期刊
BIOMARKERS IN MEDICINE
卷 14, 期 12, 页码 1091-1097出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2020-0309
关键词
biomarkers; COVID-19; CRP; D-dimer; ferritin; infectious diseases; interleukin-6; LDH
Aim: To describe the association between D-dimer, CRP, IL-6, ferritin, LDH and the clinical outcomes in a cohort of 299 novel coronavirus disease (COVID-19) patients treated on the inpatient medical service at a university hospital in the District of Columbia (DC, USA). Methodology & results: In this retrospective study, we included all laboratory confirmed COVID-19 adults admitted to the inpatient medicine service at the GeorgeWashington University Hospital between March 12, 2020 andMay 9, 2020. We analyzed the association of biomarkers on intensive care unit transfer, intubation and mortality. Threshold values for all biomarkers were found to be statistically significant and independently associated with higher odds of clinical deterioration and death. Conclusion: Laboratory markers of inflammation and coagulopathy can help clinicians identify patients who are at high risk for clinical deterioration in COVID-19.
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