyperplasia of fibrous connective tissue and severe thickening of alveolar walls in the lung.
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Mamello Sekhoacha, Keamogetswe Riet, Paballo Motloung, Lemohang Gumenku, Ayodeji Adegoke, Samson Mashele
Summary: Prostate cancer is a malignancy that affects men globally and presents either as localized or advanced disease. This article aims to provide a comprehensive overview of prostate cancer, including disease diagnosis, pathogenic gene mutations, and treatment options. Ongoing research is focusing on alternative treatment approaches such as traditional medicine, nanotechnologies, and gene therapy to combat prostate cancer, drug resistance, and reduce adverse effects.
Article
Pharmacology & Pharmacy
A. J. Salemcity, John Oludele Olanlokun, A. O. Olowofolahan, F. O. Olojo, Ayodeji Mathias Adegoke, O. O. Olorunsogo
Summary: This study investigated the effects of the chloroform fraction of Ocimum gratissimum (OG) leaf in reversing tissue wastage in diabetes mellitus. The results showed that CFOG reversed diabetic-induced cell death, reduced insulin resistance, improved insulin β-cell function, and promoted pancreatic cell regeneration.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ipeleng Kopano Rosinah Kgosiemang, Ayodeji Mathias Adegoke, Samson Sitheni Mashele, Mamello Patience Sekhoacha
Summary: This study synthesized iron oxide and iron dioxide nanoparticles using E. tirucalli plants and analyzed their potential antiproliferative effect against cancer cell lines. The results showed promising activity, highlighting the environmentally friendly and safe application of iron oxide nanoparticles in cancer therapy.
JOURNAL OF EXPERIMENTAL NANOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ayodeji Mathias Adegoke, Michael Adedapo Gbadegesin, Oyeronke Adunni Odunola
PHARMACOGNOSY RESEARCH
(2017)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)